Treating cancer with electric fields
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The document discusses a new non-invasive cancer treatment called Tumor Treating Fields which uses electric fields to disrupt cell division in tumors. It was developed by Dr. Yoram Palti who was motivated to create an alternative treatment to surgery, chemotherapy and radiation that improves patients' quality of life. The treatment delivers low-intensity electric fields to the tumor site via transducer arrays placed on the skin.
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The Nervous and Chemical Regulation of Respiration
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
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In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
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Treating cancer with electric fields
- 1. Treating cancer with electric fields
- 2. A new approach, called : Tumor Treating Fields which uses electric fields to interrupt cancer cell division. —the treatment comes with one big benefit: quality of life. October,2011
- 3. INTRODUCTIONS • Bill Doyle is the executive chair of Novocure, a company commercializing a new therapeutic modality for solid tumors. He graduated of MIT(Massachusetts Institute of Technology ) • Dr Yoram Palti, M.D., Ph.D. is a veteran scientist and entrepreneur in the field of bio- physics, bio-sensors, and electrophysiology. Dir. Of Neuro-oncology cancer center He is is the author of more than 40 patents and 70 scientific papers.
- 4. What has motivated the research? • As we know surgery, chemotherapy and radiation are best known for cancer treatment methods. Yoram Palti wanted to present a new approach to search for an effective- antineoplasica therapy. Provide cancer patients a new treatment option so bringing innovative medical technologies to physicians and patients. For him, this treatment comes with one big advantage: the quality of life.
- 10. we will make big strides on reducing that death rate that has been so challenging in this disease.
- 11. THANK YOU