This document discusses biodiversity conservation. It defines biodiversity as the variety of species found within a region, including genetic, species, and ecosystem diversity. Biodiversity is valuable for maintaining ecological balance but is threatened by human activities. Conservation approaches include in-situ methods like national parks, wildlife sanctuaries, and biosphere reserves, and ex-situ methods such as seed banks, botanical gardens, zoos, and tissue culture which protect species outside their natural habitats. Both approaches are needed to effectively conserve biodiversity.
Biodiversity or biological diversity is the variety and variability of life on Earth. Biodiversity is a measure of variation at the genetic (genetic variability), species (species diversity), and ecosystem (ecosystem diversity) level.Biodiversity is not evenly distributed, rather it varies greatly across the globe as well as within regions. Among other factors, the diversity of all living things (biota) depends on temperature, precipitation, altitude, soils, geography and the presence of other species. The study of the spatial distribution of organisms, species and ecosystems, is the science of biogeography.A biodiversity hotspot is a region with a high level of endemic species that have experienced great habitat loss. The term hotspot was introduced in 1988 by Norman Myers. While hotspots are spread all over the world, the majority are forest areas and most are located in the tropics.The existence of a global carrying capacity, limiting the amount of life that can live at once, is debated, as is the question of whether such a limit would also cap the number of species. While records of life in the sea show a logistic pattern of growth, life on land (insects, plants and tetrapods) shows an exponential rise in diversity.[16] As one author states, "Tetrapods have not yet invaded 64 percent of potentially habitable modes and it could be that without human influence the ecological and taxonomic diversity of tetrapods would continue to increase exponentially until most or all of the available eco-space is filled."A variety of objective means exist to empirically measure biodiversity. Each measure relates to a particular use of the data, and is likely to be associated with the variety of genes. Biodiversity is commonly measured in terms of taxonomic richness of a geographic area over a time interval.In 2006, many species were formally classified as rare or endangered or threatened; moreover, scientists have estimated that millions more species are at risk which have not been formally recognized. About 40 percent of the 40,177 species assessed using the IUCN Red List criteria are now listed as threatened with extinction—a total of 16,119.[151] The five main drivers to biodiversity loss are : habitat loss, invasive species, overexploitation (extreme hunting and fishing pressure), pollution, and climate change.The number of morphological attributes that can be scored for diversity study is generally limited and prone to environmental influences; thereby reducing the fine resolution required to ascertain the phylogenetic relationships. DNA based markers- microsatellites otherwise known as simple sequence repeats (SSR) were therefore used for the diversity studies of certain species and their wild relatives.
In the case of cowpea, a study conducted to assess the level of genetic diversity in cowpea germplasm and related wide species, where the relatedness among various taxa was compared, primers useful for classification of taxa identified, and the origin.
Biodiversity or biological diversity is the variety and variability of life on Earth. Biodiversity is a measure of variation at the genetic (genetic variability), species (species diversity), and ecosystem (ecosystem diversity) level.Biodiversity is not evenly distributed, rather it varies greatly across the globe as well as within regions. Among other factors, the diversity of all living things (biota) depends on temperature, precipitation, altitude, soils, geography and the presence of other species. The study of the spatial distribution of organisms, species and ecosystems, is the science of biogeography.A biodiversity hotspot is a region with a high level of endemic species that have experienced great habitat loss. The term hotspot was introduced in 1988 by Norman Myers. While hotspots are spread all over the world, the majority are forest areas and most are located in the tropics.The existence of a global carrying capacity, limiting the amount of life that can live at once, is debated, as is the question of whether such a limit would also cap the number of species. While records of life in the sea show a logistic pattern of growth, life on land (insects, plants and tetrapods) shows an exponential rise in diversity.[16] As one author states, "Tetrapods have not yet invaded 64 percent of potentially habitable modes and it could be that without human influence the ecological and taxonomic diversity of tetrapods would continue to increase exponentially until most or all of the available eco-space is filled."A variety of objective means exist to empirically measure biodiversity. Each measure relates to a particular use of the data, and is likely to be associated with the variety of genes. Biodiversity is commonly measured in terms of taxonomic richness of a geographic area over a time interval.In 2006, many species were formally classified as rare or endangered or threatened; moreover, scientists have estimated that millions more species are at risk which have not been formally recognized. About 40 percent of the 40,177 species assessed using the IUCN Red List criteria are now listed as threatened with extinction—a total of 16,119.[151] The five main drivers to biodiversity loss are : habitat loss, invasive species, overexploitation (extreme hunting and fishing pressure), pollution, and climate change.The number of morphological attributes that can be scored for diversity study is generally limited and prone to environmental influences; thereby reducing the fine resolution required to ascertain the phylogenetic relationships. DNA based markers- microsatellites otherwise known as simple sequence repeats (SSR) were therefore used for the diversity studies of certain species and their wild relatives.
In the case of cowpea, a study conducted to assess the level of genetic diversity in cowpea germplasm and related wide species, where the relatedness among various taxa was compared, primers useful for classification of taxa identified, and the origin.
Conservation of biodiversity isThus, variability among living organisms from all sources including inter alia, terrestrial, marine & other aquatic ecosystems and ecological complexes of which they are part of.
Sustainable development is the organizing principle for meeting human development goals while at the same time sustaining the ability of natural systems to provide the natural resources and ecosystem services upon which the economy and society depend. The desired result is a state of society where living conditions and resource use continue to meet human needs without undermining the integrity and stability of the natural system and sustainable development can be classified as development that meet the needs of the present without compromising the ability of the future generation.
