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Dr. Priyanka Ingle-Jadhav,
Postdoctoral Research Fellow
Department of Pathology,
Immunology and Laboratory
Medicine, College of Medicine,
University of Florida,
Gainesville, FL, USA
Ayurveda Update 2014
 Health care budget gets 27% hike in 2014-15
 AYUSH gets 36% hike nearing Rs.1,272.15 crore
 High hopes in terms of:
 Improving public health (health restoration ,
disease modulation)
 Contribution in drug discovery
 Increasing India’s share in global business
 Creating sustainable environment for
cultivation and exports, job generation
 Outreach to the remote parts of India to
support economic and easily accessible health
care option
http://www.business-standard.com/article/news-ians/india-s-health-budget-gets-27-percent-hike-third-lead-114071001282_1.html
 Currently >1000 medicinal plant product companies
 Annual revenues >US $60 billion
 Statistics indicative of rapid growth: >15%/year in the
marketplace for natural plant products
Newmaster SG, et.al. BMC Medicine 2013, 11:222
Pie Chart: World market for herbal medicine in 2002 (Source Laird and Pierce, 2002)
India <1%
B-Biologicals, N- Natural Product, ND-Derived from Natural product, S- Synthetic,
V-Vaccine, S*- Pharmacophore from a natural product, NM- Natural product mimic
Wasay, M. et al. (2014) Nat. Rev. Neurol. doi:10.1038/nrneurol.2014.13.
Indian J Palliat Care. 2013 Sep-Dec; 19(3): 131–138.
(http://www.idf.org/diabetesatlas/5e/the-global-burden)
Why is this happening….??
• Unorganized sector
• Inconspicuous attributes to public
health
• Obscure economic effects
• Minimal impact on and by policy
changes
• Issues: malpractice, quality,
standardization, subjectivity, research
support, ……
What is translational research?
Translational research means different things to different
people, but it seems important to almost everyone.
“bench-to-bedside”
For us- “book” to “bedside”!!
Woolf S.H. JAMA. 2008;299(2):211-213.
Health care
innovations
Public health interventions
- Policy
changes
-Economic
effects
Blumberg R.S. Nature Medicine 18, 35–41 (2012)
http://www.aprn.org.au/sb_cache/resources/id/143/f/Figure1%20Translational%20pathway.JPG
i
The Hindu. October 7, 2013 India’s October 28 Mars mission on schedule: ISRO
http://vidrc-thsti.res.in/index.php
http://www.tmckolkata.com/tmc/ttcrc.php
• Integration of two or more scientific approaches to
solve a complex, multifaceted problem
 Enhancing the rate of discovery
 Novel methods to solve old problems
 Expands the realms of knowledge
 Application of specialized knowledge to new
problems
“Collaborations are common;
but true co-ordinated teamwork is
rare”
In academics or industry
Lone inventor/innovator or
the multifunded
“independent” lab head
pinnacle of success!!!!!
we are wrong to persist in
this single ideal
If we need to
“improve health”
Lone inventor as source of breakthroughs:
myth or reality
Single inventor Teams
Singh et al.,Manage Sci. 2010
Patents were twice likely to be cited
more than the “single inventor”
Transitioning to team science is
“culture change”
intensive commitment
Infrastructure - share the resources
Incentives for participation in team science
Message from leaders
This is where we are
heading for future!!
True leadership stands up and
says “Follow me. I’m
accountable to ALL of you!”
