SlideShare a Scribd company logo
ACUTE AND CHRONIC
RENAL FAILURE
M.MALARVANNAN & M.ELAVARASAN
2ND B.PHARM
THANTHAI ROEVER COLLEGE OF PHARMACY
ACUTE RENAL FAILURE.
DEFINITION:
 Acute renal failure is a decline in renal function by the inability of the
kidney to excrete metabolic waste products (nitrogenous waste and
water) and maintain acid-base balance.
 The waste substances build up to dangerous levels in the body and the
chemical balance of the blood is upset. The condition is life-threatening
and requires immediate hospital treatment.
AZOTEMIA:
Elevation in nitrogenous waste products.
e.g. (creatinine and urea nitrogen).
UREMIA:
clinical syndrome resulting from azotemia characterized by anorexia,
nausea, vomiting and mental status changes.
CAUSES.
 Hypotension, due to fall in blood pressure of reduced blood supply.
 Glomerulonephrosis, inflammation of glomeruli, the tiny filtering unit.
 Hydronephrosis, blockage in the urinary tract causes both kidneys to
swell with urine.
HYDRONEPHROSIS & INFLAMMATION OF THE
GLOMERULI.
PATHOPHYSIOLOGY.
 Acute renal failure result in alterations to any of the four basic
components they are
 VASCULATURE.
 GLOMERULI.
 TUBULES.
 INTERSTITIUM.
 AZOTEMIA (decreased renal perfusion).
 Azotemia is a elevation of blood urea nitrogen (BNU) and serum creatinine
levels. The reference range for BUN is 8-20 mg/dL and normal range for
serum creatinine 0.7-1.4 mg/dL.
 INTRINSIC RENAL FAILURE (structural damage to kidney).
 Vascular disease, renal artery obstruction (atherosclerosis, thrombosis).
 I schema (lack of blood flow to an organ), toxins.
 POST RENAL OBSTRUCTION (obstruction of urine flow from the kidney
out of the body).
SYMPTOMS.
o Greatly reduced urine volume.
o Nausea.
o Vomiting.
o Drowsiness.
o Headache.
o Back pain.
DROWSINESS AND BACK PAIN.
DIAGNOSIS.
KIDNEY BIOPSY.
 Ultra sound scanning or
computed tomography scanning.
 Kidney biopsy to examine
kidney tissue.
TREATMENT.
 CRITICAL CARE UNIT: To care people in a critical or unstable
condition, who requires continuous monitoring.
 DIALYSIS: Replacing the function of kidney, excess fluid and waste
products can be from blood stream.
 Blood transfusion.
CHRONIC RENAL FAILUR.
 Chronic renal failure is defined as chronic renal insufficiency (CRI)
denotes a creatinine clearance Crcl 50-80 ml/min; moderate CRI 30-
50 ml/min; severe 15-30 ml/min. gradual and progress loss of function
in kidneys.
 Patients requiring chronic dialysis or renal transplantation for relief of
uremic symptom are said to be end-stage renal disease (ESRD).
PATHOPHYSIOLOGY:
 Multiple risk factors identified for renal disease includes the following
 Diabetes.
 High blood pressure.
 Proteinuria.
 Increasing age.
 Hyperlipidaemia.
 Family history of renal disease.
HYPERLIPIDEMIA.
 Hyperlipidemia is
abnormally elevated
levels of any or all lipid
and / or lipoproteins in
the blood.
Abnormal amount of protein
is present in the urine. Due to
the disease in the glomerulus.
PROTINURIA:
SYMPTOMS:
 Frequent urination, during night.
 Pale, itchy, easily brushed skin.
 Shortness of breath.
 Persistent hiccups.
 Nausea and vomiting.
 Muscular twitching.
 Cramps in the legs.
HICCUPS AND MUSCULAR TWITCHING.
DIAGNOSIS:
 Ultra sound scanning or CT scanning to assess the size of
the kidney.
 KIDNEY BIOPSY: Small piece of kidney tissue is removed
and examined under microscope to determine the nature
of kidney damage.
TREATMENT USE DRUGS.
 Corticosteroids
Beclomethazone.
Dexamethazone.
Prednisolone.
Triamcinolone.
PREDNISOLONE.
 Prednisolone is a corticosteroid
it works by modifying the
body's immune response to
various conditions and
deceasing inflammation.
Acute and Chronic Renal Failure

