This document discusses antiprotozoal agents used to treat various protozoal infections including malaria. It focuses on the life cycle and types of malaria parasites, describing the asexual and sexual cycles that occur in humans and mosquitos. The major classes of antimalarial drugs are discussed in depth, including quinoline derivatives like chloroquine, aminoquinolines like primaquine, aryl amino alcohols like mefloquine, hydroxynapthoquinone derivatives like atovaquone, folate antagonists, and antibiotics. Combination therapies are emphasized as a way to reduce resistance.
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At the end of this e-learning session you are able to…
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Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
A review of the growth of the Israel Genealogy Research Association Database Collection for the last 12 months. Our collection is now passed the 3 million mark and still growing. See which archives have contributed the most. See the different types of records we have, and which years have had records added. You can also see what we have for the future.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Introduction to AI for Nonprofits with Tapp NetworkTechSoup
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
Normal Labour/ Stages of Labour/ Mechanism of LabourWasim Ak
Normal labor is also termed spontaneous labor, defined as the natural physiological process through which the fetus, placenta, and membranes are expelled from the uterus through the birth canal at term (37 to 42 weeks
2. Protozoal Infections
Parasitic protozoa: live in or on humans
• Malaria
• Leishmaniasis
• Amebiasis
• Giardiasis
• Trichomoniasis
• Pneumocystis
• African trypanosomiasis (sleeping disease)
Transmission
Person to person
Ingestion of contaminated water or food
Direct contact with the parasite
Insect bite (mosquito)
2
Medchem, Alemu T.
3. Malaria
• Malaria is a mosquito-borne infectious disease of humans and other animals
caused by parasitic protozoans (a group of single-celled microorganism) belonging
to the genus Plasmodium
• Transmitted by the infected female anopheles mosquito
• The protozoan organisms causing malaria are the genus plasmodium
• Only four of approximately 100 spps cause malaria in humans. The remaining
affect birds, monkeys, livestock, rodents and repitiles
• The four spps that affect human are P. falciparum, P. vivax, P. malariae, and P.
ovale
• Malaria is present all over the tropics and is now extended to more than 40% of
the world’s population
3
Medchem, Alemu T.
4. Malarial Parasite
Two interdependent life cycles
• Sexual cycle: occurs in the mosquito
• Asexual cycle: occurs in the human
– Knowledge of the life cycles is essential in
understanding antimalarial drug treatment
– Drugs are effective only during the asexual cycle
4
Medchem, Alemu T.
5. Plasmodium Life Cycle
Asexual cycle: two phases
• Exoerythrocytic phase
– Occurs “outside” the erythrocyte
– Also known as the tissue phase
• Erythrocytic phase
– Occurs “inside” the erythrocyte
– Also known as the blood phase
Erythrocytes = RBCs
5
Medchem, Alemu T.
7. Life cycle of malarial parasites
– Bite of an infected female Anopheles mosquito carrying
malaria-causing parasites called sporozoites and injects
them in to human skin dermis.
– After inoculation, the sporozoites travel to the liver and
invade liver cells with some getting in to lymph nodes
through lymph vessel.
– the sporozoites grow, divide, and produce tens of
thousands of haploid forms, called merozoites; per liver
cell. Then the merozoites rupture the liver cells and re-
enter the bloodstream.
7
Medchem, Alemu T.
8. - Beginning a cycle of invasion of red blood cells, asexual
replication, and release of newly formed merozoites from the
red blood cells repeatedly over 1-3 days.
- Some of the merozoite-infected blood cells leave the asexual
cycle and instead develop into sexual forms of the parasite,
called male and female gametocytes that circulate in the
bloodstream.
- When a mosquito bites an infected human, it ingests the
gametocytes. 8
Medchem, Alemu T.
9. - In the mosquito gut; the gametocytes, which develop further into
mature sex cells called gametes (Male and female) fuse to form
diploid zygotes.
- which develop into actively moving ookinetes that burrow into the
mosquito midgut wall and form oocysts. Each oocyst grows,
produces thousands of active haploid forms called sporozoites.
- The cycle of human infection re-starts when the mosquito takes a
blood meal, injecting the sporozoites from its salivary glands into the
human bloodstream
- Some of the released merozoites are sequestered in vital organs
(brain, and heart) where they continue to grow.
9
Medchem, Alemu T.
