In this white paper, you will discover instances where innovation in technology and organisational operations are connecting patients to healthcare providers and are sharing secure clinical data with researchers. Others have disrupted traditional manufacturing methods to improve processes and some have even transformed organisational operations to create customer trust, value, and to improve outcomes for patients.
The future of patient data the danish perspective 2018Future Agenda
The Danish perspective on implications from the future of patient data - insights from discussions in Copenhagen
Denmark is recognised as one of the leading nations for healthcare and is at the forefront of digital transformation in the sector. As new challenges and opportunities emerge over the next decade this article considers what the core drivers of change may be and explores how developments in the availability and use of more and better patient data may impact the Danish health system. Linking together previous research, a recent related Future Agenda initiative and insights from a number of expert discussions in Copenhagen, it then examines the pivotal issues that will affect healthcare providers in the future and considers how the wider sharing of exemplary data can change delivery models.
Given the overall dynamics, many conclude that Denmark is one of the most connected, well-funded and healthy nations in the world. The advent of more and better health data should therefore have additional impact. So, what about the future? How will the global changes underway impact and enhance the Danish system? Moreover, what will be the national vs regional response?
A recent global project exploring the future of patient data was undertaken by Future Agenda in partnership with leading organisations around the world. (www.futureofpatientdata.org) Twelve events across many different healthcare systems brought together over 300 experts to debate the primary shifts for the next decade as well as explore their implications. Within this, several shared ambitions in a number of different countries were identified – many of which can already be seen as existing assets of the Danish system: Good quality patient data, common access to it, and means of interacting with both the information and the different communities who form the full care system.
As the first phase of a subsequent series of more regional, national dialogues, in June 2018 additional discussions were undertaken with healthcare experts in Copenhagen to uncover more detail. Hosted by DTU Business, the aim was to both respond to the global context from the Future of Patient Data project and debate what the implications may be for Denmark. In particular, a core objective was to identify what are the primary issues for the Danish healthcare system for the next decade.
The future of patient data the danish perspective 2018Future Agenda
The Danish perspective on implications from the future of patient data - insights from discussions in Copenhagen
Denmark is recognised as one of the leading nations for healthcare and is at the forefront of digital transformation in the sector. As new challenges and opportunities emerge over the next decade this article considers what the core drivers of change may be and explores how developments in the availability and use of more and better patient data may impact the Danish health system. Linking together previous research, a recent related Future Agenda initiative and insights from a number of expert discussions in Copenhagen, it then examines the pivotal issues that will affect healthcare providers in the future and considers how the wider sharing of exemplary data can change delivery models.
Given the overall dynamics, many conclude that Denmark is one of the most connected, well-funded and healthy nations in the world. The advent of more and better health data should therefore have additional impact. So, what about the future? How will the global changes underway impact and enhance the Danish system? Moreover, what will be the national vs regional response?
A recent global project exploring the future of patient data was undertaken by Future Agenda in partnership with leading organisations around the world. (www.futureofpatientdata.org) Twelve events across many different healthcare systems brought together over 300 experts to debate the primary shifts for the next decade as well as explore their implications. Within this, several shared ambitions in a number of different countries were identified – many of which can already be seen as existing assets of the Danish system: Good quality patient data, common access to it, and means of interacting with both the information and the different communities who form the full care system.
As the first phase of a subsequent series of more regional, national dialogues, in June 2018 additional discussions were undertaken with healthcare experts in Copenhagen to uncover more detail. Hosted by DTU Business, the aim was to both respond to the global context from the Future of Patient Data project and debate what the implications may be for Denmark. In particular, a core objective was to identify what are the primary issues for the Danish healthcare system for the next decade.
The ten predictions for 2020
1. Health consumers in 2020
Informed and demanding patients are now partners in their own healthcare
2. Health care delivery systems in 2020
The era of digitised medicine - new business models drive new ideas
3. Wearables and mHealth applications in 2020
Measuring quality of life not just clinical indicators
4. Big Data in 2020
Health data is pervasive – requiring new tools and provider models
5. Regulation in 2020
Regulations reflect the convergence of technology and science
6. Research and Development in 2020
The networked laboratory - partnerships and big data amidst new scrutiny
7. The pharmaceutical commercial model in 2020
Local is important but with a shift from volume to value
8. The pharmaceutical enterprise configuration - the back office in 2020
Single, global and responsible for insight enablement
9. New business models in emerging markets in 2020
Still emerging, but full of creativity for the world
10. Impact of behaviours on corporate reputation in 2020
A new dawn of trust
2018 has finally arrived, and healthcare companies’ executives from both small and big firms have hit the ground running. With technological artificial intelligence and new drugs in the industry, below are 6 healthcare predictions for 2018.
Further to several additional expert workshops this year, we are delighted to share an updated global perspective on the future of healthcare. Produced in partnership with Duke Corporate Education (http://www.dukece.com), this adds new insights on the pivotal shifts taking place across the sector plus viewpoints on some of the core implications for leadership. Topics include the growing power of data; the rising impact of urbanisation on health; increasing patient centricity; the need for more flexible organisations and the move of innovation activity eastwards.
Available as both a report and as this accompanying presentation this is now being used to inform and provoke further debate around the world. As ever we would like to thank all those who have given their time and insight to contribute to this project.
Wendy Mayer, VP of Worldwide Innovation at Pfizer presented this at the Health Hackathon at Cornell Tech on April 9, 2015 to the audience of Cornell, MIT, Harvard, and Weill students. #HealthHack2015
In this report we set out ten provocative statements predicting the world of 2020. Each prediction is articulated and brought to life through a series of portraits which imagine how patients, healthcare professionals and life sciences organizations might behave in this new world. Our predictions lean more towards an optimistic view of the future, although we organized that many in our industry are organized about the constraints and therefore pace of change. We describe the big trends rolled forward to 2020 and some of the constraints that will need to be overcome.
We also provide examples and evidence, based on the here and now, that show that the predictions are perfectly plausible, perhaps inspiring and surprising!
Our industry is changing quickly – requiring a bold response that is often difficult to implement – and yet organizations struggle to understand how to respond effectively and build a sense of urgency. We hope this report creates rich dialogue and enables a move to action.– we have had enormous fun discussing these predictions and sharing our experiences. We hope you have the same experience within your own organizations as you peruse this report and reflect on your current situation and future scenarios.
The Consumer Study: From Marketing to Mattering, Generating Business Value by...Sustainable Brands
--The UN Global Compact-Accenture CEO Study on Sustainability
--In collaboration with Havas Media RE:PURPOSE
Consumers have been consistently identified by business leaders as the most important stakeholder in guiding their action on sustainability. However, interpreting the signals from this group is contributing to CEOs’ frustrated ambition at the pace of change in embedding sustainability into the core business and global markets.
Consumers expect more from companies, from greater honesty and transparency to greater impact on global and local challenges and a more responsible stewardship of natural resources and the environment. Yet among business leaders there is a sense that companies have failed to engage the consumer on sustainability; that companies’ reputation and performance on environmental, social and governance issues are not informing consumers’ purchasing decisions; and that industry leaders on sustainable business practices are not being rewarded by the market.
Read this companion report to the world’s largest CEO study on sustainability to date, where 30,000 consumers worldwide give their views on their quality of life, expectations on business and governments, and attitudes towards responsible brands.
20 tendencias digitales en salud digital_ The Medical FuturistRichard Canabate
Resaltado de las tendencias que darán forma a la atención médica post COVID19.
No se trata de enumerar estas tendencias, sino de dar una valiosa visión de los factores de conducción detrás de ellas mientras que es muy específico. Se trata de mostrar cuáles son las áreas exactas que deben destacarse entre todas las áreas en el tema "IA en la atención médica", por ejemplo.
Upping the "Total" in Total Rewards. Incentivizing your employees with the most sophisticated wearable technology, measuring more biomarkers than any other device, and the only device meriting being reviewed as a medical device. Included in the cost of the device - customized wellness programs designed on your employees biometrics. Our commitment to provide the most personalized corporate wellness programs, at the most affordable price and everyone gets the ultimate wearable technology. We will happily help you design a true program of reward - employee/employer contribution - rewarding commitment and motivation.
Best of 5 regenerative medicine companies 2021 Merry D'souza
Best of 5 Regenerative Medicine Companies, we came across innovative companies that are ceaselessly striving to deliver the best therapeutic provisions rooting from strong research & development.
