Embryology of the Central Nevous system and anomaliesNyombi Eric
1. The document discusses the embryology and development of the central nervous system (CNS) and peripheral nervous system (PNS). It describes how the neural tube forms from the ectoderm and develops into the brain and spinal cord (CNS) while the neural crest gives rise to the PNS.
2. Key stages of brain development are described, including the formation of the primary brain vesicles and their subdivision into the five secondary vesicles that make up the adult brain. Congenital anomalies that can affect the brain and spinal cord are also mentioned.
3. The development of the spinal cord is outlined, including the formation of the central canal and dorsal root ganglia from neural crest cells. Changes in the position
Spina bifida is a neural tube defect that occurs when the spine and spinal cord do not form properly in an embryo. It results from defective closure of the neural tube during the first month of development. There are several types of spina bifida ranging from mild cases with no protrusion to more severe cases involving protrusion of membranes or spinal tissue. Management involves surgery to close the defect along with a multidisciplinary approach to minimize physical and intellectual impairments.
USMLE neuroanatomy neuroanatomy 019 CNS development .pdfAHMED ASHOUR
The development of the CNS is a fascinating process that occurs during embryonic development and continues into early childhood.
Disruptions or abnormalities during this process can lead to a wide range of neurological disorders and developmental disabilities.
Understanding the mechanisms underlying CNS development is critical for advancing our knowledge of brain development and for developing new therapies for neurological disorders.
Embryological development of the nervous system and specialVernon Pashi
The document summarizes key stages in the embryological development of the nervous system and special senses. It describes how the neural plate forms and folds to become the neural tube. It then discusses the formation of the three germ layers and how neural induction occurs. It provides details on neurulation and neural tube formation, as well as common defects that can arise. It also summarizes the development of the main divisions and structures of the brain and spinal cord.
The document summarizes key stages of central nervous system development from neurulation through embryonic development of the brain and spinal cord. It discusses:
- Formation of the neural tube from ectoderm and neural crest cells by the 4th week
- Development of the brain into 5 vesicles and their adult structures by the 5th week
- Formation of the ventricular system and spinal cord plates, horns, and central canal
- Development of the meninges and pituitary gland from surrounding tissues
The neural tube develops from the ectoderm and forms the central nervous system. Neurulation involves the formation of the neural plate which elevates and fuses to form the neural tube. Neural crest cells dissociate and give rise to many structures. The brain develops from three primary vesicles-the prosencephalon, mesencephalon, and rhombencephalon. The spinal cord arises from the lower neural tube. Neurons and glia differentiate and migrate within the neural tube. Fusion of the neural folds and closure of neuropores must occur properly to prevent neural tube defects.
The document discusses the development of the nervous system. It begins with the formation of the neural tube from ectodermal tissue around the 3rd week of embryonic development. The neural tube then develops into the central nervous system. Around the 4th week, the neural tube develops into three primary brain vesicles - the prosencephalon, mesencephalon, and rhombencephalon. By the 5th week, these vesicles further subdivide into five secondary vesicles that will give rise to the different regions of the brain. The neural crest cells also migrate and differentiate into many cell types. Malformations like spina bifida can occur if the neural tube fails to close properly.
Neural tube defects: Importance of Folic Acid and Vitamin B12 intakeVijaya Sawant,PMP, OCP
Birth defects are a global problem, but their impact is particularly severe in middle and low income countries where more than 94 percent of the births with serious birth defects and 95 percent of the deaths of these children occur. Serious birth defect can be lethal. For those who survive, these disorders can cause lifelong mental, physical, auditory or visual disability. The report shows that at least 3.3 million children under five years of age die from birth defects each years. More than 70% of birth defects can be prevented. Educate the community about the birth defects and the opportunities for effective care and prevention.
Embryology of the Central Nevous system and anomaliesNyombi Eric
1. The document discusses the embryology and development of the central nervous system (CNS) and peripheral nervous system (PNS). It describes how the neural tube forms from the ectoderm and develops into the brain and spinal cord (CNS) while the neural crest gives rise to the PNS.
2. Key stages of brain development are described, including the formation of the primary brain vesicles and their subdivision into the five secondary vesicles that make up the adult brain. Congenital anomalies that can affect the brain and spinal cord are also mentioned.
3. The development of the spinal cord is outlined, including the formation of the central canal and dorsal root ganglia from neural crest cells. Changes in the position
Spina bifida is a neural tube defect that occurs when the spine and spinal cord do not form properly in an embryo. It results from defective closure of the neural tube during the first month of development. There are several types of spina bifida ranging from mild cases with no protrusion to more severe cases involving protrusion of membranes or spinal tissue. Management involves surgery to close the defect along with a multidisciplinary approach to minimize physical and intellectual impairments.
USMLE neuroanatomy neuroanatomy 019 CNS development .pdfAHMED ASHOUR
The development of the CNS is a fascinating process that occurs during embryonic development and continues into early childhood.
Disruptions or abnormalities during this process can lead to a wide range of neurological disorders and developmental disabilities.
Understanding the mechanisms underlying CNS development is critical for advancing our knowledge of brain development and for developing new therapies for neurological disorders.
Embryological development of the nervous system and specialVernon Pashi
The document summarizes key stages in the embryological development of the nervous system and special senses. It describes how the neural plate forms and folds to become the neural tube. It then discusses the formation of the three germ layers and how neural induction occurs. It provides details on neurulation and neural tube formation, as well as common defects that can arise. It also summarizes the development of the main divisions and structures of the brain and spinal cord.
The document summarizes key stages of central nervous system development from neurulation through embryonic development of the brain and spinal cord. It discusses:
- Formation of the neural tube from ectoderm and neural crest cells by the 4th week
- Development of the brain into 5 vesicles and their adult structures by the 5th week
- Formation of the ventricular system and spinal cord plates, horns, and central canal
- Development of the meninges and pituitary gland from surrounding tissues
The neural tube develops from the ectoderm and forms the central nervous system. Neurulation involves the formation of the neural plate which elevates and fuses to form the neural tube. Neural crest cells dissociate and give rise to many structures. The brain develops from three primary vesicles-the prosencephalon, mesencephalon, and rhombencephalon. The spinal cord arises from the lower neural tube. Neurons and glia differentiate and migrate within the neural tube. Fusion of the neural folds and closure of neuropores must occur properly to prevent neural tube defects.
The document discusses the development of the nervous system. It begins with the formation of the neural tube from ectodermal tissue around the 3rd week of embryonic development. The neural tube then develops into the central nervous system. Around the 4th week, the neural tube develops into three primary brain vesicles - the prosencephalon, mesencephalon, and rhombencephalon. By the 5th week, these vesicles further subdivide into five secondary vesicles that will give rise to the different regions of the brain. The neural crest cells also migrate and differentiate into many cell types. Malformations like spina bifida can occur if the neural tube fails to close properly.
Neural tube defects: Importance of Folic Acid and Vitamin B12 intakeVijaya Sawant,PMP, OCP
Birth defects are a global problem, but their impact is particularly severe in middle and low income countries where more than 94 percent of the births with serious birth defects and 95 percent of the deaths of these children occur. Serious birth defect can be lethal. For those who survive, these disorders can cause lifelong mental, physical, auditory or visual disability. The report shows that at least 3.3 million children under five years of age die from birth defects each years. More than 70% of birth defects can be prevented. Educate the community about the birth defects and the opportunities for effective care and prevention.
