This document summarizes MRF's healthcare initiative in Malawi to improve recognition and treatment of meningitis at the primary health level. The initiative developed a triage system using a mobile health tool to classify patients into emergency, priority, and queue categories. The triage system was implemented in 5 primary health clinics in Blantyre, where it led to quicker patient wait times and improved teamwork among health staff. While over 60% of referred patients did not reach the tertiary hospital, the triage system accurately classified patients and showed potential to strengthen primary healthcare responses to illness in Malawi when scaled up.
Current situation in the meningitis belt, impact of MenAfriVac, countries that have introduced or committed to introducing it into routine schedules, catch up campaigns, controlling outbreaks and the challenge of maintaining vaccine stockpiles, use of conjugate and polysaccharide vaccines
https://www.meningitis.org/mrf-conference-2017
What next for prevention of pneumococcal disease in light of serotype replacement? Is there a pathway to licensure for novel pneumococcal vaccines?
https://www.meningitis.org/mrf-conference-2017
Preparedness for and response to meningococcal outbreaks: preliminary results of a Canadian Immunization Research Network (CIRN) randomized controlled trial of two schedules of 4CMenB vaccine in adolescents and young adults.
https://www.meningitis.org/mrf-conference-2017
Hepatitis C Infection – Screening, Treatment and (as) Prevention in the Comm...icornpresentations
Professor Colm Bergin Consultant Physician in Infectious Diseases, St. James’s Hospital, Dublin. Clinical Professor of Medicine, Trinity College DublinAssociate Director, Wellcome Trust-HRB Clinical Research Facility at St. James’s Hospital, Dublin. Dean of Postgraduate Specialist Training, Royal College of Physicians, Ireland.
Single-dose oral ciprofloxacin prophylaxis as a meningococcal meningitis outbreak response: results of a cluster-randomized trial
https://www.meningitis.org/mrf-conference-2017
Prospects for GBS prevention - current candidates & removing barriers to licensure of a GBS vaccine for pregnant women globally
https://www.meningitis.org/mrf-conference-2017
Current situation in the meningitis belt, impact of MenAfriVac, countries that have introduced or committed to introducing it into routine schedules, catch up campaigns, controlling outbreaks and the challenge of maintaining vaccine stockpiles, use of conjugate and polysaccharide vaccines
https://www.meningitis.org/mrf-conference-2017
What next for prevention of pneumococcal disease in light of serotype replacement? Is there a pathway to licensure for novel pneumococcal vaccines?
https://www.meningitis.org/mrf-conference-2017
Preparedness for and response to meningococcal outbreaks: preliminary results of a Canadian Immunization Research Network (CIRN) randomized controlled trial of two schedules of 4CMenB vaccine in adolescents and young adults.
https://www.meningitis.org/mrf-conference-2017
Hepatitis C Infection – Screening, Treatment and (as) Prevention in the Comm...icornpresentations
Professor Colm Bergin Consultant Physician in Infectious Diseases, St. James’s Hospital, Dublin. Clinical Professor of Medicine, Trinity College DublinAssociate Director, Wellcome Trust-HRB Clinical Research Facility at St. James’s Hospital, Dublin. Dean of Postgraduate Specialist Training, Royal College of Physicians, Ireland.
Single-dose oral ciprofloxacin prophylaxis as a meningococcal meningitis outbreak response: results of a cluster-randomized trial
https://www.meningitis.org/mrf-conference-2017
Prospects for GBS prevention - current candidates & removing barriers to licensure of a GBS vaccine for pregnant women globally
https://www.meningitis.org/mrf-conference-2017
Improving acute care for children and young people, pop up uni, 10am, 3 septe...NHS England
Expo is the most significant annual health and social care event in the calendar, uniting more NHS and care leaders, commissioners, clinicians, voluntary sector partners, innovators and media than any other health and care event.
Expo 15 returned to Manchester and was hosted once again by NHS England. Around 5000 people a day from health and care, the voluntary sector, local government, and industry joined together at Manchester Central Convention Centre for two packed days of speakers, workshops, exhibitions and professional development.
