Adipose tissue as endocrine tissue.ppt
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Adipose tissue functions as an endocrine organ that secretes hormones and cytokines. It is composed of white adipose tissue, which stores energy, and brown adipose tissue, which generates body heat. Adipocytes secrete factors that affect neighboring cells and target tissues involved in processes like energy metabolism, influencing physiology and disease. As an endocrine organ, adipose tissue plays an important role beyond basic energy storage.
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Presentation NEJM.pptx
Fat, or adipose tissue, is not a single entity but rather a collection of different depots that serve important functions. It develops early in pregnancy and stores energy in the form of triglycerides. Excess visceral fat poses more health risks than subcutaneous fat. Brown fat helps regulate body temperature in infants and beige fat shares properties of both white and brown fat. Adipose tissue is dynamic and communicates with other organs to regulate metabolism. When enlarged beyond a certain size through obesity, adipose tissue becomes dysfunctional and inflammatory, increasing disease risks.
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The document discusses how obesity leads to increased production of reactive oxygen species through the secretion of adipokines like leptin, TNF-α, and IL-6 from adipose tissue, which induce oxidative stress. Adipokines are bioactive substances produced by adipose tissue that regulate processes like food intake, insulin sensitivity, and inflammation. Chronic oxidative stress and reduced antioxidant defenses that result from obesity lead to endothelial dysfunction and increased risk of diseases like atherosclerosis.
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The document discusses leptin, an adipokine that regulates energy metabolism. Leptin is produced mainly by adipose tissue and acts through the hypothalamus to inhibit food intake and increase energy expenditure. Elevated levels in obesity fail to produce these effects, resulting in leptin resistance. Leptin binds to receptors in the hypothalamus and activates signaling pathways involving JAK2/STAT3 and MAPK/ERK. It controls appetite by regulating neuropeptides in the hypothalamus. The document also provides information on antibodies for detecting leptin.
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This document reviews the role of peroxisome proliferator-activated receptor gamma (PPARγ) in adipose tissue function and how its activation can improve outcomes related to obesity, diabetes and cardiovascular disease. It discusses how adipose tissue regulates lipid and glucose metabolism as well as endocrine function. In obesity, adipose tissue becomes dysfunctional with changes in adipocyte morphology and metabolism and increased inflammation. PPARγ activation in adipose tissue alters fat distribution and phenotype, upregulates genes related to fatty acid metabolism, and affects the expression of various adipokines in a way that improves insulin sensitivity and other metabolic parameters. Therefore, PPARγ activators may help prevent progression from insulin resistance to diabetes or cardiovascular disease.
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This document discusses insulin resistance and related topics. It begins with a brief history of insulin resistance and defines it as a failure of target organs to respond normally to insulin. It then discusses various factors that can contribute to insulin resistance, including obesity, diet, genetics, and certain drugs. The document also discusses the metabolic syndrome, which includes insulin resistance along with other risk factors. It provides diagnostic criteria for metabolic syndrome and discusses treatments like weight loss, exercise, and dietary changes. The rest of the document discusses various proteins and cytokines secreted by adipose tissue, such as leptin, adiponectin, resistin, and TNF-alpha, and their roles in insulin resistance. It also discusses how lack of adipose tissue can
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Presentation NEJM.pptx
Fat, or adipose tissue, is not a single entity but rather a collection of different depots that serve important functions. It develops early in pregnancy and stores energy in the form of triglycerides. Excess visceral fat poses more health risks than subcutaneous fat. Brown fat helps regulate body temperature in infants and beige fat shares properties of both white and brown fat. Adipose tissue is dynamic and communicates with other organs to regulate metabolism. When enlarged beyond a certain size through obesity, adipose tissue becomes dysfunctional and inflammatory, increasing disease risks.
Obesità e stress ossidativo: una relazione pericolosa.
The document discusses how obesity leads to increased production of reactive oxygen species through the secretion of adipokines like leptin, TNF-α, and IL-6 from adipose tissue, which induce oxidative stress. Adipokines are bioactive substances produced by adipose tissue that regulate processes like food intake, insulin sensitivity, and inflammation. Chronic oxidative stress and reduced antioxidant defenses that result from obesity lead to endothelial dysfunction and increased risk of diseases like atherosclerosis.
