The Nicholas Conor Institute aims to improve treatments for pediatric cancer by developing personalized therapies tailored to each child's unique cancer characteristics. It plans to do this through translating medical discoveries into integrated treatment programs, developing predictive tests to guide therapy, and bringing new child-friendly treatments to clinics. The Institute was founded in memory of Nicholas "Conor" Boddy to address the lack of treatment options and high costs faced by children with cancer.
Patient involvement in R&D - setting the scene, current status and future pla...jangeissler
Jan Geissler, EUPATI: Presentation at workshop "Patient involvement in medicines development - paradigm shift towards true patient impact in regulatory science?" at the University of Copenhagen on 6 May 2015
Similarities and differences between Rare Cancers and Rare Diseasesjangeissler
Similarities and differences between Rare Cancers and Rare Diseases, presentation by Jan Geissler based on a table published by Kathy Oliver, Jan Geissler and Ariane Weinman here: http://www.eurordis.org/publication/rare-cancers-and-rare-diseases-similarities-and-differences
Tripartite dimension of interaction of patients, regulators and industry (Jan...jangeissler
Tripartite dimension of interaction of patients, regulators and industry, presented by Jan Geissler as a scene-setting presentation at the EUPATI Workshop on the interaction of patients, regulators and industry on 20 July 2016 in Berlin
5th Tumor Models Boston July 2017 BrochureDiane McKenna
Tumor Models Boston 2017 will address the preclinical & clinical developments of the most promising therapies including targeted therapies, check-point inhibitors & CAR-T therapies and how these findings can be utilized to bridge the gap between preclinical and clinical studies.
Ethical, Legal, and Social Implications of ELSI Learning Health Systems 2017 Conference, University of Michigan. Learning from the experience and outcomes of every cancer patient
Support & information for radiotherapy patients: how can social media help?KimMeeking
Slides from my presentation looking at social media for patient benefit and also for healthcare professionals in the field of cancer and radiation therapy.
Presented at the UK Radiological and Radiation Oncology Congress (UKRCO), Liverpool, July 2nd 2018
Patient involvement in R&D - setting the scene, current status and future pla...jangeissler
Jan Geissler, EUPATI: Presentation at workshop "Patient involvement in medicines development - paradigm shift towards true patient impact in regulatory science?" at the University of Copenhagen on 6 May 2015
Similarities and differences between Rare Cancers and Rare Diseasesjangeissler
Similarities and differences between Rare Cancers and Rare Diseases, presentation by Jan Geissler based on a table published by Kathy Oliver, Jan Geissler and Ariane Weinman here: http://www.eurordis.org/publication/rare-cancers-and-rare-diseases-similarities-and-differences
Tripartite dimension of interaction of patients, regulators and industry (Jan...jangeissler
Tripartite dimension of interaction of patients, regulators and industry, presented by Jan Geissler as a scene-setting presentation at the EUPATI Workshop on the interaction of patients, regulators and industry on 20 July 2016 in Berlin
5th Tumor Models Boston July 2017 BrochureDiane McKenna
Tumor Models Boston 2017 will address the preclinical & clinical developments of the most promising therapies including targeted therapies, check-point inhibitors & CAR-T therapies and how these findings can be utilized to bridge the gap between preclinical and clinical studies.
Ethical, Legal, and Social Implications of ELSI Learning Health Systems 2017 Conference, University of Michigan. Learning from the experience and outcomes of every cancer patient
Support & information for radiotherapy patients: how can social media help?KimMeeking
Slides from my presentation looking at social media for patient benefit and also for healthcare professionals in the field of cancer and radiation therapy.
Presented at the UK Radiological and Radiation Oncology Congress (UKRCO), Liverpool, July 2nd 2018
Assessing the appropriateness of CT scans among pediatric ortho patientsImage gently
Sifting through peer-reviewed studies on different options in imaging technology used in pediatric orthopedic injuries, the two doctors quantified the amount of radiation in each of the CT scans radiation and X-rays for spines, pelvis, hip and other body parts. They discovered that children who require surgery for hip dysplasia, scoliosis and leg-length discrepancy undergo X-rays or CT scans, and are the children most vulnerable to exposure risk.
