SimpleDB is Amazon's NoSQL database that provides scalability, availability, and simplicity compared to traditional RDBMS systems. It uses a schema-less data model with key-value attributes stored in a large hash table, allowing automatic indexing but limiting functionality like joins, transactions, and complex queries. Application design with SimpleDB requires handling constraints, transactions, and other features normally provided by databases. It is best suited for simple, non-critical data like game state or session management rather than analytical processing or highly structured data applications.