This year, Expo was more relevant and engaging than ever before, happening within the first 100 days of the new Government, and almost 12 months after the publication of the NHS Five Year Forward View. It was also a great opportunity to check on and learn from the progress of Greater Manchester as the area prepares to take over a £6 billion devolved health and social care budget, pledging to integrate hospital, community, primary and social care and vastly improve health and well-being.
More information is available online: www.expo.nhs.uk
ISS Service Innovation Leadership Seminar, 28 March - Mrs Chew Kwee TiangNUS-ISS
ISS Service Innovation Leadership Seminar, 28 March - "Design Thinking and Service Innovation - The Khoo Teck Puat Hospital's Journey" by Mrs Chew Kwee Tiang, CEO, Khoo Tech Puat Hospital
Acute hospitals end of life care best practiceNHSRobBenson
Delivering reliable best practice in an acute hospital setting for patients whose recovery is uncertain. Including details of the AMBER care bundle. Presentation from Anita Hayes and colleagues from England's National End of Life Care Programme as part of the Department of Health's QIPP end of life care workstream seminar series at Healthcare Innovation Expo 2011
North Thames Children's Cancer Network Coordinating GroupUCLPartners
Presentation by Darren Hargrave, Co-Chair of the North Thames Children's Cancer Network Coordinating Group at the London Cancer Children, Teenager and Young Adults Study Day, held on 25 July 2013.
Innovations conference 2014 catherine adams integrating a multidisciplinary...Cancer Institute NSW
Catherine Adams - Integrating a Multidisciplinary Stepped Care Model of Psychosocial Care for Cancer Survivors and Families into routine Clinical Practice in Rural and Remote Regions
Project ECHO (Extension for Community Health Outcomes)icornpresentations
Sanjeev Arora MD, Distinguished Professor of Medicine (Gastroenterology/Hepatology); Director of Project ECHO®
Department of Medicine, University of New Mexico Health Sciences Center
Safe transition for young people to adulthood
Dr Jacqueline Cornish,
National Clinical Director Children, Young People and Transition to
Adulthood - NHS England
NHS Improving Quality held an event in London on 31 July 2013 to progress the children and young people transition to adult services work with a focus on turning the rhetoric into practice entitled “Working to Define a Generic Service Specification for Transition”
Cancer patients’ experiences in one tertiary referral emergency department (E...Cancer Institute NSW
The demand on Australian EDs has increased by an average of 4.2% each year while the cancer incidence rate has doubled since 1991. Many patients with cancer present to EDs but may be better managed using alternative healthcare models.
3 of 4: Reducing Neonatal Mortality - Prevention, Early Detection and Treatme...JSI
This presentation by Luke C. Mullany of Johns Hopkins University, "Neonatal Infections: Global and Regional Burden and Interventions" was part of a dynamic panel moderated by JSI's Dr. Penny Dawson on February 13, 2015 at the 14th World Congress on Public Health in Kolkata, India. Four speakers summarized evidence for interventions proven to reduce newborn mortality (e.g., chlorhexidine) and shared important policy and programmatic experiences in prevention and treatment of neonatal infections. JSI's Leela Khanal and Dr. Nosa Orobaton spoke about experiences from Nepal and Nigeria in scaling up chlorhexidine use in those countries. Another speaker shared results from the COMBINE trial in Ethiopia, implemented primarily by JSI with support from SAVE/SNL, which evaluated the impact on neonatal mortality of health extension worker-led management of bacterial infections.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
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We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
3. Barriers to recognition and treatment of
meningitis at Primary Health Level
Primary health
level
misdiagnoses
High numbers
of patients
Erratic
consultation
systems
Unsystematic
& informal
triage
Desmond et al 2013 PLOSone
4. Desmond et al 2013 PLOSone
• Negative perceptions of health services
• Low level of awareness of meningitis
• Gender and age-based decision making
in community
• Financial constraints
Barriers to seeking timely treatment for
meningitis at community level
Desmond et al 2013 PLOSone
5. Action Meningitis
• Improved recognition of severe illness
• Appropriate referral
Primary Health Level
Community Level
• Community recognition & awareness of
meningitis and triage system
• Initiation of timely treatment
Triage
system
Theatre
Radio
7. Theatre for Development
• Partnering with local theatre group
• Establish a community-level
intervention to encourage recognition
and response to illness
9. • Severe illness regularly
missed
• Limited number of HCW,
equipment & supplies
• HCW overwhelmed
• Long queues
Primary Health Clinics: Blantyre
10. Aims:
1. To develop a triage system, tailored for PHCs
2. To implement this system within 5 PHCs in
Blantyre
3. To encourage appropriate referral decisions
to hospital & track referrals
4. To monitor, evaluate and refine this system
Implementation of Triage System
11. ‘mHealth’ Triage Tool
• Emergency Triage, Assessment and Treatment (ETAT)
protocol developed by the WHO.