Dr. Leonard Saltz, MD; Chief, Gastrointestinal Oncology Service; Head, Memorial Sloan Kettering
Dr. Saltz will discuss selected successes and failures in cancer research efforts, and what we can learn from each, and will take a frank look at costs of care, and at business and government policies that are undermining progress and creating disparities in access to affordable, effective care.
Data sharing drivers in precision oncology, biomedical research, and healthcare. Accelerating discovery, innovation, providing credit for all stakeholders - patients, researchers, care providers, payers.
An overview of the oncology clinical trials network (CTNeT) which is being implemented throughout Texas.
The non-profit network is a first of its kind and combines the innovative science of Texas cancer centers with the expertise and resources of both academic and community oncologists throughout the state.
To learn more, visit www.ctnet.org
An Assessment of Problems and Preferences in Medical Imaging of Pediatric Pat...ijtsrd
Medical Imaging is extremely valuable as a diagnostic tool in the pediatric population, but it comes with a number of distinct challenges as compared to the imaging of adults. This is because of the following: It requires dedicated imaging protocols to acquire the images, there is need for sedation or general anesthesia for longer procedures such as MRI, specific training is required for the healthcare personnel involved, thorough knowledge and expertise should be applied for evaluating the images, and most importantly, it requires consideration for radiation exposure if ionizing radiation is being used. One of the challenges for clinical care personnel is to gain the childs trust and co-operation before and throughout the duration of an examination, which can prove to be difficult in children who may be ill and have pain. This is important to acquire quality images and prevent repeat examinations. Even with a quality examination, the accurate interpretation of images requires a thorough knowledge of the intricate and dynamic face of anatomy and specific pathological presentations in children. The increased radiation sensitivity of growing organs and childrens longer expected life spans make them more susceptible to the harmful effects of radiation. Imaging pediatric patients in a dedicated pediatric imaging department with dedicated pediatric CT technologists may result in greater compliance with pediatric protocols and significantly reduced patient dose. In order to prevent the harmful effects of ionizing radiation, As Low As Reasonably Achievable (ALARA) principle should be strictly followed. This article seeks to draw attention to various challenges of pediatric imaging and the ways to overcome them Tamijeselvan S"An Assessment of Problems and Preferences in Medical Imaging of Pediatric Patients" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-3 , April 2018, URL: http://www.ijtsrd.com/papers/ijtsrd11012.pdf http://www.ijtsrd.com/medicine/radiology/11012/an-assessment-of-problems-and-preferences-in-medical-imaging-of-pediatric-patients/tamijeselvan-s
KCA Big Data and Immunotherapeutics Symposium, August 31st, 2018, SydneyMichael Evtushenko
Kids Cancer Alliance warmly invites you to this symposium featuring the latest developments in big data analytics, bioinformatics and, immunotherapeutic targeting.
An all-day symposium on the genomics of childhood cancer and germline predisposition, immune epitope targeting and CAR T cell therapeutics, and, single-cell transcriptomic and proteomic diagnostics in cancer.
For more details please contact Dr Michael Evtushenko MEvtushenko@ccia.unsw.edu.au
The Networked Patient Group: How technology changes the face of patient advocacyjangeissler
"The Networked Patient Group: How technology changes the face of patient advocacy", presented by Jan Geissler (@jangeissler) at European Patient Innovation Summit on 4 Oct 2016
Assessing the appropriateness of CT scans among pediatric ortho patientsImage gently
Sifting through peer-reviewed studies on different options in imaging technology used in pediatric orthopedic injuries, the two doctors quantified the amount of radiation in each of the CT scans radiation and X-rays for spines, pelvis, hip and other body parts. They discovered that children who require surgery for hip dysplasia, scoliosis and leg-length discrepancy undergo X-rays or CT scans, and are the children most vulnerable to exposure risk.
Dr. Leonard Saltz, MD; Chief, Gastrointestinal Oncology Service; Head, Memorial Sloan Kettering
Dr. Saltz will discuss selected successes and failures in cancer research efforts, and what we can learn from each, and will take a frank look at costs of care, and at business and government policies that are undermining progress and creating disparities in access to affordable, effective care.
Data sharing drivers in precision oncology, biomedical research, and healthcare. Accelerating discovery, innovation, providing credit for all stakeholders - patients, researchers, care providers, payers.
An overview of the oncology clinical trials network (CTNeT) which is being implemented throughout Texas.