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1. Lysosomal storage disorders: These occur due to defects in lysosomal enzymes or transport proteins that are responsible for breaking down macromolecules. This causes substrates to accumulate within lysosomes, leading to cellular dysfunction. Over 100 lysosomal storage disorders have been identified.
2. Impaired autophagy: Lysosomes play a key role in autophagy, the process by which cells break down and recycle damaged organelles and proteins. Defects in autophagy-lysosomal pathways have been linked to neurodegenerative diseases, myopathies, cancers and other disorders.
3. Sphingolipid storage diseases: These
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The document discusses leptin, an adipokine that regulates energy metabolism. Leptin is produced mainly by adipose tissue and acts through the hypothalamus to inhibit food intake and increase energy expenditure. Elevated levels in obesity fail to produce these effects, resulting in leptin resistance. Leptin binds to receptors in the hypothalamus and activates signaling pathways involving JAK2/STAT3 and MAPK/ERK. It controls appetite by regulating neuropeptides in the hypothalamus. The document also provides information on antibodies for detecting leptin.
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This document reviews the role of peroxisome proliferator-activated receptor gamma (PPARγ) in adipose tissue function and how its activation can improve outcomes related to obesity, diabetes and cardiovascular disease. It discusses how adipose tissue regulates lipid and glucose metabolism as well as endocrine function. In obesity, adipose tissue becomes dysfunctional with changes in adipocyte morphology and metabolism and increased inflammation. PPARγ activation in adipose tissue alters fat distribution and phenotype, upregulates genes related to fatty acid metabolism, and affects the expression of various adipokines in a way that improves insulin sensitivity and other metabolic parameters. Therefore, PPARγ activators may help prevent progression from insulin resistance to diabetes or cardiovascular disease.
Adipose tissue histology
- Adipose tissue contains adipocytes that store triglycerides and regulate energy metabolism through secretion of hormones. There are two types: white and brown adipose tissue.
- White adipose tissue is the main site for energy storage. It is found throughout the body. Brown adipose tissue helps generate heat and is found in newborns and certain regions of adults.
- White and brown adipocytes differ in lipid droplet size, mitochondrial content, and gene expression factors that regulate their differentiation and function. Recent research focuses on browning of white fat, adipose tissue engineering, and stem cells.
Insulin Resistance
This document discusses insulin resistance and related topics. It begins with a brief history of insulin resistance and defines it as a failure of target organs to respond normally to insulin. It then discusses various factors that can contribute to insulin resistance, including obesity, diet, genetics, and certain drugs. The document also discusses the metabolic syndrome, which includes insulin resistance along with other risk factors. It provides diagnostic criteria for metabolic syndrome and discusses treatments like weight loss, exercise, and dietary changes. The rest of the document discusses various proteins and cytokines secreted by adipose tissue, such as leptin, adiponectin, resistin, and TNF-alpha, and their roles in insulin resistance. It also discusses how lack of adipose tissue can
Hunger, Eating, and HealthWhy Do Many People Eat Too Muc.docx
Hunger, Eating,
and Health
Why Do Many People
Eat Too Much?
12.1 Digestion, Energy Storage, and
Energy Utilization
12.2 Theories of Hunger and Eating: Set Points
versus Positive Incentives
12.3 Factors That Determine What, When, and
How Much We Eat
12.4 Physiological Research on Hunger and Satiety
12.5 Body Weight Regulation: Set Points
versus Settling Points
12.6 Human Obesity: Causes, Mechanisms,
and Treatments
12.7 Anorexia and Bulimia Nervosa
12
IS
B
N
0-558-78571-9
Biopsychology, Eighth Edition, by John P.J. Pinel. Published by Allyn & Bacon. Copyright © 2011 by Pearson Education, Inc.
source of serious personal and health problems.