• Designed for hospital settings, in resource-poor countries.
• Specifically aimed at lower cadre staff.
12. Emergency
Priority
CHILDIS VERY
SICK. PRIORITY
MUST BE GIVEN IN
THE QUEUE
Queue
CHILDHAS MINOR
INJURY/ILLNESS.
TO WAIT IN THE
QUEUE
CHILDIS
EXTREMELY SICK.
TO BE SEEN
IMMEDIATELY
Triage classification
‘Chipatala Robot’
13. Improving patient pathways
Patient
enters
PHC
HCW conducts
rapid triage
Patient assigned
E, P, Q
Clinician conducts
consultation &
enters dataAdapted from Sarah Bar-Zeev (2012)
Patient follows
clinician
instructions
Patient
Triage
PHC
ClinicianQECH
Fieldworker
If referred to QECH
data entered on arrival
17. • Measured agreement between
HSA triage assessment and
clinician triage assessment.
• Above chance agreement for
concordance between triage
and clinician assessment
(kappa = 0.71)
Accuracy of triage
18. (Anova P < 0.001)
Triage
evaluation
Time
taken
(mins)
Paediatric
cases
Emergency 28.3 131
Priority 44.6 13,585
Queue 59.0 26,452
Mean clinic waiting times
19. • Out of 41,358 children triaged
1.6% (644) were referred to QECH
• From the 644 referrals 37.3%
(240) arrived at QECH
• Overall mean time to QECH
5.5hrs
• 62.7% (404) of referrals from
PHCS did not reach QECH
Referrals
20. “At Bangwe we are now working together
as a team. It is helping us manage the
children so much better. We are seeing them
far more quickly than before”
“At Bangwe we are now working together
as a team. It is helping us manage the
children so much better. We are seeing them
far more quickly than before”
Medical Assistant, 2013
Qualitative findings
21. Chikhwawa District
• Rural setting, 2.5hrs outside Blantyre
• Chipatala Robot triage system at two
additional Primary Clinics
• Also in District Hospital
• 40 HCW trained
23. Next steps
• Continue triage system in 8 centres.
- High drop-out between primary level referral and
arrival at tertiary (63%).
- How best to adapt triage for primary setting?
- Provide evidence that triage can be successfully
implemented in a sustainable and cost-effective way.
Primary Health Level
Community Level
• Continue to develop theatre and radio interventions.
24. Mphatso
Cheonga, 2012
“I only wish the primary
health centres could
improve on diagnosis
and recognising
symptoms quicker...”
“I only wish the primary
health centres could
improve on diagnosis
and recognising
symptoms quicker...”
25. Acknowledgments
MLW
Nicola Desmond
Rob Heyderman
Deborah Nyirenda
Queen Dube
Elizabeth Molyneux
Rob Heyderman
MRF
Linda Glennie
Chris Head
Thomasena O’Byrne
Zione Kalvosi
Meliya Kwelepeta
Bernadetta Payesa
MoH
Norman Lufesi
Dr Owen Malema
Dr Amber Manjidu
ETAT Registrars
Dr Zondiwe Mwanza
Dr Thembi Chirwa
Dr Yabwile Mulambia
Mtisunge Gondwe
D-Tree International
Dr Marije Geldof
Dr Marc Mitchell
Phidelis Suwedi
Primary Clinics
Bangwe: Tinkhani Bophani
Chilomoni: Dalitso Namasani
Ndirande: Francis Phiri
Mpemba: Rodgers Kuyokwa
Zingwangwa: Margaret
Chingona
All photos reproduced by kind permission of
participants
26. Referrals arriving at QECH with mean time taken between
primary and tertiary
(Anova P = 0.39)
mHealth
Triage
evaluation
Time
taken
(hours)
Paediatric
cases
E 3.5 33
P 5.7 193
Q 6.8 14
Overall mean time 5.5 hours
27. Background Research
• £700K MRF research in Malawi
• Late presentation at tertiary level contributes to
mortality from acute bacterial meningitis (ABM)
• Study into barriers of recognition and action in
treating ABM in Malawi…
Editor's Notes
Hi.
