This document provides an overview of principles of amputation. It discusses indications for amputation including irreversible ischemia, uncontrolled infection, and certain tumors or anomalies. Common causes requiring amputation are also summarized, such as peripheral vascular disease, trauma, burns, frostbite, and infection. The document outlines considerations for determining the appropriate amputation level based on factors like a patient's age, medical comorbidities, and potential for rehabilitation. Surgical techniques and post-operative care are also briefly addressed.