Advanced monitoring in clinical trials involves the use of various tools, techniques, and strategies to ensure the safety and efficacy of experimental treatments while minimizing risks and maximizing benefits for study participants. This approach goes beyond traditional monitoring methods, such as on-site visits and source data verification, to include more innovative approaches that rely on technology and data analytics. One such technique is remote monitoring, which allows for the collection of data in real-time from study participants using electronic devices, such as smartphones or wearable sensors. This allows researchers to closely monitor participants without requiring them to visit the study site regularly, reducing the burden on both patients and study staff. Advanced statistical methods can be used to analyze this data to identify any potential safety concerns or adverse events. Another approach is risk-based monitoring, which involves using a risk assessment to identify the areas of the study that are most likely to have issues and focus monitoring efforts in those areas. This approach allows for a more targeted and efficient monitoring strategy, saving time and resources while still ensuring participant safety. Advanced monitoring may also involve the use of centralized monitoring, where a team of experts remotely review study data and identify any issues or trends that may require additional investigation. This can include data management errors, protocol deviations, and safety concerns.