The document discusses retrosynthetic analysis approaches for synthesizing 1-phenylhexanol. It presents 6 different retrosynthetic disconnections and proposed syntheses, considering factors like availability of reagents and minimizing synthetic steps. The best synthesis is the one that uses readily available reagents and fewest steps, while breaking carbon-carbon bonds in the center of the molecule.

1. RETROSYNTHETIC APPROCH TO ORGANIC SYNTHESIS Dr. Shaikh S. Nizami Department of Chemistry University of Karachi

2. BASIC CONCEPTS (Part 2)

3. CONTENTS Examples of Retrosynthetic analysis of: 1-Phenylhexanol (TM 1.1)

4. RETROSYNTHETIC ANALYSIS 1-PHENYLHEXANOL (TM 1.1)

5. 1 st RETROSYNTHETIC ANALYSIS 1-PHENYLHEXANOL

6. SYNTHESIS

7. 2 nd RETROSYNTHETIC ANALYSIS 1-PHENYLHEXANOL

8. SYNTHESIS

9. 3 rd RETROSYNTHETIC ANALYSIS 1-PHENYLHEXANOL

10. SYNTHESIS

11. 4 th RETROSYNTHETIC ANALYSI 1-PHENYLHEXANOL

12. SYNTHESIS

13. 5 th RETROSYNTHETIC ANALYSIS 1-PHENYLHEXANOL

14. SYNTHESIS

15. 6 th RETROSYNTHETIC ANALYSIS 1-PHENYLHEXANOL

16. SYNTHESIS

17. What is the best synthesis ? Availability of the reagent Synthetic step should be kept minimum unless there is an advantage of FGI Disconnection of C-C bond should be in the center of a molecule

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