The document provides an overview of neural development from the first three weeks of embryogenesis through neurulation and the formation of the spinal cord and brain. It discusses the formation and differentiation of the three germ layers and neural tube. It also summarizes the development of the brain vesicles and flexures that form the hindbrain, midbrain, and forebrain. Finally, it discusses some clinical correlations including neural tube defects and Chiari malformations.
Spina bifida is a birth defect where the spine and spinal cord do not form properly. It occurs when the neural tube fails to close fully during early embryonic development. The most common type is myelomeningocele, where parts of the spinal cord and meninges protrude out of an opening in the spine. This can cause paralysis, loss of feeling, and problems with bladder and bowel control below the level of the defect. Treatment involves surgery to close the opening and manage any related complications like hydrocephalus. Prevention focuses on adequate folic acid intake before and during early pregnancy.
1. The formation and development of the spine and spinal cord occurs through several key embryonic stages including gastrulation, neurulation, and organogenesis.
2. During gastrulation, the neural plate forms from ectoderm and folds to become the neural tube in a process called neurulation. The neural tube then undergoes craniocaudal closure.
3. Spinal dysraphism refers to defects in the closure of neural, bony, or other tissues along the midline of the spine during development. This results in open defects like myelomeningocele or closed defects like lipomyelomeningocele.
This randomized controlled trial compared the effectiveness of weekly iron-folic acid supplements containing 2.8 mg of folic acid versus the standard 0.4 mg in reducing the risk of neural tube defects in Malaysia. The study found that supplements containing 2.8 mg folic acid were associated with a lower risk of neural tube defects compared to the current practice of 0.4 mg. This provides evidence that switching to supplements with the higher 2.8 mg dose of folic acid recommended by WHO could further reduce the risk of these birth defects.
The central nervous system develops from the ectoderm and forms the neural tube which will become the brain and spinal cord. The neural tube develops brain vesicles which become the forebrain, midbrain and hindbrain. The hindbrain further develops into the cerebellum, pons and medulla. Neuroepithelial cells form the inner layer and produce neuroblasts which migrate outward to form the mantle layer and later the gray matter. Glial cells and neurons develop from progenitor cells. The spinal cord develops basal and alar plates which form motor and sensory areas. Spinal nerves form from ventral motor and dorsal sensory roots. The central nervous system continues developing after birth with myelination of axons.
The central nervous system develops from the ectoderm and forms the neural tube which will become the brain and spinal cord. The neural tube develops brain vesicles which become the forebrain, midbrain and hindbrain. The hindbrain further develops into the cerebellum, pons and medulla. Neuroepithelial cells form the inner layer and produce neuroblasts which migrate outward to form the mantle layer and later the gray matter. Glial cells and neurons develop from progenitor cells. The spinal cord develops basal and alar plates which form motor and sensory areas. Spinal nerves form from ventral motor and dorsal sensory roots. The central nervous system continues developing after birth with myelination of axons.
During the 3rd week of development, gastrulation occurs which involves the formation of the three germ layers - ectoderm, mesoderm, and endoderm. This transforms the bilaminar embryo into a trilaminar embryo with distinct layers. Neurulation also occurs, forming the neural tube which will later become the central nervous system. By the end of the 3rd week, the foundation is laid for all major organ systems as each germ layer gives rise to specific tissues and organs.
Lecture fourteen neuroanatomy, Embryology of the CNS.pdfNatungaRonald1
The central nervous system develops from the neural plate which forms the neural tube. The cephalic end forms three brain vesicles - the prosencephalon, mesencephalon, and rhombencephalon. The prosencephalon forms the telencephalon and diencephalon. The telencephalon develops into the cerebral hemispheres and the diencephalon forms the thalamus, hypothalamus, and pituitary gland. The rhombencephalon forms the cerebellum, pons, and medulla. Neuroepithelial cells lining the neural tube differentiate into neuroblasts which form the gray matter surrounded by white matter. Basal and alar plates in the spinal cord and brain
The document discusses the 12 pairs of cranial nerves. It provides detailed information on the olfactory, optic, oculomotor, trochlear, trigeminal, abducent, and facial cranial nerves. It describes the embryology, course, distribution and functions of these nerves. It also discusses various clinical conditions that can arise from injuries or lesions to the different cranial nerves.
Neural tube defects are among the most common human malformations, occurring in approximately 1-5 per 1,000 live births. They result from the failure of the neural tube to close properly during early embryonic development. There are several types of neural tube defects including anencephaly, encephalocele, spina bifida, and myelomeningocele. Folic acid supplementation before and during early pregnancy has been shown to significantly reduce the risk of neural tube defects.
1. Congenital hemivertebrae occur due to failure of somite formation during embryonic development and can cause spinal curvature or neurological problems by narrowing the spinal canal.
2. Tethered cord syndrome occurs when the spinal cord is attached at the caudal end, most commonly due to defective degeneration of the caudal cell mass.
3. Conditions that can lead to tethered cord include lipomyelomeningocele, diastematomyelia, anterior sacral meningocele, and dermal sinus, which may require surgical intervention such as laminectomy and cord release to prevent neurological problems.
Basics of Embryology and short review of congenital errors of CNS in radiolog...Dr. Dipesh Yadav
1) The central nervous system develops through primary and secondary neurulation forming the neural tube which closes between the 25th-27th day of gestation.
2) Brain vesicles form between 4-7 weeks developing into the primary brain structures. Cortical development and histogenesis of neurons and glia occurs from 5-35 weeks.
3) Common abnormalities include neural tube defects occurring from failed closure and malformations of cortical development due to abnormal proliferation, migration or organization of neurons.
Neural Induction in human brain: principles and processesNitish kumar
The document discusses neural induction and development of the nervous system from the ectoderm. It describes how the dorsal-most ectoderm thickens to form the neural plate during gastrulation. Through the process of neurulation, the neural plate folds in on itself to form the neural tube, which will later develop into the central nervous system. Neural crest cells emerge along the edges of the neural tube and go on to form many peripheral nervous system structures and other tissues. Failure of the neural tube to close properly can result in neural tube defects such as spina bifida.
The document summarizes key stages in the development of the neural tube and brain during embryogenesis. It discusses how the neural tube forms from the ectoderm and closes, forming the brain vesicles and flexures that give rise to the distinct brain regions. It describes the migration and differentiation of cells from the alar and basal plates that develop into various neuronal populations and structures of the brainstem and spinal cord. The formation and differentiation of the cerebellum, pons, midbrain, hindbrain, diencephalon and telencephalon are also covered. Critical signaling molecules that pattern the early neural tube are also mentioned.
Neurulation, Formation of Nervous System.pptxInshaPervaiz
Neurulation is the process by which the neural tube forms in the embryo. It is a critical stage in the development of the central nervous system (CNS), which includes the brain and spinal cord.
Here are the key points about neurulation:
1. *Neural plate formation*: The neural plate is a flat sheet of cells that forms from the ectoderm layer of the embryo.
