Brands can successfully differentiate themselves through strategic differentiation using various approaches such as product differentiation by providing additional features, channel differentiation by choosing unique distribution methods, and image differentiation by crafting a distinctive brand personality. The document discusses how brands like Singapore Airlines and McDonald's have differentiated based on personnel by having courteous flight attendants and employees. It notes that competitive advantages can come from differentiating products, channels, images, personnel, technology or other leverageable advantages.