10. Types of malaria
Plasmodium falciparum
• This spps is estimated to cause approxmately 50% of all
malaria
• P. falciparum malaria is the most serious and most lethal
form of the disease
• It is responsible for 90% of the deaths from malaria
• The parasitemia achieved can be quite high and will be
associated with an increased incidence of serious
complications
• P. falciparum leaves the patient so weak because it infects
up to 65% of the patients erythrocytes
• It has an incubation period (time from mosquito bite to
clinical symptoms) of 1-3 weeks (average of 12days)
10
Medchem, Alemu T.
11. • The symptoms of P. falciparum malaria are periodic acute attacks
of chills and fever, profuse sweating, enlarged spleen and liver,
vomiting, anemia, abdominal pain, headaches, and lethargy
Plasmodium vivax
• It is the second most common spps accounting for about 40% of
all malaria cases. It can be very chronic, because it can reinfect
liver cells
• It has an incubation period of 1-4 weeks (average of 2 weeks)
• Can cause spleen rupture and anemia
• It is the most prevalent type of infection and is characterized by
periodic acute attacks of chills and fever, profuse sweating,
enlarged spleen and liver, anemia, vomiting abdominal pain,
headaches, and lethargy
NB:-If P. vivax malaria is not treated, the symptoms may subside for
several weeks or months and then recur
11
Medchem, Alemu T.
12. Plasmodium malariae
• It accounts for 9.8% of all malaria cases
• It has an incubation period of 2-4 weeks (average of 3
weeks)
• The asexual cycle occurs every 72 hours
• Mildest form of malaria and non-relapsing
• Unlikely to be resistant
Plasmodium Ovale
• This is the least common type of Plasmodium
• Has an incubation period of 9-18 days (14 days
average)
• Relapse has been known to occur.
12
Medchem, Alemu T.
14. Antimalarials
The main classes of active antimalarials are:-
A. Quinoline derivatives
➢ 8-Aminoquinolines, ex. Primaquine
➢ 4-Aminoquinolines, ex. Chloroquine
➢ Aryl amino alcohols, ex. Quinine, Mefloquine
B. Hydroxynaphtoquinone derivative
C. Folate antagonists
D. Antibiotics/Antimicrobials
E. Newer Agents
➢Artemisinin derivatives (peroxides)
14
Medchem, Alemu T.
15. • The amino quinoline nucleus is very important for binding
• Substitution on the C3 position of the ring produces inactive compound
• Alkyl amino/diamino group at C4 or C8 position is very important
• Optimum activity if side chain = 2-6 carbons, if more or less activity will
decrease
• Terminal amino group may be 10, 20 or 30 for 4- amino quinolines, 30 for others
• C6-OMe, C6-OEt, C6 halogens are not essential for activity and may produce
toxicity
• Substitution of C7 with halogen increases activity but other groups decrease
activity
• Methylation at position C8 position decrease activity
Medchem, Alemu T. 15
N
R4
R6
R7 1
2
R8
Quinoline
16. Antimalarials (quinolines)
8-Aminoquinolines
▪ This is the only class of gametocytocides
▪ Pamaquine (prevent relapses) was first introduced for
treatment of malaria in 1926 and since has been
replaced with primaquine
N
H3CO
HN
N
CH3
H3C
CH3
Pamaquine 16
Medchem, Alemu T.
17. Antimalarials (quinolines)
▪ Primaquine is the only 8-aminoquinoline in clinical use
▪ Primaquine is the only agent that can lead to radical cures
of the relapsing forms of P. vivax and P. oval
▪ However, primaquine was recently reconsidered for
malaria chemoprophylaxis to eliminate P. falciparum at
the early stage of infection, when parasite develops in the
liver, thus preventing the clinical disease
▪ Despite its good oral absorption, this molecule has a short
half-life and needs to be administered daily.
▪ Primaquine is the least toxic and most effective of the 8-
aminoquinoline antimalarial compounds
17
Medchem, Alemu T.
18. Antimalarials (quinolines)
• Tafenoquine is a primaquine analog with a longer elimination
half-life (14 days compared to 4 hours for primaquine)
• It has also a larger therapeutic index than primaquine. This
molecule may be useful for chemoprophylaxis of P.
falciparum and for prevention of relapses of vivax malaria
18
Medchem, Alemu T.
19. Antimalarials (quinolines)
4-Aminoquinolines
• The main antimalarials are the 4-aminoquinolines
because they have proven to be the most highly
successful class of compounds for the treatment and
prophylaxis of malaria
• They are easily synthesized, cheap, and generally well
tolerated
• These compounds, as well as the quinoline-alcohols, are
active against the intra-erythrocytic stages of the
parasite
19
Medchem, Alemu T.