More Related Content

What's hot

Renal failure
Renal failure Renal failure
Renal failure
Mathew Varghese V
 
Notes on renal failure
Notes on renal failureNotes on renal failure
Notes on renal failure
Babitha Devu
 
Acute renal failure
Acute renal failureAcute renal failure
Acute renal failure
Abhay Rajpoot
 
Acute renal failure
Acute renal failureAcute renal failure
Acute renal failure
DR .PALLAVI PATHANIA
 
Acute and chronic renal failure
Acute and chronic renal failureAcute and chronic renal failure
Acute and chronic renal failure
Subramani Parasuraman
 
Renal disease.ppt
Renal disease.pptRenal disease.ppt
Renal disease.ppt
Shama
 
Acute and chronic renal failure
Acute and chronic renal failureAcute and chronic renal failure
Acute and chronic renal failure
Hizbullah Khan
 
Liver cirrhosis
Liver cirrhosisLiver cirrhosis
Liver cirrhosis
Nikhil Vaishnav
 
Rheumatoid arthritis
Rheumatoid arthritisRheumatoid arthritis
Rheumatoid arthritis
Syed Muhammad Ali Shah
 
Rheumatoid arthritis ppt by ann..
Rheumatoid arthritis ppt by ann..Rheumatoid arthritis ppt by ann..
Rheumatoid arthritis ppt by ann..
Anjali Rarichan
 
Acute Kidney Injury
Acute Kidney InjuryAcute Kidney Injury
Acute Kidney Injury
Hayelom Michael Deyo
 
Liver failure
Liver failureLiver failure
Liver failure
Phani Kumar Reddy
 
Nephrosis period1
Nephrosis period1Nephrosis period1
Nephrosis period1
romswinckel
 
Acute renal failure
Acute renal failureAcute renal failure
Acute renal failure
Jijo G John
 
Nephortic syndrome
Nephortic syndromeNephortic syndrome
Nephortic syndrome
ANILKUMAR BR
 
Chronic Renal Failure
Chronic Renal Failure Chronic Renal Failure
Chronic Renal Failure
YOUAN BI BENIET MARIUS
 
Glomerulonephritis
GlomerulonephritisGlomerulonephritis
Glomerulonephritis
Sachin Gadade
 
Chronic renal failure
Chronic renal  failureChronic renal  failure
Chronic renal failure
ROMAN BAJRANG
 
Management of ckd
Management of ckdManagement of ckd
Management of ckd
Adams Inusah
 
Acute and Chronic Renal Failure. Easy Slides.
Acute and Chronic Renal Failure. Easy Slides.Acute and Chronic Renal Failure. Easy Slides.
Acute and Chronic Renal Failure. Easy Slides.
Anubhav Singh
 

What's hot (20)

Renal failure
Renal failure Renal failure
Renal failure
 
Notes on renal failure
Notes on renal failureNotes on renal failure
Notes on renal failure
 
Acute renal failure
Acute renal failureAcute renal failure
Acute renal failure
 
Acute renal failure
Acute renal failureAcute renal failure
Acute renal failure
 
Acute and chronic renal failure
Acute and chronic renal failureAcute and chronic renal failure
Acute and chronic renal failure
 
Renal disease.ppt
Renal disease.pptRenal disease.ppt
Renal disease.ppt
 
Acute and chronic renal failure
Acute and chronic renal failureAcute and chronic renal failure
Acute and chronic renal failure
 
Liver cirrhosis
Liver cirrhosisLiver cirrhosis
Liver cirrhosis
 
Rheumatoid arthritis
Rheumatoid arthritisRheumatoid arthritis
Rheumatoid arthritis
 
Rheumatoid arthritis ppt by ann..
Rheumatoid arthritis ppt by ann..Rheumatoid arthritis ppt by ann..
Rheumatoid arthritis ppt by ann..
 
Acute Kidney Injury
Acute Kidney InjuryAcute Kidney Injury
Acute Kidney Injury
 
Liver failure
Liver failureLiver failure
Liver failure
 
Nephrosis period1
Nephrosis period1Nephrosis period1
Nephrosis period1
 
Acute renal failure
Acute renal failureAcute renal failure
Acute renal failure
 
Nephortic syndrome
Nephortic syndromeNephortic syndrome
Nephortic syndrome
 
Chronic Renal Failure
Chronic Renal Failure Chronic Renal Failure
Chronic Renal Failure
 
Glomerulonephritis
GlomerulonephritisGlomerulonephritis
Glomerulonephritis
 
Chronic renal failure
Chronic renal  failureChronic renal  failure
Chronic renal failure
 
Management of ckd
Management of ckdManagement of ckd
Management of ckd
 
Acute and Chronic Renal Failure. Easy Slides.
Acute and Chronic Renal Failure. Easy Slides.Acute and Chronic Renal Failure. Easy Slides.
Acute and Chronic Renal Failure. Easy Slides.
 

