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Ectodermal Placodes
and the Epidermis
Placodes
All of our senses started out
as placodes- thickenings in
the surface ectoderm in the
cephalic region
After the neural ectoderm
moves inward to form the
CNS and PNS, the non-neural
ectoderm forms the
placodes.
Sensory placodes give rise to
among the following:
Lens of the eye
Part of the inner ear
Nasal organs
Olfactory epithelium
Cranial Placodes
• These are thickenings of the head and neck regions of the embryo
• They will eventually migrate away from the ectoderm and become sensory
tissue (except the lens and adenohypophyseal placode)
• A lot of this is from the Wht signaling which comes from the neural tube. This
will induce the ectoderm to differentiate into the different placodes.
The
Anterior
Cranial
Placodes
Adenohypophyseal placode- will
become the anterior lobe of the
pituitary gland
Lens placode- will become the
lens of the eye
Olfactory placode- will become
the 1st cranial nerve (CN I) and
contribute to smell
Intermediate Cranial Placodes
• Trigeminal placode- this is subdivided into
• Ophthalmic placode
• Maxillomandibular placode
• These will become CNV (5th cranial nerve), which is a facial nerve and
also contribute to the nasal cavity
• Otic placode- sensory epithelium of the inner ear and the 8th cranial nerve
(coclear-vestibular). This is involved in hearing and balance
• Epibranchial placodes
• Geniculate- taste buds, tonsils
• Petrosal- tongue, carotid bodies
• Nodose- heart, lungs, GI tract
Cranial Placode Induction
• FGF will turn neural crest cells into pre-neural cells.
• If Anti-BMP and Anti Wnt is expressed, then they will become neural cells
• Otherwise, they become border cells
• If Anti-BMP and Anti-Wnt are expressed in the border cells at this point, they
become Pan-Placodal cells
• From this point, they can differentiate into other placodes
The Epidermis and Its Cutaneous Appendages
• The epidermis comes from ectodermal cells
• The surface ectoderm becomes the epidermis instead of neural tissue because
of BMPs (bone morphogenic proteins)
• BMPs promote epidermal specification and blocks the neural pathway
The Epidermis
• The basal layer of the epidermis contains the
stratum basale (germinavitium)
• This layer sits on the basal lamina
• This layer of cells are asymmetrical stem cells
• This layer will rise to upper layers of the skin
and become:
• More keratinized (waterproofed and
hardened)
• Flat (they go from a cuboidal shape to a
squamous shape)
• Dead
• The most superficial layer of the skin is the
stratum corneum
The Ectodermal
Appendages
• Examples of ectodermal
appendages are:
• Hair
• Teeth
• Sweat glands
• Mammary glands
• Forming these appendages
require interaction between
ectodermal epithelium and
mesenchyme.
• They form the epidermal placodes

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BIO420 Chapter 16

  • 2. Placodes All of our senses started out as placodes- thickenings in the surface ectoderm in the cephalic region After the neural ectoderm moves inward to form the CNS and PNS, the non-neural ectoderm forms the placodes. Sensory placodes give rise to among the following: Lens of the eye Part of the inner ear Nasal organs Olfactory epithelium
  • 3. Cranial Placodes • These are thickenings of the head and neck regions of the embryo • They will eventually migrate away from the ectoderm and become sensory tissue (except the lens and adenohypophyseal placode) • A lot of this is from the Wht signaling which comes from the neural tube. This will induce the ectoderm to differentiate into the different placodes.
  • 4. The Anterior Cranial Placodes Adenohypophyseal placode- will become the anterior lobe of the pituitary gland Lens placode- will become the lens of the eye Olfactory placode- will become the 1st cranial nerve (CN I) and contribute to smell
  • 5. Intermediate Cranial Placodes • Trigeminal placode- this is subdivided into • Ophthalmic placode • Maxillomandibular placode • These will become CNV (5th cranial nerve), which is a facial nerve and also contribute to the nasal cavity • Otic placode- sensory epithelium of the inner ear and the 8th cranial nerve (coclear-vestibular). This is involved in hearing and balance • Epibranchial placodes • Geniculate- taste buds, tonsils • Petrosal- tongue, carotid bodies • Nodose- heart, lungs, GI tract
  • 6. Cranial Placode Induction • FGF will turn neural crest cells into pre-neural cells. • If Anti-BMP and Anti Wnt is expressed, then they will become neural cells • Otherwise, they become border cells • If Anti-BMP and Anti-Wnt are expressed in the border cells at this point, they become Pan-Placodal cells • From this point, they can differentiate into other placodes
  • 7. The Epidermis and Its Cutaneous Appendages • The epidermis comes from ectodermal cells • The surface ectoderm becomes the epidermis instead of neural tissue because of BMPs (bone morphogenic proteins) • BMPs promote epidermal specification and blocks the neural pathway
  • 8. The Epidermis • The basal layer of the epidermis contains the stratum basale (germinavitium) • This layer sits on the basal lamina • This layer of cells are asymmetrical stem cells • This layer will rise to upper layers of the skin and become: • More keratinized (waterproofed and hardened) • Flat (they go from a cuboidal shape to a squamous shape) • Dead • The most superficial layer of the skin is the stratum corneum
  • 9. The Ectodermal Appendages • Examples of ectodermal appendages are: • Hair • Teeth • Sweat glands • Mammary glands • Forming these appendages require interaction between ectodermal epithelium and mesenchyme. • They form the epidermal placodes