20. Antimalarials (quinolines)
• The 4-aminoquinolines are able to accumulate to high
concentrations within the acid food vacuole of
Plasmodium, to kill the parasite
Chloroquine (CQ)
• Was introduced in 1944 –1945 and soon became the
mainstay of therapy and prevention, since this drug was
cheap, non-toxic, and active against all strains of malaria
parasites
• In 1994, CQ was the third most widely consumed drug in
the world after aspirin and paracetamol
• CQ is not active against the pre-erythrocytic plasmodium
and does not cause radical cure 20
Medchem, Alemu T.
21. Antimalarials (quinolines)
• Chloroquine has activity against the blood stages of
Plasmodium ovale, P. malariae, and susceptible strains of
P. vivax and P. falciparum.
• Widespread resistance in most malaria-endemic
countries has led to decline in its use for the treatment
of P. falciparum, although it remains effective for
treatment of P. ovale, P. malariae, and, in most regions, P.
vivax.
• Used to treat nonfalciparum and sensitive falciparum
malaria.
• Primaquine must be added for the radical cure of P vivax
and P ovale, because chloroquine does not eliminate
dormant liver forms of these species. 21
22. Antimalarials (quinolines)
• Rapidly and almost completely absorbed from
the gastrointestinal tract.
• Very large apparent volume of distribution of
100-1000 L/kg
22
Chloroquine
Amodiaquine
Medchem, Alemu T.
taken off the market
Hydroxychloroquine
23. Antimalarials (quinolines)
Pyronaridine
• Is a synthetic drug widely used in China that may have
utility for multiresistant falciparum malaria
• It seems likely that drug resistance would emerge
rapidly if pyronaridine is used as monotherapy
23
Medchem, Alemu T.
24. Antimalarials (quinolines)
Aryl amino alcohols
Halofantrine
• Is effective against chloroquine-resistant malaria
• Despite this, cardiotoxicity has limited its use as a therapeutic
agent.
Lumefantrine
• is an antimalarial drug that is only used in combination with
artemether (Coartem)
24
Medchem, Alemu T.
25. Mefloquine:-Is structurally related to quinine, and its long
half-life (14 –21 days) has probably contributed to the
rapid development of resistance
• For this reason, mefloquine should be used in
combination with other antimalarial agents
• Clinical Uses:- Chemoprophylaxis, mainly for
chloroquine-resistant falciparum malaria.
25
N
CF3
CF3
H
C
HN
HO
Medchem, Alemu T.
26. Antimalarials (quinolines)
Cinchona alkaloids
Quinine
• The active ingredient of cinchona bark, had the longest period of
effective use, but there is now a decrease of the clinical response of
P. falciparum in some areas
• Quinine and quinidine remain first-line therapies for falciparum
malaria, especially severe disease.
• Reserved for severe infestations and for malarial strains that are
resistant to other agents, such as chloroquine
• Highly effective blood schizonticide against the four species of
human malaria paresites.
• Clinical Uses: mainly for chloroquine-resistant falciparum malaria,
especially for cerebral malaria.
26
Medchem, Alemu T.
27. Antimalarials (quinolines)
• The addition of a single dose of artemisinin enhances
the parasite elimination rate and thus increases the cure
rate
• Quinine interacts weakly with heme, but has been
shown to inhibit heme polymerization in vitro
• Association of quinine and clindamycine significantly
shorten the duration of treatment with respect to
quinine used alone
27
Quinine
28. Antimalarials (quinolines)
• Quinidine is a pharmaceutical agent that acts as a class I
antiarrhythmic agent (Ia) in the heart. It is a stereoisomer
of quinine, originally derived from the bark of the
cinchona tree
• Quinidine is the more cardiotoxic than quinine
• Cardiac monitoring including serial blood pressure
measurements should always be in place when quinidine
is administered, to monitor for prolongation of the QT
interval and ventricular tachycardia.
28
Quinidine
Medchem, Alemu T.
30. Folate antagonists/Antifolates
• Antifolates include guanidine analogues (proguanil
hydrochloride, cycloguanil,chloroproguanil), pyrimidine
analogues (pyrimethamine and trimethoprim) and
sulfones (sulfonamides and dapsone).
• These drugs act synergistically to target enzymes
involved in folate synthesis, a pathway required for
parasite DNA synthesis.