Most eating-related health problems in industrialized
nations are associated with eating too much—the average
American consumes 3,800 calories per day, about twice
the average daily requirement (see Kopelman, 2000). For
example, it is estimated that
65% of the adult U.S. popu-
lation is either overweight or
clinically obese, qualifying
this problem for epidemic status (see Abelson & Kennedy,
2004; Arnold, 2009). The resulting financial and personal
costs are huge. Each year in the United States, about $100
billion is spent treating obesity-related disorders (see Ol-
shansky et al., 2005). Moreover, each year, an estimated
300,000 U.S. citizens die from disorders caused by their
excessive eating (e.g., diabetes, hypertension, cardiovas-
cular diseases, and some cancers). Although the United
States is the trend-setter when it comes to overeating and
obesity, many other countries are not far behind (Sofsian,
2007). Ironically, as overeating and obesity have reached
epidemic proportions, there has been a related increase in
disorders associated with eating too little (see Polivy &
Herman, 2002). For example, almost 3% of American
adolescents currently suffer from anorexia or bulimia,
which can be life-threatening in extreme cases.
The massive increases in obesity and other eating-
related disorders that have occurred over the last few
decades in many countries stand in direct opposition to
most people’s thinking about hunger and eating. Many
people—and I assume that this includes you—believe
that hunger and eating are normally triggered when the
body’s energy resources fall
below a prescribed optimal
level, or set point. They ap-
preciate that many factors in-
fluence hunger and eating, but they assume that the
hunger and eating system has evolved to supply the body
with just the right amount of energy.
This chapter explores the incompatibility of the set-
point assumption with the current
epidemic of eating disorders. If we
all have hunger and eating systems
whose primary function is to maintain energy resources
at optimal levels, then eating disorders should be rare.
The fact that they are so prevalent suggests that hunger
and eating are regulated in some other way. This chapter
will repeatedly challenge you to think in new ways about
issues that impact your health and longevity and w.
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Obesity and psychotic disorders
Obesity is associated with various comorbidities known as metabolic syndrome. Excess fat storage can exceed the capacity of adipose tissue, leading to fat accumulation in other tissues and lipotoxicity. Lipidomics research studies the complete lipid profile and has revealed lipids associated with insulin resistance and diabetes risk. Beyond metabolic syndrome, obesity is also linked to increased risk of psychotic disorders. Lipid abnormalities have been found in the brains of schizophrenia patients. Monitoring one's lipid profile through diet and exercise can help prevent metabolic disturbances.
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CVD is a major health problem caused by plaque buildup in arteries. Vitamin E helps prevent CVD by protecting LDL from oxidation, a key step in plaque formation. The document discusses how vitamin E works as an antioxidant, the bioavailability of its different forms, and dietary sources of vitamin E like vegetables, nuts and seeds that are part of heart-healthy diets like the AHA and DASH diets and may help reduce CVD risk.
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adipocytes.ppt
1. Adipose-derived stem cells hold promise for regenerative medicine applications including transformation into beta-like cells. They can be isolated from adipose tissue using collagenase digestion.
2. Studies show human adipocyte stem cells can differentiate into insulin-producing cells expressing pancreatic genes, though further studies are needed on cell function.
3. Leptin administration may help reduce the number of islet cells needed for transplantation by improving glucose control and insulin sensitivity in diabetes models.
Adiponectin
1. Adiponectin is a hormone produced by adipose tissue that plays an important role in glucose regulation and fatty acid catabolism. Low levels are associated with obesity, diabetes, and other insulin resistant states.
2. The document discusses the history, structure, receptors and metabolic effects of adiponectin. It acts through receptors AdipoR1/R2 to increase fatty acid oxidation and insulin sensitivity.
3. Dysregulation of adiponectin is implicated in metabolic syndrome and related conditions. Certain drugs like thiazolidinediones are shown to increase adiponectin levels and may have therapeutic potential.
Cell
The document discusses key aspects of cell biochemistry and structure. It summarizes that the cell is the basic structural and functional unit of all organisms, and is made up of a membrane, nucleus, cytoplasm and organelles. The main organelles, including the mitochondria, endoplasmic reticulum, ribosomes, Golgi apparatus and lysosomes are described along with their specific functions in cellular processes like respiration, protein synthesis, packaging and secretion, and digestion. Cellular functions require energy generated through metabolic pathways that take place within these organellar compartments and the cytosol.
