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Society for biocuration panel discussion, April 2013
Society for biocuration panel discussion, April 2013
Ivone Cabral – WG5: Scientific Publishing Innovations and the Future of Peer ...
Ivone Cabral – WG5: Scientific Publishing Innovations and the Future of Peer ...
Scholarly Communication - Not just for scholars anymore
Scholarly Communication - Not just for scholars anymore
Daniel Feerst - What is Ethical Publishing and unethical Publishing
Daniel Feerst - What is Ethical Publishing and unethical Publishing
More from Roger Watson
Research into mealtimes and older people with dementia.pptx
This document discusses research into helping older people with dementia during mealtimes. Dementia can cause problems with intelligence, memory, language, wandering, aggression and more. It also discusses the ethical issues around feeding those with dementia. The Edinburgh Feeding Evaluation in Dementia scale is presented as the most widely used and validated measure of feeding difficulty. Several studies testing interventions like music or Montessori-based activities found positive outcomes, though more rigorous research is still needed. Spaced retrieval training was found to reduce mealtime difficulties and promote independence. Creating the right environment, social interactions and individualized care can help prolong eating ability in dementia patients.
Research into mealtimes and older people with dementia
This document discusses research into helping older people with dementia during mealtimes. Dementia can cause problems with intelligence, memory, language, wandering, aggression and more. It also raises ethical questions around feeding. The Edinburgh Feeding Evaluation in Dementia scale is presented as the most validated measure of feeding difficulty. Several studies testing interventions like music or Montessori-based activities found positive outcomes, though more rigorous research is still needed. Factors like environment, social interaction and individualizing care can help promote independence in feeding for longer. Spaced retrieval training also showed promise in reducing mealtime difficulties. While numbers of those with dementia will rise, targeted interventions may help alleviate associated problems like eating.
Manuscript organisation
This document provides tips for organizing a manuscript. It recommends including sections for the title, abstract, introduction/background, methods, results, discussion, and conclusion, followed by references. The abstract should be structured and summarize the aims, background, design, methods, results, and conclusions. Keywords should match the title and abstract. The introduction should place the study in context and state the problem and research questions. The methods should describe the design, sample, data collection, and analysis in enough detail to allow replication. The results should report findings without interpretation. The discussion should interpret the results in relation to the research questions and implications. The conclusion should briefly summarize key findings and implications for future research.
How to be a good supervisor
This document provides guidance for supervisors on best practices for supporting PhD candidates. It outlines criteria for good supervision, including: recruiting and selecting candidates; developing strong supervisory relationships; supporting candidates' research projects and writing; keeping the research on track; and helping candidates develop professionally and disseminate their research. The document emphasizes establishing clear expectations, providing feedback on written work, dealing constructively with challenges, and reflecting on one's practice to continually enhance supervision skills.
Clinical research design
This document discusses key considerations for clinical research design such as having a clear research question, selecting an appropriate design that best answers the question, considering feasibility factors, ensuring the work is interesting, relevant, novel, and ethical. It provides examples of common research designs like randomized controlled trials, surveys, qualitative research, and systematic reviews. It highlights common mistakes like having an overly ambitious project or deciding on methods before the research question. The conclusion emphasizes having a clear research question to guide design, methods, and getting necessary support and approvals.
Alternative experimental designs
The document discusses various alternative experimental designs for clinical research studies, including quasi-experiments, cohort studies, case control studies, pragmatic trials, non-inferiority trials, and studies of complex interventions. Traditional randomized controlled trials are described as well as their key features of randomization, control groups, blinding, and intention-to-treat analysis. Cluster randomized trials and differences from individual randomized trials are also covered.
Clinical research ethics and regulation
This document discusses several topics related to clinical research ethics and regulation, including ethical principles, privacy and confidentiality, research data management, research ethics, research misconduct, publication ethics, and informed consent. The four main ethical principles discussed are beneficence, nonmaleficence, autonomy, and justice. The document also covers topics such as anonymization, conflicts of interest, the Committee on Publication Ethics, and regulations around informed consent.
