This document provides an overview of national survey data sources relevant for research on American Indians and Alaska Natives (AIAN). It describes data available from the National Center for Health Statistics (NCHS) including natality, mortality, linked birth/infant death data, and the National Health Interview Survey. It also discusses Centers for Disease Control and Prevention (CDC) data sources like the Behavioral Risk Factor Surveillance System, Pregnancy Risk Assessment Monitoring System, and Youth Risk Behavior Surveillance System. Procedures for accessing public use and restricted files from the NCHS Research Data Center are outlined.