Animal models are useful for understanding the pathophysiology of asthma and developing new treatments. Common animal models include mice, rats, and guinea pigs that are sensitized to induce asthma-like symptoms including airway inflammation and hyperresponsiveness. One study evaluated the anti-asthmatic effects of the plant Leucas aspera by treating sensitized guinea pigs with the plant extract. The extract significantly increased the time before histamine-induced convulsions compared to the control group, demonstrating anti-inflammatory and bronchodilatory effects. In conclusion, animal models are valuable for screening potential anti-asthmatic drugs and further research on plant extracts may yield novel therapies.