This document summarizes the BioVision 2013 conference held in Lyon, France. It discusses several topics related to biomedical research and innovation. Key points include the importance of supporting young researchers, the potential of gene research this century, positive indicators for the healthcare sector in France, and over 200 million euros currently spent on translational research. The conference featured discussions on synergizing research efforts, supporting startups, new medical treatments, and catalyzing innovation through cross-disciplinary approaches. Speakers represented industry, government, and academia and addressed issues like climate change, regulating drug development and access, and enabling new biomanufacturing technologies.
Presentation by Fred Unger at a training course for the Philippine Council for Agriculture, Aquatic and Natural Resources Research and Development (PCAARRD) project team, Pampanga, the Philippines, 30-31 July 2014.
Presentation by Fred Unger at a training course for the Philippine Council for Agriculture, Aquatic and Natural Resources Research and Development (PCAARRD) project team, Pampanga, the Philippines, 30-31 July 2014.
Presented by Jeff Gilbert at a meeting on sharing the experiences on the application of One Health approaches in China, Beijing, China, 8-9 August 2013.
Presented by Hung Nguyen-Viet and Jakob Zinsstag at a technical workshop of the Food and Agriculture Organization of the United Nations (FAO) regional initiative on One Health, Bangkok, Thailand, 11–13 October 2017.
Ecohealth perspectives: From Ecohealth theory to practice (case studies)ILRI
Presentation by Fred Unger at an FAO-APHCA/OIE/USDA regional workshop on prevention and control of neglected zoonoses in Asia, Obihiro, Hokkaido, Japan, 15-16 July 2015.
One Health – an interdisciplinary approach in combating emerging diseasesILRI
Presentation by Hung Nguyen-Viet, Delia Grace and Jakob Zinsstag at the International Symposium of Health Sciences (iSIHAT 2013), Kuala Lumpur, Malaysia, 20-21 August 2013.
GenSearch - Innovation in Healthcare: What is the Point?Alix Aubert
In this white paper, you will discover instances where innovation in technology and organisational operations are connecting patients to healthcare providers and are sharing secure clinical data with researchers. Others have disrupted traditional manufacturing methods to improve processes and some have even transformed organisational operations to create customer trust, value, and to improve outcomes for patients.
Working in Global HealthChapter 18Chapter 18 Working irosacrosdale
Working in Global Health
Chapter 18
Chapter 18: Working in Global Health
1
Positions in Global Health
Universities
NGOs
Social entrepreneurships
Bilateral and multilateral aid organizations
Consulting
Global health is a growing field and there are many opportunities to work in it.
2
When considering a job in Global health
Understand the skills, knowledge, and experience this type of career would entail and how you might fill gaps you have in terms of the required background for a position.
May require a good understanding of economic development.
Should appreciate cultures.
Have the ability to write and speak well.
Be willing to live and work in low and middle income countries.
If you are considering a job in global health, you should: Understand the skills, knowledge, and experience this type of career would entail and how you might fill gaps you have in terms of the required background for a position.
May require a good understanding of economic development.
Should appreciate cultures.
Have the ability to write and speak well.
Be willing to live and work in low and middle income countries.
3
Other valuable points
Get your degree in an area related to the one in which you want to work.
Build on that area through internships, fellowships, and other opportunities to live and work abroad.
Consider a graduate program to build in your studies and experiences.
Work with mentors who work directly in the field.
Other things to consider are: Get your degree in an area related to the one in which you want to work.
Build on that area through internships, fellowships, and other opportunities to live and work abroad.
Consider a graduate program to build in your studies and experiences.
Work with mentors who work directly in the field.
4
Resources for careers
DEVEX http://globalhealth.org/
The Global Health Council http://globalhealth.org/
Global Health Hub www.globalhealthhub.org
International Jobs Center http://www.internationaljobs.org/
Idealist www.idealist.org
U.S Government
USAID https://www.usaid.gov/
CDC http://www.cdc.gov/
Here are a few resources to consider when looking for a career in global health.
5
Personal Quote
“Working in global health has been my dream as long as I can remember. And just imagine how reality could be better than a dream- and that’s exactly how I feel working in this field. It’s the most fulfilling career that I could ever imagine.”
Dr. Tara Rava Zolnikov
Assistant Professor
National University
Water project in Narok, Kenya
HIV/AIDS project in Busia, Kenya
Access to water research in Kitui, Kenya
Science, Technology, and Global Health
Chapter 17
1
Chapter 17: Science, Technology, and Global Health
The Need for New Products
Characteristics of new technologies must reflect the following:
Most important target groups are poor people.
Quality of care and injection safety is often low.
Many low- and middle-income countries have poorly organized health systems.
Science and technology ...
