Beta blockers may benefit patients with acute traumatic brain injury by reducing the systemic hyperadrenergic state and associated increases in cardiac and cerebral oxygen demands. Evidence suggests beta blockers can decrease mortality and improve outcomes following TBI. Propranolol and labetalol are recommended for treating tachycardia, tachypnea and hypertension associated with TBI. Initiation after 24-48 hours with continuation for at least 14 days may help while carefully monitoring for side effects.