Macromolecules
This document discusses nutrients and their importance for human health. It begins by explaining how food provides energy and building blocks for the body through macromolecules like carbohydrates, lipids, proteins, and nucleic acids. It then goes on to describe each of these macromolecules in more detail, including their components, structures, and roles in the body. The document also discusses vitamins, minerals, water and what can happen if essential nutrients are not obtained, like conditions such as kwashiorkor and scurvy. Overall, the document provides a comprehensive overview of different nutrients and their significance for proper bodily function.
Nutrient sensing and metabolic disturbances
This document summarizes potential causes of metabolic syndrome and insulin resistance, including ectopic fat accumulation, impaired fat oxidation, defects in mitochondrial function, and impaired lipid metabolism. It also discusses adipose tissue as an endocrine organ and the roles of adipocytokines like adiponectin and resistin. Finally, it examines nutrient sensing pathways such as AMPK that regulate cellular energy levels and metabolism.
Visceral Obesity Final
The document discusses how fat tissue is essential but obesity has become a worldwide epidemic. It describes several factors that have contributed to increased obesity rates, including changes to the human diet with the introduction of cereal grains, refined sugars and oils through agriculture, a more sedentary lifestyle, and genetic factors. The rise in obesity is linked to various metabolic diseases like type 2 diabetes, dyslipidemia, and insulin resistance.
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Hunger, Eating, and HealthWhy Do Many People Eat Too Muc.docx
Hunger, Eating,
and Health
Why Do Many People
Eat Too Much?
12.1 Digestion, Energy Storage, and
Energy Utilization
12.2 Theories of Hunger and Eating: Set Points
versus Positive Incentives
12.3 Factors That Determine What, When, and
How Much We Eat
12.4 Physiological Research on Hunger and Satiety
12.5 Body Weight Regulation: Set Points
versus Settling Points
12.6 Human Obesity: Causes, Mechanisms,
and Treatments
12.7 Anorexia and Bulimia Nervosa
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IS
B
N
0-558-78571-9
Biopsychology, Eighth Edition, by John P.J. Pinel. Published by Allyn & Bacon. Copyright © 2011 by Pearson Education, Inc.
source of serious personal and health problems.
Most eating-related health problems in industrialized
nations are associated with eating too much—the average
American consumes 3,800 calories per day, about twice
the average daily requirement (see Kopelman, 2000). For
example, it is estimated that
65% of the adult U.S. popu-
lation is either overweight or
clinically obese, qualifying
this problem for epidemic status (see Abelson & Kennedy,
2004; Arnold, 2009). The resulting financial and personal
costs are huge. Each year in the United States, about $100
billion is spent treating obesity-related disorders (see Ol-
shansky et al., 2005). Moreover, each year, an estimated
300,000 U.S. citizens die from disorders caused by their
excessive eating (e.g., diabetes, hypertension, cardiovas-
cular diseases, and some cancers). Although the United
States is the trend-setter when it comes to overeating and
obesity, many other countries are not far behind (Sofsian,
2007). Ironically, as overeating and obesity have reached
epidemic proportions, there has been a related increase in
disorders associated with eating too little (see Polivy &
Herman, 2002). For example, almost 3% of American
adolescents currently suffer from anorexia or bulimia,
which can be life-threatening in extreme cases.
The massive increases in obesity and other eating-
related disorders that have occurred over the last few
decades in many countries stand in direct opposition to
most people’s thinking about hunger and eating. Many
people—and I assume that this includes you—believe
that hunger and eating are normally triggered when the
body’s energy resources fall
below a prescribed optimal
level, or set point. They ap-
preciate that many factors in-
fluence hunger and eating, but they assume that the
hunger and eating system has evolved to supply the body
with just the right amount of energy.
This chapter explores the incompatibility of the set-
point assumption with the current
epidemic of eating disorders. If we
all have hunger and eating systems
whose primary function is to maintain energy resources
at optimal levels, then eating disorders should be rare.
