Is the increasing availability of automated image analysis a possibility to strengthen the application of diffusion-MRI as a biometric parameter, and to enhance the future of image biobanks? Or is this evolution threatening the position of radiologists as medical doctors. Is a redefinition of radiologist as computer technicians inevitable?
Is the increasing availability of automated image analysis a possibility to strengthen the application of diffusion-MRI as a biometric parameter, and to enhance the future of image biobanks? Or is this evolution threatening the position of radiologists as medical doctors. Is a redefinition of radiologist as computer technicians inevitable?
TCGC The Clinical Genome Conference 2015Nicole Proulx
Bio-IT World and Cambridge Healthtech Institute are again proud to host the Fourth Annual TCGC: The Clinical Genome Conference, inviting stakeholders impacting clinical genomics to share new findings and solutions for advancing the applications of clinical genome medicine.
From Bits to Bedside: Translating Big Data into Precision Medicine and Digita...Dexter Hadley
Lecture Objectives:
1) To use examples from my research to define and introduce the ideals of precision medicine and digital health. 2) To introduce how large scale population-wide analysis of data can be used to facilitate these two ideals. 3) To introduce how freely available open data can be used to facilitate these two ideals. 4) To show how mobile technology can be used to facilitate these two ideals.
Towards Digitally Enabled Genomic Medicine: the Patient of The FutureLarry Smarr
12.02.22
Invited Speaker
Hacking Life
TTI/Vanguard Conference
Title: Towards Digitally Enabled Genomic Medicine: the Patient of The Future
San Jose, CA
Oncology Big Data: A Mirage or Oasis of Clinical Value? Michael Peters
The title of the presentation, Oncology Big Data: A Mirage or Oasis of Clinical Value, reflects what I believe the field of Oncology is challenged with on a growing basis, from a clinical and business side perspective.
FDA NGS and Big Data Conference September 2014Warren Kibbe
Presentation for the FDA NGS and Big Data Conference September 2014 held on the NIH campus. NCI initiatives, including Cancer Genomics Data Commons, NCI Cloud Pilots, big data issues for cancer
di Pier Giuseppe Pelicci, MD-PhD, Istituto Europeo di Oncologia IEO, Università degli Studi di Milano.
Slide per l'intervento tenuto in Fondazione Giannino Bassetti in occasione del primo incontro del ciclo "La medicina di precisione", primo progetto dalla convenzione tra Università di Pavia e Fondazione Bassetti.
12 marzo 2018
ZOOM ON: Breast cancer: what’s new?
• NEWS: Big pharma acquire a new collection of PDX
• IMODI around the world: Meet the experts!
• FOCUS on: The Leon Berard Clinical Center
• ADVERT: A new web catalogue for IMODI products
ZOOM: Pancreatic Cancer
• NEWS: Publication by Juan IOVANNA
• IMODI around the world: Meet the experts!
• FOCUS: From the bench to the bedside, INSERM U1068
• WEB-CATALOGUE: 20 in-vitro cell models available
Exploring the Potential of Computational Immuno-Oncology.pdfMrMed.in
Computational immuno-oncology, a burgeoning discipline at the intersection of computer science, immunology, and oncology, holds the potential to revolutionise cancer treatment by harnessing the power of the immune system and cutting-edge computational technologies.
TCGC The Clinical Genome Conference 2015Nicole Proulx
Bio-IT World and Cambridge Healthtech Institute are again proud to host the Fourth Annual TCGC: The Clinical Genome Conference, inviting stakeholders impacting clinical genomics to share new findings and solutions for advancing the applications of clinical genome medicine.
From Bits to Bedside: Translating Big Data into Precision Medicine and Digita...Dexter Hadley
Lecture Objectives:
1) To use examples from my research to define and introduce the ideals of precision medicine and digital health. 2) To introduce how large scale population-wide analysis of data can be used to facilitate these two ideals. 3) To introduce how freely available open data can be used to facilitate these two ideals. 4) To show how mobile technology can be used to facilitate these two ideals.
Towards Digitally Enabled Genomic Medicine: the Patient of The FutureLarry Smarr
12.02.22
Invited Speaker
Hacking Life
TTI/Vanguard Conference
Title: Towards Digitally Enabled Genomic Medicine: the Patient of The Future
San Jose, CA
Oncology Big Data: A Mirage or Oasis of Clinical Value? Michael Peters
The title of the presentation, Oncology Big Data: A Mirage or Oasis of Clinical Value, reflects what I believe the field of Oncology is challenged with on a growing basis, from a clinical and business side perspective.