The non-profit network is a first of its kind and combines the innovative science of Texas cancer centers with the expertise and resources of both academic and community oncologists throughout the state.
To learn more, visit www.ctnet.org
An Assessment of Problems and Preferences in Medical Imaging of Pediatric Pat...ijtsrd
Medical Imaging is extremely valuable as a diagnostic tool in the pediatric population, but it comes with a number of distinct challenges as compared to the imaging of adults. This is because of the following: It requires dedicated imaging protocols to acquire the images, there is need for sedation or general anesthesia for longer procedures such as MRI, specific training is required for the healthcare personnel involved, thorough knowledge and expertise should be applied for evaluating the images, and most importantly, it requires consideration for radiation exposure if ionizing radiation is being used. One of the challenges for clinical care personnel is to gain the childs trust and co-operation before and throughout the duration of an examination, which can prove to be difficult in children who may be ill and have pain. This is important to acquire quality images and prevent repeat examinations. Even with a quality examination, the accurate interpretation of images requires a thorough knowledge of the intricate and dynamic face of anatomy and specific pathological presentations in children. The increased radiation sensitivity of growing organs and childrens longer expected life spans make them more susceptible to the harmful effects of radiation. Imaging pediatric patients in a dedicated pediatric imaging department with dedicated pediatric CT technologists may result in greater compliance with pediatric protocols and significantly reduced patient dose. In order to prevent the harmful effects of ionizing radiation, As Low As Reasonably Achievable (ALARA) principle should be strictly followed. This article seeks to draw attention to various challenges of pediatric imaging and the ways to overcome them Tamijeselvan S"An Assessment of Problems and Preferences in Medical Imaging of Pediatric Patients" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-3 , April 2018, URL: http://www.ijtsrd.com/papers/ijtsrd11012.pdf http://www.ijtsrd.com/medicine/radiology/11012/an-assessment-of-problems-and-preferences-in-medical-imaging-of-pediatric-patients/tamijeselvan-s
KCA Big Data and Immunotherapeutics Symposium, August 31st, 2018, SydneyMichael Evtushenko
Kids Cancer Alliance warmly invites you to this symposium featuring the latest developments in big data analytics, bioinformatics and, immunotherapeutic targeting.
An all-day symposium on the genomics of childhood cancer and germline predisposition, immune epitope targeting and CAR T cell therapeutics, and, single-cell transcriptomic and proteomic diagnostics in cancer.
For more details please contact Dr Michael Evtushenko MEvtushenko@ccia.unsw.edu.au
The Networked Patient Group: How technology changes the face of patient advocacyjangeissler
"The Networked Patient Group: How technology changes the face of patient advocacy", presented by Jan Geissler (@jangeissler) at European Patient Innovation Summit on 4 Oct 2016
Presentation "The Impact of All Data on Healthcare"
Keith Perry
Associate VP & Deputy CIO
UT MD Anderson Cancer Center
With continuing advancement in both technology and medicine, the drive is on to make all data meaningful to drive medical discovery and create actionable outcomes. With tools and capabilities to capture more data than ever before, the challenge becomes linking existing structured and unstructured clinical data with genomic data to increase the industry’s analytical footprint.
Learning Objectives:
∙ Discuss the need to make all data meaningful in order to speed discovery of new knowledge
∙ Provide examples of an analytical direction that supports evolution in medicine
∙ Expose the challenges facing the industry with respect to ~omits
Why Precision Medicine and Personalized Healthcare and Why Now? Links to Canada’s Rare Disease Strategy The Future is Now
1) Marc LePage, Genome Canada
2) Michael Duong, Roche
3) Danica Stanimirovic, National Research Council
4) Daniel Gaudet, University of Montreal
5) Christine Dalgleish, Patient Perspective
6) Jamie Bruce, Khure Health
The 10 Most Impactful Leaders in Life Science.pdfTHECIOWORLD
This edition features a handful of The Most Impactful Leaders in Life Science that are leading us into a better future
Read More: https://thecioworld.com/the-10-most-impactful-leaders-in-life-science-september2023/
Michael Chin details the recent news that The Damon Runyon Cancer Research Foundation has named four exceptional researchers as beneficiaries of the prestigious Damon Runyon-Sohn Pediatric Cancer Research Fellowship Award, submitting about $1 million to address a basic lack of subsidizing for pediatric disease research.
