AIDS is the advanced stage of HIV infection where the immune system is weakened, making one susceptible to infections and conditions like cancer. More than 25 million people have died from AIDS in Africa, where over 2/3 of AIDS deaths occur. Africa is likely where HIV first transferred to humans. The AIDS epidemic has reduced life expectancy in Africa by 20 years and orphaned 12 million children. One cause of AIDS in Africa is lower status of women preventing negotiation of condom use or fidelity. There are organizations that help raise money for treatment and prevention campaigns, such as PEPFAR.