The 10 most innovative pharma and life sciences solutions providers jan 2018Merry D'souza
With great enthusiasm Insights Success has selected some of the most prominent organizations around the globe in the issue of “The 10 Most Innovative Pharma and life sciences Solution Providers 2018,”
There is increasing awareness that seniors represent a diverse group ranging in age, ability, and needs. As a result, senior care solutions are not “one size fits all” – an important lesson as innovators aim to scale solutions. Solutions geared towards seniors must be easy-to-use and solve a specific problem. This helps ensure technology actually improves quality of life and wellbeing, and does not become a nuisance. Ideally, developing senior care solutions should involve various stakeholders including clinicians, designers, and seniors themselves. Mass market products aimed at improving convenience and livability (e.g., Blue Apron, Amazon’s Alexa) have the opportunity to enable independent living. However, large companies need to better market their products to seniors and their caregivers. Venture capitalists are realizing that seniors represent a significant opportunity, but usually tend to invest in solutions that have a broader impact across any one single population or disease state (with some exception).
MSD Policy Passport on pharmaceutical innovation - October 2023 v2.pdfBoris Azaïs
Presentation of the key public policies at the source of all medicines ever developed and a review of about 40+ key issues often raised when discussing pharmaceutical policy in a crisp format with references supporting the presentation.
The ten predictions for 2020
1. Health consumers in 2020
Informed and demanding patients are now partners in their own healthcare
2. Health care delivery systems in 2020
The era of digitised medicine - new business models drive new ideas
3. Wearables and mHealth applications in 2020
Measuring quality of life not just clinical indicators
4. Big Data in 2020
Health data is pervasive – requiring new tools and provider models
5. Regulation in 2020
Regulations reflect the convergence of technology and science
6. Research and Development in 2020
The networked laboratory - partnerships and big data amidst new scrutiny
7. The pharmaceutical commercial model in 2020
Local is important but with a shift from volume to value
8. The pharmaceutical enterprise configuration - the back office in 2020
Single, global and responsible for insight enablement
9. New business models in emerging markets in 2020
Still emerging, but full of creativity for the world
10. Impact of behaviours on corporate reputation in 2020
A new dawn of trust
2018 has finally arrived, and healthcare companies’ executives from both small and big firms have hit the ground running. With technological artificial intelligence and new drugs in the industry, below are 6 healthcare predictions for 2018.
Further to several additional expert workshops this year, we are delighted to share an updated global perspective on the future of healthcare. Produced in partnership with Duke Corporate Education (http://www.dukece.com), this adds new insights on the pivotal shifts taking place across the sector plus viewpoints on some of the core implications for leadership. Topics include the growing power of data; the rising impact of urbanisation on health; increasing patient centricity; the need for more flexible organisations and the move of innovation activity eastwards.
Available as both a report and as this accompanying presentation this is now being used to inform and provoke further debate around the world. As ever we would like to thank all those who have given their time and insight to contribute to this project.
Wendy Mayer, VP of Worldwide Innovation at Pfizer presented this at the Health Hackathon at Cornell Tech on April 9, 2015 to the audience of Cornell, MIT, Harvard, and Weill students. #HealthHack2015
In this report we set out ten provocative statements predicting the world of 2020. Each prediction is articulated and brought to life through a series of portraits which imagine how patients, healthcare professionals and life sciences organizations might behave in this new world. Our predictions lean more towards an optimistic view of the future, although we organized that many in our industry are organized about the constraints and therefore pace of change. We describe the big trends rolled forward to 2020 and some of the constraints that will need to be overcome.
We also provide examples and evidence, based on the here and now, that show that the predictions are perfectly plausible, perhaps inspiring and surprising!
Our industry is changing quickly – requiring a bold response that is often difficult to implement – and yet organizations struggle to understand how to respond effectively and build a sense of urgency. We hope this report creates rich dialogue and enables a move to action.– we have had enormous fun discussing these predictions and sharing our experiences. We hope you have the same experience within your own organizations as you peruse this report and reflect on your current situation and future scenarios.
The Consumer Study: From Marketing to Mattering, Generating Business Value by...Sustainable Brands
--The UN Global Compact-Accenture CEO Study on Sustainability
--In collaboration with Havas Media RE:PURPOSE
Consumers have been consistently identified by business leaders as the most important stakeholder in guiding their action on sustainability. However, interpreting the signals from this group is contributing to CEOs’ frustrated ambition at the pace of change in embedding sustainability into the core business and global markets.
Consumers expect more from companies, from greater honesty and transparency to greater impact on global and local challenges and a more responsible stewardship of natural resources and the environment. Yet among business leaders there is a sense that companies have failed to engage the consumer on sustainability; that companies’ reputation and performance on environmental, social and governance issues are not informing consumers’ purchasing decisions; and that industry leaders on sustainable business practices are not being rewarded by the market.
Read this companion report to the world’s largest CEO study on sustainability to date, where 30,000 consumers worldwide give their views on their quality of life, expectations on business and governments, and attitudes towards responsible brands.
20 tendencias digitales en salud digital_ The Medical FuturistRichard Canabate
Resaltado de las tendencias que darán forma a la atención médica post COVID19.
No se trata de enumerar estas tendencias, sino de dar una valiosa visión de los factores de conducción detrás de ellas mientras que es muy específico. Se trata de mostrar cuáles son las áreas exactas que deben destacarse entre todas las áreas en el tema "IA en la atención médica", por ejemplo.
Upping the "Total" in Total Rewards. Incentivizing your employees with the most sophisticated wearable technology, measuring more biomarkers than any other device, and the only device meriting being reviewed as a medical device. Included in the cost of the device - customized wellness programs designed on your employees biometrics. Our commitment to provide the most personalized corporate wellness programs, at the most affordable price and everyone gets the ultimate wearable technology. We will happily help you design a true program of reward - employee/employer contribution - rewarding commitment and motivation.
Best of 5 regenerative medicine companies 2021 Merry D'souza
Best of 5 Regenerative Medicine Companies, we came across innovative companies that are ceaselessly striving to deliver the best therapeutic provisions rooting from strong research & development.
The 10 most innovative pharma and life sciences solutions providers jan 2018Merry D'souza
With great enthusiasm Insights Success has selected some of the most prominent organizations around the globe in the issue of “The 10 Most Innovative Pharma and life sciences Solution Providers 2018,”
There is increasing awareness that seniors represent a diverse group ranging in age, ability, and needs. As a result, senior care solutions are not “one size fits all” – an important lesson as innovators aim to scale solutions. Solutions geared towards seniors must be easy-to-use and solve a specific problem. This helps ensure technology actually improves quality of life and wellbeing, and does not become a nuisance. Ideally, developing senior care solutions should involve various stakeholders including clinicians, designers, and seniors themselves. Mass market products aimed at improving convenience and livability (e.g., Blue Apron, Amazon’s Alexa) have the opportunity to enable independent living. However, large companies need to better market their products to seniors and their caregivers. Venture capitalists are realizing that seniors represent a significant opportunity, but usually tend to invest in solutions that have a broader impact across any one single population or disease state (with some exception).
MSD Policy Passport on pharmaceutical innovation - October 2023 v2.pdfBoris Azaïs
Presentation of the key public policies at the source of all medicines ever developed and a review of about 40+ key issues often raised when discussing pharmaceutical policy in a crisp format with references supporting the presentation.
Powering the Future of Healthcare in Asia | The Propell Group | Baker & McKenzieJulien de Salaberry
"Powering the Future of Healthcare in Asia Pacific" is a six-part report series produced by Baker & McKenzie in partnership with The Propell Group. The Report, which will be released over the period of six months, considers the impact of technological innovation on healthcare in the region and highlights some of the legal concerns which start-up innovators, and pharmaceutical and medical devices companies may face in this new paradigm of e-Health
#healthtechasia
Future of Healthcare – Leadership Challenges
Further to several additional expert workshops this year, we are delighted to share an updated global perspective on the future of healthcare. Produced in partnership with Duke Corporate Education (http://www.dukece.com), this adds new insights on the pivotal shifts taking place across the sector plus viewpoints on some of the core implications for leadership. Topics include the growing power of data; the rising impact of urbanisation on health; increasing patient centricity; the need for more flexible organisations and the move of innovation activity eastwards.
Available as both this report and as an accompanying presentation (https://www.slideshare.net/futureagenda2/future-of-healthcare-15-october-2019-182433390) this is now being used to inform and provoke further debate around the world. As ever we would like to thank all those who have given their time and insight to contribute to this project.
Report capturing the content of the MSD Access, Innovation, and Affordability Forum organized by MSD in 2007 (Munich) and 2008 (Istanbul). The report was produced for the third edition of the AIA Forum, which took place in Warsaw in 2009.
