Ankle sprains can range from mild to severe and are most common in physically active individuals and those who participate in high-impact sports like running due to awkward landings or sudden directional changes. While x-rays can help diagnose sprains, over-the-counter anti-inflammatory drugs may relieve mild to moderate pain, and surgery may be needed for persistent pain or if osteoarthritis develops from repeated sprains. With proper treatment and rehabilitation, most people regain full ankle strength and mobility.