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AFFINImeter: una herramienta avanzadda para el análisis de datos de Calorimetría de Titulación Isotérmica (ITC)
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This document discusses differential scanning calorimetry (DSC), a thermal analysis technique where the temperature and heat flow of a sample are measured as it is subjected to a controlled temperature program. DSC provides quantitative and qualitative data on physical and chemical changes that involve endothermic or exothermic processes, such as phase transitions, melting points, heat capacity, and oxidation. The document outlines the components of a DSC instrument and how it works, as well as applications of DSC in various fields including polymers, pharmaceuticals, and biochemistry.
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form very quickly by streaming instability, which is a process to concentrate particles enough to cause gravitational
collapse and rapid formation of planetesimals or moonlets. Here, we investigate the effect of the streaming
instability in the Moon-forming disk for the first time and find that this instability can quickly form ∼100 km-sized
moonlets. However, these moonlets are not large enough to avoid strong drag, and they still fall onto Earth quickly.
This suggests that the vapor-rich disks may not form the large Moon, and therefore the models that produce vaporpoor disks are supported. This result is applicable to general impact-induced moon-forming disks, supporting the
previous suggestion that small planets (<1.6 R⊕) are good candidates to host large moons because their impactinduced disks would likely be vapor-poor. We find a limited role of streaming instability in satellite formation in an
impact-induced disk, whereas it plays a key role during planet formation.
Unified Astronomy Thesaurus concepts: Earth-moon system (436)
Mechanics:- Simple and Compound Pendulum
a compound pendulum is a physical system with a more complex structure than a simple pendulum, incorporating its mass distribution and dimensions into its oscillatory motion around a fixed axis. Understanding its dynamics involves principles of rotational mechanics and the interplay between gravitational potential energy and kinetic energy. Compound pendulums are used in various scientific and engineering applications, such as seismology for measuring earthquakes, in clocks to maintain accurate timekeeping, and in mechanical systems to study oscillatory motion dynamics.
Hariyalikart Case Study of helping farmers in Bihar
Helping farmers all across India through our latest technologies of modern farming like drones for irrigation and best pest control For more visit : https://www.hariyalikart.com/case-study
JAMES WEBB STUDY THE MASSIVE BLACK HOLE SEEDS
The pathway(s) to seeding the massive black holes (MBHs) that exist at the heart of galaxies in the present and distant Universe remains an unsolved problem. Here we categorise, describe and quantitatively discuss the formation pathways of both light and heavy seeds. We emphasise that the most recent computational models suggest that rather than a bimodal-like mass spectrum between light and heavy seeds with light at one end and heavy at the other that instead a continuum exists. Light seeds being more ubiquitous and the heavier seeds becoming less and less abundant due the rarer environmental conditions required for their formation. We therefore examine the different mechanisms that give rise to different seed mass spectrums. We show how and why the mechanisms that produce the heaviest seeds are also among the rarest events in the Universe and are hence extremely unlikely to be the seeds for the vast majority of the MBH population. We quantify, within the limits of the current large uncertainties in the seeding processes, the expected number densities of the seed mass spectrum. We argue that light seeds must be at least 103 to 105 times more numerous than heavy seeds to explain the MBH population as a whole. Based on our current understanding of the seed population this makes heavy seeds (Mseed > 103 M⊙) a significantly more likely pathway given that heavy seeds have an abundance pattern than is close to and likely in excess of 10−4 compared to light seeds. Finally, we examine the current state-of-the-art in numerical calculations and recent observations and plot a path forward for near-future advances in both domains.
一比一原版美国佩斯大学毕业证如何办理
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留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
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6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
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办理美国佩斯大学毕业证【微信：741003700 】格式相对统一，各专业都有相应的模板。通常包括以下部分：
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校名:学校英文全称
授予学位：本部分将注明获得的具体学位名称。
毕业生姓名：这是最重要的信息之一，标志着该证书是由特定人员获得的。
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Mites,Slug,Snail_Infesting agricultural crops.pdf
Order : Trombidiformes (Acarina) Class : Arachnida
Mites normally feed on the undersurface of the leaves but the symptoms are more easily seen on the uppersurface.
Tetranychids produce blotching (Spots) on the leaf-surface.
Tarsonemids and Eriophyids produce distortion (twist), puckering (Folds) or stunting (Short) of leaves.
Eriophyids produce distinct galls or blisters (fluid-filled sac in the outer layer)
Rodents, Birds and locust_Pests of crops.pdf
Mole rat or Lesser bandicoot rat, Bandicotabengalensis
•Head -round and broad muzzle
•Tail -shorter than head, body
•Prefers damp areas
•Burrows with scooped soil before entrance
•Potential rat, one pair can produce more than 800 offspringsin one year
Evaluation and Identification of J'BaFofi the Giant Spider of Congo and Moke...