Motivators
Moderators
Mentors
Transformational Leadership
Join forces
Duda GN et.al., Science Translational Medicine, Nov 2014: 6(124)
Anti-HSV activity
Anti-Influenza activity
Anti-malarial activity
Infrastructure (Physical and Organizational)
 Environment development
Never forget the elephant in the room
Duda GN et.al., Science Translational Medicine, Nov 2014: 6(124)
Streamlining funding mechanisms : Govt of India
and AYUSH
Development of specialties in Ayurveda:
Immunology
Endocrinology
Gastroenterology
Basic principle specialties
Infectious diseases
Orientation of research and its conduct :
At graduate, post graduate, doctoral levels
Involving & encouraging teaching faculty
for research
Education programs:
Current updates on statistics, literature
review, ethics, new research tools
Promoting the translational medicine approach
Education – Masters, PhD programs at Each
University
Training - teachers first
Fellowships- Masters and PhD, Post Doc level
Seed Funding for TR- Young faculty
Start it at grass root level and not only at top notch
cities/ Universities/ centers
Adapt a public private partnership model
Share information on research projects of
national importance and perform in compliance
with the national health policy
Go–no go
Duda GN et.al., Science Translational Medicine, Nov 2014: 6(124)
Collaborative efforts
 Time to build trust
 Environment to sustain openness
and data sharing
 Preparedness for disagreements
 Clarification on roles and
responsibilities
“C’mon, put some muscle into it…we’re not getting anywhere!”
Science Commons (http://creativecommons.org/science)
Zink C. Collaboration & Team Science presentation.
JCR: Journal of Clinical Rheumatology & Volume 19, Number 4, June 2013, 227
Dr. Mike Conlon
Dr. Linda Cottler
Dr. Mark Atkinson
Dr. Renuka Munshi-
Kulkarni
Dr. Prema Varthakavi
Topiwala National Medical
College & BYL Nair Ch.
Hospital
www.sacaccp.org
Current work:
• Combination therapy for Type 1
diabetes in NOD mice model
• Use of purified natural compounds also
regarded as GRAS
If you want to go
fast, go alone.
If you want to go
far, go together!
Dr.Nilima Kshirsagar
Dr. Mark Atkinson
“Co-operation”
over
“Competition”
Ekam shastram adhiyano na vidyat
shastranishchaya |
Tasmat bahushrut shastro vijaniyat chikitsakah ||
(Sushruta Samhita/Sutra sthana)
One who knows only one shastra cannot come to any
decisive conclusion. That is why one who has learnt
from many shastras is indeed a physician.
Dhuri K.D., et.al. J Ayurveda Integr Med. 2013 Jan-Mar; 4(1): 40–44.
Acknowledgement :
Acknowledgement :
Acknowledgement :
http://www.visitgainesville.com/gainesville-favorite/?id=71961
http://www.floridarambler.com/florida-bike-hike-trails/paynes-prairie-
preserve-state-park-gainesville/
http://www.pinterest.com/pin/171840542001634363/
http://captainkimo.com/curacao-beach-sunset/

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Advancing ayurveda medicine research public

  • 1. Dr. Priyanka Ingle-Jadhav, Postdoctoral Research Fellow Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA Ayurveda Update 2014
  • 2.  Health care budget gets 27% hike in 2014-15  AYUSH gets 36% hike nearing Rs.1,272.15 crore  High hopes in terms of:  Improving public health (health restoration , disease modulation)  Contribution in drug discovery  Increasing India’s share in global business  Creating sustainable environment for cultivation and exports, job generation  Outreach to the remote parts of India to support economic and easily accessible health care option http://www.business-standard.com/article/news-ians/india-s-health-budget-gets-27-percent-hike-third-lead-114071001282_1.html
  • 3.  Currently >1000 medicinal plant product companies  Annual revenues >US $60 billion  Statistics indicative of rapid growth: >15%/year in the marketplace for natural plant products Newmaster SG, et.al. BMC Medicine 2013, 11:222 Pie Chart: World market for herbal medicine in 2002 (Source Laird and Pierce, 2002) India <1%
  • 4. B-Biologicals, N- Natural Product, ND-Derived from Natural product, S- Synthetic, V-Vaccine, S*- Pharmacophore from a natural product, NM- Natural product mimic
  • 5. Wasay, M. et al. (2014) Nat. Rev. Neurol. doi:10.1038/nrneurol.2014.13. Indian J Palliat Care. 2013 Sep-Dec; 19(3): 131–138. (http://www.idf.org/diabetesatlas/5e/the-global-burden)
  • 6.