Instrument development and psychometric validation 030222
This document discusses instrument development and validation. It covers questionnaire design, including response formats and standardizing questions. It also discusses establishing validity through content validity, including item-content validity index and scale-content validity index. Other topics covered include reliability, criterion validity, construct validity, and factorial validity. The document also discusses screening questionnaires, sensitivity and specificity, receiver operating characteristic curves, and how they are used to optimize diagnostic accuracy when developing screening tools.
The research process steps
The document outlines the key steps in the research process, including developing the research project, reviewing literature, creating a research proposal, conducting a pilot study, and project management. It discusses developing a research question and aims, reviewing background literature and gaps, designing methodology, and plans for analysis, reporting, and writing up results. Methods of searching literature systematically using databases and evaluating sources are also covered. The importance of a pilot study and a clear timetable for the research proposal and project are emphasized.
Effective online teaching
The document discusses effective online teaching. It begins by defining online learning as courses offered over the internet that are 100% virtual, excluding MOOCs. It states online learning should be innovative, granular, varied, interactive, and interesting. Blended learning combines online and in-person elements. The document outlines synchronous learning, which occurs in real-time, and asynchronous learning, which is flexible and self-paced. It provides strategies for asynchronous learning and notes online teaching requires front-loading work and new skills from instructors.
Global health & nursing
Global nursing aims to promote sustainable planetary health and equity for all people through an evidence-based nursing process. It considers social determinants of health and includes individual, population-level care, research, education, leadership, advocacy and policy initiatives. Global nurses engage ethically and respect human dignity, rights and diversity, partnering with communities and other providers.
Effective online teaching
Looks at online teaching generally and more specifically at asynchronous delivery of online programmes and modules
Open access, predatory journals and open science
Explains open access and other aspects of open science and the rise of predatory publishers and how to avoid them.
Better writing techniques
Inexperienced writers often struggle with presenting simple concepts clearly. They tend to use sentences that are too long with too many ideas, poor grammar, and sentence structure. As a result, the point is lost by the time the reader reaches the end of the sentence. They also make mistakes using single sentence paragraphs. Effective writing requires using shorter, clearer sentences and varying paragraph length.
Organising a manuscript
This document provides guidance on organizing a manuscript for publication. It discusses key elements like the title, abstract, introduction, methods, results, discussion and conclusion sections. For the title, it recommends being short and clearly related to the topic. The abstract should be structured with aims, background, design, methods, results and conclusions. It also discusses writing clear research questions or hypotheses in the introduction. The methods section should describe the design, sample, data collection and analysis. The results section states the findings without discussion. The discussion section interprets the results in relation to the research questions and implications. The conclusion briefly summarizes the key points and implications.
The four rules of writing
This document provides guidance on writing for publication. It discusses common motivations for writing such as career progression or sharing research findings. It emphasizes that the main barriers to writing are a lack of reading and writing. To overcome these barriers, the document recommends reading widely from various genres and writing regularly and frequently. It also suggests setting word count targets, seeking feedback, and treating rejections as opportunities to improve for future submissions. The overall message is that regular writing and revising are essential skills for any writer.
The publishing process
The document discusses the publishing process for the journal Nurse Education in Practice. It provides information about the journal's international editorial board, publication frequency, and impact factor. It outlines what types of papers are most likely to contribute to the journal's impact factor, such as review papers, methodological papers, and original research. The document also discusses the aims and scope of the journal, the double-blind peer review process, guidelines for enhancing quality and transparency in health research, authorship standards, and reasons for article retraction such as plagiarism or duplicate publication.