The fact that they are so prevalent suggests that hunger
and eating are regulated in some other way. This chapter
will repeatedly challenge you to think in new ways about
issues that impact your health and longevity and w.
Fat cells.pdf
Adipose tissue, also known as body fat, is an important metabolic tissue composed primarily of adipocytes or fat cells. It exists in two main types - white adipose tissue which stores excess calories, and brown adipose tissue which generates heat by burning calories through non-shivering thermogenesis. Increasing levels of adipose tissue have been linked to health problems like obesity, diabetes and heart disease. Adipose tissue performs important endocrine functions by secreting hormone-like molecules called adipokines that regulate processes like energy balance, food intake and inflammatory response. Crosstalk between adipose tissue and epithelial tumors can accelerate cancer through several mechanisms.
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Obesity is associated with various comorbidities known as metabolic syndrome. Excess fat storage can exceed the capacity of adipose tissue, leading to fat accumulation in other tissues and lipotoxicity. Lipidomics research studies the complete lipid profile and has revealed lipids associated with insulin resistance and diabetes risk. Beyond metabolic syndrome, obesity is also linked to increased risk of psychotic disorders. Lipid abnormalities have been found in the brains of schizophrenia patients. Monitoring one's lipid profile through diet and exercise can help prevent metabolic disturbances.
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adipocytes.ppt
1. Adipose-derived stem cells hold promise for regenerative medicine applications including transformation into beta-like cells. They can be isolated from adipose tissue using collagenase digestion.
2. Studies show human adipocyte stem cells can differentiate into insulin-producing cells expressing pancreatic genes, though further studies are needed on cell function.
3. Leptin administration may help reduce the number of islet cells needed for transplantation by improving glucose control and insulin sensitivity in diabetes models.
Adiponectin
1. Adiponectin is a hormone produced by adipose tissue that plays an important role in glucose regulation and fatty acid catabolism. Low levels are associated with obesity, diabetes, and other insulin resistant states.
2. The document discusses the history, structure, receptors and metabolic effects of adiponectin. It acts through receptors AdipoR1/R2 to increase fatty acid oxidation and insulin sensitivity.
3. Dysregulation of adiponectin is implicated in metabolic syndrome and related conditions. Certain drugs like thiazolidinediones are shown to increase adiponectin levels and may have therapeutic potential.
Cell
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Macromolecules
This document discusses nutrients and their importance for human health. It begins by explaining how food provides energy and building blocks for the body through macromolecules like carbohydrates, lipids, proteins, and nucleic acids. It then goes on to describe each of these macromolecules in more detail, including their components, structures, and roles in the body. The document also discusses vitamins, minerals, water and what can happen if essential nutrients are not obtained, like conditions such as kwashiorkor and scurvy. Overall, the document provides a comprehensive overview of different nutrients and their significance for proper bodily function.
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This document summarizes potential causes of metabolic syndrome and insulin resistance, including ectopic fat accumulation, impaired fat oxidation, defects in mitochondrial function, and impaired lipid metabolism. It also discusses adipose tissue as an endocrine organ and the roles of adipocytokines like adiponectin and resistin. Finally, it examines nutrient sensing pathways such as AMPK that regulate cellular energy levels and metabolism.
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Canine Obesity: An Inflammatory Disease Related To Oxidative Stress-Crimson ...
