This document summarizes acute kidney injury (AKI), including causes, risk factors, diagnosis, management, and treatment options like renal replacement therapy. It emphasizes early detection of AKI to prevent further injury, and notes that fluid overload and late initiation of dialysis are associated with higher mortality. Management involves identifying and avoiding nephrotoxic agents, maintaining fluid balance, and considering renal replacement therapy with peritoneal dialysis, hemodialysis, or continuous renal replacement therapy depending on the clinical situation and local expertise. The goal is to recognize patients at risk and improve AKI care worldwide so that no one dies of preventable AKI by 2025.