Alabidi 1Alabidi 3Darwinian Medicine and US-style Bi.docxnettletondevon
Alabidi 1
Alabidi 3
Darwinian Medicine and US-style Biomedicine
Also known as the Evolutionary Medicine, Darwinian Medicine refers to the application and inclusion of modern theory of evolution in the understanding of health and diseases. Unlike other medical researchers and approaches, Darwinian Medicine focuses on the link between evolution and the ways mechanisms of microevolution shape our susceptibility to diseases (Darwinian Medicine, 2015). Its inclusion of broad concepts, theories and principles have helped in framing health and wellness relative to mainstream US-style biomedicine. The impact of Darwinian Medicine on US-style biomedicine has helped in building the latter's’ understanding of human diseases and approaches to counter them. While other biomedicine organizations focus on the molecular and physiological mechanism of health and diseases, the US-style biomedicine is a notch higher
, thanks to Darwinian Medicine incorporation
.
Discordance Hypothesis and Environment of Evolutionary Adaptedness (EEA)
Discordance hypothesis is a theory that assesses the disjunction between previous and modern environments and predicts the numerous points of vulnerability, due to rapid environmental changes. Through its disjunction, it addresses the fundamental disease process which has resulted to the declaration of several chronic civilization diseases. On the other hand, Environment Evolutionary Adaptiveness (EEA) offers a vital approach towards understanding functional properties of different species in relation to its environment (Hagen, 2015). From the above definitions, it is important to point out that our information age society primarily differs from the Environment of Evolutionary Adaptedness based on diet, exercise, exposure to toxins and reprosuctive pattenrs; the in-depth assessment of environmental vulnerabilities as compared to EEA’s functional properties.
Evolutionary Perspective on Diseases and Conditions
Being products of evolution, the evolutionary perspective might be able to expound on our understanding of a particular disease, its causes and treatment approaches (Konner, 2001). A good example of a disease that is explained by the evolutionary perspective is the heart disease. The evolutionary perspective offers an interesting perspective that looks at the evolutionary process of this disease up to where we are today. For instance, modern heart disease is attributed to evolutionary mismatches between the human genes and our modern social environment.
The presence of heart disease in today’s world is as a result of dissimilarities between our past and present environments and lifestyles
. Evolutionary perspectives point out that, the development of heart disease is linked to the dramatic change in our environment leading to increased incidences and prevalence of the disease. With the increased number of heart disease cases today suggests that healthy living is the possible prevention approach against the disease.
Barr.
Powering the Future of Healthcare in Asia Pacific | Full ReportGalen Growth
How technology will change healthcare delivery
1) The creative destruction of healthcare
2) Data driven healthcare
3) Funding
4) Disruption in Healthcare
5) Opportunity to leapfrog to accelerate change
American Healthcare Industrial RevolutionRobert Bond
Breakthroughs in information technology, telecommunications, and medical science have set the stage for a dramatic transformation of healthcare. The realities of large numbers of aging, chronically ill people will spark a crisis that will galvanize public opinion and lead to rapid change. Here’s what you should know regarding challenges and opportunities in the new landscape.
Europe's Top 5 Effective Leaders in Healthcare Edition.pdfinsightscare
Insights Care’s team carried out its own research and found the ‘Europe's Top 5 Effective Leaders in Healthcare,’ and depicted their revolutionary tales
Could a ‘cancer megafund’ persuade investors to put serious money into researching the killer disease? Three alumni debate financial engineering in healthcare.
This was first published in AlumniNews, Issue 130, July 2013. Find out more about our alumni community at http://www.london.edu/alumni
Future of health - Insights from Discussions Building on the future of health...Future Agenda
Insights from Discussions Building on the future of health by Dr Devi Shetty, Chairman and Founder of Narayana Health in India. This includes insights from events already completed adding to the starting point for the global future agenda discussions taking place through 2015 as part of the the futureagenda2.0 programme. www.futureagenda.org
Using technology-enabled social prescriptions to disrupt healthcareDr Sven Jungmann
As chronic diseases are increasingly straining healthcare systems, social factors are gaining importance. Since the birth of social medicine (19th century), we saw many failed attempts to beat the dominance of the biomedical model. Social prescriptions have come, raising hopes that non-biomedical solutions will improve outcomes and optimise resource use. Social Prescriptions connect citizens to support to address social determinants of health and encourage self-care for physical and mental health. Social prescriptions can make us healthier cheaper and with fewer side effects than most drugs. Social prescriptions can become a disruptive force as they can be personalised, improve lifestyle-related diseases, and support non-biomedical issues affected by social determinants of health.
The 10 most innovative bio tech solution providersMerry D'souza
Recognizing such professionals that are revolutionizing the Bio-Tech Solution Providers’ segment and keeping innovation on their radar by staying up-to-speed with the developments, we have come up with this special edition of "The 10 Most Innovative Bio Tech Solution Providers to Watch in 2020".
This issue has featured a handful of companies offering a diverse and engaging mix of commitment and distinctiveness. It will help you to walk through a list of experts embracing a multi-disciplinary approach and covering a range of relevant issues in its sector.
On the Cover of the issue is DiponEd – an innovative healthcare biotechnology R&D driven company.
Deep Leg Vein Thrombosis (DVT): Meaning, Causes, Symptoms, Treatment, and Mor...The Lifesciences Magazine
Deep Leg Vein Thrombosis occurs when a blood clot forms in one or more of the deep veins in the legs. These clots can impede blood flow, leading to severe complications.
R3 Stem Cells and Kidney Repair A New Horizon in Nephrology.pptxR3 Stem Cell
R3 Stem Cells and Kidney Repair: A New Horizon in Nephrology" explores groundbreaking advancements in the use of R3 stem cells for kidney disease treatment. This insightful piece delves into the potential of these cells to regenerate damaged kidney tissue, offering new hope for patients and reshaping the future of nephrology.
Medical Technology Tackles New Health Care Demand - Research Report - March 2...pchutichetpong
M Capital Group (“MCG”) predicts that with, against, despite, and even without the global pandemic, the medical technology (MedTech) industry shows signs of continuous healthy growth, driven by smaller, faster, and cheaper devices, growing demand for home-based applications, technological innovation, strategic acquisitions, investments, and SPAC listings. MCG predicts that this should reflects itself in annual growth of over 6%, well beyond 2028.
According to Chris Mouchabhani, Managing Partner at M Capital Group, “Despite all economic scenarios that one may consider, beyond overall economic shocks, medical technology should remain one of the most promising and robust sectors over the short to medium term and well beyond 2028.”
There is a movement towards home-based care for the elderly, next generation scanning and MRI devices, wearable technology, artificial intelligence incorporation, and online connectivity. Experts also see a focus on predictive, preventive, personalized, participatory, and precision medicine, with rising levels of integration of home care and technological innovation.
The average cost of treatment has been rising across the board, creating additional financial burdens to governments, healthcare providers and insurance companies. According to MCG, cost-per-inpatient-stay in the United States alone rose on average annually by over 13% between 2014 to 2021, leading MedTech to focus research efforts on optimized medical equipment at lower price points, whilst emphasizing portability and ease of use. Namely, 46% of the 1,008 medical technology companies in the 2021 MedTech Innovator (“MTI”) database are focusing on prevention, wellness, detection, or diagnosis, signaling a clear push for preventive care to also tackle costs.
In addition, there has also been a lasting impact on consumer and medical demand for home care, supported by the pandemic. Lockdowns, closure of care facilities, and healthcare systems subjected to capacity pressure, accelerated demand away from traditional inpatient care. Now, outpatient care solutions are driving industry production, with nearly 70% of recent diagnostics start-up companies producing products in areas such as ambulatory clinics, at-home care, and self-administered diagnostics.
One of the most developed cities of India, the city of Chennai is the capital of Tamilnadu and many people from different parts of India come here to earn their bread and butter. Being a metropolitan, the city is filled with towering building and beaches but the sad part as with almost every Indian city
The Importance of Community Nursing Care.pdfAD Healthcare
NDIS and Community 24/7 Nursing Care is a specific type of support that may be provided under the NDIS for individuals with complex medical needs who require ongoing nursing care in a community setting, such as their home or a supported accommodation facility.
Explore our infographic on 'Essential Metrics for Palliative Care Management' which highlights key performance indicators crucial for enhancing the quality and efficiency of palliative care services.
This visual guide breaks down important metrics across four categories: Patient-Centered Metrics, Care Efficiency Metrics, Quality of Life Metrics, and Staff Metrics. Each section is designed to help healthcare professionals monitor and improve care delivery for patients facing serious illnesses. Understand how to implement these metrics in your palliative care practices for better outcomes and higher satisfaction levels.
