This document provides an overview of upper extremity anatomy as it relates to brachial plexus blocks. It discusses the branches and innervation of the brachial plexus, as well as anatomical variations that are important to consider when performing blocks. Specific techniques like interscalene, supraclavicular, infraclavicular, and axillary blocks are described, highlighting relevant landmarks, spread of local anesthetic, and risks like phrenic nerve palsy or pneumothorax. Detailed dissections of the brachial plexus at different levels are also shown.
Regional Blocks of the Upper Limb and Thorax RRTRanjith Thampi
Blocks of the UL and Thorax made easy. Most methods mentioned here are modifications and not classical methods used that maybe be required for examination writing purpose.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Anatomy of Brachial plexus
1. ANATOMY, A LAUNCH PAD FOR RA!
UPPER EXTREMITY ANATOMY
DR KALPESH SHAH
M.D.,D.A (Anaesthesia )
Consultant Anaesthesiologist
Mumbai
2. “The understanding of innervations are of basic
importance and is the basis for
Neuro-electrostimulation.”
Dr Sandip Diwan
(Regional Nerve Blocks book)
3. Brachial plexus block becomes the analogues to
epidural anaesthesia, i.e. once the compartment is
entered ,a single injection of an adequate volume
of local anesthetic results in successful
anaesthesia.
18. DIVISIONS
• Each trunk divides to form an anterior and
posterior division posterior to the mid clavicle.
• In general, anterior divisions supply muscles of the
anterior compartments (flexors) where as the
posterior division supply muscles of the posterior
compartments(extensors)
• No branches arises from the divisions.
19. • The dorsal rami course posteriorly into the spinal
extensors (erector spine)and do not contribute to
the brachial plexus.
• The ventral rami of C4 & C5 also contribute to
the brachial plexus
• The ventral ramus of T1 also contribute to the
first intercostal nerve.
23. • The ant scalene muscle arises from anterior
tubercle of the transverse process of the 3
rd,4 th,5 th and 6 th cervical vertebra.
• It inserts on the scalene tubercle of the first
rib.
• Brachial plexus is situated lateral and
superior to the subclavian artery.
24. • Middle scalene muscle arises from the
posterior tubercles of the transverse process
of lower six cervical vertebrae.
• The trunks that are stacked on each other
now divides into anterior and posterior
division are enclosed in the scalene sheath
and come to lie superolateral to the
subclavian artery.
25. • The topography changes from almost vertical
arrangement of trunks of brachial plexus to a
horizontal one.
• Quiet often, the trunks are short in length and
divide and rejoin immediately at the
supraclavicular area(division), thus at times the
interscalene or supraclavicular produces mixed
neurostimulation induced evoked muscle
response.
26.
27. PREVERTEBRAL FACIA
• The prevertebral fascia of the neck
extends down to ensheth the axillary
artery and cords.
• It is this axillary sheath that local
anesthetic is injected when performing the
brachial plexus block
28. • Once the needle tip penetrates the
prevertebral cervical fascia its really
undecided whether the tip is in the
interscalene groove or in the anterior or
middle scalene muscle.
• Increasing resistance on bolus injection will
suggest the tip in the muscle ,while a smooth
flow will be definitive that tip is in the groove.
29. ANATOMICAL VARIATIONS
• Commonly described anatomical relationship
of brachial plexus lying between the anterior
scalene and middle scalene muscle was
found in only 60% of instance.
• The most common variation was the
penetration of AS by the C5 and/or C6 ventral
rami.
30. • The C5 &C6 roots may fuse before
piercing Anterior Scalene. (15%cases).
• The C5 root alone pierce the belly of AS
(13%cases)
• The C5 root was found completely anterior
to AS in 3% of cases.
31. • VERTEBRAL FORAMEN IS AT A
DISTANCE OF 3.7 CMS APPROX FROM
SKIN…..BEWARE OF INTRAFORAMINAL
INJECTION
32. • SYMPATHETIC CHAIN BLOCKADE WITH
ISB CAN CAUSE BRONCHOSPASM DUE
TO UNOPPOSED VAGAL
PARASYMPATHETIC ACTION
33. • HEAD ROTATION MORE THAN 30
DEGREES DISTORTS THE ANATOMICAL
GROOVE AND VASCULAR RELATIONSHIP
• INTERCOSTOBRACHIAL NERVE TO BE
INFILTRATED FOR ANESTHESIA AROUND
MEDIAL PART OF SHOULDER AND
FOREARM
34. IMPORTANCE OF VARIATION IN
ANATOMY
• No neurostimulation
• Inappropriate neurostimulation
• Appropriate neurostimulation but
inadequate block
• Total block failure
35. The posterior cord is discrete in 25%,in 71%
continues as various nerves and in 4%
directly as the radial nerve.