One Health: A Holistic Approach to Achieving Global Well-beinggreendigital
Introduction:
In an interconnected world where the boundaries between humans, and animals. and the environment blurred. One Health has emerged as a comprehensive approach to addressing complex health challenges. One Health recognizes the intricate connections between the Health of humans and animals. and ecosystems, emphasizing the need for collaborative efforts across disciplines to achieve optimal well-being for all. This article delves into the fundamental principles of It, and its historical roots. and its potential to revolutionize the way we approach global Health.
Follow us on: Pinterest
Understanding One Health:
A- Definition and Scope:
It is an integrative approach that considers the Health of humans, animals. and the environment as interdependent entities. It acknowledges that the Health of one component influences the Health of the others. and disruptions in any of these systems can have far-reaching consequences. This approach goes beyond traditional silos in health management. and embraces a holistic perspective. recognizing the intricate web of connections that shape our Health.
B- Historical Roots:
The roots of the It concept can traced back to ancient civilizations. where the interconnectedness of human and animal health acknowledged. But, the formal recognition of It as a distinct field gained momentum in the late 20th century. The emergence of zoonotic diseases transmitted between animals. and humans highlighted the need for a collaborative approach to disease prevention and control.
Key Principles of One Health:
A- Interdisciplinary Collaboration:
At the heart of It is interdisciplinary collaboration. This principle involves breaking down the traditional barriers between medical, veterinary. and environmental sciences. Professionals from various fields work together to understand the complex dynamics of Health. and to develop effective strategies for prevention, surveillance, and response to emerging threats.
B- Zoonotic Disease Surveillance:
Given the increasing frequency of zoonotic disease outbreaks. It emphasizes surveillance and early detection. Monitoring diseases at the human-animal-environment interface is crucial for identifying potential threats before. they escalate into global pandemics. This proactive approach involves close collaboration between public health agencies. veterinary services, and environmental monitoring bodies.
C- Environmental Stewardship:
It recognizes the impact of environmental degradation on Health. Climate change, deforestation, and pollution can exacerbate the spread of diseases. affect water and food sources, and compromise the well-being of ecosystems. Integrating environmental stewardship into health policies is essential for safeguarding the Health of present and future generations.
Examples of One Health in Action:
A- Pandemic Preparedness:
The ongoing COVID-19 pandemic has underscored the importance of a It approach. The virus, believed to have originated in bats.
Could a ‘cancer megafund’ persuade investors to put serious money into researching the killer disease? Three alumni debate financial engineering in healthcare.
This was first published in AlumniNews, Issue 130, July 2013. Find out more about our alumni community at http://www.london.edu/alumni
Future of health - An initial perspective - Devi ShettyFuture Agenda
An initial perspective on the future of health by Dr Devi Shetty, Chairman and Founder of Narayana Health in India. This is the starting point for the global future agenda discussions taking place through 2015 as part of the the futureagenda2.0 programme. www.futureagenda.org
Presented by Jeff Gilbert at a meeting on sharing the experiences on the application of One Health approaches in China, Beijing, China, 8-9 August 2013.
Presented by Hung Nguyen-Viet and Jakob Zinsstag at a technical workshop of the Food and Agriculture Organization of the United Nations (FAO) regional initiative on One Health, Bangkok, Thailand, 11–13 October 2017.
Ecohealth perspectives: From Ecohealth theory to practice (case studies)ILRI
Presentation by Fred Unger at an FAO-APHCA/OIE/USDA regional workshop on prevention and control of neglected zoonoses in Asia, Obihiro, Hokkaido, Japan, 15-16 July 2015.
One Health – an interdisciplinary approach in combating emerging diseasesILRI
Presentation by Hung Nguyen-Viet, Delia Grace and Jakob Zinsstag at the International Symposium of Health Sciences (iSIHAT 2013), Kuala Lumpur, Malaysia, 20-21 August 2013.
GenSearch - Innovation in Healthcare: What is the Point?Alix Aubert
In this white paper, you will discover instances where innovation in technology and organisational operations are connecting patients to healthcare providers and are sharing secure clinical data with researchers. Others have disrupted traditional manufacturing methods to improve processes and some have even transformed organisational operations to create customer trust, value, and to improve outcomes for patients.
Working in Global HealthChapter 18Chapter 18 Working irosacrosdale
Working in Global Health
Chapter 18
Chapter 18: Working in Global Health
1
Positions in Global Health
Universities
NGOs
Social entrepreneurships
Bilateral and multilateral aid organizations
Consulting
Global health is a growing field and there are many opportunities to work in it.
2
When considering a job in Global health
Understand the skills, knowledge, and experience this type of career would entail and how you might fill gaps you have in terms of the required background for a position.
May require a good understanding of economic development.
Should appreciate cultures.
Have the ability to write and speak well.
Be willing to live and work in low and middle income countries.