Global launch of the Healthy Ageing and Prevention Index 2nd wave – alongside...ILC- UK
The Healthy Ageing and Prevention Index is an online tool created by ILC that ranks countries on six metrics including, life span, health span, work span, income, environmental performance, and happiness. The Index helps us understand how well countries have adapted to longevity and inform decision makers on what must be done to maximise the economic benefits that comes with living well for longer.
Alongside the 77th World Health Assembly in Geneva on 28 May 2024, we launched the second version of our Index, allowing us to track progress and give new insights into what needs to be done to keep populations healthier for longer.
The speakers included:
Professor Orazio Schillaci, Minister of Health, Italy
Dr Hans Groth, Chairman of the Board, World Demographic & Ageing Forum
Professor Ilona Kickbusch, Founder and Chair, Global Health Centre, Geneva Graduate Institute and co-chair, World Health Summit Council
Dr Natasha Azzopardi Muscat, Director, Country Health Policies and Systems Division, World Health Organisation EURO
Dr Marta Lomazzi, Executive Manager, World Federation of Public Health Associations
Dr Shyam Bishen, Head, Centre for Health and Healthcare and Member of the Executive Committee, World Economic Forum
Dr Karin Tegmark Wisell, Director General, Public Health Agency of Sweden
2. A WHITE PAPER BY GENSEARCH - All rights reserved - 2017
What is the Point?
Innovation:
The Life Science Industry and in particular healthcare, is currently
undergoing considerable change. Healthcare systems are facing
ever increasing demands. One of the drivers for this increasing
burden in developed countries is ageing and rising chronic
disease. In emerging countries, providing high quality care to all as
affordably as possible is critical, as well as dealing with infectious
and other diseases.
All around the world healthcare systems are having to deal with
difficult challenges in a complex environment ranging from
tightening national healthcare budgets in developed countries
to limited resources in other emerging countries. This, ultimately,
means delivering more with less.
Paradoxically, new technologies can drive up costs in healthcare.
The innovation driven Life Sciences industry will be forced to find
new ways to create innovative solutions to meet these challenges.
The 2017 Life Sciences Talks illustrate just a few examples of the
creation of innovation that have successfully transformed different
levels of life science businesses to create value for key stakeholders.
In this white paper, you will discover instances where innovation in
technology and organisational operations are connecting patients
to healthcare providers and are sharing secure clinical data with
researchers. Others have disrupted traditional manufacturing
methods to improve processes and some have even transformed
organisational operations to create customer trust, value, and to
improve outcomes for patients.
SÉBASTIEN STOITZNER, CEO – GENSEARCH
2
3. A WHITE PAPER BY GENSEARCH - All rights reserved - 2017
MARIE-CAROLINE CHAUVET
Partner,
Insigniam
MARIE-CAROLINE CHAUVET
Partner,
Insigniam
Talk of innovation and its
importance is everywhere in
Life Sciences as in all industries.
We don’t always take the
time to ensure that we have
the same understanding of
what we mean by innovation
even within an organization. Is
innovation limited to R&D, or
R&I, or D&I as some design &
innovation functions are now
called? Does innovation expand
to all functions and employees
in an organization, including
innovating the culture? Do we
sufficiently have our attention on
creating the conditions required
for innovation to flourish?
A useful question to ask
ourselves is: “who are we
innovating for?” When you
use the following definition of
innovation, “anything novel or
new that creates new value”,
your attention is immediately
drawn to the end-user and
the person or people who will
benefit from the value and
those who will be willing to
pay for it.
BENJAMIN DAMIEN
Director of Business Development
Univercells
DAVID MANSET
CEO, CSO & Blockchain Entrepreneur
almerys
PROFESSOR JAMES BARLOW
Professor of Technology and
Innovation Management
Imperial College London
LUKASZ KOWALIK
Head of the Innovation Think Tank
Merck Group
TheSpeakers
NEAL WILLIAMS
Director. Front-End Innovation:
Head of Connected Health
Medicom, a Phillips-Medisize Company
COLLEEN SCHULLER
Vice President, Global Head of Selling
Excellence at GlaxoSmithKline
3
4. A WHITE PAPER BY GENSEARCH - All rights reserved - 20174
ExecutiveSummaryGenSearch is a European Executive Search and HR services consultancy
dedicated to the Life Sciences. Its focus covers the Pharmaceutical, Medical Devices
and Biotech industries. Over the years, the firm has gradually acquired a profound
interest and insight into the transformation of the European healthcare systems and
their stakeholders.
Each year GenSearch holds the Life Science Talks from which a white paper is
written. The conference focuses on the challenges and current changes in healthcare
by showcasing actual examples and experiences from key stakeholders.
The theme for 2017 was “Innovation: What is the Point?”
The speakers, game changers in their domain, were invited to present the innovative
changes they have made or contributed to and give their advice on breaking down
barriers to change.
The Life Sciences Industry is facing significant challenges today as it continues to
provide solutions for new health problems, while facing the burden of an increasingly
ageing and obese population in complex health systems. Complexity in the health
sector differs around the world. In developed countries, technological advances
have driven the cost of healthcare to unsustainable levels. The developed world
needs cost-effective healthcare solutions. Emerging countries lack key resources
and infrastructure and so will need to develop their own solutions to provide quality
healthcare. They can both find inspiration from each other and the innovative
solutions that emerge from different health systems worldwide.
Providers of scientific innovation and new R&D business models are emerging
as a response to the rising challenges. Science is becoming increasingly open to
anyone with an innovative idea. New sources of funding for research are making the
development of these ideas possible.
Access to secure health data is a key issue to improving patient outcomes. Monitoring
health data for patients with chronic conditions can improve patient adherence to
medication, reduce morbidity and mortality associated with poor adherence. At
this event we discussed how connected healthcare can improve patient adherence.
People living with chronic conditions can also make their health data available for
Medical research. We also explored how Blockchain technology is being used to
provide high quality and secure health data for medical research.
Finally, as large pharmaceutical companies are being challenged to become more cost
effective while developing new products, there is also a real need to build customer
trust. As a result, innovation is also disrupting bio manufacturing, pharmaceutical
sales and innovation production models. We will discuss three examples of successful
innovation in this environment.
This white paper shows that innovation in healthcare can disrupt the old business
models and create value for patients, providers and the industry. These examples show
that innovation can be placed at any point in the industry and within organisations,
no matter their size, while new stakeholders are also joining this journey towards
better healthcare.
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5A WHITE PAPER BY GENSEARCH - All rights reserved - 2017
Sébastien Stoitzner, CEO – GenSearch
The Speakers
Executive Summary
1. Challenges in the Life Sciences industry
1.1 Introduction
1.2 Emerging health challenges
1.3 Healthcare systems: different, but complex
1.4 Innovation and R&D productivity
1.5 Adoption of technology is slow
1.6 Technological improvements: increasing healthcare costs
1.7 Healthcare challenges and innovation
2. Improving patient outcomes with innovation in technology
2.1 Introduction
2.2 Connected health: patient engagement
2.3 Focus on Medicom – a Phillips-Medisize company
2.4 Health data for real-life studies
2.5 Focus on MyHealthMyData – almerys
2.6 Innovation in technology: What is the point?
3. Gaining more from process innovation
3.1 Introduction
3.2 Vaccines: a need for supply on demand
3.3 Vaccine manufacturing today
3.4 Focus on Univercells: Process innovation to improve affordability and access to vaccines
3.5 Process innovation: What is the point?
4. Creating Value with organisational innovation
4.1 Focus on GSK: disrupting the employee motivation and sales model
4.2 Innovation by breaking down silos
4.3 Focus on Merck: Innovative interfaces disrupting company culture
4.4 The think tank idea generator
4.5 Organisational innovation: What is the point?
Conclusion
Contents
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1.ChallengesintheLife
Sciencesindustry
of the world’s population – are either obese or overweight1
Today, the Life Sciences industry is facing
significant challenges. The industry needs
to continue to provide solutions for new
health problems linked with an increasingly
ageing and obese population.
According to Professor James Barlow of
Imperial College London, Health systems
are complex not only in developed
countries, but also in emerging countries.
In these different parts of the world, a mix
of challenges are preventing patient access
to quality healthcare. However, the reasons
behind the complexity of healthcare
systems is different. Paradoxically, in
developed countries, healthcare has become
increasingly expensive with the rise in new
technological developments. In emerging
countries, challenges arise from their severe
lack of resources.
The 2017 Life Sciences Talks gives some
examples of where the Life Sciences industry
is already applying innovative solutions
in digital technology and new thinking to
create value for patients, physicians and
providers.
