airway remodelling.pptx
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This document discusses various drug classes used to treat airway remodelling, including cromones like cromolyn sodium and nedocromil sodium which protect against allergen challenge without bronchodilation. Mast cell stabilizers like sodium cromoglycate inhibit mast cell degranulation and mediator release. Ketotifen has some cromoglycate-like action as well as reducing immunogenic and inflammatory cell stimulation. Corticosteroids reduce bronchial hyperreactivity, mucosal edema, and suppress the inflammatory response. Recent advances include targeted therapies like omalizumab, an anti-IgE antibody administered subcutaneously that neutralizes free IgE. Other monoclonal antibodies in development include mepolizumab,
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- 2. CROMONES • Cromolyn sodium is a derivative of Khellin, Egyptian herbal remedy. • Protect against allergen challenge without any bronchodilator effect. • A structurally related drug nedocromil sodium was also developed. • Have good safety profile.
- 3. MAST CELL STABILIZERS • SODIUM CROMOGLYCATE : - Synthetic chromone derivative which inhibits degranulation of mast cells. - Mediator release is restricted. - Not absorbed orally. - Administered as aerosol through MDI. - Rapidly excreted unchanged in urine & bile.
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- 5. CORTICOSTEROIDS • No bronchodilatory action. • Reduce bronchial hyperreactivity,mucosal edema,suppress inflammatory response. • Corticosteroids afford more complete and sustained symptomatic relief.
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- 9. DRUGS IN PIPELINE • Other monoclonal antibodies used for the control of severe asthma are 1. Mepolizumab 2. Reslizumab 3. Benralizumab 4. Dupilumab
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