36. • The upper two roots join to form the upper
trunk, this is C5-6.
• This is exactly the position of the
stimulating needle tip,
37. • The trunks lay above each other with
sparse connective tissue between them.
• Drug injected at the upper trunk will slowly
disperse along a concentration gradient.
38. • The distance between the interscalene
and the subclavian area is too small, drug
injected correctly in the sheath will spread
across the entire length from the cervical
root to the supraclavicular area.
39. • The scalene muscle and the brachial
plexus are in same plan ,thus the needle
should be perpendicular to this plane.
40. PHRENIC NERVE
• The phrenic nerve is in close relation to
the trunks of brachial plexus in the
inrerscalene area.
• It lies on the anterior scalene muscle and
courses from the lateral aspect of scalene
to the medial.
41. • The higher level interscalene block ,the
more the incidence of phrenic nerve block.
42. • Contrast study showed, the spread of contrast is
linear and compressed between the two scalene
muscle and widens lower down at the midpoint of
the clavicle.
• The contrast spreads close to the anterior scalene
muscle thus blocking the phrenic nerve.
43. • Combining low volume LA and digital
pressure was thought to reduce incidence
of phrenic nerve palsy.
44. SUPRASCAPULAR NERVE
• This nerve accompanies the trunks for a
considerable distance and then leaves
posteriorly through the middle scalene
muscle.
45. • Stimulation of the suprascapular nerve is
possible and provides a false feeling of the
needle tip in the sheath of brachial plexus.
46. One branch arises from the trunks.
Suprascapular nerve, it arises from the
upper trunk and supplies the supraspinatus
and infraspinatus muscles, and sensation to
the glenohumeral and acromioclavicular
joints.
50. • BLOCK IS AT THE LEVEL OF DIVISIONS
• BRACHIAL PLEXUS IS SUPPOSED TO
BE COMPACT AT THIS LOCATION,
DENSE ACTION EXPECTED
51. • ANATOMICAL LANDMARK -
SUBCLAVIAN ARTERY ( BP IS
POSTEROLATERAL )
• 0.5 -6 % CHANCES OF
PNEUMOTHORAX
• VASCULAR INJURIES COMMON
52. INFRACLAVICULAR
ANATOMY
• The divisions pass over the first rib close
to the dome of the lung and continue
under the clavicle as cords immediately
posterior to the subclavian artery.
• The sheath is completely stripped off the
infraclavicular cords.
53. • The cords are identified according to their
relationship to the axillary artery.
• The lateral cord lies more laterally and
superficially and is first to be encountered
during an infraclavicular block.
54. • The lateral cord always lies anterior to
either the posterior or medial cord and
cranial to the axillary artery.
• The posterior cord was always cranial to
the medial cord and both cords were
always located dorsal to the artery.
55. • There are at least 13 branches at infraclavicular
area.
• The musculocutaneous nerve has an anomalous
origin or connection to the median nerve in
11%,and a connection carrying C7 fibers from the
lateral cord to the ulnar nerve occurs in 42% of
anatomic specimens
56. • The lateral root of the median nerve may
pass posterior to the axillary artery and the
axillary and radial nerves may arises
directly from the division such that a true
posterior cord is not present.
57. • The musculocutaneous nerve (MCN)
leaves the brachial plexus sheath high in
the axilla at the level of the lower border of
the teres major muscle and passes into
the substances of coracobrachialis
muscle.
58. • The MCN exits out of the lateral cord early
in the course and is reliably blocked in
infraclavicular area.
60. • BLOCK GIVEN AT THE LEVEL OF
CORDS
• ANATOMICAL LANDMARK – AXILLARY
ARTERY
• CORDS SURROUND THE ARTERY IN
2’O CLOCK TO 11’O CLOCK POSITION
61. • VASCULAR INJURIES VERY COMMON
• TOO MEDIALLY DIRECTED NEEDLE
INCREASE THE CHANCE OF
PNEUMOTHORAX
62. • TARGETTING POSTERIOR CORD
STIMULATION GIVES EQUAL SPREAD
TO ALL THE CORDS
• FINGER/WRIST – FLEXION /
EXTENSION AS END POINT OF
NEUROSTIMULATION
63. • BICEPS CONTRACTION SUGGESTIVE
OF MUSCULOCUTANEOUS…DO NOT
ACCEPT AS THIS NERVE EXITS THE
PLEXUS BEFOREHAND
• TOURNIQUET PAIN POSSIBLE WITH
PLAIN AXILLARY BLOCK
64. AXILLARY NERVE
• It supplies the shoulder joint, the surgical
neck of humurus, the deltoid, and the teres
minor muscle before ending as the
superior lateral brachial cutaneous nerve,
which innervates the superolateral part of
proximal arm.