This ppt gives you the information under the broad topic "willife conservation and management". It includes the brief knowledge about 'cover construction' along with it here also discussed about
'genetic diversity' and it's preservation. Also I added a few slides about strategies to restore the degraded biodiversity.
Conservation of biodiversity isThus, variability among living organisms from all sources including inter alia, terrestrial, marine & other aquatic ecosystems and ecological complexes of which they are part of.
Sustainable development is the organizing principle for meeting human development goals while at the same time sustaining the ability of natural systems to provide the natural resources and ecosystem services upon which the economy and society depend. The desired result is a state of society where living conditions and resource use continue to meet human needs without undermining the integrity and stability of the natural system and sustainable development can be classified as development that meet the needs of the present without compromising the ability of the future generation.
This ppt gives you the information under the broad topic "willife conservation and management". It includes the brief knowledge about 'cover construction' along with it here also discussed about
'genetic diversity' and it's preservation. Also I added a few slides about strategies to restore the degraded biodiversity.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
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Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
1. S.S.G. PAREEK PG COLLEGE
SUBMITTED BY :-
AJAY KUMAR YADAV
M.Sc (FINAL)
ZOOLOGY
SUBMITTED TO:-
RAJNEESH MISHRA
(HOD)
ZOOLOGY
CONSERVATION OF
BIODIVERSITY
2. CONTENT :-
BIODIVERSITY
VALUE OF BIODIVERITY
TYPES OF BIODIVERSITY
CONSERVATION OF
BIODIVERSITY
IN-SITU CONSERVATION
EX-SITU CONSERVATION
3. What is BIODIVERSITY ?
BIO means “life” and DIVERSITY means
“variety”. Hence the biodiversity refers to wide
variety of life on the earth.
Definition :- The presence of different species of
plants, animals, reptiles, birds, etc over a
particular piece of land.
Variety in the species is influenced by many
factors like – physical ,chemical , climatic. Which
results in the formation of new species.
4. VALUE OF BIODIVERSITY :-
BIODIVERSITY is very important for maintaining
the ecological balance of a place.
It provide so much of useful resources necessary
for the survival.
Without biodiversity, there would be no life and
almost all species will extinct.
Biodiversity is threatened by several human
activities.
Therefore, all the biodiversity reserves must be
protected at all costs by taking necessary steps.
7. 1) Genetic diversity:-
Within individual species there
are number of varieties which
are slightly different from one
another.
These differences are due to
difference in the combination of
genes.
Genes are the basic unit of
hereditary information,
transmitted from one generation
to another.
8. 2) Species diversity:-
It refers to the variety of
species with in a region.
Species diversity is an
index that in corporates
the number of species in
an area.
9. 3) Ecosystem diversity:-
Ecosystem diversity refers to the
diversity of a place at the level of
ecosystems.
A large region with different
ecosystems can be considered
as ecosystem diversity.
The ecosystem also show
variation with respect to physical
parameters like moisture,
temperature, altitude,
precipitation, …etc.
10. THERE ARE TWO APPROACHES OF
BIODIVERSITY CONSERVATION:-
In-situ conservation(with in habitat):- this
is achieved by protection of wild flora and
fauna in nature itself.
example- biosphere reserve, national park,
sanctuaries…etc.
Ex-situ conservation(outside habitats):-this
is done by establishing of gene banks,
seed banks, zoo, botanical garden…etc.
12. IN-SITU CONSERVATION
1. NATIONAL PARKS:-
A national park is an area which is strictly reserved
for the betterment of the wildlife.
Where activities like forestry, grazing on cultivation
are not permitted.
In these parks, even private ownership rights are not
allowed.
Their boundaries are well marked and
circumscribed. They are usually small reserves
spreading in an area of 100 Sq. km. to 500 sq. km. .
13. IN-SITU CONSERVATION
2. WILDLIFE SANCTUARIES:-
A sanctuary is a protected area which is
reserved for the conservation of only animals.
Human activities like harvesting of timber,
collecting minor forest products and private
ownership rights are allowed as long as they
do not interfere with well-being of animals.
Boundaries of sanctuaries are not well
defined and controlled biotic interference is
permitted, e.g., tourist activity.
14. IN-SITU CONSERVATION
3. BIOSPHERE RESERVES:-
It is a special category of protected areas where
human population also forms a part of the system.
They are large protected area of usually more than
5000 sq.km.
A biosphere reserves has 3 parts-
Core
Buffer
Transition zone.
15. EX-SITU CONSERVATION
1. SEED GENE BANK:-
These are cold storages where seeds are
kept under controlled temperature and
humidity for storage.
This is easiest way to store the germ plasma
of plants at low temperature.
Seeds preserved under controlled conditions
(minus temperature) remain viable for long
durations of time.
16. EX-SITU CONSERVATION
2. GENE BANK:-
Genetic variability also is preserved by
gene bank under normal growing
conditions.
These are cold storages where genes are
kept under controlled temperature and
humidity for storage; this is an important
way of preserving the genetic resources.
17. EX-SITU CONSERVATION
3. BOTANICAL GARDENS:
A botanical garden is a place where flowers,
fruits and vegetables are grown.
The botanical gardens provide beauty and
calm environment.
Most of them have started keeping exotic
plants for educational and research
purposes.
18. EX-SITU CONSERVATION
4. ZOOLOGICAL GARDENS:
In zoos, captivity and conservation of wild
animals (rare, endangered species).
. In world there are about 800 zoos.
The oldest zoo, which exists today also, was
established in VIENNA in 1759.
In India, the 1st zoo is in Chennai (formerly
known as madras zoo) formed in 1855.