Similar to Acute and Chronic Renal Failure

Diseases of urogenital tract
Diseases of urogenital tractDiseases of urogenital tract
Diseases of urogenital tract
DrRavi Jain
 
Renal disase [autosaved]
Renal disase [autosaved]Renal disase [autosaved]
Renal disase [autosaved]
Ibrahim Muneim
 
Renal diseases 2.ppt
Renal diseases 2.pptRenal diseases 2.ppt
Renal diseases 2.ppt
Isatoubah3
 
acutekidneyinjuryinchildren-180409134138.pdf
acutekidneyinjuryinchildren-180409134138.pdfacutekidneyinjuryinchildren-180409134138.pdf
acutekidneyinjuryinchildren-180409134138.pdf
drmanzoor234
 
Acute kidney injury in children 2018
Acute kidney injury in children 2018Acute kidney injury in children 2018
Acute kidney injury in children 2018
Raghav Kakar
 
AKI AND CKD
AKI AND CKDAKI AND CKD
AKI AND CKD
Eric General
 
Renal function test
Renal function testRenal function test
Renal function test
IPMS- KMU KPK PAKISTAN
 
ACUTE RENAL FAILURE OR ACUTE KIDNEY DISEASE
ACUTE RENAL FAILURE OR ACUTE KIDNEY DISEASEACUTE RENAL FAILURE OR ACUTE KIDNEY DISEASE
ACUTE RENAL FAILURE OR ACUTE KIDNEY DISEASE
JITENDRAKUMARDAS15
 
MUCLecture_2022_4117770.pptx by Dr.Raafat.
MUCLecture_2022_4117770.pptx by Dr.Raafat.MUCLecture_2022_4117770.pptx by Dr.Raafat.
MUCLecture_2022_4117770.pptx by Dr.Raafat.
ssuser47b89a
 
Renal disease wps office
Renal disease wps officeRenal disease wps office
Renal disease wps office
home
 
Group 3 Fisher
Group 3 FisherGroup 3 Fisher
Group 3 Fisher
shenell delfin
 
RENAL FAILURE
RENAL FAILURERENAL FAILURE
RENAL FAILURE
Keagan Kirugo
 
GENITO URINARY DISORDERS-2.pptx
GENITO URINARY DISORDERS-2.pptxGENITO URINARY DISORDERS-2.pptx
GENITO URINARY DISORDERS-2.pptx
Sushil Humane
 
CKD MANAGEMENT.pdf
CKD MANAGEMENT.pdfCKD MANAGEMENT.pdf
CKD MANAGEMENT.pdf
Moses Dumbuya
 
Acute Kidney Injury.pptx
Acute Kidney Injury.pptxAcute Kidney Injury.pptx
Acute Kidney Injury.pptx
Mahima Panhalkar
 
Guideline, management of acute kidney injury
Guideline, management of acute kidney injuryGuideline, management of acute kidney injury
Guideline, management of acute kidney injury
vita madmo
 
Dr tasnim acute & chronic renal failure
Dr tasnim acute & chronic renal failureDr tasnim acute & chronic renal failure
Dr tasnim acute & chronic renal failure
dr Tasnim
 
renalfunctiontests01.ppt
renalfunctiontests01.pptrenalfunctiontests01.ppt
renalfunctiontests01.ppt
FarhanAbbas43
 
Acute renal failure.
Acute renal failure.Acute renal failure.
Acute renal failure.
hatch_jane
 
GENITO-URINARY SYSTEM DISORDERS PART-1.
GENITO-URINARY SYSTEM DISORDERS PART-1.GENITO-URINARY SYSTEM DISORDERS PART-1.
GENITO-URINARY SYSTEM DISORDERS PART-1.
DR .PALLAVI PATHANIA
 

Similar to Acute and Chronic Renal Failure (20)

Diseases of urogenital tract
Diseases of urogenital tractDiseases of urogenital tract
Diseases of urogenital tract
 