Edith, who’s five, lives in Mpemba District of Blantyre, Malawi’s second largest city.
She was just 2 when her meningitis was misdiagnosed as malaria
Edith is now 5
No longer see, no longer hear, no longer sit upright
Why am I telling you about the story of Edith?
Edith is a case study from MRF-funded research carried at Malawi Liverpool Wellcome Trust
This study, conducted in 2010 explored health seeking pathways for patients with bacterial meningitis.
It found that there are barriers to recognition and treatment of meningitis.
Both at Primary Health Clinics, and within communities
And these contribute to the high mortality from meningitis in Malawi ..........
Barriers to recognition and treatment of meningitis identified at primary level include:
1. Misdiagnosis of meningitis, commonly with malaria (as in case of Edith)
2. Unsystematic and informal triage (prioritising the patients in most need of attention) – adults and children sitting together and seen on a first come first served basis rather than prioritised systematically.
High numbers of patients on a daily basis in busy PHCs create additional burdens on healthcare workers, which
further exacerbates an erratic consultation system
The study also identified barriers to seeking timely treatment for meningitis, including:
Negative perceptions of health services in Blantyre - appropriate HSB discouraged by long wait times, and expectation of poor care at Primary level
Low recognition of meningitis and its symptoms within communities
Cultural decision making practises within households in Malawi. For example Gender and age-based decision making in community
Financial constraints in community
The research very much pointed to the need for an intervention to focus on the recognition of and response to severe illness, both within community and at primary care level.
Action Meningitis is MRF’s health initiative to improve outcomes from meningitis in children in Malawi.
This project is a direct follow on from the MRF-funded barriers study. This initiative began early 2012.
2 arms of the project:
The first targetted to primary health level:
- Improving recognition of severe illness by HCW at primary clinics and making appropriate decisions on referrals.
TRIAGE SYSTEM Improving patient pathway through the clinic
The community level arm aims to promote positive health seeking behaviour complements the primary health level intervention.
The community health education aspect improves the recognition of child illness by parents and guardians & encourage timely HSB
Concentrate on Primary Level intervention today, but just briefly explain work MRF is doing in communities. Primarily through radio and theatre.....
Partnered with MLW and Malawi Broadcasting Corporation - ‘Health Talk’ weekly radio programme on national radio, covered health topics, and MLW research.
Broadcast to general public & Radio Listening Clubs. Include panel discussions and opportunities for general public to ask questions, via text or phone in
8 episodes focusing on meningitis were Aired in 2013. Of all the topics covered, Meningitis episodes – Generated most interest from public.
Build on this success and air another 8 episodes this Autumn.
Another approach to tackling the barriers to seeking care is through theatre for Dev
Through partnership with local theatre groups, Theatre performances will be carried out in the 8 communities where the Primary triage system implemented,
With the aim of improving knowledge and awareness of meningitis in male and female parents and carers.
Confront some of the cultural norms for health decision-making in communities (getting permission from husbands / within families).
Also Provide an opportunity to educate about the after-effects of the disease.
And address some of the stimga’s faced by families and individuals who are left with the life-long impact of devastating disabilities following meningitis.
MRF carried out a Situation analysis, visited all primary clinics within Blantyre, (of which there are 17 run by MOH),
consulting clinicians at QECH,
health workers at PHCs,
and MoH officials at national and district level.
Found that:
lack of effective triage at PHCs meant that severe illnesses were regularly missed.