If you are considering a job in global health, you should: Understand the skills, knowledge, and experience this type of career would entail and how you might fill gaps you have in terms of the required background for a position.
May require a good understanding of economic development.
Should appreciate cultures.
Have the ability to write and speak well.
Be willing to live and work in low and middle income countries.
3
Other valuable points
Get your degree in an area related to the one in which you want to work.
Build on that area through internships, fellowships, and other opportunities to live and work abroad.
Consider a graduate program to build in your studies and experiences.
Work with mentors who work directly in the field.
Other things to consider are: Get your degree in an area related to the one in which you want to work.
Build on that area through internships, fellowships, and other opportunities to live and work abroad.
Consider a graduate program to build in your studies and experiences.
Work with mentors who work directly in the field.
4
Resources for careers
DEVEX http://globalhealth.org/
The Global Health Council http://globalhealth.org/
Global Health Hub www.globalhealthhub.org
International Jobs Center http://www.internationaljobs.org/
Idealist www.idealist.org
U.S Government
USAID https://www.usaid.gov/
CDC http://www.cdc.gov/
Here are a few resources to consider when looking for a career in global health.
5
Personal Quote
“Working in global health has been my dream as long as I can remember. And just imagine how reality could be better than a dream- and that’s exactly how I feel working in this field. It’s the most fulfilling career that I could ever imagine.”
Dr. Tara Rava Zolnikov
Assistant Professor
National University
Water project in Narok, Kenya
HIV/AIDS project in Busia, Kenya
Access to water research in Kitui, Kenya
Science, Technology, and Global Health
Chapter 17
1
Chapter 17: Science, Technology, and Global Health
The Need for New Products
Characteristics of new technologies must reflect the following:
Most important target groups are poor people.
Quality of care and injection safety is often low.
Many low- and middle-income countries have poorly organized health systems.
Science and technology ...
One Health: A Holistic Approach to Achieving Global Well-beinggreendigital
Introduction:
In an interconnected world where the boundaries between humans, and animals. and the environment blurred. One Health has emerged as a comprehensive approach to addressing complex health challenges. One Health recognizes the intricate connections between the Health of humans and animals. and ecosystems, emphasizing the need for collaborative efforts across disciplines to achieve optimal well-being for all. This article delves into the fundamental principles of It, and its historical roots. and its potential to revolutionize the way we approach global Health.
Follow us on: Pinterest
Understanding One Health:
A- Definition and Scope:
It is an integrative approach that considers the Health of humans, animals. and the environment as interdependent entities. It acknowledges that the Health of one component influences the Health of the others. and disruptions in any of these systems can have far-reaching consequences. This approach goes beyond traditional silos in health management. and embraces a holistic perspective. recognizing the intricate web of connections that shape our Health.
B- Historical Roots:
The roots of the It concept can traced back to ancient civilizations. where the interconnectedness of human and animal health acknowledged. But, the formal recognition of It as a distinct field gained momentum in the late 20th century. The emergence of zoonotic diseases transmitted between animals. and humans highlighted the need for a collaborative approach to disease prevention and control.
Key Principles of One Health:
A- Interdisciplinary Collaboration:
At the heart of It is interdisciplinary collaboration. This principle involves breaking down the traditional barriers between medical, veterinary. and environmental sciences. Professionals from various fields work together to understand the complex dynamics of Health. and to develop effective strategies for prevention, surveillance, and response to emerging threats.
B- Zoonotic Disease Surveillance:
Given the increasing frequency of zoonotic disease outbreaks. It emphasizes surveillance and early detection. Monitoring diseases at the human-animal-environment interface is crucial for identifying potential threats before. they escalate into global pandemics. This proactive approach involves close collaboration between public health agencies. veterinary services, and environmental monitoring bodies.
C- Environmental Stewardship:
It recognizes the impact of environmental degradation on Health. Climate change, deforestation, and pollution can exacerbate the spread of diseases. affect water and food sources, and compromise the well-being of ecosystems. Integrating environmental stewardship into health policies is essential for safeguarding the Health of present and future generations.
Examples of One Health in Action:
A- Pandemic Preparedness:
The ongoing COVID-19 pandemic has underscored the importance of a It approach. The virus, believed to have originated in bats.
Could a ‘cancer megafund’ persuade investors to put serious money into researching the killer disease? Three alumni debate financial engineering in healthcare.
