This topic comes under PRODUCT DEVELOPMENT AND TECHNOLOGY TRANSFER...... This is useful for M.Pharm (Pharmaceutical Quality Assurance) Students who studying in First year sem II and also for b.pharm and medical related students. This Presentation Contain following... #Introduction #Objectives #Process Flow #Working of aseptic process #Sterilization of Equipments #Sterilization of Product #Sterilization of container or packaging materials #Aseptic packaging of Milk #Packaging materials #Aseptic packaging systems #Benefits of aseptic packaging systems #Storage #References

1. Mr. Pritam P. Kolge
M. Pharm (QA)
Bharati Vidyapeeth College of Pharmacy Kolhapur

2. Introduction
 Aseptic packaging is the filling of sterile containers
with a commercially sterile product under aseptic
conditions, and then sealing them so that re-infection
is prevented; that is, so that they are hermetically
sealed.
 Sources of contamination: microorganism may be in
the product, on the surface of packaging material or
the part coming in contact with the product.

3. objectives
 To sterile the product that provide the higher quality
product
 To take advantage of high temperature short
time(HTST)
 To extend the shelf life of products at normal
temperature by packaging them aseptically

4. Process Flow

5. Working of aseptic process
sterilization of equipment
sterilization of food/drugs
sterilization of container
Filling and closure of presterilized product into
sterilized container under aseptic conditions
Maintenance of sterility

6. Sterilization of Equipments
Radiation
• UV-C radiation
• Infrared radiation
• Ionizing radiation
Heat
• Saturated steam
• Superheated steam
• Hot air
• Hot air and steam
Chemical
• Hydrogen peroxide
• Ethanol
• Ethylene oxide
• Paraceticacid

7. Sterilization of Product
• 63◦C/30 min
• 72◦C/15 sec
HTST
• 130◦C – 150◦C/ fractions of sec
UHT

8. Sterilization of container or packaging
materials
Thermal treatment
Irradiation
chemical treatment

9. Aseptic packaging of Milk

10. Packaging materials
Packaging materials:
paper and paper based products
Glass
Tin plate
Aluminums foil
Plastics

11. Aseptic packaging systems
 Bottle system
 Sachet and pouch systems
 Cup systems

12. Bottle System

13. Sachet And Pouch System

14. Cup System

15. Benefits of aseptic packaging systems
 Keeps the product for several months
 Conserve the nutritive value of foods
 Less space requirement
 Cheaper packaging cost
 Permits storage and handling without refrigeration
 Eliminates the use of preservatives

16. Storage
❖ To maintain at a low temperature so as to prevent any
deterioration in quality prior to processing/product
manufacturing
❖ To facilitate bulking of the raw materials supply,
which will ensure uniform composition
❖ To allow for uninterrupted operation during
processing

17. References
 www.sciencedirect.com
 www.google.co.in

18. Thank You