If we do not fix our
healthcare system
the US may go the way
of General Motors –
paying more, getting
less and going broke
Barack Obama 2009
1.1 Introduction
Nearly30%
6
7. A WHITE PAPER BY GENSEARCH - All rights reserved - 2017
1.2 Emerging
health challenges
The world is currently undergoing an
epidemiological transition which is
characterised by an increasingly ageing
population. This change is shifting the focus
of healthcare away from treating infectious
diseases towards managing chronic
conditions such as obesity and diabetes.
Other key issues that we are facing are: the
widespread use and misuse of antibiotic
therapies which has led to an increasing level
of antimicrobial resistance. Climate change
is also allowing new epidemics to emerge
and spread, with significant numbers of
people around the world already affected.
At present the Life Sciences and MedTech
industriesareworkingonfindingnewsolutions
to dealt with emerging health challenges
within the constraints mentioned above.
1.3 Healthcare
systems: different,
but complex
Healthcare models in developed countries
are complex and unsustainable. In these
countries, the problems with healthcare
systems revolve around the rapid uptake of
technology leading to escalating healthcare
costs in a climate of constrained resources
and rising demand. These issues are driving
healthcare providers and systems to seek
new solutions to pay for and control rising
costs.
Although their focus is different, emerging
countries also have complex healthcare
systems. Their challenge is to provide
better healthcare and most importantly, to
improve accessibility for the population, as
affordably as possible. However, while new
technological solutions might exist, they
remain inaccessible partly because costs
oftenpreventhealthcaresystemsfromtaking
up new technology. This inaccessibility is
also due to lack of training or supporting
infrastructure, or inappropriate technology
for the local context. Nevertheless, some
innovative solutions in the industry are
appearing that significantly improve access
to healthcare for patients in these countries.
According to Professor Barlow, it would be
dangerous for emerging countries to copy
the developed world’s healthcare model,
which is unsustainable. Both the developed
and developing worlds will need to re-
evaluate how healthcare is delivered and
paid for while also learning from new ideas
coming from other countries.
The current climate in
developed nations with
complex healthcare systems
obstructs innovation at
three levels: Innovation
productivity, innovation
adoption and innovation
cost inflation paradox.
Professor Barlow, Imperial College
1. Global, regional, and national prevalence of overweight and
obesity in children and adults during 1980–2013: a systematic
analysis for the Global Burden of Disease Study 2013,”
7
8. A WHITE PAPER BY GENSEARCH - All rights reserved - 2017
How fast is the pace
of change in medical
knowledge?
Medical information doubles every 19 years
Today it is recognized that medical
knowledge doubles every
6-8 years,
with new medical procedures
emerging everyday
Medical knowledge doubles every
two years...
and with that kind of growth it is nice
to know that the Children’s Hospital
of Michigan offers plenty of research
Medical information doubles every
four years
Clinical Knowledge is estimated
to double every
18 months
Medical knowledge doubles itself every 19 years - physician needs
2 million facts to practice
There are about 20.000 - 30.000
medical journals published
and the amount of medical
information doubles every
fifth year
Volume of new medical information doubles every 10 to 15 yearsand increases tenfold in 23 to 50 years
Source: partly derived from
The Organization of
Knowledge. Concepts of
Information i218, Geoff
Nunberg, UC Berkeley school
of Information ,17 Feb 2009
8
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1.4 Innovation and
R&D productivity
The traditional closed innovation model in
Research and Development is changing.
This research model assumes that only
qualified professionals have expertise. The
research to development process used to
be like a funnel where research projects
were conducted in professional silos and
filtered into development according to
their expected success, one at a time.
Now, research innovation is becoming
more open. Research funding is at present
more accessible with crowdfunding.
Expertise is also becoming more
available with crowdsourcing platforms
that have allowed individual experts to
be sourced from outside the company,
when needed for specific projects. Also,
science culture is opening up to anyone
interested in biology and willing to try
out their ideas. This open science culture
is known as Biohacking. Biohacking2
is a
new way of conducting research. It takes
place in unconventional labs, garages or
workspaces where individuals or small
groups work on specific projects. Recently,
La Paillasse3
in Paris, which is one of the
largest Biohacking spaces in Europe has
taken Biohacking to another level by
creating an interdisciplinary space, which
helps, funds and connects a wide variety
of research projects. This interdisciplinary
proximity creates an environment for
innovation that brings more projects to
development.
One surprising finding from the GDHI 2016
report4
is that patients are cited almost as
frequently as professional colleagues as
sources of ideas for health professionals.
Recognising that patients are an important
source of ideas to improve healthcare is
part of the open innovation agenda – ideas
and solutions can come from anywhere5
.
There is clearly an advantage in stimulating
the search for solutions outside the profes-
sional environment.
1.5 Adoption of
technology is slow
The amount of science available is not
the issue. Medical knowledge, in terms
of publications, and information as well
as the number of new medical entities
made available continues to increase.
The problem lies in our complex health
systems.
Many developed countries invest heavily in
researching and developing new techno-
logies and medicines, but fail to support
these innovations further down the line,
so the adoption of new ideas is often
slow. Sometimes it can take up to 17
It takes a long time for an
idea to come through from
a fledgling PhD idea. After
a serendipitous meeting
with almerys, a company
specialising in the treatment
of industrial data, I realised
that my research in healthcare
was similar to other areas.
Dr David Manset
2. The Beginner’s Guide to Biohacking: What Is It & How To Do It, https://supplementpolice.com/health-guides/biohacking/
3. La Paillasse is the largest biohacking and open science space in Europe. https://citiesintransition.eu/place/la-paillasse
4. Global Diffusion of Healthcare Innovation: Making the Connections, Report of the Global Diffusion of Healthcare Innovation
(GDHI) Working Group, Professor the Lord Ara Darzi, World Innovation Summit for Health - 2016
5. Global Diffusion of Healthcare Innovation: Making the Connections, Report of the Global Diffusion of Healthcare Innovation (GDHI)
9
10. A WHITE PAPER BY GENSEARCH - All rights reserved - 2017
years for a new research idea or product
to be adopted into clinical practice. In
some European countries like France
and Germany, adoption tends to be early
but implementation slow, where other
countries like the UK and Nordic regions
adopt new ideas later, but implement them
faster.
Professor Barlow suggests that government
support for healthcare could be more
balanced throughout the development of
new medicines and technology from the
idea stage all the way to its final adoption
and implementation, rather than focusing
largely on the basic science and initial
R&D phases. In addition, there is a need
to simplify our highly complex healthcare
systems. Integrating healthcare systems
need to share innovation across primary,
secondary or social care systems to
breakdown budgetary silos and therefore
share risk and reward.
6.Income, insurance, and technology: why does health spending outpace economic growth?’ Smith S, Newhouse JP, Freeland MS
(2009). ‘Health Affairs.
1.6 Technological Improvements:
increasing healthcare costs
1.7 Healthcare
Challenges and
Innovation
According to Professor Barlow, the
combination of changing healthcare needs
around the world and the rising costs of
healthcare solutions are challenges that
will continue to require new thinking
to break-down traditional barriers and
produce new solutions.
Meeting 21st century global
healthcare challenges is going
to require a holistic perspective
on innovation; Innovation in
research and development
productivity, improve adoption
of new ideas and solve the
technological paradox.
■ Technological change
■ Avoidable administration
expenses
■ Relative medical
price inflation
■ Income growth
■ Insurance
■ Ageing
Contributiontorealgrowth(%)
In most other industries
improvements in technology
have reduced costs, in healthcare
technology they are driving
costs up.
Adopting new medical technology
was responsible for inflating
healthcare costs from
27% to 48%, between
1960 until 2007.5
Source: John Appleby (2013)
Spending on health and social care
over the next 50 years. Why think
long term? The King’s Fund.
Newhouse (1992) Cutler (1992)
0
10
20
30
40
50
60
70
80
90
100
Professor Barlow suggests
combining three focal points
for innovation.
10
11. A WHITE PAPER BY GENSEARCH - All rights reserved - 2017
7. IMPACT INNOVATION OF MEDICAL DEVICES TO SERVE LOW-INCOME PATIENTS, KRISTA DONALDSON | AJ VIOLA | KELLY
BLANK, 2016 - http://d-rev.s3-us-west-2.amazonaws.com/wordpress/wp-content/uploads/2016/02/Impact-Innovation-Paper.pdf
2.1 Introduction
2.Improvingpatientoutcomes
withinnovationintechnology
Advances in technology in the Life
Sciences industry is a paradox. Instead
of driving prices down as has occurred in
other sectors, technology has been driving
healthcare costs up, without necessarily
improving patient outcomes.