This was first published in AlumniNews, Issue 130, July 2013. Find out more about our alumni community at http://www.london.edu/alumni
Future of health - An initial perspective - Devi ShettyFuture Agenda
An initial perspective on the future of health by Dr Devi Shetty, Chairman and Founder of Narayana Health in India. This is the starting point for the global future agenda discussions taking place through 2015 as part of the the futureagenda2.0 programme. www.futureagenda.org
The Life After COVID-19: A Frontliner's Perspective.MaMonicaRivera
These slides are uploaded for information and as partial requirement of Philippine Women's University in Master of Nursing (MAN); Subject: Nursing Practicum
By: Ma. Monica Rivera, BSN, RN
Multiple health problems in elderly peoplepage 950Ex.docxgilpinleeanna
Multiple health
problems in
elderly people
page 950
Excessive
drinking in
young women
page 952
Adverse drug
reactions in
elderly people
page 956
Palliative care
beyond cancer
page 958
Drug resistant
infections in
poor countries
page 948
Management
of chronic pain
page 954
M
A
K
IN
G
A
D
IF
FE
R
E
N
C
E
945BMJ | 26 APRIL 2008 | VOLUME 336
BMJ | Making a difference | 26 april 2008 | VoluMe 336 947
Running the gauntlet to improve
patient care
This supplement is the result of a gauntlet
thrown down, and picked up, during a dinner
in London just over a year ago. The gauntlet
thrower was Don Berwick, president of the
Institute for Healthcare Improvement in Boston.
What, he asked, was the BMJ Publishing Group
really for? What were we trying to achieve? In
reply, I and our chief executive, Stella Dutton,
were quick to quote the BMJ’s mission, which
ends with the crucial words “to improve
outcomes for patients.” Fine, said Don, but how
about being more specific: which outcomes,
what patients, by how much?
We took his suggestion seriously. Why not
target a few important healthcare problems,
taking a quality improvement approach
and focusing on the evidence on how to
make a difference in these areas? But how
to choose which issues to tackle among
the many millions of pressing healthcare
challenges facing the world? We turned in the
first instance to BMJ readers. In May 2007
we asked you to tell us what information was
most needed to improve the quality of care of
patients in clinical practice. From your many
rapid responses we harvested more than 200
ideas. After categorising these and matching
them against the priorities of national and
international bodies, we created a shortlist
of 12. With the help of an expert panel (see
http://makingadifference.bmj.com) we cut
these down to six.
Inevitably the choice of topics is subjective
rather than scientific, but the six we have
ended up with are interesting. Several turn the
spotlight on areas that are less than glamorous
and are perhaps all too often passed over, even
as their impact on individual lives and society
increases. Two topics deal with problems of
old age: multiple illness and adverse drug
reactions. Two deal with palliation: of chronic
pain and in dying from non-malignant disease.
The remaining topics deal with two very
different but serious and growing public health
challenges: drug resistant infections in the
developing world and excessive drinking in
young women. You will no doubt find important
gaps in what we have chosen. But if this
initiative proves useful we can expand it further.
On each of the six topics we’ve invited
leading commentators to write the pairs
of articles that make up this supplement.
One article in each pair aims to describe
the importance of the problem in terms of
its health and societal impact. The other
looks at the available evidence on quality
improvement initiat ...
WHO Director-General's opening remarks at the media briefing on COVID-19 - 23 March 2020. President of FIFA, to talk about our joint campaign to “Pass the message to kick out coronavirus”. More than 300,000 cases of COVID-19 have now been reported to WHO, from almost every country in the world. That's heartbreaking. Some countries are struggling with the capacity to carry out these offensive measures.
Overview of the Decade of Vaccines Collaboration including background, structure and vision for creation of the Global Vaccines Action Plan.
www.dovcollaboration.org
For US election, it seems USA is heading toward new Future (real count map) while D TRUMP is criticizing election administration and results, telling it might be fraud or delay that are not acceptable. He also said during meeting he would "fire" Antony FAUCI if he would be re elected, the man who is telling the truth about pandemic and health management in North America. Joe Biden is doing is best for winning last votes. It has more interesting aspects to follow american election campaigns since events happened every hours. The current President says he may declare winner before the end of count and would not recognise election process if he is not winning himself. This is often the case in african countries, he also declare "what is happening in this country?". CNN hectic women presenters help a lot to increase interest in the topic they cover.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Maxilla, Mandible & Hyoid Bone & Clinical Correlations by Dr. RIG.pptx
Bio vision 2013 lyon
1. BioVision 2013 Lyon
Il faut donner un nouveau souffle à la recherche et les actions pour favoriser la formation des
futurs chercheurs vont dans ce sens. Ce siècle sera celui du gène, comme les précédents ont été
ceux de la vapeur et de l'industrialisation.
Biovision 2013. Ouverture de l'édition 2013.
Mme Fioraso, Ministre de l'Education supérieure et de la Recherche.
Le secteur de la Santé enregistre un chiffre d'affaire deux fois plus élevé en France quand
Allemagne et les indicateurs sont bien plus positifs que les autres domaines industriels. Plus de
200 millions d'euro sont actuellement consacrés à la recherche translationnelle en France.