Renal disase [autosaved]
Renal disase [autosaved]Renal disase [autosaved]
Renal disase [autosaved]
 
Renal diseases 2.ppt
Renal diseases 2.pptRenal diseases 2.ppt
Renal diseases 2.ppt
 
acutekidneyinjuryinchildren-180409134138.pdf
acutekidneyinjuryinchildren-180409134138.pdfacutekidneyinjuryinchildren-180409134138.pdf
acutekidneyinjuryinchildren-180409134138.pdf
 
Acute kidney injury in children 2018
Acute kidney injury in children 2018Acute kidney injury in children 2018
Acute kidney injury in children 2018
 
AKI AND CKD
AKI AND CKDAKI AND CKD
AKI AND CKD
 
Renal function test
Renal function testRenal function test
Renal function test
 
ACUTE RENAL FAILURE OR ACUTE KIDNEY DISEASE
ACUTE RENAL FAILURE OR ACUTE KIDNEY DISEASEACUTE RENAL FAILURE OR ACUTE KIDNEY DISEASE
ACUTE RENAL FAILURE OR ACUTE KIDNEY DISEASE
 
MUCLecture_2022_4117770.pptx by Dr.Raafat.
MUCLecture_2022_4117770.pptx by Dr.Raafat.MUCLecture_2022_4117770.pptx by Dr.Raafat.
MUCLecture_2022_4117770.pptx by Dr.Raafat.
 
Renal disease wps office
Renal disease wps officeRenal disease wps office
Renal disease wps office
 
Group 3 Fisher
Group 3 FisherGroup 3 Fisher
Group 3 Fisher
 
RENAL FAILURE
RENAL FAILURERENAL FAILURE
RENAL FAILURE
 
GENITO URINARY DISORDERS-2.pptx
GENITO URINARY DISORDERS-2.pptxGENITO URINARY DISORDERS-2.pptx
GENITO URINARY DISORDERS-2.pptx
 
CKD MANAGEMENT.pdf
CKD MANAGEMENT.pdfCKD MANAGEMENT.pdf
CKD MANAGEMENT.pdf
 
Acute Kidney Injury.pptx
Acute Kidney Injury.pptxAcute Kidney Injury.pptx
Acute Kidney Injury.pptx
 
Guideline, management of acute kidney injury
Guideline, management of acute kidney injuryGuideline, management of acute kidney injury
Guideline, management of acute kidney injury
 
Dr tasnim acute & chronic renal failure
Dr tasnim acute & chronic renal failureDr tasnim acute & chronic renal failure
Dr tasnim acute & chronic renal failure
 
renalfunctiontests01.ppt
renalfunctiontests01.pptrenalfunctiontests01.ppt
renalfunctiontests01.ppt
 
Acute renal failure.
Acute renal failure.Acute renal failure.
Acute renal failure.
 
GENITO-URINARY SYSTEM DISORDERS PART-1.
GENITO-URINARY SYSTEM DISORDERS PART-1.GENITO-URINARY SYSTEM DISORDERS PART-1.
GENITO-URINARY SYSTEM DISORDERS PART-1.
 

Recently uploaded

Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Oleg Kshivets
 
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
rishi2789
 
Role of Mukta Pishti in the Management of Hyperthyroidism
Role of Mukta Pishti in the Management of HyperthyroidismRole of Mukta Pishti in the Management of Hyperthyroidism
Role of Mukta Pishti in the Management of Hyperthyroidism
Dr. Jyothirmai Paindla
 
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.GawadHemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
NephroTube - Dr.Gawad
 
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptxVestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
Dr. Rabia Inam Gandapore
 
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachIntegrating Ayurveda into Parkinson’s Management: A Holistic Approach
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
Ayurveda ForAll
 
Chapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptxChapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptx
Earlene McNair
 
Efficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in AyurvedaEfficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in Ayurveda
Dr. Jyothirmai Paindla
 
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdfCHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
rishi2789
 
Artificial Intelligence Symposium (THAIS)
Artificial Intelligence Symposium (THAIS)Artificial Intelligence Symposium (THAIS)
Artificial Intelligence Symposium (THAIS)
Josep Vidal-Alaball
 
Post-Menstrual Smell- When to Suspect Vaginitis.pptx
Post-Menstrual Smell- When to Suspect Vaginitis.pptxPost-Menstrual Smell- When to Suspect Vaginitis.pptx
Post-Menstrual Smell- When to Suspect Vaginitis.pptx
FFragrant
 