2. *Folding and invagination*: The neural plate folds inwards to form a groove, which then deepens and closes to form a tube.
3. *Neural tube formation*: The neural tube is formed by the fusion of the neural folds.
4. *Closure of the neural tube*: The neural tube closes at both ends, forming the anterior (head) and posterior (spinal cord) neuropores.
5. *Brain and spinal cord development*: The neural tube differentiates into the brain and spinal cord.
Neurulation occurs around 3-4 weeks after fertilization and is a complex process that involves the coordination of multiple cellular and molecular mechanisms.
Abnormalities in neurulation can lead to neural tube defects (NTDs), such as spina bifida and anencephaly, which are birth defects that affect the CNS.
Here are some key terms related to neurulation:
- *Neural plate*: A flat sheet of cells that forms from the ectoderm layer of the embryo.
- *Neural fold*: A fold in the neural plate that forms during neurulation.
- *Neural groove*: A groove that forms in the neural plate during neurulation.
- *Neural tube*: A tube formed by the fusion of the neural folds.
- *Neuropore*: An opening at either end of the neural tube.
- *Neural crest*: A group of cells that form from the neural tube and migrate to other parts of the embryo to form various tissues.
Fate of embryonic layers and structures develope from themNizadSultana
Fate of embryonic layers and structures develope from it. Embryonic layers ectoderm mesoderm and endoderm form different structures during embryonic development.
The document discusses the development of the central nervous system and neural tube defects. It covers:
1. The CNS appears in the third week as a neural plate that folds to form the neural tube, which closes from head to tail between 4-5 weeks. Failure of closure can cause neural tube defects.
2. The most common neural tube defects are spina bifida occulta, meningocele, myelomeningocele, anencephaly, and encephalocele. Myelomeningocele is the most severe form with exposed nerves and spinal cord.
3. Prevention focuses on adequate folic acid intake before and during early pregnancy to reduce neural tube defect risk, as f
Neural tube defects are developmental abnormalities where the neural tube fails to close, leaving the brain or spinal cord exposed. The most common types are spina bifida, where part of the spine does not fully close; meningocele, where the membrane around the spinal cord pushes through an opening; and myelomeningocele, where the spinal cord and nerves push through. Risk factors include folic acid deficiency, family history, certain medications, and fever during early pregnancy. Treatment may involve surgery before or after birth as well as physical therapy to prevent deformities and support mobility.
The nervous system begins developing in the 3rd week of gestation from ectodermal tissue. The central nervous system starts as a neural plate that folds into a neural groove and then fuses to form the neural tube. The neural tube will develop into the brain and spinal cord. Neural crest cells emerge from the neural tube and migrate throughout the body, giving rise to many cell types. By the 5th week, the brain has divided into five vesicles that will form the structures of the adult brain.
The document provides an overview of neural development from the first three weeks of embryogenesis through neurulation and the formation of the spinal cord and brain. It discusses the formation and differentiation of the three germ layers and neural tube. It also summarizes the development of the brain vesicles and flexures that form the hindbrain, midbrain, and forebrain. Finally, it discusses some clinical correlations including neural tube defects and Chiari malformations.
Spina bifida is a birth defect where the spine and spinal cord do not form properly. It occurs when the neural tube fails to close fully during early embryonic development. The most common type is myelomeningocele, where parts of the spinal cord and meninges protrude out of an opening in the spine. This can cause paralysis, loss of feeling, and problems with bladder and bowel control below the level of the defect. Treatment involves surgery to close the opening and manage any related complications like hydrocephalus. Prevention focuses on adequate folic acid intake before and during early pregnancy.
1. The formation and development of the spine and spinal cord occurs through several key embryonic stages including gastrulation, neurulation, and organogenesis.
2. During gastrulation, the neural plate forms from ectoderm and folds to become the neural tube in a process called neurulation. The neural tube then undergoes craniocaudal closure.
3. Spinal dysraphism refers to defects in the closure of neural, bony, or other tissues along the midline of the spine during development. This results in open defects like myelomeningocele or closed defects like lipomyelomeningocele.
This randomized controlled trial compared the effectiveness of weekly iron-folic acid supplements containing 2.8 mg of folic acid versus the standard 0.4 mg in reducing the risk of neural tube defects in Malaysia. The study found that supplements containing 2.8 mg folic acid were associated with a lower risk of neural tube defects compared to the current practice of 0.4 mg. This provides evidence that switching to supplements with the higher 2.8 mg dose of folic acid recommended by WHO could further reduce the risk of these birth defects.
The central nervous system develops from the ectoderm and forms the neural tube which will become the brain and spinal cord. The neural tube develops brain vesicles which become the forebrain, midbrain and hindbrain. The hindbrain further develops into the cerebellum, pons and medulla. Neuroepithelial cells form the inner layer and produce neuroblasts which migrate outward to form the mantle layer and later the gray matter. Glial cells and neurons develop from progenitor cells. The spinal cord develops basal and alar plates which form motor and sensory areas. Spinal nerves form from ventral motor and dorsal sensory roots. The central nervous system continues developing after birth with myelination of axons.
The central nervous system develops from the ectoderm and forms the neural tube which will become the brain and spinal cord. The neural tube develops brain vesicles which become the forebrain, midbrain and hindbrain. The hindbrain further develops into the cerebellum, pons and medulla. Neuroepithelial cells form the inner layer and produce neuroblasts which migrate outward to form the mantle layer and later the gray matter. Glial cells and neurons develop from progenitor cells. The spinal cord develops basal and alar plates which form motor and sensory areas. Spinal nerves form from ventral motor and dorsal sensory roots. The central nervous system continues developing after birth with myelination of axons.
During the 3rd week of development, gastrulation occurs which involves the formation of the three germ layers - ectoderm, mesoderm, and endoderm. This transforms the bilaminar embryo into a trilaminar embryo with distinct layers. Neurulation also occurs, forming the neural tube which will later become the central nervous system. By the end of the 3rd week, the foundation is laid for all major organ systems as each germ layer gives rise to specific tissues and organs.
Lecture fourteen neuroanatomy, Embryology of the CNS.pdfNatungaRonald1
The central nervous system develops from the neural plate which forms the neural tube. The cephalic end forms three brain vesicles - the prosencephalon, mesencephalon, and rhombencephalon. The prosencephalon forms the telencephalon and diencephalon. The telencephalon develops into the cerebral hemispheres and the diencephalon forms the thalamus, hypothalamus, and pituitary gland. The rhombencephalon forms the cerebellum, pons, and medulla. Neuroepithelial cells lining the neural tube differentiate into neuroblasts which form the gray matter surrounded by white matter. Basal and alar plates in the spinal cord and brain
The document discusses the 12 pairs of cranial nerves. It provides detailed information on the olfactory, optic, oculomotor, trochlear, trigeminal, abducent, and facial cranial nerves. It describes the embryology, course, distribution and functions of these nerves. It also discusses various clinical conditions that can arise from injuries or lesions to the different cranial nerves.