Targeted nanoparticle tumor ablation. Multi-walled Carbon Nanotubes (MWCNT) are designed with internal antennae tuned to a specific Near Infrared (NIR) laser frequency, which when activated, oscillate at high speeds, generating thermal energy (heat) sufficient to cause cell apoptosis. Using targeting probes, the MWCNT only seek out, attach to, and within, specific cancer cells. The NIR laser is non-invasive, and does not injure the skin. The MWCNT can also be conjugated with probes for very specific imaging for diagnostics purposes using existing MRI technology.
On Dec. 20th 2016, the HRB published their "Health Research In Action" booklet that detailed a small selection of recent success stories from their research funding portfolio which "...really show health research in action".
The corneal-limbal stem cell research work carried out at NICB (by Finbarr O’Sullivan and Prof. Martin Clynes) and which led to the first corneal-limbal stem cell transplant in Ireland (carried out by Mr. William Power of the RVEEH) on June 7th, 2016 got an honorable mention (Page 17)
Personalized Medicine: Are we there yet?Reid Robison
Slides on the future of healthcare, entitled "Personalized Medicine: Are we there yet?" form a lecture given by Reid Robison, MD MBA at Brigham Young University in the College of Life Sciences in December 2014. The presentation covers the arrival of genome-guided precision medicine as well as the digital health movement and the shift towards a patient-centric, consumer-driven healthcare system.
2. By translating biomedical discoveries into an integrated, personalized treatment program for children with cancer By developing cancer-specific predictive tests to guide cancer therapy for each child By bringing to the clinic new therapies that considers the unique molecular physiology of the child and their cancer THE NICHOLAS CONOR INSTITUTE for Pediatric Cancer Research Our Mission is to meet this disease head on with better detection, diagnostic tools and kid friendly treatments that bring hope to all those involved…
3. THE NICHOLAS CONOR INSTITUTE Date of Dx: 7/19/05 High-Risk Neuroblastoma Combinatorial Chemotherapy, Surgery & Retinoic Acid Therapy NED: 2 ½ years post treatment for Pediatric Cancer Research What kind of treatments option does a child like Conor have? Beth Anne Baber, Ph.D., Co-founder, President and CEO Mother of Nicholas “Conor” Boddy “ Not very many. Radiation was not an option … surgery was not an option. The only thing left was high intensity chemotherapy. Often children with his condition are given 10X the adult dose of chemotherapy that obviously leads to long-term side effects … You may not see these effects immediately, these long-term side- effects will occur as they grow into adulthood.” -Beth Anne Baber, Conor’s Mom Burrill Report Patient Perspective Podcast July 2009
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5. Unacceptable Market Reality SITUTATION: If the projected revenue is <$800 M/yr, then NO new pediatric oncology drug development. CURRENT STRATEGY: Piggyback onto adult products for the lack of pediatric targeted therapies AND often give the children 10X the adult dose. PROBLEM: Small market and modest overlap between adult & childhood cancers. CURRENT COST: ~ $500,000 to >$2,500,000 to treat each child Leukemia (30%) Brain & NS (22.3%) Lymphomas (8%) Neuroblastoma (7.3%) Other cancers (32.4%)
6. Our advantage is the value we create Develop Validate Apply Baseline 6 months to 1 year Acquire Identify Technology & Industry Partner(s) TNCI Value Creation Time Horizon: 2-5 years Translate Research (Other Institutions) Time Clinic
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8. TACTiC TM iChanneX & GenVault TBA TBA Prognosys BioSc & others TBA AltheaDx CollabRx & others TBA Industry Partners: Genomics Proteomics Bio- informatics CDx MDx Centers of Excellence for Childhood Cancer: The Nicholas Conor Institute Academia Children’s Oncology Group & Clinical Research Centers International Consortiums Pediatric Cancer Outcome Exchange
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11. THE NICHOLAS CONOR INSTITUTE Board of Directors Beth Alton Chair of the Board of Directors Founder and CEO of Keene Solutions Beth Anne Baber, Ph.D., MBA Co-founder and CEO Martin Latterich, Ph.D. Co-founder and CSO John Wooley, Ph.D. Assoc. Vice Chancellor of Research-UCSD Geoff Wahl, Ph.D. Professor at the Salk Institute Former President of the AACR Trustee of the AACR Foundation Tony Hunter, Ph.D. Prof. & Director of the Salk Institute Cancer Center Bud Bromley President and COO of Psynomics Mort Freedman Former Chair of Steele Children’s Research Center Jeff Wolf Founded and CEO of Wolf Management Consultants Janet Vohariwatt Founder and CEO of iChanneX David Geerdes Attorney at Law
12. THE NICHOLAS CONOR INSTITUTE for Pediatric Cancer Research TheNicholasConorInstitute.org (TNCI.org)
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Editor's Notes
NED, No Evidence of Disease.