▪ There are two groups of antifolates:-
✓The dihydrofolate reductase (DHFR) inhibitors like
pyrimethamine and proguanil
✓The dihydropteroate synthase (DHPS) inhibitors that
are sulfones and sulphonamides like sulfadoxine and
dapsone, respectively 30
Medchem, Alemu T.
32. • Due to a marked synergistic effect, a drug of the first group is
usually used in combination with a drug of the second one
• Pyrimethamine – Sulfadoxine (SP) is the most widely used
combination
• SP is also particularly prone to rapid emergence of resistance
• The development of the combination of proguanil and atovaquone
(Malarone) also provide another useful way for the treatment
• Doxycycline is commonly used in the treatment of falciparum
malaria in conjunction with quinidine or quinine, allowing a shorter
and better-tolerated course of quinine.
32
Medchem, Alemu T.
33. • Current practice in threatening cases of malaria
is based on the concept f combination therapy,
since this offers several advantages
✓reduced risk of treatment failure
✓reduced risk of developing resistance
✓enhanced convenience and
✓reduced side effects
33
Medchem, Alemu T.
35. Antibiotics/Antimicrobials
• Tetracycline, doxycycline and clindamycin target prokaryotic
protein synthesis
• In malaria parasites, these drugs appear to target the apicoplast,
an organelle derived from prokaryotic ancestors
• They have relatively slow antimalarial activity because they exert
their toxic effects in the subsequent cycle of cell division
• They are typically paired with fast-acting antimalarials (usually
quinine)
• Doxycycline has a longer half life than tetracycline so is used more
commonly
• Resistance has not been detected to tetracycline, doxycycline or
clindamycin
• Clindamycin is the preferred alternative in these groups
35
Medchem, Alemu T.
37. Artemisinin derivatives/Sesquiterpene Lactones
(newer agents)
• Artemisinin derivatives are the most potent and rapid acting
blood schizonticides
• Most of artemisinin derivatives are highly active against
plasmodium genera that cause malaria.
• Four compounds have been used, the parent one,
artemisinin, extracted from Artemisia annua and four
derivatives that are actually more active than artemisinin
itself
✓dihydroartemisinin
✓artesunate: a water-soluble hemisuccinate
✓artemether :oil-soluble
✓artemotil (arteether) :oil-soluble 37
Medchem, Alemu T.
38. • All of them are readily metabolized to the
biologically active metabolite, dihydroartemisinin
• Artemisinin is active at nanomolar concentrations
in vitro on both CQ-sensitive or -resistant P.
falciparum strains
• These classes of drugs are also less toxic than
other antimalarial agents.
• Artemisinin and its derivatives appear to be the
best alternative for the treatment of severe
malaria
38
Medchem, Alemu T.
39. • Institute of research has patented a stable,
water-soluble derivative called artelinic acid
that is now being tested in animals.
39
Medchem, Alemu T.
40. • A key advantage of these endoperoxide-containing
antimalarial agents, which have been used for nearly
two decades, is the absence of any drug resistance
• The major drawback of artemisinin derivatives is their
short half-life. When used in monotherapy, a treatment
as long as 5 days is required for complete elimination of
the parasites
• They are then preferentially used in combination with
other antimalarial agents such as sulfadoxine-
pyrimethamine, benflumetol, or mefloquine to increase
cure rates and to shorten the duration of therapy in
order to minimize the emergence of resistant parasites
40
Medchem, Alemu T.
41. Mechanism of action
• These compounds have presence of endoperoxide bridge
• Endoperoxide bridge interacts with heme in parasite
• Heme iron cleaves this endoperoxide bridge
• There is generation of highly reactive free radicals which
damage parasite membrane by covalently binding to
membrane proteins
Medchem, Alemu T. 41
42. Common combinations
• Chloroquine/sulfadoxine-pyrimethamine
• Quinine/ Doxycycline
• Artemether/lumefantrine (Coartem/Banflumetol)
• Atovaquone-proguanil (Malarone)
• Artesunate/amodiaquine (Coarsucam)
• Sulfadoxine-pyrimethamine (Fansidar)
• Artesunate + sulfadoxine-pyrimethamine (Supysunate)
• Artesunate + mefloquine (Artequin)
• Artemether + lumefantrine (Banflumetol) is the most
viable artemisinin combination treatment available at
the moment
42
Medchem, Alemu T.