There are different approaches to inno-
vation, some of which are described below:
Reverse innovation is the phenomenon
by which products and services initially
intended for low-income countries
spread to high-income countries;
Frugal innovation is the process of
reducing the complexity and cost
of technologies or delivery models
in order to sell them to overlooked
customers7
.
Disruptive innovation is happening in
resource-poor contexts and is driving
innovation in areas such Diagnostics.
11
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Therefore, can disruptive innovation cure
healthcare? In what ways are developed
countries applying technology to attempt
to reduce costs and improve patient
outcomes?
Connected solutions are being applied to
improve access to healthcare for patients
and improve patient outcomes. This is
done by providing accurate clinical data to
key individuals in the healthcare network
that surrounds patients living with chronic
illness.
Complex programming technology for
protecting data (Blockchain) is being
used in healthcare to make sensitive data
available for research. This is improving
the quality of epidemiological research.
The challenge remains to provide such
advanced technology at a lower cost.
8. Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005 Aug 4;353(5):487–497
9. Long-term persistence in use of statin therapy in elderly patients. Benner JS, Glynn RJ, Mogun H, Neumann PJ, Weinstein MC, Avorn J
10. Adherence to medication. Osterberg L, Blaschke T N Engl J Med. 2005 Aug 4; 353(5):487-97
11. The $289 Billion Cost of Medication Noncompliance, and What to Do About It, Brian Fung Sep 11, 2012 The Atlantic
Frugal Engineering:
improving access to
diagnostics
Frugal engineering has allowed diagnostic
machinery to be made simpler and at a lower
cost.
In India, the GE MAC 400 ECG machine was
developed to improve patient access to
cardiac diagnostic technology. The challenge
was to simplify modern technology to achieve
the same result with a simpler, cheaper
machine. This resulted in an ECG machine
that cost $800 per unit, as opposed to its
equivalent at $2000.
This machine is now helping developed
countries like Finland and Germany provide
state of the art care, less expensively.
People living with chronic conditions are
part of a complex ecosystem where value
is created through their adherence to
medication as well as to the measured and
expected health outcomes.
Yet in reality,
50% of all medicines are not taken as
prescribed.8
Numerous studies have shown that
patients with chronic conditions
adhere only to 50-60% of medications
as prescribed despite evidence that
medical therapy prevents death and
improves quality of life.9
Poor treatment adherence has been
estimated to account for 33% to 69% of
medication-related hospital admission.10
Failure to follow prescriptions causes
some 125,000 deaths a year in the
United States and up to 10 percent of
all Emergency Department admissions.
This is equivalent to 8 airplanes falling
out of the sky per week.11
People living with chronic
conditions: part of a complex
ecosystem
Source: Market-Relevant Design: Making ECGs Available across
India, The Pulse on Health, Science and Tech - http://newsroom.
gehealthcare.com/ecgs-india-reverse-innovation/
12
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2.3 Focus on
Medicom Innovation
Partner – a Philips-
Medisize company
Although mobile technology is everywhere,
only 9% of mHealth apps allow for data
export, fewer still effectively share health
data with 2% of mHealth apps allowing for
data sharing.
68% of 14,500 respondents reported
behavioural change as a result of using
devices and services to manage their
chronic conditions12
More than 33% of physicians
recommend mHealth apps13
Payers are becoming increasingly deman-
ding for evidence that the medicines work
as predicted by clinical trials. A P-value
from a clinical trial is no longer enough.
Yet, connected health can disrupt the
traditional way data flows from the patient
to the healthcare professional to a database
by providing a direct contact between
the patient their carers and healthcare
professionals. Having direct contact and
insight from the consumer and providing
professional feedback, can improve
compliance and thereby patient retention
and re-prescription of their medication.
2.4 Health Data for
Real-life Studies
Health data from patients is increasingly
required for: medical research, health
surveillance and pharmacovigilance. To
conduct this research, clinical researchers
and epidemiologists require a secure
(anonymous), high quality (homogeneous)
data source. Yet, hospital systems in Europe
struggle to record data in a systemic way.
Standards and protocols vary between
hospitals and across borders. Existing,
stored data is therefore often incomplete or
inadequate for clinical research use.
12. McKinsey “Unlocking Digital health” April 2015 / McKinsey Consumer Health Insights Survey
13. IMS Institute for Healthcare Informatics “Patient Adoption of mHealth” September 2015
What is blockchain technology?
Source: How Blockchain is eliminating online fraud - It has the potential to eliminate common frauds perpetrated online and help
secure financial services from cyber hackers 2016 https://www.raconteur.net/business/how-blockchain-is-eliminating-online-fraud
14
A digital ledger that
keeps a record of all
transactions taking
place on a peer-to-
peer network
All information
transferred via
blockchain in en-
crypted and every
occurrence record-
ed, meaning it can-
not be altered
It is decentralised, so
there’s no need for
any central, certify-
ing authority
It can be used for
much more than the
transfer of currency;
contracts, records
and other kinds of
data can be shared
Encrypted informa-
tion can be shared
across multiple pro-
viders without risk
of a privacy breach
15. A WHITE PAPER BY GENSEARCH - All rights reserved - 2017
14. Big Data and Privacy: Fundamentals of Digital Trust Toward a Digital Skin D. Manset. In L. Menvielle (ed.), Connected Health: New
Challenges for The 21st Century
Additionally, the current data privacy
laws have become increasingly tighter at
both national and regional levels. Privacy
directives in the European Union suggest 8
directives for collecting data and ensuring
patient confidentiality14
.
Blockchain technology is a new way of
generating, storing and transmitting data in
a highly secure manner, whilst also making
it available for specifically identified needs.
This programming technology creates
specific data contracts between patients
and individual stakeholders to protect
sensitive clinical data from unwanted users.
Blockchain technology defines who can have
access to the data and for which purpose.
This means that individuals can choose to
make their specific data points available for
medical research or to accelerate access to
healthcare providers or solutions.
2.5 Focus on
MyHealthMyData –
almerys
15
source: https://www.almerys.com/
10 years ago we were
struggling to structure
patient health data so
it could be shared for
medical research. Each
research centre had
different standards and
protocols. Also, we had to
ensure that this sensitive
data could be made
available across borders.
Dr David Manset, Head of Research
and Innovation, almerys.
16. A WHITE PAPER BY GENSEARCH - All rights reserved - 2017
This inspired them to develop
MyHealthMydata. A new model for medical
data storage and access. This model uses
Blockchain technology to record and
cryptographically sign medical data sources.
It then assigns specific access rights for
each piece of clinical information and for
each pre-defined stakeholder.
Therefore, this system creates a network
between the patient, medical researchers
and healthcare providers who all require
access to secure, patient information.
The patient is empowered to choose which
pieces of clinical data to release (or not to
release). This data may include demographic,
clinical or lifestyle information. The patient
also chooses which end-user has the right
to use each piece of data and how it can be
used. An end-user may be a carer, a health
professional, a clinical research group or a
patient association.
The Blockchain software protects the data,
makes it anonymous and unrecognisable to
a third party in line with the current legal and
regulatory framework and best practices.
2.6 Innovation in
Technology: What
is the Point?
Where innovation in technology usually
drives prices down and increases value for
consumers in healthcare, technology has
been driving costs up with little perceived
added value for the patient or healthcare
provider.
To respond to this challenge, innovation in
the Life Sciences industry is rethinking the
use of connected solutions. For healthcare
professionals managing patients with
chronic diseases, this means they will
have access to accurate, updated patient
information. In clinical research, researchers
will soon have access to large pools of
homogenous clinical data that can be used
for epidemiological research.
16
So far, big drug makers have been
slow to join the m-health revolution,
though there are some exceptions...15
The Economist, 2016
15. Things are looking app, Mobile health apps are becoming more capable and potentially rather useful – 2016 - https://www.economist.
com/news/business/21694523-mobile-health-apps-are-becoming-more-capable-and-potentially-rather-useful-things-are-looking
17. A WHITE PAPER BY GENSEARCH - All rights reserved - 2017
3.1 Introduction
3.Gainingmorefromprocess
innovation
Manufacturing in the pharmaceutical
industry has created significant barriers that
are preventing small players from emerging.
They also hinder reactivity to manage many
priority health problems such as in times of
epidemics or when new diseases emerge.
Barriers in healthcare manufacturing include
complex internal processes, costly and
inefficient manufacturing structures.
Disruptive innovation in healthcare manufa-
cturing and organisations means breaking
these barriers down to impact global health
and create real added-value for patients by
improving access to priority healthcare.
Changing the Manufacturing Rules
One of the early disruptive innovators
in manufacturing was Henry Ford, who
began by building cars on a continuous
assembly line. In the chemical industry,
continuous manufacturing was applied to
streamline the industrial chemical industry
evolving from stone furnaces towards
the development of continuous metal
casting. Manufacturers were therefore
able to reduce factory sizes, simplify
quality checking and automate processes.