Neural tube defects are among the most common human malformations, occurring in approximately 1-5 per 1,000 live births. They result from the failure of the neural tube to close properly during early embryonic development. There are several types of neural tube defects including anencephaly, encephalocele, spina bifida, and myelomeningocele. Folic acid supplementation before and during early pregnancy has been shown to significantly reduce the risk of neural tube defects.
1. Congenital hemivertebrae occur due to failure of somite formation during embryonic development and can cause spinal curvature or neurological problems by narrowing the spinal canal.
2. Tethered cord syndrome occurs when the spinal cord is attached at the caudal end, most commonly due to defective degeneration of the caudal cell mass.
3. Conditions that can lead to tethered cord include lipomyelomeningocele, diastematomyelia, anterior sacral meningocele, and dermal sinus, which may require surgical intervention such as laminectomy and cord release to prevent neurological problems.
Basics of Embryology and short review of congenital errors of CNS in radiolog...Dr. Dipesh Yadav
1) The central nervous system develops through primary and secondary neurulation forming the neural tube which closes between the 25th-27th day of gestation.
2) Brain vesicles form between 4-7 weeks developing into the primary brain structures. Cortical development and histogenesis of neurons and glia occurs from 5-35 weeks.
3) Common abnormalities include neural tube defects occurring from failed closure and malformations of cortical development due to abnormal proliferation, migration or organization of neurons.
Neural Induction in human brain: principles and processesNitish kumar
The document discusses neural induction and development of the nervous system from the ectoderm. It describes how the dorsal-most ectoderm thickens to form the neural plate during gastrulation. Through the process of neurulation, the neural plate folds in on itself to form the neural tube, which will later develop into the central nervous system. Neural crest cells emerge along the edges of the neural tube and go on to form many peripheral nervous system structures and other tissues. Failure of the neural tube to close properly can result in neural tube defects such as spina bifida.
The document summarizes key stages in the development of the neural tube and brain during embryogenesis. It discusses how the neural tube forms from the ectoderm and closes, forming the brain vesicles and flexures that give rise to the distinct brain regions. It describes the migration and differentiation of cells from the alar and basal plates that develop into various neuronal populations and structures of the brainstem and spinal cord. The formation and differentiation of the cerebellum, pons, midbrain, hindbrain, diencephalon and telencephalon are also covered. Critical signaling molecules that pattern the early neural tube are also mentioned.
Neurulation, Formation of Nervous System.pptxInshaPervaiz
Neurulation is the process by which the neural tube forms in the embryo. It is a critical stage in the development of the central nervous system (CNS), which includes the brain and spinal cord.
Here are the key points about neurulation:
1. *Neural plate formation*: The neural plate is a flat sheet of cells that forms from the ectoderm layer of the embryo.
2. *Folding and invagination*: The neural plate folds inwards to form a groove, which then deepens and closes to form a tube.
3. *Neural tube formation*: The neural tube is formed by the fusion of the neural folds.
4. *Closure of the neural tube*: The neural tube closes at both ends, forming the anterior (head) and posterior (spinal cord) neuropores.
5. *Brain and spinal cord development*: The neural tube differentiates into the brain and spinal cord.
Neurulation occurs around 3-4 weeks after fertilization and is a complex process that involves the coordination of multiple cellular and molecular mechanisms.
Abnormalities in neurulation can lead to neural tube defects (NTDs), such as spina bifida and anencephaly, which are birth defects that affect the CNS.
Here are some key terms related to neurulation:
- *Neural plate*: A flat sheet of cells that forms from the ectoderm layer of the embryo.
- *Neural fold*: A fold in the neural plate that forms during neurulation.
- *Neural groove*: A groove that forms in the neural plate during neurulation.
- *Neural tube*: A tube formed by the fusion of the neural folds.
- *Neuropore*: An opening at either end of the neural tube.
- *Neural crest*: A group of cells that form from the neural tube and migrate to other parts of the embryo to form various tissues.
Fate of embryonic layers and structures develope from themNizadSultana
Fate of embryonic layers and structures develope from it. Embryonic layers ectoderm mesoderm and endoderm form different structures during embryonic development.
The document discusses the development of the central nervous system and neural tube defects. It covers:
1. The CNS appears in the third week as a neural plate that folds to form the neural tube, which closes from head to tail between 4-5 weeks. Failure of closure can cause neural tube defects.
2. The most common neural tube defects are spina bifida occulta, meningocele, myelomeningocele, anencephaly, and encephalocele. Myelomeningocele is the most severe form with exposed nerves and spinal cord.
3. Prevention focuses on adequate folic acid intake before and during early pregnancy to reduce neural tube defect risk, as f
Neural tube defects are developmental abnormalities where the neural tube fails to close, leaving the brain or spinal cord exposed. The most common types are spina bifida, where part of the spine does not fully close; meningocele, where the membrane around the spinal cord pushes through an opening; and myelomeningocele, where the spinal cord and nerves push through. Risk factors include folic acid deficiency, family history, certain medications, and fever during early pregnancy. Treatment may involve surgery before or after birth as well as physical therapy to prevent deformities and support mobility.
The nervous system begins developing in the 3rd week of gestation from ectodermal tissue. The central nervous system starts as a neural plate that folds into a neural groove and then fuses to form the neural tube. The neural tube will develop into the brain and spinal cord. Neural crest cells emerge from the neural tube and migrate throughout the body, giving rise to many cell types. By the 5th week, the brain has divided into five vesicles that will form the structures of the adult brain.
Similar to KCMC Surgical NEUROTUBE DEFECTS_101932.ppt (20)
Breast cancer screening aims to detect breast cancer early through methods like breast self-exams, clinical exams, and mammography. Some key points covered in the document include:
- Breast cancer occurs when abnormal breast cells grow out of control and can spread to nearby tissues or distant sites if left untreated.
- Risk factors for breast cancer include being female, increasing age, family history, early menarche, late first pregnancy.
- Screening goals are to find cancer early before symptoms occur when it may be more easily treated and cured.
- Screening methods discussed are breast self-exam to inspect for changes each month, clinical exam by a provider, and mammography to detect cancers too
Burn injuries can result from heat, cold, chemicals, electricity or radiation. They cause tissue damage and systemic effects. The document defines burn injury and discusses the epidemiology, classifications, etiology, pathophysiology and local/systemic responses to burns. It notes that burn incidence is approximately 1% worldwide each year, with higher rates in children under 5 from scalds and adults from flames. Extensive burns often lead to high morbidity and mortality.
This document provides an overview of the evaluation and management of abdominal injuries. It discusses the important differences between penetrating and blunt trauma, key CT findings, and general principles of care. Damage control surgery techniques are described that aim to rapidly control bleeding and limit gastrointestinal spillage to break the lethal triad of hypothermia, acidosis, and coagulopathy in critically injured patients. Post-operative intensive care is focused on resuscitation and monitoring for abdominal compartment syndrome.
A spinal cord injury can result in permanent impairment if not properly diagnosed and managed. The document defines spinal cord injury and discusses epidemiology, anatomy, pathophysiology, and management. It describes the structure and blood supply of the spine, classification systems for fractures, and associated conditions like spinal and neurogenic shock. Key tracts and myotomes are also outlined.
