Overview of the Decade of Vaccines Collaboration including background, structure and vision for creation of the Global Vaccines Action Plan. www.dovcollaboration.org

1. OverviewSeptember 2011

2. Contents Setting the Stage – A Decade of Vaccines Why we should prioritise vaccines & immunization – progress, proof and momentum Decade of Vaccines vision Why act now? Vaccine life cycle What is the Decade of Vaccines Collaboration? Decade of Vaccines Collaboration structure Working Groups overview and cross-cutting issues Further information

3. Setting the Stage – A “Decade of Vaccines” In January 2010, Bill & Melinda Gates called for the next ten years to be the “Decade of Vaccines.” The announcement included a commitment from their foundation of US$10 billion over the next 10 years to realize a vision embraced by the global community: “to help research, develop and deliver vaccines for the world’s poorest countries” Millions of deaths could be averted by significantly scaling up the delivery of life-saving vaccines in developing countries to 90% coverage and rapidly introducing new vaccines

4. Vaccines & Immunization – Real progress made in recent years Last 20 years has seen a huge rise in the number of new vaccines – especially against the leading causes of child deaths: pneumonia & diarrhea WHO data show global vaccination rates have reached all-time highs – rebounding from years of decline in the 1990s 106 million children were vaccinated in 2008 and global immunization rates are at their highest level ever BUT… despite this progress, nearly 23.5 million children are still not fully immunized every year

5. Vaccines prove that smart aid works Vaccines are the most cost effective way to prevent disease and give children a healthy start to life Vaccines are proven – 20 years ago, global health leaders resolved to wipe polio off the planet and today we’re 99 percent of the way there Major vaccine manufacturers have announced significant price cuts for their vaccines Reducing prices of available vaccines and creating opportunities for better, cheaper vaccines will ensure that current and future funding can save even more lives

6. Momentum is building for vaccines & immunization All 193 Member States approved the need for a global vaccine action plan at the 64th World Health Assembly, May 2011 In June 2011, donors committed $4.3 billion in funding to the GAVI Alliance – to help immunize more than 250 million peoplein developing countries by 2015

7. “We envision a world where children, families, and communities enjoy life protected from the threat of disease. The purpose of the Decade of Vaccines is to extend the full benefits of immunization to all people, regardless of where they live” Decade of Vaccines vision

8. This is a unique moment in time that we must seize, turning the moment into a movement: Why now? A unique opportunity New and existing vaccines are ready for country immunization programs: pneumonia, diarrheal disease, meningitis A, cervical cancer, polio and measles Candidate vaccines are in the pipeline: malaria, HIV, tuberculosis Demand for vaccines is increasing, and national governments are prioritizing vaccines in their health strategies

9. Vaccine Life Cycle from Optimize: Immunization Systems and Technologies for Tomorrow, PATH and the World Health Organization

10. Decade of Vaccines (DoV) Collaboration The aim of the DoV Collaboration is to enhance coordination across the global community by creating a global vaccine action plan: The DoV Collaboration represents the first step in the Decade of Vaccines It is a time-limited global effort, led by a Steering Committee of global health experts, to outline how the international community can best use vaccines to save lives The consultation process was launched at the World Health Assembly (WHA) in 2011 and the plan will be presented in 2012

11. Our Structure Leadership Council Steering Committee Co-Chairs: Prof. Pedro Alonso Dr Christopher Elias Secretariat At–Large Steering Committee Members Public & Political Support Co-Chairs Delivery Co-Chairs R&D Co-Chairs Global Access Co-Chairs Public & Political Support Working Group Delivery Working Group R&D Working Group Global Access Working Group

12. Leadership Council Mr. Anthony Lake Executive Director UNICEF Dr. Margaret Chan Director General World Health Organization Dr. Rajeev VenkayyaDirector, Global Health Vaccine DeliveryBill & Melinda Gates Foundation Dr. Anthony Fauci Director National Institute of Allergy and Infectious Diseases Ms. Joy Phumaphi Executive Secretary African Leaders Malaria Alliance