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办理毕业证(UPenn毕业证)宾夕法尼亚大学毕业证成绩单快速办理
官方原版办理宾夕法尼亚大学毕业证【微信176555708】学历认证怎么做：原版仿制宾夕法尼亚大学电子版成绩单毕业证认证【宾夕法尼亚大学毕业证成绩单】、宾夕法尼亚大学文凭证书成绩单复刻offer录取通知书、购买UPenn圣力嘉学院本科毕业证、【宾夕法尼亚大学毕业证办理UPenn毕业证书哪里买】、宾夕法尼亚大学 Offer在线办理UPenn Offer宾夕法尼亚大学Bachloer Degree。（留信学历认证永久存档查询）采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
◆◆◆◆◆ — — — — — — — — 【留学教育】留学归国服务中心 — — — — — -◆◆◆◆◆
【主营项目】
一.毕业证【微信：176555708】成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！
二.真实使馆公证(即留学回国人员证明,不成功不收费)
三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）
四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度)
如果您处于以下几种情况：
◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【微信：176555708】
◇面对父母的压力，希望尽快拿到；
◇不清楚认证流程以及材料该如何准备；
◇回国时间很长，忘记办理；
◇回国马上就要找工作，办给用人单位看；
◇企事业单位必须要求办理的
◇需要报考公务员、购买免税车、落转户口
◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分→ 【关于价格问题（保证一手价格）
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
选择实体注册公司办理，更放心，更安全！我们的承诺：可来公司面谈，可签订合同，会陪同客户一起到教育部认证窗口递交认证材料，客户在教育部官方认证查询网站查询到认证通过结果后付款，不成功不收费！
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
学历顾问：微信：176555708
假文凭国外(Adelaide毕业证)澳大利亚国立大学毕业证成绩单办理
购买澳大利亚国立大学毕业证>【微信176555708】办理澳大利亚国立大学毕业证成绩单【微信176555708】Adelaide毕业证成绩单Adelaide学历证书Adelaide文凭【Adelaide毕业套号文凭网认证澳大利亚国立大学毕业证成绩单】【哪里买澳大利亚国立大学毕业证文凭Adelaide成绩学校快递邮寄信封】【开版澳大利亚国立大学文凭】Adelaide留信认证本科硕士学历认证(诚招代理)微信：176555708办理国外高校毕业证成绩单文凭学位证,真实使馆公证（留学回国人员证明）真实留信网认证国外学历学位认证雅思代考国外学校代申请名校保录开请假条改GPA改成绩ID卡
1.高仿业务:【本科硕士】毕业证,成绩单（GPA修改）,学历认证（教育部认证）,大学Offer,,ID,留信认证,使馆认证,雅思,语言证书等高仿类证书；
2.认证服务: 学历认证（教育部认证）,大使馆认证（回国人员证明）,留信认证（可查有编号证书）,大学保录取,雅思保分成绩单。
3.技术服务：钢印水印烫金激光防伪凹凸版设计印刷激凸温感光标底纹镭射速度快。
办理澳大利亚国立大学澳大利亚国立大学毕业证成绩单流程：
1客户提供办理信息：姓名生日专业学位毕业时间等（如信息不确定可以咨询顾问：我们有专业老师帮你查询）；
2开始安排制作毕业证成绩单电子图；
3毕业证成绩单电子版做好以后发送给您确认；
4毕业证成绩单电子版您确认信息无误之后安排制作成品；
5成品做好拍照或者视频给您确认；
6快递给客户（国内顺丰国外DHLUPS等快读邮寄）
-办理真实使馆公证（即留学回国人员证明）
-办理各国各大学文凭（世界名校一对一专业服务,可全程监控跟踪进度）
-全套服务：毕业证成绩单真实使馆公证真实教育部认证。让您回国发展信心十足！
（详情请加一下 文凭顾问+微信:176555708）欢迎咨询！
不能毕业如何获得(USYD毕业证)悉尼大学毕业证成绩单一比一原版制作
挂科购买☀【悉尼大学毕业证购买】【微信176555708】【USYD毕业证模板办理】加拿大文凭、本科、硕士、研究生学历都可以做,二、业务范围：
★、全套服务：毕业证、成绩单、化学专业毕业证书伪造【悉尼大学大学毕业证】微信176555708【USYD学位证书购买】◆◆◆◆◆ — — — 归国服务中心 — — -◆◆◆◆◆
【主营项目】
一.毕业证、成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！
二.真实使馆公证(即留学回国人员证明,不成功不收费)
三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）
四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度)
国外毕业证、学位证、成绩单办理流程：
1、客户提供办理信息：姓名、生日、专业、学位、毕业时间等（如信息不确定可以咨询顾问：【微信176555708】我们有专业老师帮你查询）；
2、开始安排制作毕业证、成绩单电子图；
3、毕业证、成绩单电子版做好以后发送给您确认；
4、毕业证、成绩单电子版您确认信息无误之后安排制作成品；
5、成品做好拍照或者视频给您确认；
6、快递给客户（国内顺丰，国外DHL、UPS等快读邮寄）。
专业服务，请勿犹豫联系我！本公司是留学创业和海归创业者们的桥梁。一次办理，终生受用，一步到位，高效服务。详情请在线咨询办理,欢迎有诚意办理的客户咨询!洽谈。
◆招聘代理：本公司诚聘英国、加拿大、澳洲、新西兰、加拿大、法国、德国、新加坡各地代理人员，如果你有业余时间，有兴趣就请联系我们咨询【微信176555708】
没文凭怎么找工作。让您回国发展信心十足！
★、真实教育部学历学位认证；（一对一专业服务，可全程监控跟踪进度）