The perineum is the diamond-shaped area between the thighs that is divided into two triangles by an imaginary line between the ischial tuberosities. The anal triangle posteriorly contains the anal canal and anus. The urogenital triangle anteriorly contains the urethra and external genitalia. The perineum is bounded anteriorly by the pubic symphysis and posteriorly by the tip of the coccyx.
How to Manage Your Lost Opportunities in Odoo 17 CRMCeline George
Odoo 17 CRM allows us to track why we lose sales opportunities with "Lost Reasons." This helps analyze our sales process and identify areas for improvement. Here's how to configure lost reasons in Odoo 17 CRM
Reimagining Your Library Space: How to Increase the Vibes in Your Library No ...Diana Rendina
Librarians are leading the way in creating future-ready citizens – now we need to update our spaces to match. In this session, attendees will get inspiration for transforming their library spaces. You’ll learn how to survey students and patrons, create a focus group, and use design thinking to brainstorm ideas for your space. We’ll discuss budget friendly ways to change your space as well as how to find funding. No matter where you’re at, you’ll find ideas for reimagining your space in this session.
ISO/IEC 27001, ISO/IEC 42001, and GDPR: Best Practices for Implementation and...PECB
Denis is a dynamic and results-driven Chief Information Officer (CIO) with a distinguished career spanning information systems analysis and technical project management. With a proven track record of spearheading the design and delivery of cutting-edge Information Management solutions, he has consistently elevated business operations, streamlined reporting functions, and maximized process efficiency.
Certified as an ISO/IEC 27001: Information Security Management Systems (ISMS) Lead Implementer, Data Protection Officer, and Cyber Risks Analyst, Denis brings a heightened focus on data security, privacy, and cyber resilience to every endeavor.
His expertise extends across a diverse spectrum of reporting, database, and web development applications, underpinned by an exceptional grasp of data storage and virtualization technologies. His proficiency in application testing, database administration, and data cleansing ensures seamless execution of complex projects.
What sets Denis apart is his comprehensive understanding of Business and Systems Analysis technologies, honed through involvement in all phases of the Software Development Lifecycle (SDLC). From meticulous requirements gathering to precise analysis, innovative design, rigorous development, thorough testing, and successful implementation, he has consistently delivered exceptional results.
Throughout his career, he has taken on multifaceted roles, from leading technical project management teams to owning solutions that drive operational excellence. His conscientious and proactive approach is unwavering, whether he is working independently or collaboratively within a team. His ability to connect with colleagues on a personal level underscores his commitment to fostering a harmonious and productive workplace environment.
Date: May 29, 2024
Tags: Information Security, ISO/IEC 27001, ISO/IEC 42001, Artificial Intelligence, GDPR
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This document provides an overview of wound healing, its functions, stages, mechanisms, factors affecting it, and complications.
A wound is a break in the integrity of the skin or tissues, which may be associated with disruption of the structure and function.
Healing is the body’s response to injury in an attempt to restore normal structure and functions.
Healing can occur in two ways: Regeneration and Repair
There are 4 phases of wound healing: hemostasis, inflammation, proliferation, and remodeling. This document also describes the mechanism of wound healing. Factors that affect healing include infection, uncontrolled diabetes, poor nutrition, age, anemia, the presence of foreign bodies, etc.
Complications of wound healing like infection, hyperpigmentation of scar, contractures, and keloid formation.
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Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...Dr. Vinod Kumar Kanvaria
Exploiting Artificial Intelligence for Empowering Researchers and Faculty,
International FDP on Fundamentals of Research in Social Sciences
at Integral University, Lucknow, 06.06.2024
By Dr. Vinod Kumar Kanvaria
Main Java[All of the Base Concepts}.docxadhitya5119
This is part 1 of my Java Learning Journey. This Contains Custom methods, classes, constructors, packages, multithreading , try- catch block, finally block and more.
How to Build a Module in Odoo 17 Using the Scaffold MethodCeline George
Odoo provides an option for creating a module by using a single line command. By using this command the user can make a whole structure of a module. It is very easy for a beginner to make a module. There is no need to make each file manually. This slide will show how to create a module using the scaffold method.
A workshop hosted by the South African Journal of Science aimed at postgraduate students and early career researchers with little or no experience in writing and publishing journal articles.
How to Make a Field Mandatory in Odoo 17Celine George
In Odoo, making a field required can be done through both Python code and XML views. When you set the required attribute to True in Python code, it makes the field required across all views where it's used. Conversely, when you set the required attribute in XML views, it makes the field required only in the context of that particular view.
2. INTRODUCTION
•The central nervous system (CNS) consists of
the brain and spinal cord and is protected by
the cranium and vertebral column.
•At the end of week two, a structure called the
Primitive streak appears as a groove in the
epiblast layer of the bilaminar disk.
•Cells within the epiblast migrate downward
through the primitive streak, giving rise to the
three layers from the initial two.
•These three germinal layers form the
trilaminar embryonic disc: Endoderm,
Mesoderm and the Ectoderm.
•The CNS is derived from the ectoderm, which
is the outermost layer of the embryonic disc.
3. SECOND WEEK
Differentiation of the embryo
into three germ layers :
•Ectoderm.
•Mesoderm.
•Endoderm.
•The Ectoderm will form
•(1) Central nervous system.
•(2) Epidermis of Skin.
4. NEURULATION
• In the 3rd week, the
notochord appears in the
mesoderm, which then
secretes growth factor i.e.
Sonic hedgehog (SHH), and
bone morphogenic proteins
(BMPs) which stimulates the
differentiation of the
underlying ectoderm into
Neuroectoderm, forming a
structure known as the
neural plate.
• On lateral edges of the
plate, form neural folds,
which meet in the midline,
fusing to form the Neural
tube which is a precursor to
the brain and spinal cord.
• During fusion of the neural
folds, some cells within the
folds migrate to form a
distinct cell population
known as Neural crest.
• The neural crest give rise to
diverse cell lineage
including melanocytes,
craniofacial cartilage and
bone, smooth muscles,
peripheral and enteric
neurons and glia.
• So, neurulation is the
formation of neural tube,
which is achieved by the
end of 4th week in the
region of 4th to 6th somites.
5. • So the first indications of
the developing nervous
system appear during the
third week as the neural
plate and neural groove
develop on the posterior
aspect of the trilaminar
embryo.
• At this stage, the cranial
two thirds of the neural
plate and tube as far
caudal as the fourth pair
of somites represent the
future brain, and the
caudal one third of the
plate and tube
represents the future
spinal cord.
• Fusion of the neural folds
and formation of the
neural tube begins at the
fifth somite and proceeds
in cranial and caudal
directions until only
small areas of the tube
remain open at both
ends.
• The lumen of the neural
tube becomes the neural
canal, which
communicates freely
with the amniotic cavity.
• The rostral neuropore
closes at approximately
the 25th day, and the
caudal neuropore closes
at approximately the
27th day.
6. • Syndecan 4 (SDC4) and
van gogh–like 2 (VANGL2)
proteins appear to be
involved with neural tube
closure.
• The neuroprogenitor cells
of the wall of the neural
tube thicken to form the
brain and spinal cord.
• The neural canal forms
the ventricular system of
the brain and the central
canal of the spinal cord.