13. Steering Committee Prof. Pedro Alonso(Co-chair) Dr. Christopher Elias (Co-chair) Ms. Helen Evans Dr. Lola Dare Dr. Zulfiqar Bhutta Dr. Ciro de Quadros Dr. Lee Hall Dr. Jos Vandelaer Dr. Orin Levine Dr. Jean Marie Okwo-Bele Dr. T. Jacob John Dr. Nicole Bates Dr. Peter Singer Dr. Anne Schuchat Prof. David Salisbury Ms. Sandy Wrobel Dr. Seth Berkley Dr. Lucky Slamet Dr. Gina Tambini

14. Charter: Prevent, eliminate or eradicate diseases by means of achieving high and equitable coverage with effective and safe immunization along with other essential healthcare interventions Scope: Build upon the current Global Immunization Vision and Strategy Help ensure country consultation and engagement Develop recommendations for improving immunization systems as a platform to prevent mortality and morbidity Create estimates of costs and financing for delivery Co-Chairs:Dr. Jean Marie Okwo-Bele (Director, WHO Department of Immunization, Vaccines and Biologicals) and Dr. Jos Vandelaer (Chief, Immunization, Programme Division, UNICEF) Working Group: Delivery

15. Working Group: Global Access Charter:Develop an action plan that helps to ensure global access to an adequate supply of high quality affordable vaccines with formulations and presentations that meet the needs of all countries Scope: Efficient and effective supply procurement strategy Affordable pricing strategy Comprehensive financing strategy Approaches to meet projected financing needs Approaches to get greater return on available financing Improved demand forecasting methods and tools Co-Chairs: Dr. Orin Levine (Executive Director, International Vaccine Access Center (IVAC) at the Johns Hopkins Bloomberg School of Public Health) and Ms. Sandy Wrobel (CEO and Managing Director, Applied Strategies)

16. Working Group: Public & Political Support Charter:Strengthen public and political support for vaccines Scope: To facilitate networking of the academic and advocacy communities around a shared agenda To synthesize key foci related to the existing evidence base, identifying gaps and essential policy research questions To advise other DoV Collaboration Working Groups by applying an advocacy filter to technical products Co-Chairs: Dr. Nicole Bates (Senior Program Officer, Global Health Policy and Advocacy, Bill & Melinda Gates Foundation) and Dr. Peter Singer (Director, McLaughlin Rotman Centre for Global Health, University of Toronto)

17. Working Group: Research & Development Charter: Maintain a strong pipeline of research and developmentto ensure that vaccines will improve the lives of children beyond this decade Scope: Rationalize the balance between priority vaccines based on objective criteria and feasibility for product development Identifying a process for translating Working Group outputs / recommendations into funded research programmes / projects Costing of outputs / recommendations Co-Chairs: Dr. Seth Berkley (CEO, GAVI Alliance) and Prof. David Salisbury (Director of Immunization, UK Department of Health)

18. Examples of emerging cross-cutting themes

19. Consultation: Seeking input It will be an entirely transparent process, both in fact and appearance As a first step, the DoV Collaboration will make information available on how to participate and how to input – either in person or online Consultation to target ALL the stakeholders and themes of the DoV Collaboration Regional consultations to take place in Africa, Americas, Asia, Europe Input solicited around four working group themes and cross-cutting topics The output will be a global vaccine action plan delivered in 2012

20. Global Vaccine Action Plan The global vaccine action plan will incorporate input from the consultation process and build on current work and include recommendations on: Expanding the delivery and use of new and under-utilized vaccines Forging mutually beneficial alliances with the private sector to develop and deliver vaccines Cultivating a robust scientific enterprise to discover and develop new vaccines Empowering communities to advocate for policies that will improve the health of their children and families

21. Critical Success Factors of the DoV Collaboration To foster active participation of the international vaccine community to define and execute a comprehensive effort to improve and save lives through vaccines To deliver a global vaccine action plan that turns the Decade of Vaccines vision into a reality To ensure continued engagement of groups and individuals, who are all committed to the plan’s implementation

22. Access to safe and effective vaccines is human right not currently enjoyed by everyone, particularly those in low- and middle-income countries. In this decade, we can significantly advance global health and save millions of lives. “The Decade of Vaccines needs unprecedented action. It’s absolutely crucial that both governments and the private sector step up efforts to provide life-saving vaccines to children who need them most” Margaret ChanWHO Director-General

23. For further information Website: www.dovcollaboration.org Email: info@dovcollaboration.org @DofVC