This document provides an overview of acute pancreatitis, including:
- The epidemiology, with highest rates in the US and among males related to alcohol use.
- The pathophysiology, involving premature activation of digestive enzymes within the pancreas.
- Diagnosis is based on abdominal pain plus elevated pancreatic enzymes or imaging findings. Severity is assessed using scores like Ranson's criteria or CT severity index.
- Treatment involves fluid resuscitation, nutritional support, pain management, and antibiotics only for proven or suspected infected pancreatic necrosis. The goals are to prevent complications and infections.
An inflammatory condition of the pancreas
Acute pancreatitis is a reversible process,
whereas Chronic pancreatitis (CP) is irreversible
Acinar Cell Injury
This includes a brief account on epidemiology, pathophysiology, clinical presentation, investigation, treatment, complications and disposition of a patient presenting with acute pancreatitis.
Management of Acute Pancreatitis By Dr. Dhaval Mangukiya
https://drdhavalmangukiya.com/
http://www.youtube.com/c/DrDhavalMangukiyaGastrosurgeonSurat
https://gastrosurgerysurat.blogspot.com/
An inflammatory condition of the pancreas
Acute pancreatitis is a reversible process,
whereas Chronic pancreatitis (CP) is irreversible
Acinar Cell Injury
This includes a brief account on epidemiology, pathophysiology, clinical presentation, investigation, treatment, complications and disposition of a patient presenting with acute pancreatitis.
Management of Acute Pancreatitis By Dr. Dhaval Mangukiya
https://drdhavalmangukiya.com/
http://www.youtube.com/c/DrDhavalMangukiyaGastrosurgeonSurat
https://gastrosurgerysurat.blogspot.com/
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
9. Mechanisms against Auto-digestion
of Pancreas
• Packing of enzyme in precursor form
• Synthesis of trypsin inhibitor
• Low calcium level inside acinar cell promote trypsin destruction
10. Gallstone pancreatitis
• Reflux of bile into the pancreatic duct due to
transient obstruction of the ampulla during
passage of gallstones
• Obstruction at the ampulla secondary to stone(s) or
edema resulting from the passage of a stone .
16. DIAGNOSIS
AP established by the presence of 2 of
the 3 following criteria:
• 1. Abdominal pain consistent with the
disease
• 2. Serum amylase and / or lipase greater
than three times the upper limit of normal
• 3.Characteristic findings from abdominal
imaging
18. SERUM AMYLASE
• ONSET: almost immediately
• PEAK: within several hours
• 3-4 times upper limit of normal within 24 hrs (90%)
• RETURN to normal depends on severity(3-5 days)
• normal at time of admission in 20% cases
• Compared with lipase, returns more quickly to values below
the upper limit of normal.
19.
20. • more sensitive/specific than amylase
• Remains elevated longer than amylase(12 days)
• Useful if late presentation
• Serum Lipase:
21. DIAGNOSIS
Contrast-enhanced computed tomography (CECT)
and / or magnetic resonance imaging (MRI) of the pancreas
should be reserved for patients in whom (3- 5 days later )
• The diagnosis is unclear
• Who fail to improve clinically within the first 48– 72 h after
hospital admission
• Evaluate complications
22.
23. DIAGNOSIS
MRI is helpful in patients with :
• A contrast allergy
• Renal insufficiency where T2-weighted images
without gadolinium contrast can diagnose pancreatic
necrosis
The American Journal of Gastroenterology , (30 July 2013) | doi:10.1038/ajg.2013.218
Guideline: Management of Acute Pancreatitis
24. ETIOLOGICALINVESTIGATIONS
• Abdominal ultrasound should be performed in all patients with AP
• In the absence of gallstones and / or history of significant history of
alcohol use, serum triglyceride should be obtained and
considered the etiology if >1000 mg/dl
The American Journal of Gastroenterology , (30 July 2013) | doi:10.1038/ajg.2013.218
Guideline: Management of Acute Pancreatitis
25. • Alcohol-induced pancreatitis the diagnosis
should not be entertained unless a person has a
history of over 5 years of heavy alcohol
consumption ( > 50 g per day, but is often
much higher )
• In a patient > 40 years old, a pancreatic tumor
should be considered as a possible cause of AP
26. • Genetic testing may be considered in
young patients (< 30 years old) if no
cause is evident & a family history of
pancreatic disease is present
27. IDIOPATHIC AP
• IAP is defined as pancreatitis with no etiology
established after initial laboratory (including lipid and
calcium level) and imaging tests (transabdominal
ultrasound and CT in the appropriate patient)
28. A focal dilated proximal jejunal loop in the left upper quadrant.
A focal area of adynamic ileus close to an intraabdominal
inflammatory process The sentinel loop sign may aid in
localizing the source of inflammation.