7. THIRD WEEK
•Neural Plate :
•It is a dorsal midline
thickening of the
ectoderm overlying the
notochord
(Neuroectoderm) .
8. THIRD WEEK
•Neural Folds :
•They are the elevated
lateral margins of the
neural plate.
•They are on each side of
the longtudinal midline
(Neural Groove).
9. NEURAL TUBE
•It is formed from the
apposition and fusion
of the neural folds
which seal the neural
groove and create the
tube.
10. FOURTH WEEK
•The neural tube is completed
and transformed into the adult
CNS.
•This growth is maximal at the
rostral part which becomes
the brain.
•The caudal portion becomes
the spinal cord.
•The axis of the neural tube
(neuroaxis) is straight.
11. NEURAL GROOVE
•The central cavity
within the neural tube
becomes :
•Ventricles of the brain
and
•Central canal of the
spinal cord.
12. NEURAL CREST
• They are separated cells from the
apices of the neural folds.
• They are dorsolateral to the neural
tube.
• They give rise to :
• Autonomic ganglia.
• Sensory ganglia of spinal and cranial
nerves.
• Melanocytes.
• Cells of supra renal medulla.
13. DIFFERENTIATION OF SPINAL CORD
•The Grey matter is
located centrally
around the central
canal.
•The White matter
forms the outer
coat.
14. DIFFERENTIATION OF SPINAL CORD
• Sulcus Limitans :
• It is a longitudinal groove along the
inner surface of the lateral walls of
the developing spinal cord.
• It differentiates the grouping of
cells (gray matter),cells on the
dorsal side form the Alar plate,
which becomes the dorsal horn
(posterior) and cells at the ventral
end form the Basal plate, which
then becomes the ventral horn (
Anterior).
15. DIFFERENTIATION OF SPINAL CORD
•The Alar plate is
predominantly
sensory in function.
•The Basal plate is
predominantly
motor in function.
16. BIRTH DEFECTS OF SPINAL CORD
• Most defects result from failure of fusion of one or
more neural arches of the developing vertebrae during
the fourth week.
• NTDs affect the tissues overlying the spinal cord:
meninges, neural arches, muscles, and skin.
• Defects involving the embryonic neural arches are
referred to as spina bifida; subtypes of this defect are
based on the degree and pattern of the NTD.
• The term spina bifida denotes nonfusion of the halves
of the embryonic neural arches, which is common to
all types of spina bifida .
• Spina bifida ranges from clinically significant types to
minor defects that are functionally unimportant.
17. DERMAL SINUS
• A dermal sinus is lined with epidermis and skin
appendages extending from the skin to a deeper-lying
structure, usually the spinal cord.
• The sinus (channel) is associated with closure of the
neural tube and formation of the meninges in the
lumbosacral region of the spinal cord.
• The birth defect is caused by failure of the surface
ectoderm (future skin) to detach from the
neuroectoderm and meninges that envelop it. As a
result, the meninges are continuous with a narrow
channel that extends to a dimple in the skin of the
sacral region of the back.
• The dimple indicates the region of closure of the
caudal neuropore at the end of the fourth week and
therefore represents the last place of separation
between the surface ectoderm and the neural tube.
18. SPINA BIFIDA OCCULTA
•Spina bifida occulta is an NTD resulting from
failure of the halves of one or more neural
arches to fuse in the median plane
•This NTD occurs in the L5 or S1 vertebra in
approximately 10% of otherwise normal
people.
• In the minor form, the only evidence of its
presence may be a small dimple with a tuft of
hair arising from it .
•Spina bifida occulta usually produces no
symptoms.
• A few affected infants have functionally
significant defects of the underlying spinal
cord and dorsal roots
19. SPINA BIFIDA CYSTICA
• These are the severe types of spina bifida, which involve
protrusion of the spinal cord and/or meninges through
defects in the vertebral arches.
• The spinal cord and spinal roots are in the normal position,
but there may be spinal cord defects.
• If the spinal cord or nerve roots are contained within the
meningeal cyst, the defect is spina bifida with
meningomyelocele.
• Severe cases involving several vertebrae are associated
with absence of the calvaria (skullcap), absence of most of
the brain, and facial abnormalities; these severe defects
are called meroencephaly, for these neonates, death is
inevitable.
• Spina bifida cystica shows various degrees of neurologic
deficit, depending on the position and extent of the lesion.
20. SPINAL BIFIDA CYSTICA
• Sphincter paralysis (bladder or anal sphincters) is
common with lumbosacral meningomyelocele.
• Meroencephaly is strongly suspected in utero when
there is a high level of alpha fetoprotein (AFP) in the
amniotic fluid
• The level of AFP may also be elevated in maternal
blood serum. Amniocentesis is usually performed on
pregnant women with high levels of serum AFP for the
determination of the AFP level in the amniotic fluid.
• An ultrasound scan may reveal an NTD that has
resulted in spina bifida cystica.
• The fetal vertebral column can be detected by
ultrasound at 10 to 12 weeks, and if there is a defect
in the vertebral arch, a meningeal cyst may be
detected in the affected area .
21. MYELOSCHISIS
•Myeloschisis is the most severe type of spina
bifida.
• In this defect, the spinal cord in the affected
area is open because the neural folds failed to
fuse.
•As a result, the spinal cord is represented by a
flattened mass of nervous tissue.
•Myeloschisis usually results in permanent
paralysis or weakness of the lower limbs.
25. CAUSES OF NEURAL TUBE DEFECTS
•Nutritional and environmental factors
undoubtedly play a role in the production of
NTDs.
•Gene-gene and gene-environment interactions
are likely involved in most cases.
•Food fortification with folic acid and folic acid
supplements taken before conception and
continued for at least 3 months during
pregnancy reduce the incidence of NTDs.
26. CONTINUE………
•In 2015, the Centers for Disease Control and
Prevention urged “all women of childbearing
age who can become pregnant to get 0.4 mg
of folic acid every day to help reduce the risk
of neural tube defects.
• Epidemiologic studies have also shown that
low maternal B12 levels may significantly
increase the risk of NTDs.
•Certain drugs (e.g., valproic acid) increase the
risk of meningomyelocele. This anticonvulsant
drug causes NTDs in 1% to 2% of pregnancies if
taken during early pregnancy, when the neural
folds are fusing.
27. BRAIN
•In the 5th week of development, the swellings
appear at the cranial end of the neural tube.
Three primitive vesicles appears first, and
subsequently they develop into five secondary
vesicles.
•These vesicles will give rise to all the
structures of the brain and cerebellum, as well
as the ventricular system.
•Meanwhile, the neuroderm cells begin to
differentiate into neurons and glial cells.
•Neurons migrate throughout the brain, and
once they have reached their final destination
they develop axons and dendrites, forming
synapses.
29. FLEXURES
•The neuroaxis is bent
by two flexures :
•Cephalic ( Mid brain)
flexure at the
junction of the fore
and mid brains.
•Cervical flexure :
•Between the brain
and spinal cord.
39. BRAIN CENTERS
• They consist of :
• Bilateral paired centers for
the senses of :
• Smell, Vision, Hearing and
• A symmetrical midline
Vestibular center for the
maintenance of equilibrium.
