Bo Norby Associate Professor Dept. of Large Animal Clinical Sciences College of Veterinary Medicine

1. Bo Norby
Dept. of Large Animal Clinical Sciences
College of Veterinary Medicine
Michigan State University
Antimicrobial Resistance:
An Animal Ag Perspective

2. • More
than
12
colleagues
involved
in
research
of:
– An7bio7c
use
and
use
pa:erns
and
its
impact
on
immunity
and
resistance
in
zoono7c
and
animal
pathogens
– Interven7ons
to
reduce
an7microbial
resistance
– Non-­‐an7bio7c
alterna7ves
to
treat
bacterial
infec7ons
– Human
behaviors
regarding
an7bio7c
use
in
treatment
of
mas77s
– Classroom
and
online
educa7on
College of Veterinary Medicine and Dept. of
Large Animal Clinical Sciences

3. • livestock
produc/on
Antibiotic Use and Resistance in
Livestock Production

4. • An7bio7c
use
leads
to
the
emergence,
accumula7on
and
dissemina7on
of
AR
within
and
among
popula7ons
of
subjects
and
the
environment
• An7bio7c
use
in
agriculture
considered
a
major
contributor
to
AR
and
risk
to
human
health
• Easy
to
get
the
impression
that
reducing
or
banning
an7bio7c
use
in
livestock
produc7on
will
take
care
of
the
resistance
problem
– President’s
Council
of
Advisors
on
Science
and
Technology
(PCAST)
– Union
of
concerned
scien7sts
– News
stories:
PBS
Frontline
Monday
night
Antibiotic Use and Resistance in
Livestock Production

5. • All
produc7on
uses
of
an7bio7cs
in
livestock
produc7on
to
be
phased
out
by
2016
• May
affect
– Produc7vity
– Health
– Welfare
Antibiotic Use and Resistance in
Livestock Production

6. • A
prudent
ques7on
is
if
reducing
an7bio7c
use
will
be
considered
enough?
• Lessons
from
Europe
and
comparing
AR
in
organic
vs
conven7onal
livestock
produc7on
– Some
reduc7on
in
an7bio7c
use
• Increased
use
of
others
– Some
reduc7on
in
AR
• But
increase
for
others
– A
slow
process
– Not
a
silver
bullet!
Reducing Antibiotic Use in Livestock

7. • Can
we
do
more
to
reduce
an7bio7c
use?
– Alterna7ves
to
an7bio7cs
• For
preven7on
and
treatment
– Be:er
treatment
programs
&
use
policies
– Changing
human
behavior
• If
we
really
want
to
make
an
impact
– We
need
to
look
for
new
innova7ve
interven7ons
to
reduce
an7bio7c
use
in
general
(rather
than
just
banning
them)
and
to
reduce
AR
Can We Do More?

8. A Dutch Farmer Conquers MRSA Colonizing
His Family and His Pigs

9. • Eric
van
den
Heulen
• Pig
farmer
from
Holland
• Four
of
five
in
his
family
and
his
pigs
were
colonized
by
MRSA
• Daughter
denied
access
to
hospital
for
heart
surgery
because
of
MRSA
coloniza7on
• What
would
be
the
point
in
clearing
her
and
the
rest
of
the
family
of
MRSA
if
they
would
just
get
re-­‐colonized
from
the
pigs?
Can we do more?

10. • van
den
Heulen
started
two
things:
– Be:er
sanita7on
– Feeding
probio7cs
AND
spraying
probio7cs
on
pigs
and
the
environment
several
7mes
weekly
Can we do more?

11. • 3
years
later:
– MRSA
was
gone,
and
– He
only
uses
5%
of
the
an7bio7cs
he
used
3
years
ago
– His
barns
smell
be:er
• Perhaps
it
is
possible
to
do
more
than
merely
banning
an7bio7c
use
in
order
to
reduce
AR…!?
• At
the
same
7me
improve
overall
health
of
animals
and
people
working
with
them
Can we do more?

12. Thank you!