Génopole Rhône-Alpes et d'autres projets ont affirmé les compétences de la Région dans ces
expertises avec des influences sur les activités Européennes et Internationales. L'orientation des
recherches va dans le sens de la guérison des maladies qui infligent des coûts important à notre
Société.
Les différentes formes de Recherches doivent maintenant dialoguer et agir pour une synergie des
efforts. Les Start-up doivent être soutenues pour devenir les groupes internationaux du futur.
Entre avril 2004 et avril 2012 plus d'une dizaine de traitements ont été mis en place pour des
maladies enfin vaincues. Principalement dans les pays développés, le potentiel des nouvelles
filières doit être mis en valeur parce qu'elles représentent des enjeux important pour les jeunes
et leur avenir. Biovision est donc un événement décisif en ce qui concerne les orientations de
Recherche et la confiance portée aux objectifs de traitements médicaux.
Transversal approaches to catalyze innovation.
Mr Andrew JACK, journalist.
Lyon is a good place for the conference of research on medical treatments. French and
international speakers have their vision on future of innovation and partnership.
Mr Chris Viehbacher.
Innovation is important for running a company and also for the Society. There is a virtual cycle of
innovation and influence on longer lifetime of famillies and health. There are more new
treatments since 2000 than before even if the financial risk is higher. The Bio tech community is
financed also by pension fund who want to make sure yo have money when you will be retired.
39 new medecines and vaccins have been approved in the US lately. They come from emerging
companies. The most important is not the building or the finance but where you find the best
professionals. Some project can create conflict between reality and dream. We have to
communicate the failing in order to avoid several teams to work on the same issues. Patient
privacy is important and it is not possible to share data. For HIV it has been posible to share
more details because data was shared without personnal indication.
Pr Jean-Marie Lehn.
Changing paradygm is needed to come to action. Innovation is under the light for long time
because it is a way of going forward in economy and discovering new treatments. A scientific
research must wait for being in time. To publish failure in the Research activity is not very good
because it shows bad result, but enquiry about why it failed might be interesting. Innovation is a
mean for structure while it is a goal for funding partners.
2. Mr Jean-Yves Gilet.
A lot of life science structures are supported for bringing success in treatment. Investor's
perspective take in account four factors: new model of patient care, increasing regulatory
pressure, limitation of public funds but more enforcement of law, a change in research effort that
will increase the competition, beside major companies some structures with innovative attitude
are emerging. Within the global finance team there is a death valey. What we need is an effort
toward the industrialization. What are the main challenges for investors? To develop partnership
is emerging structure along with public and private structures. Cooperation is a daily work for
capital venture and InnoBio is the symposium of six companies in that matter.
Mr Antoine Frérot.
Innovation is a key issue for Veolia. The company was fonded in Lyon for providing clean water
to the population. Pasteur said "we drink 90% of our illness". Water, Energy and Wastes must be
linked for a better use and recycling. More creativity must develop partnership between Mérieux
and Veolia to detect infections in drinkable water. Scarcity of natural ressource is also an issue in
term of research and use of water. Research and dreams must be linked to make a better futur.
Mr Fukuda.
WHO have an office in Lyon and this is because it is the place of work for health and treatments.
The office is working on critical points. Influenza have been a remarkable step in the will to
analyze and cure illness. An Inter-Governmental process is on-going to understand what is the
most important way to make the medical world more efficient and relevant. What needs to be
done is linked to major medical issues the world is facing. The next few decades will follow the
discovery of Penicilin. The global issue on parasites, diseases shows that combination of medical
troubles is life threatening. In addition, drug resistance problem is causing hospitals to close in
northern Europe. The struggle is why are we in a situation where the population is using drugs in
uncontroled way and this is a concern for international partners. Sharing of information with
transparency attitude is a complex issue because the structures have to change.
Mr Greg Perry.
Increasing HIV treatment access is a significant goal we have to focuse on. Where we can bring
innovation together with (...) To full fill the needs of medecines amogst population. The need for
improving regulatory and intellectual property is on of the goals. Economicaly valuable scheeme
and Business models can be improved for small scale research. The pulling of innovation and
intellectual property should become a norm and following the success it should be a pionneer
attitude.
Plenary session.
Living with micro organisms, risks and opportunities.
Pr Jules Offman.
Multi resistence to medicines has become an issue. The inside mecanisms is studied and stored
for research. Thousand of cases are under review. It is reasonable to be enthousiastic because
defense reaction is gradually better known. Contribution to knowledge is huge and there can be
10 microbs in each humans cells amongst thousand various kinds. 50 bacterias only are a threat
to human life. New strategies are arriving for both research and curation.
3. Pr Alice Dautry.
It is important to remind that one single bacteria can cause huge damage into a Nation as it has
happen before. The disease transmitted by birds is a great challenge because it can cause many
human deaths. The big fear is about virus mutation that could make the research more difficult.
