This document provides information on physical examination of urine, including volume, color, odor, reaction/pH, and specific gravity. It discusses normal ranges and causes for conditions like nocturia (urinating frequently at night), polyuria (excessive urine production), oliguria (low urine output), and anuria (no urine production). The color, odor, reaction/pH, and specific gravity of urine can provide clues to normal functioning or abnormalities in the urinary system and kidneys. The document was written by Adnan adil, son of Md. Monir alam, a student at USHA MARTIN UNIVERSITY, RANCHI.
The aim of this practical was to sort out mistakes in the hospital biochemistry laboratory where as laboratory has mixed up some urine samples because the label has been lost
WHAT IS URINE ANALYSIS?
Urine analysis, also called Urinalysis – one of the oldest laboratory procedures in the practice of medicine.
Also knows as Urine- R&M (routine & microscopy)
Is an array of tests performed on urine
WHY URINALYSIS?
General evaluation of health
Diagnosis of disease or disorders of the kidneys or urinary tract
Diagnosis of other systemic disease that affect kidney function
Monitoring of patients with diabetes
Screening for drug abuse (eg. Sulfonamide or aminoglycosides)
COLLECTION OF URINE SPECIMENS
Improper collection---- may invalidate the results
Containers for collection of urine should be wide mouthed, clean and dry.
Analyzed within 2 hours of collection else requires refrigeration.
URINE CULTURE
Culture within 1 hour after collection or stored in a refrigerator at 4oC for no more than 18 hours.
Culture is performed when Polynephritis or Cystitis is suspected.
UTI is most frequent caused by E.Coli.
Other common agents are Enterobacter, Proteus, and Enterococcus faecalis.
URINALYSIS; WHAT TO LOOK FOR?
• Urinalysis consists of the following measurements:
Macroscopic or physical examination
Chemical examination
Microscopic examination of the sediment
Urine culture
PHYSICAL EXAMINATION OF URINE
Examination of physical characteristics:
Volume
Color
Odor
pH
Specific gravity
The refractometer or a reagent strip is used to measure specific gravity
PHYSICAL EXAMINATION
Normal- 1-2.5 L/day
Oliguria- Urine Output < 400ml/day
Dehydration
Shock
Acute glomerulonephritis
Renal Failure
Polyuria- Urine Output > 2.5 L/day
Increased water ingestion
Diabetes mellitus and insipidus.
Anuria- Urine output < 100ml/day
Seen in renal shut down Volume
PHYSICAL EXAMINATION
Normal
pale yellow in color due to pigments urochrome (different colour pigments in urine), urobilin (When urobilinogen- degraded product of bilirubin, is exposed to air, it is oxidized to urobilin, giving urine its yellow color) and uroerythrin (red pigment in urine).
Cloudiness
may be caused by excessive cellular material or protein, crystallization or precipitation of non pathological salts upon standing at room temperature or in the refrigerator.
Color
Colour of urine depending upon it’s constituents.
PHYSICAL EXAMINATION
Abnormal Colors:
Colorless – diabetes, diuretics.
Deep Yellow – concentrated urine, excess bile pigments, jaundice Color
Blue-Green – Methylene Blue, Pseudomonas (Bactrium), Riboflavin (Vitamin B2, in FAD give Yellow Orange Color)
Pink-Orange-Red – Hemoglobin, Myoglobin, Phenolphthalein, Porphyrins, Rifampicin (antibiotic against TB give orange color to urine)
Red-Brown-Black - Hemoglobin, Myoglobin, Red Blood Cells, Homogentisic acid (Homogentisic acid present in Blood and its oxidized form alkapton are excreted in the urine, giving it an unusually dark color), L-DOPA (Levodopa, is the most effective drug for Parkinson’s disease), Melanin (brown Pigment)
The aim of this practical was to sort out mistakes in the hospital biochemistry laboratory where as laboratory has mixed up some urine samples because the label has been lost
WHAT IS URINE ANALYSIS?
Urine analysis, also called Urinalysis – one of the oldest laboratory procedures in the practice of medicine.
Also knows as Urine- R&M (routine & microscopy)
Is an array of tests performed on urine
WHY URINALYSIS?
General evaluation of health
Diagnosis of disease or disorders of the kidneys or urinary tract
Diagnosis of other systemic disease that affect kidney function
Monitoring of patients with diabetes
Screening for drug abuse (eg. Sulfonamide or aminoglycosides)
COLLECTION OF URINE SPECIMENS
Improper collection---- may invalidate the results
Containers for collection of urine should be wide mouthed, clean and dry.
Analyzed within 2 hours of collection else requires refrigeration.
URINE CULTURE
Culture within 1 hour after collection or stored in a refrigerator at 4oC for no more than 18 hours.
Culture is performed when Polynephritis or Cystitis is suspected.
UTI is most frequent caused by E.Coli.
Other common agents are Enterobacter, Proteus, and Enterococcus faecalis.
URINALYSIS; WHAT TO LOOK FOR?
• Urinalysis consists of the following measurements:
Macroscopic or physical examination
Chemical examination
Microscopic examination of the sediment
Urine culture
PHYSICAL EXAMINATION OF URINE
Examination of physical characteristics:
Volume
Color
Odor
pH
Specific gravity
The refractometer or a reagent strip is used to measure specific gravity
PHYSICAL EXAMINATION
Normal- 1-2.5 L/day
Oliguria- Urine Output < 400ml/day
Dehydration
Shock
Acute glomerulonephritis
Renal Failure
Polyuria- Urine Output > 2.5 L/day
Increased water ingestion
Diabetes mellitus and insipidus.