NED, No Evidence of Disease.
In the US, ~1.4 million adults are diagnosed with cancer each year compared to ~13,000 children. Childhood cancer is the leading cause of death in children by a disease, killing more children than asthma, diabetes, CF and AIDS combined. In 2007, National Cancer Institute (NCI) provided $4.8 Billion in cancer research grants. However, the childhood cancer only received $172 Million in research grants, only 3.5% of NCI funds. $41 Million of the $172 Million in childhood cancer research funds is awarded to the National Childhood Cancer Foundation to assist the Children’s Oncology Group in performing clinical trials.
Through TACTiC, TNCI value is derived from being able to bridge the gap between the research done at other research institutions and clinical application.
TNCI through TACTiC will significantly reduce R&D cost for pediatric oncology products through the physical sharing of available resources with our industry partners (e.g. collaborative grants, space, equipment, reagents, etc.). Our industry partnerships will be in the following domians: Genomics, Proteomics, Bioinformatics, Molecular Diagnostics (Dx), Drug Development, Companion Diagnostics (Dx), Immunotherapy, Vaccine Development, Nanotechnology and Wireless Technology. These domains are necessary research components of understanding, diagnosing and treating disease. Assuming most non-profits research institutions are operating with over 80% in indirects, TACTiC automatically saves $23 Million. TNCI will submit its first wave of non-profit/for-profit collaborative grants in August 2009 with Prognosys Bioscience and AltheaDx. As these grants are funded, we will establish TNCI laboratories within these companies and share available resources to move the identified technology forward. One biomedical industry partnership will be established every year for the first 5 years.
TNCI through TACTiC will significantly reduce R&D cost for pediatric oncology products through the physical sharing of available resources with our industry partners (e.g. collaborative grants, space, equipment, reagents, etc.). Our industry partnerships will be in the following domians: Genomics, Proteomics, Bioinformatics, Molecular Diagnostics (Dx), Drug Development, Companion Diagnostics (Dx), Immunotherapy, Vaccine Development, Nanotechnology and Wireless Technology. These domains are necessary research components of understanding, diagnosing and treating disease. Assuming most non-profits research institutions are operating with over 80% in indirects, TACTiC automatically saves $23 Million. TNCI will submit its first wave of non-profit/for-profit collaborative grants in August 2009 with Prognosys Bioscience and AltheaDx. As these grants are funded, we will establish TNCI laboratories within these companies and share available resources to move the identified technology forward. One biomedical industry partnership will be established every year for the first 5 years.