43. WHO recommends that all countries experiencing
resistance to conventional monotherapies should
use combination therapy, preferably containing
artemisinins [ACTs -artemisinin-based combination
therapies].
WHO recommends the following therapeutic
options:-
1. Artemether/lumefantrine (coartem)
2. Artesunate + amodiaquine
3. Artesunate + SP
4. Artesunate + mefloquine [area with low to
moderate transmission.
5. Amodiaquine+SP
43
Medchem, Alemu T.
44. • The advantages of artemisinin based combination
therapy (ACT) relate to the unique properties and mode
of action of the artemisinin component, which include
the following
✓ rapid substantial reduction of the parasite biomass
✓ rapid resolution of clinical symptoms
✓ effective action against multidrug-resistant P. Falciparum
✓ reduction of gametocyte carriage, which may reduce
transmission of resistant alleles (in areas with low or moderate
malaria transmission)
✓ no parasite resistance documented as yet with the use of
artemisinin and its derivatives
✓ few reported adverse clinical effects, however pre-clinical
toxicology data on artemisinin derivatives are limited.
, Alemu T. 44
45. Amebiasis
• Amebiasis is an infection of the intestines with
a parasite called Entamoeba histolytica (E. histolytica).
• The parasite is an amoeba, a single-celled organism.
• People can get this parasite by eating or drinking something that's
contaminated with it.
• In many cases, the parasite that causes amebiasis lives in a
person's large intestine without causing any symptoms. Other
times, it causes: diarrhea (which may be bloody), stomach pains,
abdominal cramping, loose stool, nausea, loss of appetite and
fever
• In rare cases, it can spread into other organs such as the liver,
lungs, and brain.
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47. Trichomoniasis
• Trichomoniasis is a common sexually transmitted infection caused
by the protozoan Trichomonas vaginalis
• Trichomoniasis signs and symptoms for women include: an often
foul-smelling vaginal discharge, genital redness, burning and
itching, pain with urination or sexual intercourse
• Trichomoniasis rarely causes symptoms in men. When men do
have signs and symptoms, however, they might include: irritation
inside the penis, burning with urination or after ejaculation,
discharge from the penis
• Treatment:- Metronidazole or tinidazole
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N
N CH3
O2N
CH2CH2-SO2-CH2CH3
48. Giardiasis
• Giardia infection is an intestinal infection marked by abdominal
cramps, bloating, nausea and bouts of watery diarrhea. Giardia
infection is caused by a microscopic parasite called Giardia
lamblia that is found worldwide, especially in areas with poor
sanitation and unsafe water.
• G. lamblia are found in animal and human feces. These
parasites also thrive in contaminated food, water, and soil, and
can survive outside a host for long periods of time. Accidentally
consuming these parasites can lead to an infection
• Treatment:-Metronidazole or tinidazole
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49. Pneumocystis
• Pneumocystis jiroveci (previously classified as Pneumocystis
carinii), the organism that causes pneumocystis pneumonia.
• The symptoms of pneumocystis pneumonia (PCP) include
dyspnea (difficulty breathing), nonproductive cough, and fever.
• Pneumocystis carinii can also cause extrapulmonary disease in
immunocompromised patients (AIDS, etc)
Treatment:-Co-trimoxazole (TMP/SMX) is an antibiotic used to treat
a variety of bacterial, fungal, and protozoal infections
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50. Trypanosomiasis (sleeping sickness)
• It is caused by the hemoflagellates Trypanosoma bru-cei
rhodesiense and Trypanosoma brucei gambiense.
• There are two types of trypanosomiasis that affect humans,
they are divided according to their geographical location
• In Africa the largest number of cases is in Congo.
• Fever, severe headaches, irritability, extreme fatigue, swollen
lymph nodes, and aching muscles and joints are
common symptoms of sleeping sickness
Treatment:- Melarsoprol, Eflornithine, benznidazole or nifurtimox
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52. Leishmaniasis
• Leishmaniasis is a disease caused by an intracellular
protozoan parasite (genus Leishmania) transmitted by the
bite of a female phlebotomine sandfly.
• Visceral leishmaniasis (kala azar) is caused mainly by
Leishmania donovani in the Indian subcontinent and East
Africa
• Cutaneous leishmaniasis is caused mainly by Leishmania
tropica, L. major, and L. donovani.
• Treatment:-Sodium stibogluconate, meglumine
antimoniate, amphotericin B, Meltefosine and
paromomycin.
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