The Nervous and Chemical Regulation of Respiration
The Nervous and Chemical Regulation of RespirationThe Nervous and Chemical Regulation of Respiration
The Nervous and Chemical Regulation of Respiration
MedicoseAcademics
 
Identifying Major Symptoms of Slip Disc.
 Identifying Major Symptoms of Slip Disc. Identifying Major Symptoms of Slip Disc.
Identifying Major Symptoms of Slip Disc.
Gokuldas Hospital
 
Histopathology of Rheumatoid Arthritis: Visual treat
Histopathology of Rheumatoid Arthritis: Visual treatHistopathology of Rheumatoid Arthritis: Visual treat
Histopathology of Rheumatoid Arthritis: Visual treat
DIVYANSHU740006
 
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
19various
 
Osteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdfOsteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdf
Jim Jacob Roy
 
Medical Quiz ( Online Quiz for API Meet 2024 ).pdf
Medical Quiz ( Online Quiz for API Meet 2024 ).pdfMedical Quiz ( Online Quiz for API Meet 2024 ).pdf
Medical Quiz ( Online Quiz for API Meet 2024 ).pdf
Jim Jacob Roy
 
Adhd Medication Shortage Uk - trinexpharmacy.com
Adhd Medication Shortage Uk - trinexpharmacy.comAdhd Medication Shortage Uk - trinexpharmacy.com
Adhd Medication Shortage Uk - trinexpharmacy.com
reignlana06
 
Complementary feeding in infant IAP PROTOCOLS
Complementary feeding in infant IAP PROTOCOLSComplementary feeding in infant IAP PROTOCOLS
Complementary feeding in infant IAP PROTOCOLS
chiranthgowda16
 
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấuK CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
HongBiThi1
 

Recently uploaded (20)

Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
 
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
 
Role of Mukta Pishti in the Management of Hyperthyroidism
Role of Mukta Pishti in the Management of HyperthyroidismRole of Mukta Pishti in the Management of Hyperthyroidism
Role of Mukta Pishti in the Management of Hyperthyroidism
 
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.GawadHemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
 
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptxVestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
 
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachIntegrating Ayurveda into Parkinson’s Management: A Holistic Approach
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
 
Chapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptxChapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptx
 
Efficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in AyurvedaEfficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in Ayurveda
 
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdfCHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
 
Artificial Intelligence Symposium (THAIS)
Artificial Intelligence Symposium (THAIS)Artificial Intelligence Symposium (THAIS)
Artificial Intelligence Symposium (THAIS)
 
Post-Menstrual Smell- When to Suspect Vaginitis.pptx
Post-Menstrual Smell- When to Suspect Vaginitis.pptxPost-Menstrual Smell- When to Suspect Vaginitis.pptx
Post-Menstrual Smell- When to Suspect Vaginitis.pptx
 
The Nervous and Chemical Regulation of Respiration
The Nervous and Chemical Regulation of RespirationThe Nervous and Chemical Regulation of Respiration
The Nervous and Chemical Regulation of Respiration
 
Identifying Major Symptoms of Slip Disc.
 Identifying Major Symptoms of Slip Disc. Identifying Major Symptoms of Slip Disc.
Identifying Major Symptoms of Slip Disc.
 
Histopathology of Rheumatoid Arthritis: Visual treat
Histopathology of Rheumatoid Arthritis: Visual treatHistopathology of Rheumatoid Arthritis: Visual treat
Histopathology of Rheumatoid Arthritis: Visual treat
 
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
 
Osteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdfOsteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdf
 
Medical Quiz ( Online Quiz for API Meet 2024 ).pdf
Medical Quiz ( Online Quiz for API Meet 2024 ).pdfMedical Quiz ( Online Quiz for API Meet 2024 ).pdf
Medical Quiz ( Online Quiz for API Meet 2024 ).pdf
 
Adhd Medication Shortage Uk - trinexpharmacy.com
Adhd Medication Shortage Uk - trinexpharmacy.comAdhd Medication Shortage Uk - trinexpharmacy.com
Adhd Medication Shortage Uk - trinexpharmacy.com
 
Complementary feeding in infant IAP PROTOCOLS
Complementary feeding in infant IAP PROTOCOLSComplementary feeding in infant IAP PROTOCOLS
Complementary feeding in infant IAP PROTOCOLS
 