This allowed steel to become affordable
and available in large quantity, leading
to the development of steel construction
(Rail transportation, bridges, steel boats,
skyscrapers, etc.).
How can this be useful in healthcare?
3.2 Vaccines: a
Need for Supply
on Demand
Vaccines are the most efficient tools in
the medical arsenal to prevent infectious
diseases. These have corresponding
economic and societal value in averted
costs, gains in productivity and reduced
poverty.
In developed countries, regular vaccination
programs protect children from common,
debilitating and deadly childhood infections.
In emerging countries vaccination rates
are often lower than expected due to high
prices and limited production capacity which
creates shortages. Around the world, there is
a constant need for stable supply of vaccines.
The global vaccine
market will reach
48Bn$ in 2021, and
90% in the developed
countries.
Source: Vaccine Market by Technology Route (IM, SC, ID, Oral),
End User (Pediatric, Adult) & Type - Forecast to 2022
17
18. A WHITE PAPER BY GENSEARCH - All rights reserved - 2017
In emerging countries, access to priority
vaccines is exceedingly low, as the
manufacturing and transport costs
associated with acquiring these vaccines
from traditional suppliers, makes them
unaffordable. There is a need to empower
third world countries to make their own
vaccines.
Increasingly the need arises to create large
amounts of specific vaccines in specific
places at specific times to deal with
these new infections. Vaccines need to be
readily available when and where they are
needed. According to Univercells, this will
require an industry paradigm shift from the
current, centralised manufacturing model
to a distributed manufacturing model,
where local production facilities could
supply local populations with affordable
treatments.
21,053 0
117,333 11,049
530,217 61
200,752 13,506
16,316 0
152 1
580 14
20,000 243
66,232 11,269
162,344 982
16,049 4,167
47,745 4
29,005 0
4,085,120 449,363
DIPHTHERIA
100%
PRE-VACCINE ERA
ESTIMATED ANNUAL
MORBIDITY IN THE U.S.
MOST RECENT
REPORTS OF
CASES IN THE U.S.%DECREASE
H.INFLUENZA
99%
HEPATITIS A
91%
MEASLES
99%
HEPATITIS B
83%
MUMPS
99%
PERTUSSIS
93%
PNEUMOCOCCAL DISEASE
74%
POLIO
100%
RUBELLA
99%
CONGENITAL RUBELLA
99%
SMALLPOX
100%
TETANUS
98%
VARICELLA
89%
18
Source: How Vaccines Have Changed Our World In One Graphic, 2013 -Leon Farran, 2013 FORBES - https://www.forbes.com/sites/
matthewherper/2013/02/19/a-graphic-that-drives-home-how-vaccines-have-changed-our-world/#62fdf7c33302
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3.3 Vaccine
Manufacturing
Today
Vaccines are produced in laboratories by
growing living cells on a flat surface in a
controlled environment. When scaled up
to a factory level, this requires housing
many thousands of flat bottles, which are
cumbersome to handle, expensive and take
up a considerable amount of space.
These manufacturing processes are
associated with significant financial and
logistical barriers that are preventing small
players from emerging in developing markets
to manage vaccine supply when needed.
For example:
A high number of manual aseptic
operations that are sources of potential
contamination.
Regulatory and quality control are
expensive and complex
The processes are highly complex and
require a well-trained workforce
Production capacity is low and costs
are high
3.4 Focus on
Univercells: Process
Innovation to
Improve Affordability
and Access to
Vaccines
Univercells have completely disrupted
the traditional manufacturing processes
and changed the paradigm for vaccine
production. They have re-invented the way
vaccines are manufactured by designing
single-use bioprocess solutions which are
changing the rules in biomanufacturing.
The first step in this process has been
to develop a single-use bioreactor. This
bioreactor has replaced the flat bottles
with a honeycomb-like matrix structure on
which many more cells could grow. This
honeycomb structure has increased the
surface area for cell growth in a given space,
therefore increasing the number of cells
that can be grown to produce the vaccine.
However, additional steps are still required
to purify the product.
Taking inspiration from continuous
manufacturing in other industries,
Univercells has developed manufacturing
processes implementing single-use cost-
effective bioreactors operated in fed-batch
or perfusion modes, with in-line clarification
and capture operated in simulated
continuous mode. This allows to operate on
a 24/7 basis and treat the harvests of several
bioreactors, followed by continuous feeding
of capture on small affinity chromatography
columns. Most importantly, as there is no
longer a need to prepare the factory and run
separate batches, safety is maintained and
downtime is reduced.
As the process is based on disposable
consumables (single use bioreactor and
purification columns), the units are simply
discarded at the end of a run, and replaced
by new consumables, minimizing downtime.
19
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Univercells has integrated and intensified
biomanufacturing processes, enabling
the creation of a manufacturing unit with
a sufficiently smaller footprint to make it
distributable anywhere in the world. The
whole unit fits into the floor space the size of
a cupboard around 1.8 M x 3M and ensures
the containment of the viruses, increasing
safety for the environment and the operators.
Therefore, infrastructure investment and
sales price cost of manufacturing have been
considerably reduced. In a test case using a
traditional polio vaccine (Sabin) that usually
costs $1.65, Univercells has been able to
produce the same vaccine for $0.15.
To continue to pursue the worldwide
development of this endeavour, Univercells
was awarded a grant in 2016 from the Bill &
Melinda Gates Foundation.
Univercells innovative approach breaks
entry barriers and allows clients to develop
local bioproduction facilities. These
production units are less costly to build and
to operate, while maintaining high levels of
safety and offering flexible capabilities, from
small to large batches. This means a vaccine
manufacturing unit can be set up almost
anywhere, wherever a supply of vaccine is
required, in a short amount of time.
We are extremely
honoured to partner with
the Gates Foundation
to significantly increase
global access to priority
vaccines by lowering their
manufacturing cost16
Hugues Bultot, CEO and co-founder
of Univercells
16. Univercells and consortium partners Natrix Separations
and Batavia Biosciences Receive $12 Million Grant from Bill &
Melinda Gates Foundation to Radically Reduce Vaccine Costs
for Developing Countries http://natrixseparations.com/gates-
vaccine-grant, 2016
Impact of the micro facility of the fully-loaded cost of manufacturing
Case study on the manufacturing of a trivalent Sabin Inactived polio vaccine (sIPV)
€ 0.000
€ 0.200
€ 0.400
€ 0.600
€ 0.800
€ 1.000
€ 1.200
€ 1.400
€ 1.600
€ 1.800
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
COST COMPARISON
UNIVERCELLSUNIVERCELLS REFREF
1,65€
0,15€
COST COMPARISON (RELATIVE)
■ Facility ■ QC ■ F&F ■ DSP ■ USP
20
21. A WHITE PAPER BY GENSEARCH - All rights reserved - 2017
3.5 Process
Innovation: What
is the Point?
Theaboveexamplesillustratethatcombining
process with technology creates value for
patients. By rethinking manufacturing and
internal processes, these organisations have
been able to streamline their activity to
provide lifesaving healthcare for patients at
a fraction of the cost. Process innovation
enables the healthcare industry to provide a
high standard of healthcare at a lower cost.
The aim is to be able
to develop such a small
process that you don’t
need a factory as such.
One cabinet is your cell
culture, one for your
purification, one cabinet
for deactivation all done
in a continuous process.
Benjamin Damien, Director of Business
Development, Univercells
17. Delivering World-Class Health Care, Affordably, Vijay GovindarajanRavi Ramamurti, November 2013 Issue https://hbr.org/2013/11/delivering-
world-class-health-care-affordably
Narayana Hospital:
combining technological
and process innovation to
provide cardiac care for
people on low income
Narayana Health in India, is an
innovative project emerging
from a developing country. Their
challenge was to provide state of
the art cardiac care for low income
earners. The cardiology unit was
redesigned by streamlining medical
and payment processes, improved
construction design and applied
digital technology for telemedicine.
This increased patient access to life
saving healthcare at 1/30th of the
cost in the US.17
21
22. A WHITE PAPER BY GENSEARCH - All rights reserved - 2017
4.CreatingValuewith
OrganisationalInnovation
The traditional pharmaceutical sales model
was based on building face-to-face customer
relationships between the pharmaceutical
sales representatives and key clients and
prescribers.
However, in recent years the pharmaceutical
industry has been at the centre of a number
of events that have significantly eroded
customer trust.
