The document discusses Cassini, a corneal imaging system that provides comprehensive analysis of the anterior and posterior cornea to reduce refractive surprises. It has 6 key features: 1) total corneal analysis, 2) ocular surface diagnostics, 3) iris registration, 4) integrated surgical workflow, 5) data mining, and 6) proactive solutions. Cassini provides valuable pre-op information and seamlessly integrates with other technologies. It uses multi-colored LEDs and 2nd Purkinje imaging to map total corneal astigmatism. Cassini has been used in over 300,000 cataract patients to date. It can drive premium procedures and adoption of premium IOLs while also streamlining surgical workflows.

1. 1
The Cornea Specialist Company
Your technology partner in refractive-cataract surgery and vision care

2. 2
Reducing Refractive Surprises
Total Corneal Astigmatism
Patient
Outcomes
Topography
Keratometry
Ocular Surface
Surgically
Induced
Astigmatism
Posterior
Corneal
Surface
Orientation
of Toric Lens
Postoperative
Results

3. 3
1. Total Corneal Analysis
2. Ocular Surface Diagnostics
3. Iris Registration for Laser Surgical Guidance
4. Integrated Surgical Workflow
5. Data Mining based on Population Characteristics
6. Pro-active Clinical Solutions
Preparing for refractive lens surgery
Cassini provides highly valuable pre-op information
Anterior and Posterior Cornea analysis
Including dry eye diagnosis module (WIP)
Wireless integration with Lensar Streamline
Seamless integration with TrueVision, Leica IOL Compass, Cirle Navigation
Cassini Insight data mining and cloud-based solutions (WIP)
e.g., dry-eye OTC agents and pharmaceuticals

4. Cassini Total Corneal Astigmatism
GPS-like information from anterior & posterior corneal surfaces
Multi-colored LED point-to-point ray tracing
2nd Purkinje point-to-point ray tracing technology

5. 5
Cassini Cornea Measurement
Patented Multi-color LED Ray Tracing

6. 6
Non-contact ocular surface diagnosis
Virtual Corneal Staining
Virtual Staining from
Multi-Colored LEDs
Same patient,
4 months after Xiidra

7. 7
Cassini: An Integrated Ecosystem
Seamless integration between clinic and OR
Pre Op diagnostics &
IOL selection
Post Op Analysis &
SIA Management
Refractive
Outcomes
Accuracy and
Efficiency
Femtosecond laser
assisted astigmatism
correction
Toric guidance &
verification

8. 8
Lensar Streamline Iris registration with Cassini
Seamless interaction between clinic and OR
Femtosecond iris registration to
correct for cyclotorsion

9. Cassini TCA Means Accurate Diagnosis
94% ≦ 0.5D Postoperative Manifest Refractive Cyclinder
ORA - Hatch et al
JRS 2015
n = 37
Lenstar + Barrett
n = 50
Cassini TCA
n = 50
<0.5D <0.25D <0.5D <0.25D <0.5D <0.25D
94%
84%
78%
74%
54%
38%
Retrospective study - Elizabeth Yeu MD Hatch et al JRS 2015

10. 10
Premium procedures represent real growth
Cassini Serves a Significant Part of the Premium Cataract Market
Since the launch in 2013, Cassini has provided corneal diagnosis for
more than 300,000 cataract patients, with 50,000 in Q1 20171
0
10,000
20,000
30,000
40,000
50,000
Q4 Q1
'14
Q2 Q3 Q4 Q1
'15
Q2 Q3 Q4 Q1
'16
Q2 Q3 Q4 Q1
'17
Pre operative measurements per quarter
2014 2015 2016
1 Based on installed base multiplied by average number of patients diagnosed based on data collection from sites

11. 11
Cassini: a technology partner
Multiple applications from high value cataract surgery to high volume dry eye
diagnosis and contact lens fitting
1. Refractive-cataract surgery
Drive premium procedures and adoption of premium IOL’s
2. Surgical guidance for fs laser and IOL placement
Streamline image-guided and automated surgical procedures
3. Dry Eye Disease and contact lens fitting
Low cost (handheld) application for high-volume markets