FDA NGS and Big Data Conference September 2014Warren Kibbe
Presentation for the FDA NGS and Big Data Conference September 2014 held on the NIH campus. NCI initiatives, including Cancer Genomics Data Commons, NCI Cloud Pilots, big data issues for cancer
di Pier Giuseppe Pelicci, MD-PhD, Istituto Europeo di Oncologia IEO, Università degli Studi di Milano.
Slide per l'intervento tenuto in Fondazione Giannino Bassetti in occasione del primo incontro del ciclo "La medicina di precisione", primo progetto dalla convenzione tra Università di Pavia e Fondazione Bassetti.
12 marzo 2018
ZOOM ON: Breast cancer: what’s new?
• NEWS: Big pharma acquire a new collection of PDX
• IMODI around the world: Meet the experts!
• FOCUS on: The Leon Berard Clinical Center
• ADVERT: A new web catalogue for IMODI products
ZOOM: Pancreatic Cancer
• NEWS: Publication by Juan IOVANNA
• IMODI around the world: Meet the experts!
• FOCUS: From the bench to the bedside, INSERM U1068
• WEB-CATALOGUE: 20 in-vitro cell models available
Exploring the Potential of Computational Immuno-Oncology.pdfMrMed.in
Computational immuno-oncology, a burgeoning discipline at the intersection of computer science, immunology, and oncology, holds the potential to revolutionise cancer treatment by harnessing the power of the immune system and cutting-edge computational technologies.
The maturation of genomic technologies has enabled new
discoveries in disease pathogenesis as well as new approaches to patient care.
In pediatric oncology, patients may now receive individualized genomic analysis to identify molecular aberrations of relevance for diagnosis and/or treatment.
Several recent clinical studies have begun to explore the feasibility and utility of genomics-driven precision medicine.
The 10 Most Impactful Leaders in Life Science.pdfTHECIOWORLD
This edition features a handful of The Most Impactful Leaders in Life Science that are leading us into a better future
Read More: https://thecioworld.com/the-10-most-impactful-leaders-in-life-science-september2023/
NGS for Infectious Disease Diagnostics: An Opportunity for Growth Alira Health
Infectious diseases are a major public health concern causing over 3.5 million deaths worldwide. Diagnosing patients as quickly and effectively as possible is crucial for managing disease outbreaks. Next-generation sequencing (NGS) provides unique capabilities to understand the genetic profile of infectious disease patients that no other technology can match.
Whole-genome metagenomics allows clinicians to take a deeper dive into pathogens by generating big-data about their characteristics. This data can be rapidly analyzed using complex bioinformatics software algorithms to achieve clinical-grade diagnostic accuracy. In a healthcare system shifting towards personalized medicine, NGS can provide clinicians the tools that they need to prescribe individualized treatments to save patients who were previously untreatable. The result is improved quality of care, better treatment regimes, and cost-saving healthcare.
World Cancer Day, established by the Union for International Cancer Control (UICC) in 2000, is observed every year on February 4th. Over 10 million people die each year from cancer, more than HIV/AIDS, malaria, and tuberculosis combined. This makes cancer a leading cause of death with a global impact; cancer is not specific to any one geographic region or any one demographic. Cancer can affect anyone of any age, but we are moving towards extraordinary medical breakthroughs in the fight against cancer...
When the Human Genome Project was declared complete back in 2003, there were high expectations set for genomic medicine. However, it has taken over a decade to begin moving from vision to reality. Today, the number of success stories remains relatively small, but they do stretch across the healthcare ecosystem, incorporating the prediction of drug responses, the diagnosis of diseases and the identification of targeted therapies. Stakeholders ranging from patients, healthcare providers and payers, researchers, diagnostic companies, policy-makers, life sciences businesses and governments now believe genomic medicine to be a potential game-changer
Encryption in Microsoft 365 - ExpertsLive Netherlands 2024Albert Hoitingh
In this session I delve into the encryption technology used in Microsoft 365 and Microsoft Purview. Including the concepts of Customer Key and Double Key Encryption.
The Art of the Pitch: WordPress Relationships and SalesLaura Byrne
Clients don’t know what they don’t know. What web solutions are right for them? How does WordPress come into the picture? How do you make sure you understand scope and timeline? What do you do if sometime changes?
All these questions and more will be explored as we talk about matching clients’ needs with what your agency offers without pulling teeth or pulling your hair out. Practical tips, and strategies for successful relationship building that leads to closing the deal.
Smart TV Buyer Insights Survey 2024 by 91mobiles.pdf91mobiles
91mobiles recently conducted a Smart TV Buyer Insights Survey in which we asked over 3,000 respondents about the TV they own, aspects they look at on a new TV, and their TV buying preferences.