Samples have been collected in four different markets and it is present on every. It means that it
is not so contagious because not so many people are seek. Virus are present everywhere, in
mud, house dust, animals etc. Mutations occurs went virus have been in contact with drugs.
Receptors study show that it must be under review because it has happened to see
contamination from human to human (really?) and not only bird to human. Promiscuty with birds
is a danger in term of threat to health.
Pr Nathan Wolfe.
HIV jump from chimp population to humans during the late 1980. 1991, 1992, 1993 where
different steps while AIDS was under research and US President to use the word AIDS. On way
of collecting data is the use of mobile phones. A Big data system collecting health status would
help to study new strategies.
Mr Sandeep Juneja.
It has been almost thirty years that HIV is under research. Virus affecting immunity system.
Affected person can have longer life expectancy now and there is a gap between developping
and developped countries. Health care can be monitored better in developping countries now. A
solution is to put skills together. Generic drugs must be allowed to make profit because it is not
possible to continue.
Pr Jean-Luc Belingare.
Infectious diseases create a significant number of death, like septism. Every hour that pases
without treatment is a increasing factor of death. Diagnose tools can help to understand illness
like melanoma and else. Technologies have been developped for better knowledge and
understanding. Pathogens are serious issues to be studied.
What about "good microorganisms" ?
There is significant virus number in Nature that can colaborate and have positive effects. Asking
if that colaboration can help to cure desease is very relevant, but also there no worse strategy to
build poor treatment on eratic data.
Who will organize to collect data ?
This should happen organicaly, and it just come from a meeting in Roma were major partners
were discussing.
What is the way forward of treating with microorganisms ?
The knowledge is thin about the large variety of effects of microorganisms. There is a need of
science about using microorganisms for curation.
4. Impact of Climate change, Diversity of microorganisms.
Pr Jean Jouzel.
We will face a serious problem because of Climate change and it will affect many life sectors.
Increase of temperature, floods and impact on Biodiversity are linked to our industry and use of
fossil fuels.
Agriculture modification and emerging deseases.
64% of human deseases comes from animals. By the end of 2050 there will be 9 billion people to
be fed. Then, food production must be increased of 50%. The problem is linked to the fact that
desease can affect humans through food. Food processes can create bad conditions, also
travelers with planes and animals. Prion, SARS, Influenza H5N1 and H1N1 have been the last
global infectious outbreak. 10 million cattle were killed in UK to prevent more human infection.
Also Schmallenberg affected Europe and this is a serious issue on european market. Chikungunya
and Dingues are two infectious deseases that have been brought to french riviera by urban
moskito.
Breading animals with high intensity, without choice of desease resistence is also a serious risk. A
tripartite concept note by WHO states that health is a public good. Holistic approachs must be
used for research about non hypothesis-driven studies. We must also be carrefull about the use
of insecticides because it may increase resistence. Modeling and prediction must follow
observation to have a clear overview of risks. There is a need of surveillance and management in
deseases outbreak.
Eradication is not a goal but protecting the population from infection is an appropriate strategy.
Dr Tanja Wolf.
Health and global environmental change.
Speaking to the audience because we are first humans, before being representatives of industry.
Health is at the center in the picture of all sectors that are affecting human status. Industry,
atmosphere, activity, gases are all connected. The dimension of the challenge have visible and
invisible points. All moving fast or slow, linked to poverty and human behaviour, but not easy to
change. Example can be a good strategy for influencing the Society. Now health and living
environment are really in direct connection as we can make observation of premature death
because of air pollution. In Europe, WHO regional office have been aware of the problem since
1989 Frankfurt meeting. The frame of action is leading in term of information sharing and
reduction of greenhouse gases. Actually Health indicators can show the positive impact of
sustainabiity on the society. Four examples of better attitude for energy, food, activity and
housing show good results. Air pollution have rapid effect on health, so it may be the easiest way
to immediatly create an impact.
Health system must be improved for eastern europe countries and partnership to help
coordination and allocation of funds for a better action.
5. Pr Henry Dicks.
The risk of reducing water to an abstraction.
It is a speech about philosophy. Scientists and philosophers are studying phenomens.
Phenomenology is then a way to look at water through this filter. In the consummer society it is
possible to see the products but not to realize how it was produced. Water as become a risk with
heavy metal, and other pollution. It would be a good idea to let water appear. The example of
Lyon shows that there is no more car park along the Rhone and there are walking path. The
change did not contribute in a significant maner to reduce climate change but it shows how it can
be done.
Risks and responses.
Dr Nathan Wolfe.
In the old times people were living where the food was grown-up. Now we have created a large
market where desease as well as products are shared. We see forces changing our life.
Dr Maria Naria.