40. BRAIN CENTERS
•They start to appear
as expansions from the
dorsal aspect of the
simple tubular brain.
•They are composed of
an outer cortex of
nerve cells with
underlying core of
nerve fibers.
41. BRAIN CENTERS
•The centers for vision and
hearing will form largely
automatic, reflex functions.
•They are represented by the
four colliculi (superior &
inferior).
•The motor center near the
caudal end of the brain will
be in the cerebellum.
43. PROSENCEPHALISATION
•They become the highest
levels for perception and
correlation of all sensory
modalities
•They are the highest level
for motor control.
•The other centers become
progressively subservient to
the cerebral hemispheres.
44. BIRTH DEFECTS OF BRAIN
• Because of the complexity of its embryologic history,
abnormal development of the brain is common
(approximately 3 of 1000 births).
• Most major birth defects, such as meroencephaly and
meningoencephalocele, result from defective closure
of the rostral neuropore (an NTD) during the fourth
week and involve the overlying tissues (meninges and
calvaria).
• The factors causing NTDs are genetic, nutritional, and
environmental.
• Birth defects of the brain can be caused by alterations
in the morphogenesis or histogenesis of the nervous
tissue, or they can result from developmental failures
occurring in associated structures(notochord, somites,
mesenchyme, and cranium)
45. CONTINUE…..
• Abnormal histogenesis of the cerebral cortex can
result in seizures and various degrees of mental
deficiency.
• Subnormal intellectual development may result from
exposure of the embryo or fetus during the 8- to 16-
week period to viruses such as Rubella virus and high
levels of radiation
• Prenatal risk factors, such as maternal infection or
thyroid disorder, Rh factor incompatibility, and some
hereditary and genetic conditions, but the deficit may
result from events during birth.
47. ENCEPHALOCELE
• Encephalocele is a herniation
of intracranial contents
resulting from a defect in the
cranium (cranium bifidum).
• Encephaloceles are most
common in the occipital
region.
• The hernia may contain
meninges (meningocele),
meninges and part of the brain
(meningoencephalocele), or
meninges, part of the brain,
and part of the ventricular
system
(meningohydroencephalocele).
• Encephalocele occurs in
approximately 1 of 2000
births.
48. Hydrocephalus
• From Greek hydrokephalos,
from hydr- + kephalE head
• Definition: An abnormal
increase in the amount of
cerebrospinal fluid within the
cranial cavity that is
accompanied by expansion of
the cerebral ventricles,
enlargement of the skull and
especially the forehead, and
atrophy of the brain
49. Introduction
• Significant enlargement of the
head results from an imbalance
between the production and
absorption of CSF; as a result,
there is an excess of CSF in the
ventricular system of the brain
• Hydrocephalus results from
impaired circulation and
absorption of CSF and, in rare
cases, from increased
production of CSF by a choroid
plexus adenoma (benign
tumor).
• A premature infant may develop
intraventricular hemorrhage
leading to hydrocephalus
through the obstruction of the
lateral aperture (foramen of
Luschka) and median aperture
(foramen of Magendie).
• Rarely, impaired CSF circulation
results from congenital
aqueductal stenosis the cerebral
aqueduct is narrow or consists
of several minute channels
50. Introduction
• In a few cases, stenosis results
from transmission of an X-linked
recessive trait, but most cases
appear to result from a fetal
viral infection (e.g.,
cytomegalovirus) or Toxoplasma
gondii.
• Blockage of CSF circulation
results in dilation of the
ventricles proximal to the
obstruction, internal
accumulation of CSF, and
pressure on the cerebral
hemispheres.
• This squeezes the brain
between the ventricular fluid
and the neurocranium.
• In infants, the internal pressure
results in an accelerated rate of
expansion of the brain and
neurocranium because most of
the fibrous sutures are not
fused.
• Although hydrocephalus may be
associated with spina bifida
cystica, enlargement of the
head may not be obvious at
birth
51. Overview of CSF production
• The CSF volume of an average
adult ranges from 80 to 160 ml
• The ventricular system holds
approximately 20 to 50 ml of
CSF
• CSF is produced in the choroid
plexuses at a daily rate of 14-36
ml/hr
52. Overview of CSF production
•The choroid
plexuses are the
source of
approximately 80%
of the CSF
•The blood vessels in
the subependymal
regions, and pia also
contribute to the
formation of CSF
53. Overview of CSF circulation
• The CSF flows from the
lateral ventricles downward
to the foramina of
Magendie and Luschka, to
the perimedullary and
perispinal subarachnoid
spaces, and then upward to
the basal cistern and finally
to the superior and lateral
surfaces of the cerebral
hemispheres
54. CSF circulation
• The pressure gradient is
highest in the lateral
ventricles and diminishes
successively along the
subarachnoid space
• Arterial pulsations in the
choroid plexuses help drive
the fluid from the
ventricular system
• Normally, the
periventricular tissues offer
little resistance to the flow
of CSF
+
-
55. CSF pressure
• The CSF volume and pressure
are maintained on a minute to
minute basis by the systemic
circulation
• CSF pressure is in equilibrium
with capillary pressure
(determined by the arteriolar
tone)
• An increase in blood PCO2
(hypoventilation) decreases pH
and arteriolar resistance, this in
turn gives rise to increased CSF
pressure by increasing cerebral
blood flow
• Hyperventilation has the
opposite effect
56. CSF pressure
• Normal intracranial pressure
(ICP) in an adult is between 2-8
mmHg.
• Levels up to 16 mmHg are
considered normal
• ICP higher than 40 mmHg or
lower BP may combine to cause
ischemic damage
57. CSF pressure
• Increased venous pressure has
a direct effect on CSF pressure
• Downstream block of venous
flow increases the volume of
cerebral veins, dural sinuses,
and the subarachnoid space
58. The function of the CSF
• The CSF acts as a “water jacket”
for the brain and spinal cord
• The 1300 g adult brain weighs
approximately 45 g when
suspended in CSF
59. The function of the CSF
• The CSF acts like a “sink”,
effectively flushing waste
products as new fluid is
secreted reabsorbed
• A constant CSF electrolyte
composition helps maintain a
stable medium for excitable
cells (neurons)
60. Mechanisms of increase intracranial pressure
• Brain, Blood and CSF are held in
an inelastic container
(cranium, vertebral canal and
dura)
• Changes in volume of either
element (Brain,CSF, Blood) is at
the expense of the other two
62. Communicating vs. Non-communicating
•This classification was based on the imaging
findings after injection of dye into the
ventricular system and simultaneous
injection of air into the subarachnoid space
•Diffusion of dye into the subarachnoid space
and passage of air into the ventricular space
were the criteria for communicating
hydrocephalus
63. Non-communicating hydrocephalus
•There is no communication between the
ventricular system and the subarachnoid
space. The commonest cause of this
category is aqueduct blockage or
stenosis.
64. Aqueductal stenosis
• The normal aqueduct measures
about 1 mm in diameter, and is
about 11 mm in length.
