Acute kidney injury (AKI) is a rapid decline in kidney function often due to factors like dehydration and certain medications, with significant mortality associated with it that may be preventable. Residents in care homes, particularly those with conditions such as diabetes and heart failure, are at higher risk, making it crucial for health professionals to recognize early signs and manage hydration effectively. Prevention measures include monitoring urine output, encouraging fluid intake, and understanding the specific needs of at-risk residents.