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A Continuum View of Schizotypy
Dr. Neus Barrantes-Vidal
Universitat Autònoma de Barcelona (Spain)
University of North Carolina at Greensboro (US)
Sant Pere Claver – Fundació Sanitària (Spain)
CIBERSAM – Investigación Salud Mental en Red (Spain)
Dimensional Model of Schizotypy
Genetic variation x Environm. & Epigenetic? Factors
Nervous system type
Temperamental dispositions (Continuously inherited)
Individual
Differences Vulnerability to certain disorders
Adapted from Claridge (1985, 1997)
Schizotypy
Endophenotypes
Cognitive style / Personality traits
Personality
disorders
Psychosis
Psychosis
Spectrum
G x E
Clarifications about the Dimensional Model
Kelleher & Cannon (2011); Binbay et al. (2012); van Os (2009 & 2014); Zanvos et al. 2014; Barrantes-Vidal, Grant &
Kwapil (2015)
 Shared sociodemographic and etiological risk factors
 Familial clustering
Phenotypic continuity is not isomorphic with etiological continuity, but…
 Differences in the effect size of some risk factors across the
continuum?? Continuum-threshold model?
S c h i z o t y p y
At risk syndromes
Schizotypal PD
Schizophrenia
Schizophreniform
Psychotic Experiences
Error measurement or
transdiagnostic
perspective?
Is this Relevant?
 Healthy expression and advantageous features at the non-disordered low
end of the quantitative dimension of schizotypy (NOT “bening”
schizophrenia?!?), such as creativity (Mohr & Claridge, 2015; Power et al.,
2015)
 Important to map both the positive as well as deleterious manifestations to
understand schizotypy and psychosis and to promote health and preventive
strategies in those with increasing risk (Barrantes-Vidal, 2014)

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Barrantes Vidal Schizotypy Webinar SRF

  • 1. A Continuum View of Schizotypy Dr. Neus Barrantes-Vidal Universitat Autònoma de Barcelona (Spain) University of North Carolina at Greensboro (US) Sant Pere Claver – Fundació Sanitària (Spain) CIBERSAM – Investigación Salud Mental en Red (Spain)
  • 2. Dimensional Model of Schizotypy Genetic variation x Environm. & Epigenetic? Factors Nervous system type Temperamental dispositions (Continuously inherited) Individual Differences Vulnerability to certain disorders Adapted from Claridge (1985, 1997) Schizotypy Endophenotypes Cognitive style / Personality traits Personality disorders Psychosis Psychosis Spectrum G x E
  • 3. Clarifications about the Dimensional Model Kelleher & Cannon (2011); Binbay et al. (2012); van Os (2009 & 2014); Zanvos et al. 2014; Barrantes-Vidal, Grant & Kwapil (2015)  Shared sociodemographic and etiological risk factors  Familial clustering Phenotypic continuity is not isomorphic with etiological continuity, but…  Differences in the effect size of some risk factors across the continuum?? Continuum-threshold model? S c h i z o t y p y At risk syndromes Schizotypal PD Schizophrenia Schizophreniform Psychotic Experiences Error measurement or transdiagnostic perspective?
  • 4. Is this Relevant?  Healthy expression and advantageous features at the non-disordered low end of the quantitative dimension of schizotypy (NOT “bening” schizophrenia?!?), such as creativity (Mohr & Claridge, 2015; Power et al., 2015)  Important to map both the positive as well as deleterious manifestations to understand schizotypy and psychosis and to promote health and preventive strategies in those with increasing risk (Barrantes-Vidal, 2014)