29. -Colon Cut-off Sign describes gaseous distension seen in
proximal colon
-Associated with narrowing of splenic flexure in cases
of Acute Pancreatitis
-This Appearance results from inflammatory process
extending from Pancreas into the phrenicolic ligament via
transverse mesocolon
34. Bedside index of severity in acute
pancreatitis (BISAP)score
•
•
BUN>25 mg/dL (8.9 mmol/L)
Impairment of mental status with aGlasgowcoma
score <15
SIRS(systemic inflammatory response syndrome) Age
>60 years old
Pleural effusion
•
•
•
Eachdeterminant is given one point
SIRSis defined as2 or more of the followingvariables;
• Fever of more than 38°C(100.4°F) or lessthan 36°C(96.8°F)
• Heart rate of more than 90 beats per minute
• Respiratory rate of >20 breaths per minute or PaCO2<32mm Hg
• Abnormal white blood cell count (>12,000/µL or <4,000/µL or >10%immature [band] forms)
Wu BU et al GUT 2008
Singh VK et al Am.J.Gastro 2009
41. TREATMENT GUIDELINES
• Supportive
• Transfer to intensive care
• Nutritional support
• Use of prophylactic antibiotics
• Treatment of infected necrosis
• Treatment of sterile necrosis
• Role of ERCP and biliary
sphinchterotomy
42. INITIAL MANAGEMENT
• NPO
•Obtain vital signs at frequent intervals
(such as every 4-6 h)
• ABG should be performed when oxygen
saturation is ≤95% , hypoxemia or hypotension
refractory to a bolus of IV fluids
43. PAIN MANAGEMENT
• Parenteral analgesics usually needed.
• A number of parenteral narcotics are used
• In past, morphine avoided due to a concern it cause spasm of
the SOD and worsens although no evidence in humans .
• Meperidine with the accumulation of a neurotoxic
metabolite (normeperidine) ,relatively short duration of
action, and many hospitals have severely limited its use..
• Hydromorphine may thus be preferred.
44. INITIAL MANAGEMENT
ICU
Transfer to ICU should be considered If there are :
• Signs that suggest that the pancreatitis is severe
or is likely to be severe
• Need for very aggressive fluid resuscitation to
overcome hemoconcentration, especially in an
older person who may have underlying
cardiovascular disease
• If a patient does not have hypoxemia but is
showing signs of labored respiration, transfer
should be considered to monitor pulmonary status
carefully in anticipation
45. INITIAL MANAGEMENT
• Fluid therapy in acute pancreatitis:
Adequate prompt fluid resuscitation
- Fluids are given intravenously
- Aim to maintain urine output >0.5 ml/kg
46. INITIAL MANAGEMENT
• Aggressive hydration, defined as 250-500ml per hour of
isotonic crystalloid solution should be provided to all
patients, unless cardiovascular, renal, or other related
comorbid factors exist
• Early aggressive intravenous hydration is most
beneficial during the first 12 – 24 hr, and may have little
benefit beyond this time period
• In a patient with severe volume depletion, manifest as
hypotension and tachycardia, more rapid repletion
(bolus) may be needed
47. • Lactated Ringer solution may be the preferred
isotonic crystalloid replacement fluid
• Fewer patients developing SIRS as compared with
patients receiving normal (0.9% ) saline
• Normal saline given in large volumes may lead to the
development of a non-anion gap hyperchloremic
metabolic acidosis
INITIAL MANAGEMENT
48.
49. INITIAL MANAGEMENT
• Fluid requirements should be
reassessed at frequent intervals within
6 hr of admission and for the next 24 –
48 hr
• The goal to decrease hematocrit
(demonstrating hemodilution) and
BUN (increasing renal perfusion)
and maintain a normal creatinine
during the first day of hospitalization
50. NUTRITION IN AP
• In mild AP, oral feedings can be started
immediately if there is no nausea and
vomiting, and the abdominal pain has
resolved
• In mild AP, initiation of feeding with a
low-fat solid diet appears as safe as a
clear liquid diet
51. INITIAL MANAGEMENT
Oral intake of limited amounts of calories is usually
initiated in:-
1) Abdominal pain has subsided
2) Parenteral narcotics are no longer required
3) Abdominal tenderness has markedly decreased
4) Nausea and vomiting have ceased
5) Bowel sounds are present
6) Overall assessment of the physician is that the patient
has improved
52. NUTRITION IN AP
• In severe AP, enteral nutrition is recommended to
prevent
infectious complications.