  • 7. Why is this happening….?? • Unorganized sector • Inconspicuous attributes to public health • Obscure economic effects • Minimal impact on and by policy changes • Issues: malpractice, quality, standardization, subjectivity, research support, ……
  • 8. What is translational research? Translational research means different things to different people, but it seems important to almost everyone. “bench-to-bedside” For us- “book” to “bedside”!! Woolf S.H. JAMA. 2008;299(2):211-213. Health care innovations Public health interventions - Policy changes -Economic effects
  • 9. Blumberg R.S. Nature Medicine 18, 35–41 (2012) http://www.aprn.org.au/sb_cache/resources/id/143/f/Figure1%20Translational%20pathway.JPG
  • 10.
  • 11. i The Hindu. October 7, 2013 India’s October 28 Mars mission on schedule: ISRO
  • 12.
  • 13.
  • 15. • Integration of two or more scientific approaches to solve a complex, multifaceted problem  Enhancing the rate of discovery  Novel methods to solve old problems  Expands the realms of knowledge  Application of specialized knowledge to new problems
  • 16.
  • 17.
  • 18. “Collaborations are common; but true co-ordinated teamwork is rare”
  • 19. In academics or industry Lone inventor/innovator or the multifunded “independent” lab head pinnacle of success!!!!! we are wrong to persist in this single ideal If we need to “improve health”
  • 20. Lone inventor as source of breakthroughs: myth or reality Single inventor Teams Singh et al.,Manage Sci. 2010 Patents were twice likely to be cited more than the “single inventor”
  • 21. Transitioning to team science is “culture change” intensive commitment
  • 22. Infrastructure - share the resources Incentives for participation in team science Message from leaders This is where we are heading for future!! True leadership stands up and says “Follow me. I’m accountable to ALL of you!”
  • 24. Join forces Duda GN et.al., Science Translational Medicine, Nov 2014: 6(124)
  • 25.
  • 27. Infrastructure (Physical and Organizational)  Environment development
  • 28. Never forget the elephant in the room Duda GN et.al., Science Translational Medicine, Nov 2014: 6(124)
  • 29. Streamlining funding mechanisms : Govt of India and AYUSH
  • 30. Development of specialties in Ayurveda: Immunology Endocrinology Gastroenterology Basic principle specialties Infectious diseases
  • 31. Orientation of research and its conduct : At graduate, post graduate, doctoral levels Involving & encouraging teaching faculty for research Education programs: Current updates on statistics, literature review, ethics, new research tools
  • 32. Promoting the translational medicine approach Education – Masters, PhD programs at Each University Training - teachers first Fellowships- Masters and PhD, Post Doc level Seed Funding for TR- Young faculty Start it at grass root level and not only at top notch cities/ Universities/ centers
  • 33. Adapt a public private partnership model
  • 34. Share information on research projects of national importance and perform in compliance with the national health policy
  • 35. Go–no go Duda GN et.al., Science Translational Medicine, Nov 2014: 6(124)
  • 36. Collaborative efforts  Time to build trust  Environment to sustain openness and data sharing  Preparedness for disagreements  Clarification on roles and responsibilities “C’mon, put some muscle into it…we’re not getting anywhere!”
  • 37. Science Commons (http://creativecommons.org/science) Zink C. Collaboration & Team Science presentation.
  • 38.
  • 39. JCR: Journal of Clinical Rheumatology & Volume 19, Number 4, June 2013, 227
  • 40.
  • 41.
  • 42. Dr. Mike Conlon Dr. Linda Cottler Dr. Mark Atkinson Dr. Renuka Munshi- Kulkarni Dr. Prema Varthakavi Topiwala National Medical College & BYL Nair Ch. Hospital
  • 44. Current work: • Combination therapy for Type 1 diabetes in NOD mice model • Use of purified natural compounds also regarded as GRAS
  • 45. If you want to go fast, go alone. If you want to go far, go together! Dr.Nilima Kshirsagar Dr. Mark Atkinson “Co-operation” over “Competition”
  • 46. Ekam shastram adhiyano na vidyat shastranishchaya | Tasmat bahushrut shastro vijaniyat chikitsakah || (Sushruta Samhita/Sutra sthana) One who knows only one shastra cannot come to any decisive conclusion. That is why one who has learnt from many shastras is indeed a physician. Dhuri K.D., et.al. J Ayurveda Integr Med. 2013 Jan-Mar; 4(1): 40–44.
  • 47.