For decades, it has been standard industry
practice for pharmaceutical companies
to sponsor doctors attending medical
conferences, and for them to pay salesforces
commission on the prescriptions written by
the doctors they visit. However, in recent
years these practices have come under
increased scrutiny by regulators, particularly
in the U.S. which is the world’s biggest
medicines market19
.
It’s bad for patients when sales reps are paid based
on the number of drugs that they sell. Sales targets
make sense in a retail store, they make sense at
a car dealership, and they don’t make sense in
hospitals. In fact, it’s a dangerous trend.18
Dr. Martin Makary, Professor of Surgery at John Hopkins University
We believe that it is imperative
that we continue to actively
challenge our business model
at every level to ensure we are
responding to the needs of
patients and meeting the wider
expectations of society.20
Sir Andrew Witty, Chief Executive of GSK
18. Eyeforpharma - GSK new ‘Ethical’ customer approach: Is it delivering? 2016 - https://social.eyeforpharma.com/commercial/gsks-new-ethical-
customer-approach-it-delivering
19 & 20. Why GSK sales shift is a turning-point for pharma, Catherine Boyle, 2013 - https://www.cnbc.com/2013/12/17/why-gsk-sales-shift-is-a-
turning-point-for-pharma.html |
4.1 Focus on
GSK: Disrupting
the Employee
Motivation and
Sales Model
22
23. A WHITE PAPER BY GENSEARCH - All rights reserved - 2017
GSK set themselves the objective to become
the best in class in pharmaceutical sales.
To rebuild customer trust, create value and
take away potentially perceived conflicts of
interest, they decided to turn the traditional
pharmaceutical sales model upside-
down and change the way the company
communicates with its customers.
GSK disrupted traditional sales methods
by replacing individual sales targets with
a three-dimensional relationship of trust
between employees, customers and
patients.
They changed their compensation model to
focus on patient needs by:
Removing individual sales incentives at
the sales professional and first line sales
leader level,
Removing direct sponsorship to medical
conferences, and providing indirect
medical education support,
Removing speaker sponsorship,
Modernising customer engagements
with digital capabilities.
Good selling outcomes were built on the
combination of strong leadership and
technological support.
The quantity and quality of sales leader
coaching was modernised, change
management operations were implemented
and multichannel directions were planned
and set. Remote technology engaged
the salesforce to increase knowledge and
motivation.
23
24. A WHITE PAPER BY GENSEARCH - All rights reserved - 2017
The salesforce was no longer paid on sales
targets (outputs), but on key competencies
such as technical knowledge and the Quality
of Service they provided to clients (inputs).
Lessons learned:
The need for strong leadership and
moving towards a shared goal.
Have a clear understanding of employee
motivation
Ensure sales leaders have the capabilities
for leading change
Supporting change management
4.2 Innovation by
Breaking Down
Silos
Most traditional pharmaceutical companies
tend to work in silos of expertise, even more
so, if they belong to a group of companies.
Creating innovation in this type of set-up
can therefore be a challenge due to their
size and complexity.
One of the ways in which innovation can be
introduced is by creating an environment
that facilitates the cross pollination of ideas
and breaking down barriers.
4.3 Focus on
Merck: Innovative
Interfaces
Disrupting
Company Culture
Merck has three different business sectors
(healthcare, life science and performance
materials) which are traditionally standalone
businesses. Senior management decided
that in order to continue to grow, to stay
competitive and adapt to the ever-changing
environment they needed to introduce
innovation.
They decided to create opportunities
between and beyond their business sectors
by setting up an innovation centre which
would work across the three organisations
and provide an ecosystem for innovation
bringing ideas, knowledge and people
together.
At Merck, an opportunity was identified to
create an environment for innovation from
inter-sector synergy. This idea was built
on the belief that innovation does not only
occur in laboratories and in research and
development units. Anyone in the company
is capable of creating and driving innovation.
Inputs:
Competencies
Outputs:
Sales targets
24
25. A WHITE PAPER BY GENSEARCH - All rights reserved - 2017
Merck’s 350th anniversary provided the
opportunity to build the Innovation Centre
with an objective to disrupt business models
and develop radical technologies to:
build new business
create champions for innovation
spread the culture of innovation
Implementation has proved to be a long
process. Corporate buy-in was needed and
managers needed to accept temporarily
releasing staff from their position. When
resistance was felt, key stakeholders
were invited to the centre to see, feel and
understand the value being created.
Participants also had to be willing to step
out of their comfort zone and temporarily
leave a safe job.
Although at Merck,
innovation in each business
unit was going well, the
company wondered if
further gains could be
made by driving innovation
at the intersections of
the business units.20
Lukasz Kowalik, Merck Innovation Center, Merck
The Merck Innovation Center helps ideas grow
Provide an ecosystem for innovation bringing ideas, knowledge and people together
25
Internal
External
Marketing & communication
26. A WHITE PAPER BY GENSEARCH - All rights reserved - 2017
4.4 The Think Tank:
Idea Generator
The think tank idea is a pillar of the Innovation
Centre that provides an ecosystem for
innovation bringing new ideas, knowledge
and people together. The Think Tank also
builds a strong network with external
partners such as universities, innovation
leaders etc. This innovative culture, brings
together employees from different sectors
globally. It provides the teams with the tools,
the know-how and guided support, then
leaves them to work, create and experiment.
The Merck Innovation Center helps ideas grow
One out of two people over the age of 65 can develop cataracts, making it the top
cause of blindness in the world.
To treat cataracts the opaque lens is replaced with a polymeric IntraOcular Lens (IOL).
However, in most cases, optimal vision after cataract surgery is not achieved. Patients
are often required to wear glasses following surgery.
One project team at the Innovation Centre realized that laser can be used to change
properties of the lenses inside a human eye. With laser pulses, optical properties of
lenses can be individually adjusted to the needs of each patient. .
21. The focal point: Our liquid crystal expertise - http://ar2015.emdgroup.com/magazine/a-clear-view
26
THINK TANK
01.Select topics
02. Define
topics
03. Recruit
team
06. Evolve ideas
04. Explore
& connect
05. Filter &
review ideas
07. Set up innovation
projects
IDEA GENERATOR
Source: Merck
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4.5 Organisational Innovation:
What is the Point?
In the continual process of improving business practices and finding better ways to create
products and services in the life sciences industry, these examples illustrate how innovation
can improve organisational operations to create value. Value for both the organisation as
well as healthcare providers and their customers.
27
Corporate immune system
Source: Merck
28. A WHITE PAPER BY GENSEARCH - All rights reserved - 201728
29. Conclusion
A WHITE PAPER BY GENSEARCH - All rights reserved - 2017 29
The Life Sciences Talks 2017 brought together various innovators who are breaking down
barriers in the Life Science industry to provide value for patients, healthcare providers and
payers.
At a time when the healthcare industry is facing major challenges around the world, innovation
in technology, process innovation and organisational innovation will be key to meeting those
challenges.
Healthcare systems in both developed and emerging countries are complex. The developed
world is facing various budgetary and regulatory challenges which restrict their innovation
processes. However, emerging countries are having to do more with less but with much fewer
regulatory restrictions. This freedom enables them to deliver technology based solutions which
the developed world is observing with interest and may adapt to tackle their own challenges
Connected health is providing healthcare professionals access to accurate, updated patient
information to help them manage their patients better. In clinical research, Blockchain technology
will soon give researchers access to large pools of homogenous clinical data in an appropriate
form for epidemiological research. Process innovation has made vaccine manufacturing possible
anywhere in a factory the size of a cupboard and to make critical healthcare available to people
on low incomes. Lastly, Life Sciences businesses continue to improve their own practices to
create value and build trust with their customers, patients and healthcare providers.
Innovation in Healthcare: What is the Point? The point is that not only does it create value, but
innovation can transform and bring about new ways of delivering services, new treatments and
solutions for emerging countries and mature markets alike. What has been made obvious is that
innovation no longer just sits in the hands of traditional players. We are now seeing a new influx
of non-traditional newcomers such as patients, IT and telecommunications players, as well as
other stakeholders, who are challenging the way the industry has always functioned. The aim
of these innovations is ultimately to reduce budgets increase efficiency and deliver improved
patient centric services.
30.
31. Talents for
the Life Sciences
Assessment | Coaching | Executive Search
GenSearch is an International Executive Search and HR services consultancy
dedicated to the Life Sciences. Our focus covers the Pharmaceutical, Medical
Devices and Biotechnology industries.
We work with clients who are in different stages of their business life-cycle
from small Biotechnology companies just starting out to large multinational
healthcare companies. We work closely with all of our clients to add value
and performance to their business. Our goal is to also help executives build
a successful career in line with their aspirations and the market reality using
our extensive sector knowledge.