★、真实使馆认证，可以通过大使馆查询确认；（即教育部留服认证，不成功不收费）
★、毕业证、成绩单等材料，从防伪到印刷、水印到钢印烫金，高精仿度都是跟学校原版100%相同的；（敬请放心使用）
★、可以提供钢印、水印、烫金、激光防伪、凹凸版、最新版的毕业证、百分之百让您绝对满意、
★、印刷，DHL快递毕业证、成绩单7个工作日，真实大使馆教育部认证1个月。为了达到高水准高效率。
Gen Z and the marketplaces - let's translate their needs
The product workshop focused on exploring the requirements of Generation Z in relation to marketplace dynamics. We delved into their specific needs, examined the specifics in their shopping preferences, and analyzed their preferred methods for accessing information and making purchases within a marketplace. Through the study of real-life cases , we tried to gain valuable insights into enhancing the marketplace experience for Generation Z.
The workshop was held on the DMA Conference in Vienna June 2024.
Discover the benefits of outsourcing SEO to India
"Discover the benefits of outsourcing SEO to India! From cost-effective services and expert professionals to round-the-clock work advantages, learn how your business can achieve digital success with Indian SEO solutions.
办理毕业证(NYU毕业证)纽约大学毕业证成绩单官方原版办理
退学买【纽约大学毕业证认证】【办证微信176555708】【纽约大学文凭毕业证制作】【NYU学历学位证书哪里买】办理纽约大学学位证书扫描件、办理纽约大学雅思证书！
国际留学归国服务中心【如何办纽约大学毕业证认证】【NYU学位证书扫描件哪里买】实体公司，注册经营，行业标杆，精益求精！（留信学历认证永久存档查询）采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
◆◆◆◆◆ — — — — — — — — 【留学教育】留学归国服务中心 — — — — — -◆◆◆◆◆
【主营项目】
一.毕业证【微信：176555708】成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！
二.真实使馆公证(即留学回国人员证明,不成功不收费)
三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）
四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度)
如果您处于以下几种情况：
◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【微信：176555708】
◇面对父母的压力，希望尽快拿到；
◇不清楚认证流程以及材料该如何准备；
◇回国时间很长，忘记办理；
◇回国马上就要找工作，办给用人单位看；
◇企事业单位必须要求办理的
◇需要报考公务员、购买免税车、落转户口
◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分→ 【关于价格问题（保证一手价格）
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
选择实体注册公司办理，更放心，更安全！我们的承诺：可来公司面谈，可签订合同，会陪同客户一起到教育部认证窗口递交认证材料，客户在教育部官方认证查询网站查询到认证通过结果后付款，不成功不收费！
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
学历顾问：微信：176555708
成绩单ps(UST毕业证)圣托马斯大学毕业证成绩单快速办理
一比一原版制作UST毕业证【微信176555708】圣托马斯大学毕业证书原版↑制作圣托马斯大学学历认证文凭办理圣托马斯大学留信网认证,留学回国办理毕业证成绩单文凭学历认证【微信176555708】专业为海外学子办理毕业证成绩单、文凭制作，学历仿制，回国人员证明、做文凭，研究生、本科、硕士学历认证、留信认证、结业证、学位证书样本、美国教育部认证百分百真实存档可查】（留信学历认证永久存档查询）采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
◆◆◆◆◆ — — — — — — — — 【留学教育】留学归国服务中心 — — — — — -◆◆◆◆◆
【主营项目】
一.毕业证【微信：176555708】成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！
二.真实使馆公证(即留学回国人员证明,不成功不收费)
三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）
四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度)
如果您处于以下几种情况：
◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【微信：176555708】
◇面对父母的压力，希望尽快拿到；
◇不清楚认证流程以及材料该如何准备；
◇回国时间很长，忘记办理；
◇回国马上就要找工作，办给用人单位看；
◇企事业单位必须要求办理的
◇需要报考公务员、购买免税车、落转户口
◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分→ 【关于价格问题（保证一手价格）
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
选择实体注册公司办理，更放心，更安全！我们的承诺：可来公司面谈，可签订合同，会陪同客户一起到教育部认证窗口递交认证材料，客户在教育部官方认证查询网站查询到认证通过结果后付款，不成功不收费！
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
学历顾问：微信：176555708
办理新西兰奥克兰大学毕业证学位证书范本原版一模一样
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制作毕业证书(ANU毕业证)莫纳什大学毕业证成绩单官方原版办理
在线办理莫纳什大学毕业证【微信：176555708】(ANU毕业证书)成绩单学位证【微信：176555708】，留信认证（真实可查，永久存档）纸张工艺/offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。#一整套莫纳什大学文凭证件办理#—包含莫纳什大学莫纳什大学毕业证文凭证书学历认证|使馆认证|归国人员证明|教育部认证|留信网认证永远存档教育部学历学位认证查询办理国外文凭国外学历学位认证#我们提供全套办理服务。
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4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
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国外证书(Lincoln毕业证)新西兰林肯大学毕业证成绩单不能毕业办理
退学办理新西兰林肯大学毕业证【微信176555708】学历认证怎么做：原版仿制新西兰林肯大学电子版成绩单毕业证认证【新西兰林肯大学毕业证成绩单】、新西兰林肯大学文凭证书成绩单复刻offer录取通知书、购买Lincoln圣力嘉学院本科毕业证、【新西兰林肯大学毕业证办理Lincoln毕业证书哪里买】、新西兰林肯大学 Offer在线办理Lincoln Offer新西兰林肯大学Bachloer Degree。1客户提供办理信息：姓名生日专业学位毕业时间等（如信息不确定可以咨询顾问：微信176555708我们有专业老师帮你查询）；
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Adipose tissue as endocrine tissue.ppt
- 1. ADIPOSE TISSUE AS AN ENDOCRINE ORGAN By:
- 3. o Adipose tissue: • White adipose tissue (WAT): stores energy • Brown adipose tissue (BAT: generates body heat 3
- 4. The most significant physiological functions of WAT 4
- 5. Adipose tissue as an endocrine organ 5
- 6. 6
- 7. 7
- 8. o Very little is known about the potential function of resistin. 8
- 9. o Visfatin have insulino-mimetic action: Because it bind insulin receptors at a site that differs from that of insulin and reduces blood glucose level. 9
- 10. Adipose tissue is the primary storage site for excess energy but it is also recognized as an endocrine organ. Adipocytes are now generally accepted to be a complex cell type generating a number of signals which include hormones and growth factors that not involved in cytokines, affect the only neighboring cells but also impact target tissues involved in energy metabolism and influencing physiologic and pathologic processes. 40
- 11. 11
- 12. Scheja, Ludger; Heeren, Joerg (September 2019). "The endocrine function of adipose tissues in health and cardiometabolic disease". Nature Reviews Endocrinology. 15 (9): 507–524. doi:10.1038/s41574-019-0230-6 Ge, Tongtong; Fan, Jie; Yang, Wei; Cui, Ranji; Li, Bingjin (26 October 2018). "Leptin in depression: a potential therapeutic target". Cell Death & Disease. 9 (11): 1096. doi:10.1038/s41419-018-1129- 1. PMC 6203758. PMID 30367065 Coelho, Marisa; Oliveira, Teresa; Fernandes, Ruben (2013-04-20). "Biochemistry of adipose tissue: an endocrine organ". Archives of Medical Science. 9 (2): 191–200. doi:10.5114/aoms.2013.33181 REFERENCES