Tweeting and blogging
This document discusses effective use of social media, particularly Twitter and blogging. It provides tips for using Twitter productively, such as including links, pictures, hashtags, and retweeting interesting material while avoiding trivia and offensive posts. Regarding blogging, it defines blogs and differentiates them from websites and pages. It also describes common blog post types and who typically blogs. Habits of effective bloggers are outlined as well, such as being prolific, concise, analytical, and lifelong learners who plan ahead. The document stresses developing a strategy for social media and promoting work professionally and responsibly.
Writing for different purposes
The document discusses different types of writing such as academic, scientific, journalistic, and literary. It provides tips for clear writing such as using simple words and active verbs. George Orwell's five rules for effective writing are presented which include using short words, cutting unnecessary words, using the active voice, and avoiding foreign phrases.
Philosophy in nursing: what have the Romans ever done for us?
About the place of philosophy in nursing - a non-philosophical point of view - delivered at Worcester University Nursing Philosophy Conference 2017
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Research into mealtimes and older people with dementia.pptx
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Ageing, the Elderly, Gerontology and Public Health
Challenges associated with ageing from a public health perspective
Nutritional deficiency disorder in Child
Nutritional deficiency Disorder are problems in india.
It is very important to learn about Indian child's nutritional parameters as well the Disease related to alteration in their Nutrition.
Gene Expression System-viral gene delivery Mpharm(Pharamaceutics)
Gene therapy can be broadly defined as the transfer of genetic material to cure a disease or at least to improve the clinical status of a patient.
One of the basic concepts of gene therapy is to transform viruses into genetic shuttles, which will deliver the gene of interest into the target cells.
Safe methods have been devised to do this, using several viral and non-viral vectors.
In the future, this technique may allow doctors to treat a disorder by inserting a gene into a patient's cells instead of using drugs or surgery.
The biggest hurdle faced by medical research in gene therapy is the availability of effective gene-carrying vectors that meet all of the following criteria:
Protection of transgene or genetic cargo from degradative action of systemic and endonucleases,
Delivery of genetic material to the target site, i.e., either cell cytoplasm or nucleus,
Low potential of triggering unwanted immune responses or genotoxicity,
Economical and feasible availability for patients .
Viruses are naturally evolved vehicles that efficiently transfer their genes into host cells.
Choice of viral vector is dependent on gene transfer efficiency, capacity to carry foreign genes, toxicity, stability, immune responses towards viral antigens and potential viral recombination.
There are a wide variety of vectors used to deliver DNA or oligo nucleotides into mammalian cells, either in vitro or in vivo.
The most common vector system based on retroviruses, adenoviruses, herpes simplex viruses, adeno associated viruses.
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
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Storyboard on Skin- Innovative Learning (M-pharm) 2nd sem. (Cosmetics)
Skin is the largest organ of the human body, serving crucial functions that include protection, sensation, regulation, and synthesis. Structurally, it consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous layer).
1. **Epidermis**: The outermost layer primarily composed of epithelial cells called keratinocytes. It provides a protective barrier against environmental factors, pathogens, and UV radiation.
2. **Dermis**: Located beneath the epidermis, the dermis contains connective tissue, blood vessels, hair follicles, and sweat glands. It plays a vital role in supporting and nourishing the epidermis, regulating body temperature, and housing sensory receptors for touch, pressure, temperature, and pain.
3. **Hypodermis**: Also known as the subcutaneous layer, it consists of fat and connective tissue that anchors the skin to underlying structures like muscles and bones. It provides insulation, cushioning, and energy storage.
Skin performs essential functions such as regulating body temperature through sweat production and blood flow control, synthesizing vitamin D when exposed to sunlight, and serving as a sensory interface with the external environment.
Maintaining skin health is crucial for overall well-being, involving proper hygiene, hydration, protection from sun exposure, and avoiding harmful substances. Skin conditions and diseases range from minor irritations to chronic disorders, emphasizing the importance of regular care and medical attention when needed.