Anuria- Urine output < 100ml/day
Seen in renal shut down Volume
PHYSICAL EXAMINATION
Normal
pale yellow in color due to pigments urochrome (different colour pigments in urine), urobilin (When urobilinogen- degraded product of bilirubin, is exposed to air, it is oxidized to urobilin, giving urine its yellow color) and uroerythrin (red pigment in urine).
Cloudiness
may be caused by excessive cellular material or protein, crystallization or precipitation of non pathological salts upon standing at room temperature or in the refrigerator.
Color
Colour of urine depending upon it’s constituents.
PHYSICAL EXAMINATION
Abnormal Colors:
Colorless – diabetes, diuretics.
Deep Yellow – concentrated urine, excess bile pigments, jaundice Color
Blue-Green – Methylene Blue, Pseudomonas (Bactrium), Riboflavin (Vitamin B2, in FAD give Yellow Orange Color)
Pink-Orange-Red – Hemoglobin, Myoglobin, Phenolphthalein, Porphyrins, Rifampicin (antibiotic against TB give orange color to urine)
Red-Brown-Black - Hemoglobin, Myoglobin, Red Blood Cells, Homogentisic acid (Homogentisic acid present in Blood and its oxidized form alkapton are excreted in the urine, giving it an unusually dark color), L-DOPA (Levodopa, is the most effective drug for Parkinson’s disease), Melanin (brown Pigment)
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2. *Physical examination of urine*
•AIM:-physical examination of urine.
• Introduction of physical examination of urine :- it is consists of volume, colour,
odour, reaction/P.H and specific gravity.
1. Volume:-normal range of urine Volume is 700-2500ml & average Volume of
urine are 1200ml.
• Nocturia:-Nocturia is a condition that causes you to wake up during the night
pee is called nocturnal.
• urine passed >500ml during the night is known as nocturia.
• Causes of nocturia:-
• Drinking too much fluid before bedtime.
• Reduced bladder capacity.
• Bladder obstruction, swelling & pain in you bladder.
6. • Polyuria:- Polyuria means excessive urine production is called Polyuria.
• Urine passed >2500ml in 24hrs is known as Polyuria.
• Causes of Polyuria:- Central diabetes insipidus (partial or complete).
• Amyloidosis.
• Hypercalcemia (due to cancer, hyperparathyroidism, or granulomatous disease).
• Hypokalemia.
• Obstruction uropathy.
• Sickle cell disease.
• Inherited disorder.
• Drugs (lithium, cidofovir, foscarnet).
• Kidney disease or kidney failure.
• Liver disease.
7. • Symptoms of Polyuria:-
• Feel thristy. You’re losing a lot of fluid, and that can lead to dehydration.
• Wake up often at night. Your urge to go doesn’t stop when you sleep.
• Oliguria:- Oliguria is the medical term for low urine output. If you have a blockage,
your kidney are producing urine but you aren’t able to excrete it
• If you aren’t producing urine, you may have disease of the kidneys, heart or lungs
is known as oliguria.
• Urine passed <500ml in 24hrs is called oliguria.
• Causes of oliguria:- low blood volume (Hypovolemia)
• Heavy blood loss, decrease fluid intake, burns, sepsis, liver failure and surgery.
• Heart and lung problem.
• Vascular disease of your kidneys, acute tubular necrosis & urethral stones.
8. • Anuria:- Anuria is a medical emergency. Your kidneys are responsible for
removing waste and extra fluid from your body & when the wastes and fluids
build up in your body, it can be very dangerous in fatal.
• Complete cessation of urine is passed <150ml in 24hrs is called anuria.
• Causes of anuria:- extreme dehydration.
• Blood loss.
• Severe infection.
• Shock.
• Heart & liver failure.
9. • Colour:-Normal urine colour is pale yellow & straw colour due to pigment
urochrome.
1. Red colour due to haematuria and hemoglobinuria.
2. Brown colour due to bile.
3. Orange colour due to urobilinogen.
4. Milky colour due to pus or fat.
5. Colourless colour due to diabetes inspidus and diabetes mellitus.
6. Green colour due to phenol poisoning.
7. Smoky colour due to small amount of blood.
8. Deep Amber colour due muscular excercise and high fever.
Odour:-Normal has aromatic faint odour.
• Putrid due to UTI.
10. • Fruity due to ketonacidosis.
• Mousy due to phenylketonuria.
Reaction/p.h:-It reflect of kidney maintain H+ ion concentration in plasma and
extracellar fluids.
• Normal range of p.h is 4.6 to 7.0 and average range is 6.0
Acidic urine is due to the following:-
1. High protein.
2. Respiratory and metabolic acidosis.
3. UTI by E.coli.
Alkaline urine is due to the following:-
1. Vegetable.
2. Respiratory and metabolic alkalosis.
3. UTI by proteus.
11. Specific gravity:-Normal range 1.003 to 1.030.
Low specific gravity occur in:-
• Excess water.
• Diabetes inspidus.
High specific gravity occur in:-
• Dehydration.
• Albuminuria.
• Thanks you
Written by:-
Adnan adil , S/0 Md. Monir alam.