Slack (or Teams) Automation for Bonterra Impact Management (fka Social Soluti...Jeffrey Haguewood
Sidekick Solutions uses Bonterra Impact Management (fka Social Solutions Apricot) and automation solutions to integrate data for business workflows.
We believe integration and automation are essential to user experience and the promise of efficient work through technology. Automation is the critical ingredient to realizing that full vision. We develop integration products and services for Bonterra Case Management software to support the deployment of automations for a variety of use cases.
This video focuses on the notifications, alerts, and approval requests using Slack for Bonterra Impact Management. The solutions covered in this webinar can also be deployed for Microsoft Teams.
Interested in deploying notification automations for Bonterra Impact Management? Contact us at sales@sidekicksolutionsllc.com to discuss next steps.
GDG Cloud Southlake #33: Boule & Rebala: Effective AppSec in SDLC using Deplo...James Anderson
Effective Application Security in Software Delivery lifecycle using Deployment Firewall and DBOM
The modern software delivery process (or the CI/CD process) includes many tools, distributed teams, open-source code, and cloud platforms. Constant focus on speed to release software to market, along with the traditional slow and manual security checks has caused gaps in continuous security as an important piece in the software supply chain. Today organizations feel more susceptible to external and internal cyber threats due to the vast attack surface in their applications supply chain and the lack of end-to-end governance and risk management.
The software team must secure its software delivery process to avoid vulnerability and security breaches. This needs to be achieved with existing tool chains and without extensive rework of the delivery processes. This talk will present strategies and techniques for providing visibility into the true risk of the existing vulnerabilities, preventing the introduction of security issues in the software, resolving vulnerabilities in production environments quickly, and capturing the deployment bill of materials (DBOM).
Speakers:
Bob Boule
Robert Boule is a technology enthusiast with PASSION for technology and making things work along with a knack for helping others understand how things work. He comes with around 20 years of solution engineering experience in application security, software continuous delivery, and SaaS platforms. He is known for his dynamic presentations in CI/CD and application security integrated in software delivery lifecycle.
Gopinath Rebala
Gopinath Rebala is the CTO of OpsMx, where he has overall responsibility for the machine learning and data processing architectures for Secure Software Delivery. Gopi also has a strong connection with our customers, leading design and architecture for strategic implementations. Gopi is a frequent speaker and well-known leader in continuous delivery and integrating security into software delivery.
DevOps and Testing slides at DASA ConnectKari Kakkonen
My and Rik Marselis slides at 30.5.2024 DASA Connect conference. We discuss about what is testing, then what is agile testing and finally what is Testing in DevOps. Finally we had lovely workshop with the participants trying to find out different ways to think about quality and testing in different parts of the DevOps infinity loop.
LF Energy Webinar: Electrical Grid Modelling and Simulation Through PowSyBl -...DanBrown980551
Do you want to learn how to model and simulate an electrical network from scratch in under an hour?
Then welcome to this PowSyBl workshop, hosted by Rte, the French Transmission System Operator (TSO)!
During the webinar, you will discover the PowSyBl ecosystem as well as handle and study an electrical network through an interactive Python notebook.
PowSyBl is an open source project hosted by LF Energy, which offers a comprehensive set of features for electrical grid modelling and simulation. Among other advanced features, PowSyBl provides:
- A fully editable and extendable library for grid component modelling;
- Visualization tools to display your network;
- Grid simulation tools, such as power flows, security analyses (with or without remedial actions) and sensitivity analyses;
The framework is mostly written in Java, with a Python binding so that Python developers can access PowSyBl functionalities as well.
What you will learn during the webinar:
- For beginners: discover PowSyBl's functionalities through a quick general presentation and the notebook, without needing any expert coding skills;
- For advanced developers: master the skills to efficiently apply PowSyBl functionalities to your real-world scenarios.
Builder.ai Founder Sachin Dev Duggal's Strategic Approach to Create an Innova...Ramesh Iyer
In today's fast-changing business world, Companies that adapt and embrace new ideas often need help to keep up with the competition. However, fostering a culture of innovation takes much work. It takes vision, leadership and willingness to take risks in the right proportion. Sachin Dev Duggal, co-founder of Builder.ai, has perfected the art of this balance, creating a company culture where creativity and growth are nurtured at each stage.
