This case study examines the Ayurvedic management of depression in a 27-year-old female patient presenting with symptoms for 2 years. The patient was treated with a combination of Panchakarma therapies including Shirodhara and Nasya along with oral medications like Saraswatharishta and Brahmi vati. Yoga practices like pranayama and meditation were also included. Assessment scales before and after treatment showed improvements in symptoms, appetite, sleep, mood, and weight. The Hamilton Depression Rating Scale score decreased from 21 to 10, and the Insomnia Severity Index score decreased from 16 to 5, indicating reduced clinically significant insomnia. The combined Ayurvedic treatment approach was found to effectively manage