• Parenteral nutrition should be avoided, unless the
enteral route is
- - Not available
- - Not tolerated
- - Not meeting caloric requirements
• Nasogastric delivery and Nasojejunal delivery of
enteral feeding appear comparable in efficacy and
safety
53.
54. NUTRITION IN AP
Enteral Feeding
• Stabilizes gut barrier function,
prevent systemic complications and
improve morbidity and mortality
• Enteral feeding is safer and less expensive
than TPN, but there is not major
improvements in morbidity and mortality of
acute pancreatitis
55. NUTRITION IN AP
• Role of immediate oral feeding versus
fasting in 60 patients with AP
• The orally fed group had a significant 2-day shorter
length of hospital stay without differences in
recurrent attacks of pancreatitis in a follow-up of 3
months.
56.
57. ROLE OF ANTIBIOTICS INAP
• Routine use of prophylactic antibiotics in
patients with severe AP is not recommended
• The use of antibiotics in patients with sterile
necrosis to prevent the development of
infected necrosis is not recommended
• Antibiotics should be given for an extra-
pancreatic infection, such as cholangitis,
catheter-acquired infections, bacteremia,
urinary tract infections, pneumonia
58. ROLE OF ANTIBIOTICS INAP
• Infected necrosis should be considered in
patients with pancreatic or extrapancreatic necrosis who
deteriorate or fail to improve after 7– 10 days of
hospitalization
(ii
)
(i) Initial CT-guided (FNA) for Gram stain and culture to guide
use of appropriate antibiotics or
Empiric use of antibiotics after obtaining necessary
cultures for infectious agents, without CT FNA, should
be given
59. THE ROLE OF ANTIBIOTICSIN
AP
• Once blood and other cultures are found to be
negative and no source of infection is identified,
antibiotics should be discontinued.
• In patients with infected necrosis, antibiotics
known to penetrate pancreatic necrosis, such
as carbapenems, quinolones, and
metronidazole
• Routine administration of antifungal agents along
with prophylactic or therapeutic antibiotics is not
recommended
60.
61.
62.
63. ERCP IN AP
• Patients with AP and concurrent acute
cholangitis should undergo ERCP
within 24 hr of admission
• ERCP is not needed early in most
patients with gallstone pancreatitis who
lack laboratory or clinical evidence
of ongoing biliary obstruction
64. ERCP IN AP
ERCP is indicated for clearance of bile duct
stones in patients with :
- Severe worsening biliary pancreatitis
- Cholangitis
- Poor candidates for cholecystectomy
- Post cholecystectomy
- Strong evidence of persistent biliary
obstruction
65. TREATMENT OF INFECTED
NECROSIS
• Treatment of choice in infected necrosis is surgical
debridement
(NOW minimal invasive procedure preferred )
• 33% of patients with necrotizing pancreatitis develop
infected necrosis, usually after 10 days of illness
• 48% of patients with infected necrosis have persistent
organ failure, either documented initially at admission
or sometime after admission
66. • In stable patients with infected necrosis,
surgical, radiologic, and/ or endoscopic drainage
should be delayed by preferably 4 weeks to allow the
development of a wall around the necrosis (walled-
off pancreatic necrosis).
67. TREATMENT OF
STERILE NECROSIS
• Sterile necrosis is best managed medically during the
first 2–3
wk
• After this interval, if abdominal pain persists and
prevents oral intake, debridement should be
considered.
• This is usually accomplished surgically, but
percutaneous or endoscopic debridement is a
reasonable choice in selected circumstances with
the appropriate expertise.
68.
69.
70. When to Discharge
Pain is well controlled with oral analgesia
Able to tolerate an oral diet that maintains their caloric needs,
and all complications have been addressed adequately
71. Follow up
• Routine clinical follow-up care (typically including physical
examinationand amylase and lipase assays) is needed to monitor
for potential complications of the pancreatitis, especially
pseudocysts Within 7-10 days
72. Prognosis
TYPE OF AP MORTALITY
Overall 10-15 %
(Biliary>alcholic)
Mild Acute Pancreatitis(80 % cases) 1 %
Severe Acute Pancreatitis(20 %
cases)
Severe 20-50 %
<1 week 1/3 cases MOF
>1 week 2/3 cases Sepsi
s
(+MO
F)
74. REFERENCES:
Harrison principal of internal medicine 20th edition
The American Journal of Gastroenterology , Guideline:
Management of Acute Pancreatitis
Meta-analysis of parenteral nutrition versus enteral nutrition in
patients with acute pancreatitis BMJ 2004; 328