The document describes an early warning system called AngioDefender for detecting cardiovascular disease risk. AngioDefender uses a non-invasive technique called flow-mediated dilation to measure the health of the endothelium lining blood vessels and assess a person's vascular health and risk of cardiovascular events. It provides results quickly in just 20 minutes and allows patients and doctors to monitor progress and tailor treatment plans to reduce disease risk over time by improving endothelial function.

1. AN EARLY WARNING SYSTEM FOR CARDIOVASCULAR DISEASE
DON’T WAIT UNTIL YOU HAVE SYMPTOMS.
GET THE INFORMATION YOU NEED TO
PREVENT THEM.
1
http://who.int/mediacentre/factsheets/fs310/en/; World Health Organization fact sheet. 2013.
2
In fact, many studies show that up to 64% of all heart attack victims under 60 years of age experience no symptoms prior to their first attack.
Valensi et al. Prevalence, incidence, predictive factors and prognosis of silent myocardial infarction: A review of the literature. Arch Cardio Dis 2011; 104:178-8.
Accurate: computerized procedure generates reliable data
Quick: test conducted in under 20 minutes
Non-invasive: uses a blood pressure cuff
Instant results: report available immediately
Cardiovascular disease (CVD) is responsible for nearly
one of every three deaths per year1
. Most people don’t
have symptoms before their first heart attack2
. This is
why CVD is known as “the silent killer.”
Until the AngioDefender™ system, measuring damage
to your arteries required highly technical, expensive,
and often invasive procedures. Now you can receive
an accurate, non-invasive assessment of your vascular
health and overall risk of CVD in just minutes.
A NEW WAY TO
CONSISTENTLY
MEASURE YOUR
VASCULAR HEALTH
TM

2. 1 3 5 7 9 11 13 15+
EARLY-STAGE MID-STAGE LATE-STAGE
PREDICT & PROTECT
HEALTHY
ENDOTHELIUM
DYSFUNCTIONAL
ENDOTHELIUM
DAMAGED
ENDOTHELIUM
EARLY STAGE MID STAGE LATE STAGE
INCREASING VASCULAR AGE
Blood clotsform
Eventual
blockage
Result in:
Chest pain
Heart attack
Stroke
Cardiovascular
risk factors
Result in:
Lower %FMD
Plaque formation
Calcium build-up
Result in:
Vessel stiffening
and narrowing
YEALTHYYHE
HELIUMNDOTHTHEN
DYSF
ENDO
DAMAGED
ENDOTHELIUM
blockage
Result in:
est pain
art attack
oke
Lower %FMD
Result in:
V l tiff i
THYY
Res
Che
Hea
Stro
Lower %FMD Vessel stiffening
and narrowing
FUNCT
OTHEL
DAMAGED
T
L
LIONAL
LIUM
+ Dietary
modifications
+ Exercise
+ Medications
+ Lifestyle
modifications
+ Smoking cessation
+ Diabetes controlRISK OF CVD DECREASING RISK
MEDIUM RISK
HOW ANGIODEFENDER™ WORKS
The AngioDefender™ system
measures the health of your
endothelium — the single-
cell-thick interior lining of all
blood vessels in your body.
Using a process called
Flow-Mediated Dilation
(%FMD), the device
runs through a series of
inflations and deflations
to analyze the endothelium’s
response to increased blood flow.
Then, by combining the principles of
blood pressure, pulse wave analysis, and a
proprietary data analysis algorithm, AngioDefender™
produces your unique %FMD score in just minutes.
+ 1.855.383.7478 | 709 W. Ellsworth Road Ann Arbor, MI 48108 USA | info@everisthealth.com
BE PROACTIVE
AngioDefender™ makes it easy to track your
progress toward a healthier heart. Once you’ve
received your %FMD score, you and your doctor
can create an action plan to decrease your risk
of developing cardiovascular disease. Soon after
beginning your personalized plan, you can expect
to see an improvement in your %FMD score.
Example of an age-adjusted %FMD profile for a 40-year-old male
WAYS TO IMPROVE YOUR %FMD SCOREANGIODEFENDER™ SCORE
6.5
6.5
Ask your doctor about the benefits of incorporating the AngioDefender™ system into
your wellness routine. Visit EveristHealth.com to learn more.
REF:110003The AngioDefender™ system is
not commercially available
in the United States.
™
™