Elevating Tactical DDD Patterns Through Object CalisthenicsDorra BARTAGUIZ
After immersing yourself in the blue book and its red counterpart, attending DDD-focused conferences, and applying tactical patterns, you're left with a crucial question: How do I ensure my design is effective? Tactical patterns within Domain-Driven Design (DDD) serve as guiding principles for creating clear and manageable domain models. However, achieving success with these patterns requires additional guidance. Interestingly, we've observed that a set of constraints initially designed for training purposes remarkably aligns with effective pattern implementation, offering a more ‘mechanical’ approach. Let's explore together how Object Calisthenics can elevate the design of your tactical DDD patterns, offering concrete help for those venturing into DDD for the first time!
De-mystifying Zero to One: Design Informed Techniques for Greenfield Innovati...
14 technologies that will shape the future of cancer care
1. 6/22/2018 14 Technologies That Will Shape The Future of Cancer Care - The Medical Futurist
http://medicalfuturist.com/technologies-that-will-shape-the-future-of-cancer-care/ 1/6
Future of Medicine
14 Technologies That Will Shape The Future of Cancer Care
In his State of the Union address in 2016, President Obama pledged a new national effort to find a cure for cancer. This is the
cancer “moonshot” for the future of cancer care.
Last year, he announced the launch of the Precision Medicine Initiative — a bold new research effort to revolutionize how we
improve health and treat disease. These two strategies together hold the promise of curing cancer or, at least, transforming it
into a manageable chronic disease.
Negotiations and collaborations are launching now to decide which research trends and areas deserve the most support. Only
disruptive innovations will be able to transform the status quo in cancer, leading patients to get more personalized and faster
cancer care, while letting physicians do their job more effectively. Here are the technologies and trends that could help
achieve the cancer “Moonshot”.
Prevention and diagnosis
Cancer diagnosis must be early and accurate. Many cancer types cannot be detected early enough at the moment, while others
are detected in time, but treated too severely. This notion requires not only great healthcare facilities and new diagnosis
technologies, but also the proactivity of patients.
Fluid biopsy
During cancer treatments, re-biopsies are needed many times. It means a new sample from the ever-changing tumour must
be obtained to define the next step of the therapy. With the current, invasive biopsy techniques, this is a huge challenge not
only for patients, but also for caregivers. Fluid biopsy extracts cancer cells from a simple blood sample. As Illumina, the DNA
sequencer giant, just announced a spin-off focused solely on making fluid biopsy commercially viable, it might be the next big
thing in oncology.
Real-time cancer diagnostics
An intelligent surgical knife (the iKnife) was developed by Zoltan Takats of Imperial College London and works by using an
old technology where an electrical current heats tissue to make incisions with minimal blood loss, but with iKnife the
vaporized smoke is analyzed by a mass spectrometer to detect the chemicals in the biological sample. This allows real-time
identification of malignant tissue. Surgeons will love this surgical Jedi knife which can significantly reduce the length of
operations in oncology.
The Medical Futurist | 8 minute read
2. 6/22/2018 14 Technologies That Will Shape The Future of Cancer Care - The Medical Futurist
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Understanding genetic and lifestyle causes of diseases
By getting a clear knowledge about what genetic and environmental factors lead to the different types of cancers, including
the given patient’s own genetic makeup, it would be possible to catch cancer in its infancy. This requires process innovation in
healthcare, as well as more precise and specific cancer biomarkers supported by better screening technologies. Cancer
Research UK’s Cancer Grand Challenges feature a call for researchers to discover new, previously unknown carcinogenic
events, bringing this trend closer to reality.
Treatment
Today, we either use chemotherapy to destroy any reproducing cells causing serious side effects; or targeted therapies which
show low rates of response due to heterogeneity of the tumour and the poor accuracy of matching treatments to patients. The
price of new drugs is going up steeply and personalized drugs cost even more, while effective cancer care be widely available
to everyone.
Next-generation targeted therapies
In the case of AIDS, combining drugs with different targets resulted in the treatment that finally put a dent in the disease.
Research shows the same applies to cancer, but combining the increasing number of cancer therapies has so far proven
difficult due to the sheer number of possible combinations. New approaches in the field of systems biology that use computer
models to predict therapy effects are promising to cut through this complexity, and deliver effective combinational therapies
in the coming years. All the while, new approaches like immunotherapies put emphasis on making the patient’s immune
system sensitive to cancer cells again, this way letting the immune system fight back.
Molecular cancer diagnostics
Companies like Foundation Medicine are creating customized treatment plans based on the genetic makeup of the patient’s
tumour. They sequence DNA from the patient’s tumor, and try to match the key mutations to drugs on the market or clinical
trials already on the way. Over time, this will become the standard for assigning cancer treatment regimes.