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The J'BaFofi, or "Giant Spider," is a mainly legendary arachnid by reportedly inhabiting the dense rain forests of
the Congo. As despite numerous anecdotal accounts and cultural references, the scientific validation remains more elusive.
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I am the PhD scholar of FND department, Assam down town University
Gadgets for management of stored product pests_Dr.UPR.pdf
Insectsplayamajorroleinthedeteriorationoffoodgrainscausingbothquantitativeandqualitativelosses
Wellprovedthatnogranariescanbefilledwithgrainswithoutinsectsastheharvestedproducecontainegg(or)larvae(or)pupae(or)adultinsectinthembecauseoffieldcarryoverinfestationwhichcannotbeavoidedindevelopingcountrieslikeIndia
Simpletechnologiesfortimelydetectionofinsectsinthestoredproduceandtherebyplantimelycontrolmeasures
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Affinimeter Tutorial
- 1. AFFINImeter: una herramienta avanzada para el análisis de datos de Calorimetría de Titulación Isotérmica (ITC) TUTORIAL 15 y 16 de Octubre de 2015
- 2. MOLECULAR RECOGNITION Essential for all physiological and pathological processes. • Cell grouth and development • Cell-cell communication • Bacterial/viral infections • Tumor development • etc…..
- 3. MOLECULAR RECOGNITION Ligand – receptor interactions • Protein – protein • Nucleic acid – protein • Small molecule – biomolecule……. Free species Complex A + M AM
- 4. o Understanding Biological proceses. o Pathological proceses. o Drug Discovery and development. Ligand – receptor interactions: characterization • Thermodynamics • Kinetics • Structure • How strong? • How fast? • Where/how?
- 5. Ligand – receptor interactions: characterization • Thermodynamics: heat, energy DG: free energy (K, binding constant) DH: enthalpy DS: entropy • Structure & mechanism: stoichiometry • Kinetics: speed kon: association rate constant koff: dissociation rate constant DG = RTLnKA DG = DH – TDS KA = kon/koff
- 6. ANALYSIS Thermodynamics Kinetics Structure Data (graph(s)) How to get the information? Monitor the interaction (Biophysical technique) Ligand – receptor interaction
- 7. ANALYSIS Thermodynamics Kinetics Structure Data (graph(s)) How to get the information? Ligand – receptor interaction Monitor the interaction (Biophysical technique) ITC Isothermal Titration Calorimetry (ITC)
- 8. Thermodynamics • Gold-standard technique for the thermodynamic characterization of interactions • Measures the heat change occured in the calorimetric cell throughout the titration ligand receptor The ITC titration: Power vs. Time plot (thermogram) ITC isotherm peak integration KA , DH, stoichiometry DG, DS
- 10. ANALYSIS Thermodynamics Kinetics Structure Data (graph(s)) We can get much more! Ligand – receptor interaction ITC Isothermal Titration Calorimetry (ITC) ITC
- 11. Obtaining kinetic information from ITC KinITC: obtaining kinetic information from ITC
- 12. Obtaining kinetic information from ITC • IS THERE KINETIC INFORMATION IN MY THERMOGRAM?: A VISUAL INSPECTION Mid titration: Peak broadening KinITC: obtaining kinetic information from ITC
- 13. AFFINImeter & KinITC Analytical tools to study complex data heat vs time (kinetic information!) KA = kon/koff kon = KA·koff
- 14. “Essentially, KinITC is based upon linking the kinetics of the reaction to heat power production in the measurement cell” = = = = concentration of titrand in the cell 1:1 binding Heat power KinITC: obtaining kinetic information from ITC AFFINImeter & KinITC
- 15. Wieseman parameter Stoichiometric ratio for current injection KinITC: obtaining kinetic information from ITC Equilibration time Dissociation rate constant AFFINImeter & KinITC
- 16. ANALYSIS Thermodynamics Kinetics Structure Data (graph(s)) We can get much more! Ligand – receptor interaction ITC Isothermal Titration Calorimetry (ITC)
- 17. Structure & Mechanism Simple 1:1 interaction • Competitive experiments. • Species dimerization. • Multi-site binding • Cooperative effects • etc Complex data, usually explained by the presence of several equilibria
- 18. Tailored binding model Global fitting ROBUST ANALYSIS • Structural information. • Binding mechanism. • Cooperativiy. • Competitive experiments. MODEL BUILDER AFFINImeter advanced tools
- 19. AFFINImeter advanced tools Based on Site constants Based on Stoichiometric constants CaMBD CaM k1 k2 k2a k1a k1 k2a
- 20. Analytical tools to study complex ITC data