The HARMONI Modular IOL System provides a stable foundation through a reliable base and optimized rotational stability. Its modular design allows for versatile control through safe and easy optic exchangeability and upgradeability to provide refractive care for a patient's lifetime. Clinical trials show the HARMONI IOL has best-in-class stability and visual performance that rivals traditional IOLs, while offering the ability to fine tune outcomes through optic exchange. The system aims to provide complete confidence in surgical outcomes without added costs or changes to routines.

1. HARMONI® Modular IOL System
Paul McLean
President and CEO
4 May 2017

2. 1
HARMONI Modular IOL Design
The base provides a stable foundation:
• Reliable ELP
• Optimized rotational stability
• Enhanced centration
The optic enables versatile control:
• Safe and easy exchange
• Upgradeability
• Refractive care for the patient’s lifetime
Mission: Complete confidence in surgical outcomes
without added costs or change to routines
The HARMONI modular IOL is an investigational device and is not approved for use in the United States

3. HARMONI Development at a Glance
2012
2
Technology
development
FIH Trial
#1 Innovation
3 new trials
CE Mark
IDE Submission
Confirmed:
• Stable
• Replaceable
• Versatile
• Easy
Pivotal Trial
250+ patients in trials
Data out to 3 years
Trial Enrollment
HUD for Pediatric
• Stable
• Replaceable
• Versatile
• Easy
Key clinical learnings
• HARMONI is safe to implant and exchange
• Visual performance rivals traditional IOLs
• HARMONI offers best in class stability
• Outcomes can be fine tuned with exchange
2013
2014
2015
2016
2017
2018
The HARMONI modular IOL is an investigational device and is not approved for use in the United States

4. Best-in-class stability
Rotational Stability
• HARMONI measured from Day 0
• Standard photographic assessment
• For every degree off-axis you lose ~3% of the
astigmatic correction
ACD Stability
• IOL movement is major cause of refractive surprise
• 200 microns movement ~0.25D refractive change
• Movement less than 200 microns = axially stable
33%
77%
0%
20%
40%
60%
80%
100%
Change Less than 0.2mm D0-1M post op
Percentage of IOLs that were axially stable
AcrySof HMIOL
Rotational Stability of HARMONI compared to AcrySof and
Tecnis
Product Mean/SD
(degrees)
Rotation
<5
o
Rotation
<10
o
HARMONI (n=85) 2.5 (2.0) 98% 99%
AcrySof* 3.4 (3.0) 82% 97%
Tecnis (day 1)* 1.4(6.1) 94% 97%
* Package insert data
3
The HARMONI modular IOL is an investigational device and is not approved for use in the United States

5. ClarVista Highlights
4The HARMONI modular IOL is an investigational device and is not approved for use in the United States
• Top tier IOL performance
• Best-in-class stability
• Safe and easy exchange
Accelerate AT IOL utilization
 IOL performance you can count on, versatility and control you crave
 Technology for a lifetime
– Safe & easy IOL replacement and upgrades
– One platform, all patients

6. HARMONI® Modular IOL System
For more information about the HARMONI Modular IOL please contact:
Paul McLean
pmclean@clarvistamedical.com
www.clarvistamedical.com