Pharmacology of Drugs for Congestive Heart Failure
Congestive Heart failure is caused by low cardiac output and high sympathetic discharge. Diuretics reduce preload, ACE inhibitors lower afterload, beta blockers reduce sympathetic activity, and digitalis has inotropic effects. Newer medications target vasodilation and myosin activation to improve heart efficiency while lowering energy requirements. Combination therapy, following an assessment of cardiac function and volume status, is the most effective strategy to heart failure care.
PGx Analysis in VarSeq: A User’s Perspective
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
Selective α1-Blocker.pptx
Selective alpha1 blockers are Prazosin, Terazosin, Doxazosin, Tamsulosin and Silodosin majorly used to treat BPH, also hypertension, PTSD, Raynaud's phenomenon, CHF
2nd-generation Antihistaminic Part I.pptx
CLASSIFICATION OF H1 ANTIHISTAMINICS-
FIRST GENERATION ANTIHISTAMINICS-
1)HIGHLY SEDATIVE-DIPHENHYDRAMINE,DIMENHYDRINATE,PROMETHAZINE,HYDROXYZINE 2)MODERATELY SEDATIVE- PHENARIMINE,CYPROHEPTADINE, MECLIZINE,CINNARIZINE
3)MILD SEDATIVE-CHLORPHENIRAMINE,DEXCHLORPHENIRAMINE
TRIPROLIDINE,CLEMASTINE
SECOND GENERATION ANTIHISTAMINICS-FEXOFENADINE,
LORATADINE,DESLORATADINE,CETIRIZINE,LEVOCETIRIZINE,
AZELASTINE,MIZOLASTINE,EBASTINE,RUPATADINE. Mechanism of action of 2nd generation antihistaminics-
These drugs competitively antagonize actions of
histamine at the H1 receptors.
Pharmacological actions-
Antagonism of histamine-The H1 antagonists effectively block histamine induced bronchoconstriction, contraction of intestinal and other smooth muscle and triple response especially wheal, flare and itch. Constriction of larger blood vessel by histamine is also antagonized.
2) Antiallergic actions-Many manifestations of immediate hypersensitivity (type I reactions)are suppressed. Urticaria, itching and angioedema are well controlled.3) CNS action-The older antihistamines produce variable degree of CNS depression.But in case of 2nd gen antihistaminics there is less CNS depressant property as these cross BBB to significantly lesser extent.
4) Anticholinergic action- many H1 blockers
in addition antagonize muscarinic actions of ACh. BUT IN 2ND gen histaminics there is Higher H1 selectivitiy : no anticholinergic side effects
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdf
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga
GASTROINTESTINAL INFECTIONS AND GASTRITIS
Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort. Call Girls Electronic City 🥰 Bangalore Call Girl No Advance Book Now
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biomechanics of running. Dr.dhwani.pptx
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
Patellar Instability: Diagnosis Management
Pictorial and detailed description of patellar instability with sign and symptoms and how to diagnose , what investigations you should go with and how to approach with treatment options . I have presented this slide in my 2nd year junior residency in orthopedics at LLRM medical college Meerut and got good reviews for it
After getting it read you will definitely understand the topic.
RESPIRATORY DISEASES by bhavya kelavadiya
The Children are very vulnerable to get affected with respiratory disease.
In our country, the respiratory Disease conditions are consider as major cause for mortality and Morbidity in Child.
Giloy in Ayurveda - Classical Categorization and Synonyms
Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
Storyboard on Acne-Innovative Learning-M. pharm. (2nd sem.) Cosmetics
Acne is a common skin condition that occurs when hair follicles become clogged with oil and dead skin cells. It typically manifests as pimples, blackheads, or whiteheads, often on the face, chest, shoulders, or back. Acne can range from mild to severe and may cause emotional distress and scarring in some cases.
**Causes:**
1. **Excess Oil Production:** Hormonal changes during adolescence or certain times in adulthood can increase sebum (oil) production, leading to clogged pores.
2. **Clogged Pores:** When dead skin cells and oil block hair follicles, bacteria (usually Propionibacterium acnes) can thrive, causing inflammation and acne lesions.