Places where people don't have access to water will be multiplied by two, while climate change
continues to kill our environment. Causes of death are linked to water conditions, availability, and
impact of human activity on the ressource. If we move to a green society we will see the impact
of better attitude. Prevention is the major goal and climate change adaptation for health
community means access to health care. The equity question shows that the Nations creating
climate change are the best protected and those affected by climate change are those which
have less funds to face. Using bicycles in european cities has not only an effect on reducing C0²
emission but also on individual's health.
Pr Sylvie Joussaume.
Climate have impact on everything. There is an impact of weather conditions on allergies, and for
a precise example, dust can increase meningitis and there is a study ongoing about this
hypothesis.
Dr Alexandre Brailowsky.
What does mean a solution from industry point of view ?
Human activity will turn into behavior role. The participation to change of behavior is a strategy
for efficient involvement of the population. The "river keeping" movement in USA say you cant
extend the use of water without damaging the environment. Nile water ressource management
was the reason for creating the notion of "state" in Egypt.
What is the future for human capacities?
Research shows great results in term of new way of "producing" mobility. In the first case, a rat
that had a spine injury could walk again after injection. The fluid is based on typical fluids
present in the brain. It is described by the team leader as puting the brain inside the spine, as it
is encouraging the recovery of nervous signals. The main goal of the process is to force the
mobility and tell the brain to take over legs movement command.
6. Enabling technology for Biomanufacturing challenges and opportunities by 2020.
(Protest of CGT, Confederation of Workers is on going since monday morning and we can hear
drums beating. They came from various plants to alert about SANOFI project about research)
Private companies which are producing equipments, drugs and experts will discuss market trends
and strategies.
Global market 2015 is about 150 billion. Novel technologies and regulation have an impact on
production design and quality. Clinical-trial products and production are traditionally made by
hand with CMO equipment and hybrid, or product maker own plant (wich can be fixed or
modular).
New procedures are to be taken into account. For example about specific enveloppes, packaging
must be in good shape and checked. A single small pinch made by wrong handeling or bad
machines will create a dammage. It is good to learn from community experience. A small
company can be helped for first experience.
What about the coming decade and market potential ?
1- newest trends in novel therapies ?
Sciences are to be mixed.
2 - what are the biggest opportunities for growth ?
By the end of this decade the market will represent several billion of USD. Chemical drug is made
by reaction that can be reproduce by generic because same reaction produce same drug. Biologic
medicine needs complex work for building it's structure and is really difficult to copy.
3 - how to release cost pressure and improve process efficiency ?
Analytics is a big part of the cost and pressure of the regulatory. Halogeneic, immunoterapy and
cancer are emerging opportunities. Gene therapy cost is 1,250 million euro per dosis, then for
moment very narrow market but it will be transformed by production technology to an
affordable treatment.
4 - technologies and workforce to manage risk and meeting the regulation ?
The workforce needs to have relevant skills for the new challenges and then be trained to. Clean
rooms will be installed for the new investment and improving effectivness with cost reduction.
Flexibility of equipments for different kind of production is requiered. Cooperation is accelerating
the development by puting together the development teams and production, sharing skills and
creating synergies.
Innovation approach shows that much work has to be done. R&D must be done in chemistry to
understand exactly the reaction instead of creating trials of 10% dilution. Cost solving solution is
not yet found but there must be a way with halogenic products. With manpower you can save 30
to 40% of the workforce. Also, automatisation is not the best and only solution because it needs
to invest on devices and adding daily consumming of side products.
70% of new drugs are very difficult to develop because of complexity of creating production
lines. Plant based products, and acellular also show good expectation of production. It needs
7. high professional skills and then good training for changing the existing workforce into efficient
teams. For example chemist must also be able to manage bio-ingeneering. Conversion of workers
can be long because technologies require precise activity.
In Germany it is easier to work by combining University and Work. The most difficult part is not
to train people but to find an adequate situation for each.
Quality by design is based on understanding the structure and clinical effect of a drug. If you do
that well you can save time and money. Time management, manufacturing and distribution
through commercial readiness. As suppliers, companies must bring in the correct intrants to help
drug development.
Focusing on quality and reducing the risk of polutant during process are the main goals. To work
with partners for developping efficient industrialization and controled production.
Lifescience research in Brazil. San Paolo.
Pr Eduardo Kriger. Fundacion for medical research.
Pr Raul Machado Neto. University of San Paolo.
Building trust and reliability. The country is not only sunny picture for tourists but also has a
relevant University training. Certificates are possible in many and almost all carrers. San Paolo
represent 52% of brazilian scientific papers in the country. Between 2000 and 2009, more than
58.000 articles about life sciences. There is an evident increase of publication and 24% of the
papers are written with international colaboration. Life science Post graduate programs are
amongst the more numerous within the total of graduations in Brazil. Interdisciplinary research
office establish a program for this specific groups. 123 groups are actually financed for this work.