3. 6/22/2018 14 Technologies That Will Shape The Future of Cancer Care - The Medical Futurist
http://medicalfuturist.com/technologies-that-will-shape-the-future-of-cancer-care/ 3/6
Artificial intelligence based therapy design
Even if we can extract tumour cells from blood and sequence their DNA as fast as possible, making a decision about which
treatment to choose next is still a struggle. No oncologist can see through the millions of studies and thousands of clinical
trials by keeping all of the patient’s parameters and mutations in mind. Artificial intelligence algorithms can. IBM’s
supercomputer Watson has been used in oncology for years, finding the most personalized treatment by sifting through all
available evidence in minutes.
Multi-functional radiology
Without doubt, the future belongs to interdisciplinary innovations. Neurosurgeons at the University of California, San Diego
School of Medicine and UC San Diego Moores Cancer Center used magnetic resonance imaging (MRI) guidance for delivering
gene therapy as a potential treatment for brain tumours. Similar innovations in treatment delivery would decrease side
effects significantly while boosting treatment effectiveness.
In silico trials
Current clinical trials take years and cost more than 2 billion dollars for every approved treatment. The number of failed drug
candidates is enormous, so spending years and millions on a clinical trial is no guarantee it will lead to an approved
treatment. This is a huge risk for pharma companies. In silico trials using advanced biological networks, or the organs-on-a-
chip technique would enable analysing on hundreds of thousands of drug candidates on billions of virtual human
physiological models in seconds with supercomputers. It would make drug discovery faster than ever.
DNA cages
Most cancer treatments today destroy not only cancerous cells, but also healthy ones. The ultimate goal is delivering drugs
only to cells that need to be treated. Using DNA cages holding a payload of drugs might be the answer. This method could be
used in clinical trials soon. Cancer cells can trigger the DNA cage to open and thus the drug could only make an impact on
those cells, but not the healthy ones.
4. 6/22/2018 14 Technologies That Will Shape The Future of Cancer Care - The Medical Futurist
http://medicalfuturist.com/technologies-that-will-shape-the-future-of-cancer-care/ 4/6
Precision surgery
Surgeons using surgical robots such as DaVinci are capable of performing operations with previously unachievable precision.
By making the robot an extension of the surgeon’s mind and skills, operating tumors in early stages, or tumors in close
proximity to sensitive organs might become more feasible than ever.
Monitoring and providing care
The diagnosis of cancer is a huge event in someone’s life – there’s a reason cancer patients consider their life after to be “the
New Normal”. Although patients meet their caregivers in person many times, they are left to cope with chronic pain and
powerful side effects for the rest of the year. New technologies could improve their experience forever.
Embedded, implanted and digestible sensors
In many cases, measuring health parameters at home would be a huge addition to cancer care. Measuring body temperature,
for example, is a key in monitoring the effects of chemotherapy. What if a sensor on the patient’s skin could constantly
measure body temperature and notify the patient when fever goes up? Digestible pillcams could be used to perform non-
invasive routine checkups on the digestive system at home. Implanted sensors or digital tattoos could monitor every
important vital sign, triggering an alarm to both the patient and the caregiver, so interventions can be planned as quickly as
possible.
5. 6/22/2018 14 Technologies That Will Shape The Future of Cancer Care - The Medical Futurist
http://medicalfuturist.com/technologies-that-will-shape-the-future-of-cancer-care/ 5/6
Measuring lab markers at home
Another important element of cancer care is blood tests. During chemotherapy, blood markers, especially, white blood cell
count must be checked routinely to make sure the patient’s immune system is still intact. Qloudlab plans to roll out a device
that would allow patients to check blood cell counts at home.
Social media networks
Networking sites such as SmartPatients and Inspire were designed to help patients find and support each other without
geographical limitations. These patients can discuss symptoms, offer advice and moral support, and help cope with treatment
side-effects like never before. The feeling of community and seeing others cope with the same hardships can boost not just the
mental, but the physical well-being of cancer patients as well.
Pain management
Cancer and its treatments can induce extreme, chronic pain, and in the past, cancer patients were relegated to continuous,
increasing doses of painkillers. Companies are now developing devices that help ease symptoms and side effects. A good
example is Quell, a wearable technology with intensive nerve stimulation that is clinically proven to help manage chronic
pain. Its use is FDA approved during the day while the patient is active, as well as at night during sleep.
All these technologies show amazing promise and some of them are already in use. We need to keep on pushing the
limits to get to a stage where the diagnosis of cancer is not a life-altering event that often brings an untimely end to a
patient’s life, but at least a manageable, chronic condition.