TNCI Board of Directors: Beth Alton is Founder and President of Keene Solutions. Keene Solutions provides outsourced human resource support, management coaching, training and advises non-profit clients on board governance issues. Beth spent nearly 20 years in the non-profit, bio-research sector with the Salk Institute for Biological Studies in La Jolla, CA. Her most recent role was that of Vice President, Human Resources. Beth Anne Baber, Ph.D. has over 20 years of academic experience. Her current research at The Salk Institute focuses on the understanding of the molecular mechanisms involved in DNA damage repair. Her work has led to publications in major scientific journals, including Nature and Science . Beth is the 2007 DLA Piper-Athena FlexMBA Scholarship recipient and expected to receive her MBA from UCSD Rady School of Management in August 2009. Bud Bromley has a track record of entrepreneurial leadership spanning 3 decades. Bud is the President and COO is Psynomics, Inc., a company dedicated to developing tests and software for diagnosis and drug response for psychiatric diseases. Bud has been senior business development, marketing and sales executive at four public corporations, each a startup or young company supplying high technology instrumentation, software, consumables and services for life sciences and chemical analysis. Mort Freedman has been in real estate since 1966. Mort founded Nationwide Resources Corporation in Tucson, AZ. Mort also served for ten years on board of the Jewish Federation and served for 11 years on the board of the Steele Memorial Children's Research Centre. During his tenure at the Steele, Mort has overseen the growth of a nascent research-focused organization to a well-funded and fully integrated research center for pediatric children disease. Tony Hunter, Ph.D. is Director of the Molecular and Cell Biology Laboratory at the Salk Institute and Director of the Salk Institute Cancer Center. He has received numerous awards for his scientific contributions, including a National Cancer Institute Outstanding Investigator Award, the General Motors Cancer Research Foundation Mott Prize, the Biochemical Society Hopkins Medal, the Keio Medical Science Prize, the American Cancer Society Medal of Honor, the Landon-AACR Prize for Cancer Research. He is a Fellow of the Royal Society of London, an Associate Member of the European Molecular Biology Organization (EMBO), a Fellow of the American Academy of Arts and Sciences, a Member of the National Academy of Sciences and a Member of the Institute of Medicine. Martin Latterich, Ph.D. is Sr. Director of research and Development for Biomatrica. Martin has over fifteen years of industrial and academic experience in pharmacogenomics, proteomics, and the biochemistry of proteins and small molecules. He held a faculty appointment jointly between the University of Montreal, Faculty of Pharmacy, and the Montreal Heart Institute’s Pharmacogenomics Center. Additionally, Martin served on the faculty of McGill University and the Salk Institute. He has also held senior management and executive positions at several biotechnology companies, including Illumina, Inc. Martin serves as consultant to VC firms, pharmaceutical, and biotechnical companies. Geoffrey M. Wahl, Ph.D . is a Professor at the Salk Institute and an Adjunct Professor in the Department of Biology at UCSD. Geoff was elected to and served as President of American Association for Cancer Research (AACR) for the Centennial year, 2007 and he continues to be very active in his role as Past President. In the broader scientific community, he has served on numerous special science conference and committee posts, and has been a member of the editorial boards of numerous journals. John Wooley , Ph.D. is Associate Vice Chancellor of Research at UCSD. John created the first government research funding programs in bioinformatics and computational biology. He is also an Adjunct Professor at the university, in Pharmacology, Chemistry and Biochemistry, and a strategic advisor and Senior Fellow of the San Diego Supercomputer Center. For the new UCSD California Institute for Telecommunication and Information Technology, Wooley directs the biology and biomedical applications component, termed Digitally-enabled Genomic Medicine, a step in delivering personalized medicine in a wireless clinical setting. Jeff Wolf, RCC is founder of Wolf Management Consultants. Jeff has built a valued practice that speaks to key problems confronting businesses today. Jeff is known as one of America’s most dynamic speakers , is considered one of the top executive business coaches in the country, and is a highly sought after management consultant. Jeff was a former CEO of one of the country’s largest healthcare receivables management companies and a prestigious polling and political opinion research corporation involved in strategic decisions for congressional, senatorial and presidential races. Jeff’s new book, Roadmap to Success , with management gurus Ken Blanchard and Stephen Covey has just been released and his second book, The Essence of Effective Leadership , debuts soon. David Geerdes, is an Attorney at Law and former Of Counsel of Procopio Cory Hargreaves & Savitch. David was a Management Attorney for Gray Cary Ware & Freidenrich and Heller Ehrman, LLP. David was appointed by the Mayor of San Diego to serve on the Commission on Financing the Infrastructure. In addition to many other commission appointments, David was the Legal Advisor to Board of Trustees and Executive Committee for the Salk Institute and general counsel for the San Diego Convention and Visitors Bureau. Janet Vohariwatt is a CEO and founder of iChanneX Corporation. Prior to founding iChanneX, she served as VP Global Product Development at Inasoft and VP of SAIC, Xerox Corporation, and Ford Aerospace Telecom Subsidiary-Starnet. Janet has led teams in developing innovative IT solutions for customers such as Kaiser Permanente, Saskatchewan Provincial Health, Department of Defense Health Services, and BellSouth Wireless among many others. Janet serves in the Sharp HealthCare Foundation Board of Directors, and support in UCSD Rady Mentor Program.