Internationalization strategies are both symetric and asymetric programs. An agreement is signed
with Ohio University. Both students and teachers have to be internationaly experienced.
Pr Eduardo Kriger.
San Paolo Research Fundation have 20.000 proposals of research per year. 11.000 fellowships
and up to 11 year long financed program. There is even on approval per week about life science
research. Nature publication mentionned that 152 projects in Brazil are about Life Science. The
rate of funds involved for each researcher have increased. 47% of energy in Brazil are
renewable, 18% is sugar cane. Renewable use in the World is 13% and OCDE 7%. FAPESP
Bioenergy research project is about bio fuels. Sugarcane research have the most important
number of research. BIOTA virtual institute is about collecting and disseminating data about
science in Brazil. Resolutions are made thanks to the work of BIOTA.
The supercomputer of 15 Tflops sustainable is used for several areas of research about Climate
change.
Also San Paolo is believing that exchange of scientists and students enable better work. Focus on
scientific research is not only utilitarian but also in Academic research for Humanities. Challenges
are about the impact of scientific production, international cooperation and the number of
scientists in Academia and Industry.
The Academy of UK showed a report where 50% of reports are international, and it has better
impact in the society. Then the same goal must be applied to Brazilian Academy.
8. RIDC Research, Innovation and Dissemintation Centers have a goal of cooperation between
Governmental, non-governemental, laboratories and Academic structures. Each center is ran by a
team that is managing the work.
Participants at the workshop are asking about future international cooperation with Egypt, France
and another brazilian state away from Sao Paolo area.
Plenary session
Can we avoid lifestyle diseases-individually or collectively ?
The incidence of lifestyle deseases count for several ten of million per year. It is linked to daily
life, food and activity. Being seated during one hour per day, instead of having physical activity
increase the risk of death by 5%.
It is possible to reduce life style desease. Yes it is possible to modify risk factor for heart troubles
by having better food habits and activity. Billions of dollars are still made by selling junk food and
tobacco smokers continue to raise up.
Dr Sushila Chang, Singapore.
Taking example of the study of crustaces. It is easy to see that humans and animals are not very
good at daily life. Crabs doen't make good job on filtering water and are not so usefull. Smoking
have been said to be bad for health. People are walking more instead of taking a lift. But is that
going to change anything ? Even after cancer some people can have a aadiction to tobacco.
How do we measure health behavior ? Working with very young children means to have 10
minutes of dance or funny activity because it will decrease fat. It reduces body indicator.
Infectious desease are decreasing due to vaccins. Smallpox is not anymore present. Also it is a
need to educate the population. Regulation about food is to avoid sanitery troubles but it is not a
promotion of good nutrition. Food consumption should be adapted to a better lifestyle. Models
have been included in a software that can help people to monitor their daily food habits and
physical activity. Technology can help to make some change into the society. Innovation is an
important work for better public health.
Approach of food and desease is very complex. Academic researchers have good reputation for
studies. Governments have the power to raise money through taxes and use it localy. Green and
healthy products are coming to the market through new industrial offer.
One million people died because of tobaco last century and they will be one billion during the
next one.
Closing session European commission horizon 2020.
EU plan for funding: research program to be discussed by the european council. FP7 have been
launched in 2007 and the economic situation have changed. Prioritizing medical research is also
protecting employement and activity. Europe to be a better place for investment by supporting
innovation and activity up to 20 billion euro. Lifescience Horizon 2020 means less burocraty and
better access to funds. Growth and jobs will benefit from the program.
9. We are facing a crisis in industry because of energy cost. Plans for investments are focusing on
USA because of energy price. The innovation is important to rebuilt a new network of
Biofactories. Clear market standard to be set. Public-private partnership works well and
developping activities in rural area for Biotechnologies is a part of the game. Industry can afford
that investments together with DGs Europe that will focuse on it's own role. The roadmap
stresses that research in Europe is a priority. The potential risk of lack of research funds in
Europe is that researchers may go away.
A serious problem comes from the fact that the population does not follow the advices, for
example about condoms/AIDS or Tobacco/Cancer.
Energy is not the only critical point for european industry but also the weakness of capacity for
raising funds. Pension funds and other investors are wondering if they can make money with that
projects. Buraucratic process for investment must be faster because opportunities can disappear
fast. The current generation that is still managing industry is part of the problem and carrying the
wastes. The next step is to use wastes for creating building material or else.
Partnership in Europe is mandatory for research, but it will also be opened to overseas
cooperation. Thinking to work only with european members would be forgetting the globalisation.
Commercialisation of products is the aim of investment, research and industrialization.
Awards Ceremony was the time of rewarding research of seven teams working in the field.
Published by RDM-ROW http://slideshare.net/reporter Dominique Deschamps