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấuK CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
 

Acute and Chronic Renal Failure

  • 1. ACUTE AND CHRONIC RENAL FAILURE M.MALARVANNAN & M.ELAVARASAN 2ND B.PHARM THANTHAI ROEVER COLLEGE OF PHARMACY
  • 2. ACUTE RENAL FAILURE. DEFINITION:  Acute renal failure is a decline in renal function by the inability of the kidney to excrete metabolic waste products (nitrogenous waste and water) and maintain acid-base balance.  The waste substances build up to dangerous levels in the body and the chemical balance of the blood is upset. The condition is life-threatening and requires immediate hospital treatment.
  • 3. AZOTEMIA: Elevation in nitrogenous waste products. e.g. (creatinine and urea nitrogen). UREMIA: clinical syndrome resulting from azotemia characterized by anorexia, nausea, vomiting and mental status changes.
  • 4. CAUSES.  Hypotension, due to fall in blood pressure of reduced blood supply.  Glomerulonephrosis, inflammation of glomeruli, the tiny filtering unit.  Hydronephrosis, blockage in the urinary tract causes both kidneys to swell with urine.
  • 5. HYDRONEPHROSIS & INFLAMMATION OF THE GLOMERULI.
  • 6. PATHOPHYSIOLOGY.  Acute renal failure result in alterations to any of the four basic components they are  VASCULATURE.  GLOMERULI.  TUBULES.  INTERSTITIUM.
  • 7.  AZOTEMIA (decreased renal perfusion).  Azotemia is a elevation of blood urea nitrogen (BNU) and serum creatinine levels. The reference range for BUN is 8-20 mg/dL and normal range for serum creatinine 0.7-1.4 mg/dL.  INTRINSIC RENAL FAILURE (structural damage to kidney).  Vascular disease, renal artery obstruction (atherosclerosis, thrombosis).  I schema (lack of blood flow to an organ), toxins.  POST RENAL OBSTRUCTION (obstruction of urine flow from the kidney out of the body).
  • 8. SYMPTOMS. o Greatly reduced urine volume. o Nausea. o Vomiting. o Drowsiness. o Headache. o Back pain.
  • 10. DIAGNOSIS. KIDNEY BIOPSY.  Ultra sound scanning or computed tomography scanning.  Kidney biopsy to examine kidney tissue.
  • 11. TREATMENT.  CRITICAL CARE UNIT: To care people in a critical or unstable condition, who requires continuous monitoring.  DIALYSIS: Replacing the function of kidney, excess fluid and waste products can be from blood stream.  Blood transfusion.
  • 12. CHRONIC RENAL FAILUR.  Chronic renal failure is defined as chronic renal insufficiency (CRI) denotes a creatinine clearance Crcl 50-80 ml/min; moderate CRI 30- 50 ml/min; severe 15-30 ml/min. gradual and progress loss of function in kidneys.  Patients requiring chronic dialysis or renal transplantation for relief of uremic symptom are said to be end-stage renal disease (ESRD).
  • 13. PATHOPHYSIOLOGY:  Multiple risk factors identified for renal disease includes the following  Diabetes.  High blood pressure.  Proteinuria.  Increasing age.  Hyperlipidaemia.  Family history of renal disease.
  • 14. HYPERLIPIDEMIA.  Hyperlipidemia is abnormally elevated levels of any or all lipid and / or lipoproteins in the blood.
  • 15. Abnormal amount of protein is present in the urine. Due to the disease in the glomerulus. PROTINURIA:
  • 16. SYMPTOMS:  Frequent urination, during night.  Pale, itchy, easily brushed skin.  Shortness of breath.  Persistent hiccups.  Nausea and vomiting.  Muscular twitching.  Cramps in the legs.
  • 17. HICCUPS AND MUSCULAR TWITCHING.
  • 18. DIAGNOSIS:  Ultra sound scanning or CT scanning to assess the size of the kidney.  KIDNEY BIOPSY: Small piece of kidney tissue is removed and examined under microscope to determine the nature of kidney damage.
  • 19. TREATMENT USE DRUGS.  Corticosteroids Beclomethazone. Dexamethazone. Prednisolone. Triamcinolone.
  • 20. PREDNISOLONE.  Prednisolone is a corticosteroid it works by modifying the body's immune response to various conditions and deceasing inflammation.