3. **Hormonal Factors:** Fluctuations in hormone levels, such as during puberty, menstrual cycles, pregnancy, or certain medical conditions, can contribute to acne.
4. **Genetics:** A family history of acne can increase the likelihood of developing the condition.
**Types of Acne:**
- **Whiteheads:** Closed plugged pores.
- **Blackheads:** Open plugged pores with a dark surface.
- **Papules:** Small red, tender bumps.
- **Pustules:** Pimples with pus at their tips.
- **Nodules:** Large, solid, painful lumps beneath the surface.
- **Cysts:** Painful, pus-filled lumps beneath the surface that can cause scarring.
**Treatment:**
Treatment depends on the severity and type of acne but may include:
- **Topical Treatments:** Such as benzoyl peroxide, salicylic acid, or retinoids to reduce bacteria and unclog pores.
- **Oral Medications:** Antibiotics or oral contraceptives for hormonal acne.
- **Procedures:** Such as chemical peels, extraction of comedones, or light therapy for more severe cases.
**Prevention and Management:**
- **Cleanse:** Regularly wash skin with a gentle cleanser.
- **Moisturize:** Use non-comedogenic moisturizers to keep skin hydrated without clogging pores.
- **Avoid Irritants:** Such as harsh cosmetics or excessive scrubbing.
- **Sun Protection:** Use sunscreen to prevent exacerbation of acne scars and inflammation.
Acne treatment can take time, and consistency in skincare routines and treatments is crucial. Consulting a dermatologist can help tailor a treatment plan that suits individual needs and reduces the risk of scarring or long-term skin damage.
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STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7
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Storyboard on Skin- Innovative Learning (M-pharm) 2nd sem. (Cosmetics)
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Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)
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Giloy in Ayurveda - Classical Categorization and Synonyms
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Best practice in text re-cycling
- 1. Roger Watson PhD FRCN FAAN Editor-in-Chief, JAN Editor, Nursing Open @jadvnursing
- 2. 2 Why do we need publication ethics? Publication ethics Ethical standards for publication exist to ensure high-quality scientific publications, public trust in scientific findings, and that people receive credit for their ideas. BiomedCentral - BMC “Ethical behavior is doing the right thing when no one else is watching.“ Partial quote from Aldo Leopold (1887-1948)
- 3. 3 Why do ethical issues arise? Journals exist to enhance the scientific database …and enhance seniority and income …and pharmaceutical company profits …and publishers’ profits (Courtesy of Harvey Marcovitch, COPE)
- 5. 5 Specific ethical issues in publication • Plagiarism • Duplication • Falsification • Fabrication • Authorship • Conflicts of interest
- 6. 6 Specific ethical issues in publication • Plagiarism • Duplication • Falsification • Fabrication • Authorship • Conflicts of interest
- 7. Preventing Plagiarism in Published Works
- 8. 8 Plagiarism • the unreferenced use of others’ published and unpublished ideas • submission under “new” authorship of a complete paper, sometimes in a different language
- 9. 9 Duplication • Not republishing the same findings • Not submitting the same manuscript to two or more journals at once • Not dividing one research project into many little papers (“salami slicing”)
- 10. 10 Bad practice in text re-cycling • Publishing the same study twice • Arbitrarily dividing studies to achieve more publications • Publishing multiple outcomes from RCTs • ‘Fishing’ for results in large data sets
- 11. 11 Best practice in text re-cycling • Plan your publications from projects at the start of the project • Try to publish ‘substantial’ aspects of a study • Always refer to other articles from the same study • If in doubt consult an editor in advance • If you are accused of duplication, then offer comprehensive explanations
- 12. 12 Acceptable text re-cycling • Methods sections (COPE encourage leniency) • Translations – provided permission is sought at ‘both ends’ • Different ‘levels’ of publication eg academic and clinical – provided permission is sought • PhD theses and Masters dissertations • Major reports from large projects