This document summarizes the keynote speech on internationalization of higher education in Africa given by Akilagpa Sawyerr at the 2006 International Conference of the International Association of Universities. The speech addresses: 1) The historical context of internationalization in higher education globally and in Africa. 2) Contemporary challenges for internationalization in African higher education systems including asymmetric power relations between the global North and South, and a tendency to treat Africa as an export market for foreign higher education. 3) Initiatives by African countries and institutions to participate internationally, but reliance on Northern financial support resulting in predominantly North-South relationships rather than South-South.