65. Aqueductal stenosis
• Is the most common cause of congenital
hydrocephalus(43%)
• Aqueduct develops about the 6th week of gestation
• M:F = 2:1
• Other congenital anomalies (16%): thumb deformities
• Prognosis: 11-30% mortality
66. Etiology of aqueductal stenosis
• Intrinsic Pathology of the Aqueduct
• Septum or Membrane Formation: A thin membrane of neuroglia may occlude
the aqueduct. It commonly occurs caudally. There may be a primary
developmental defect or it may follow granular ependymitis from intrauterine
infections. This is the rarest of the types of narrowing.
• Forking of the Aqueduct:Typically, there are two channels seen in midsagittal
plane unable to handle CSF volume. Most often seen with spina bifida.
• Gliosis of the Aqueduct: Usually of infectious origin showing a marked
gliofibrillary response. The lumen is devoid of ependyma.
• Stenosis of the Aqueduct: Narrowed aqueduct without evidence of gliosis. This
may have hereditary basis.
68. Clinical features of aqueductal stenosis
• Obstructive hydrocephalus:
presents with
macrocephaly and/or
intracranial hypertension.
• Parinaud's syndrome.
Inability to elevate eyes
• Collier's sign. Retraction of
the eyelids
69. Imaging of aqueductal stenosis
• Ultrasonography can detect
aqueductal stenosis in utero.
Sonogram
70. Imaging of aqueductal stenosis
• CT and MRI. MRI is essential if
third ventriculostomy is to be
considered.
71. Treatment of aqueductal stenosis
• Treatment and Results
• Remove underlying cause of
obstruction if possible.
• Third ventriculostomy as initial
treatment of choice.
• VP shunt if technical reasons do not
allow third ventriculostomy or if the
child fails after ventriculostomy.
• Aqueductal stent can be placed if
technically feasible. Usually rarely
done due to risk of upper brain stem
injury.
72. Communicating hydrocephalus
• In communicating or non-obstructive hydrocephalus there is
communication between the ventricular system and the
subarachnoid space. The commonest cause of this group is post-
infectious and post-hemorrhagic hydrocephalus.
• Usually there is an obliteration of the subarachnoid cisterns or
malfunction of the arachnoid villi.
73. Causes of communicating hydrocephalus
• Overproduction of CSF
• Blockage of CSF circulation
• Blockage of CSF resorption
• Hydrocephalus ex-vacuo
• Normal pressure hydrocephalus
74. Overproduction of CSF
• Excessive secretion of CSF by
the choroid plexus as in cases
of choroid plexus papilloma or
carcinoma. This is a rare cause.
75. Blockage of CSF circulation
• This could be at any level of the
CSF circulation. It could be at the
level of the foramen of Monro,
with either unilateral or bilateral
occlusion of the foramen of
Monro giving dilatation of one or
both lateral ventricles. This is
commonly seen in the colloid
cyst and tumors of the third
ventricle.
76. Dandy Walker Syndrome
• A common cause of
obstructive hydrocephalus
is Dandy Walker Syndrome
where there is blockage of
foramina of the 4th
ventricle. This is a
congenital condition
associated with agenesis of
the cerebellar vermis
77. Blockage of CSF resorption
• Poor resorption of CSF into the
venous sinuses caused by
scarring of the arachnoid villi
and is commonly seen after
meningitis or hemorrhage
78. Hydrocephalus Ex Vacuo
• Hydrocephalus ex-vacuo involves
the presence of too much CSF,
although the CSF pressure itself
is normal. This condition occurs
when there is damage to the
brain caused by stroke or other
form of injury or chronic
neurodegeneration, and there
may be an actual shrinkage of
brain substance.
79. Normal pressure hydrocephalus
• Normal pressure hydrocephalus
(NPH) is usually due to a gradual
blockage of the CSF drainage
pathways in the brain. NPH is an
unusual cause of dementia,
which can occur as a
complication of brain infection or
bleeding (hemorrhage).
80. Normal pressure hydrocephalus
• In some patients, no predisposing
cause can be identified.
• In patients with NPH, although
the ventricles enlarge, the
pressure of the CSF remains
within normal range.
• NPH is characterized by gradual
memory loss (dementia), balance
disorder (ataxia), urine
incontinence, and a general
slowing of activity.
• Symptoms progressively worsen
over weeks. In some patients, an
improvement of symptoms is
noted immediately after the
removal of spinal fluid with a
lumbar procedure.
81. Treatment of hydrocephalus
• The two most commonly used
shunt systems are the
ventriculoatrial (VA) and
ventriculoperitoneal (VP) shunts.
The VP shunt is most commonly
used as it is simpler to place,
extra tubing may be placed in the
peritoneum and the
consequences of infection are
less.
82. Treatment of hydrocephalus
• The VA shunt must be accurately
located in the atrium and
requires frequent revisions as
the child grows to maintain the
proper position of the distal end.
In addition, infection is a more
serious complication with a VA
shunt as its location in the blood
stream may lead to sepsis.
83. Treatment of hydrocephalus
• Recently, in situations where both
the abdomen and vascular system
can no longer function to absorb
CSF, Pediatric Neurosurgeons have
begun to place the distal catheter
in the pleural space (V-PL shunt).
The distal catheter is placed
through a small incision in the
anterior chest wall. As with the
peritoneal shunt, extra tubing can
be placed, reducing the need for
further shunt revisions.
•
84. Treatment of hydrocephalus
• Shunt systems include three
components: (1) a ventricular
catheter, (2) a one way valve and
(3) a distal catheter. The
ventricular catheter is a straight
piece of tubing, closed on the
proximal end and usually with
multiple holes for the entry of
CSF along the proximal two
centimeters of the tube.
85. Treatment of hydrocephalus
• Shunts are composed of a
material called Silastic. Silastic is
made from a family of
polymerized organic compounds
termed silicone. Silicone is the
substance that has caused
controversy in breast implants
because of the association with
auto immune disorders. So far no
cases of auto immune disease
have been linked to the Silastic
used in shunts.
86. Treatment of hydrocephalus
• The most common sites for entry
of the ventricular catheter are a
frontal position in line with the
pupil at the coronal suture, a
parietal position just above and
behind the ear, or an occipital
position three centimeters off
the posterior midline. The
position used varies with the
configuration of the ventricles,
the shape and size of the head
and the surgeon’s preference.
87. Shunt malfunction
• Common complications of VP shunt include shunt malfunction or
blockage and infection. Malfunction may be related to growth and
the shunt will need to be replaced with a longer catheter. Symptoms
of shunt malfunction or infection include headache, fever,
drowsiness,convulsions, increased head circumference and bulging
fontanelle.
88. Shunt malfunction
• If left untreated, shunt malfunction or infection is
associated with high morbidity and mortality rates. Most
patients with these complications have subtle presentations
and nonspecific signs, despite elevated ICP or CNS infection.
The workup includes a focused review of records,
information from the patient’s family or caretaker, and
elements of a unique examination to supplement routine
work-up of the patient with a ventricular shunt. A shunt
series and head CT scan are part of the initial evaluation.
Empiric antibiotic therapy is initiated to cover Gram-
positive organisms, predominantly S. epidermidis, as well as
the less common Gram-negative and anaerobic organisms
responsible for shunt infections.