Limited number of health workers, equipment and supplies
Health workers explained they were overwhelmed by high patient numbers, so emergency signs are missed.
Long waits to see a clinician or receive treatment meant some children die waiting in the queue before ever being assessed.
Mpemba clinic (top 2 photos) which is more rural.
Zingwanga clinic (bottom left) is urban, in a township, with a higher population and longer queues and wait times. (right photo- weighing child before entering clinic)
Clinics use similar systems according to MoH and WHO, but the number of personnel and patients differ, and details of processes and services depend on each clinic’s management and resources.
Basic supplies = stethoscope, thermometer, basic blood lab (malaria, TB, HIV), immunizations, first line drugs and antibiotics
Lumbar puncture and further treatment/ drugs require referral to hospital
Clinics have radios and mobile phones to call for ambulance, but ambulance can take up to 2 days to arrive, or delay trip to hospital until there are a few people to transport in 1 trip. When referred, patients/ carers are advised to get their own transport, which they have to pay for.
Embarked on a 6-mo pilot.
Aim = Implement a triage system within 5 PHCs in Blantyre.
To develop a triage algorithm, specific for Primary Health Clinics
To implement prioritisation system within each clinic
To encourage appropriate referral decisions by HCW to tertiary centre & track referrals
To evaluate triage system – in order to develop and refine it
Let’s first take a look at the Triage system itself .....
This uses the ETAT (Emergency Triage, Assessment and Treatment ) protocol, developed by the WHO (originally developed in Malawi for hospitals in resource-poor settings).
It is specifically aimed at lower cadre staff.
It has had a huge impact in hospital settings, where it has cut mortality rates.
Our triage tool is based on Emergency Triage component of ETAT
The triage tool, or triage protocol is basically an app on a mobile phone.
From a practical point of view = its an ideal tool for HCW to quickly navigate around crowded clinics, assessing patient after patient
Benefits – ensure hcws stick to protocol, don’t skip step. The phone acts as a prompt to the user to identify severely ill children.
Action Meningitis is the 1st intervention of its kind combining triage and mhealth.
In close collaboration with MOH, Action Meningitis established a triage system,
The Action Meningitis ETAT system was sucessfully implemented within 5 PHCs of Urban Blantyre
Urban and peri-urban clinics with varying catchment populations
System for triage – Chipatala Robots
The intervention was developed using the concept of the Chipatala Robots (Chipatala meaning health centre and robots meaning traffic lights). Chichewa
We created Chip as a character to guide patients and carers through the system.
The clinics’ HCWs assess a child’s symptoms on arrival using a mobile phone app. It’s based on a traffic light system of triage developed by the World Health Organisation.
Patient is triaged through a series of simple questions on the smartphone screen asking about key clinical signs to identify severe illness
Screenshot of the triage app.
Each patient is given a unique personal identification number assigned through the phone.
Helps HCWs quickly and accurately identify severe illnesses, like meningitis - so emergency cases are fast-tracked to hospital.
Responses to the series of questions lead to an assignment based on the traffic lights system where
Red depicts an emergency meaning the child is extremely sick and should be seen immediately,
Yellow ....
Green ....
Patient health passports are stamped with a Chip symbol
And patient provided with a coloured strip which helps to guide them through the system.
walk through the system...
Patient - all children under 15yrs.
Initial triage by HCW
Assigned triage classification – Emergency, Priority , Queue
Clinican triage and consultation
We expected that the system would encourage appropriate referral decisions to tertiary care (Queen Elizabeth Central in Blantyre)
We have fieldworkers at referral hosptial - phones. Collect data on all referrals that arrive to hospital, so we can track whole patient pathway, through primary to teriary
From all of the five primary centres.
[short video clip]
In this clip i hope you are about to see,
Triage system being used at a crowded clinic in Bangwe,
a healthworker assesses a sick baby girl.
Guided by a series of questions on his phone
he quickly identifies her as a ‘Priority’ for the doctor.
It improves chances of survival by helping healthworkers quickly and accurately identify severe illnesses, like meningitis - so emergency cases are fast-tracked to hospital. The clinics’ healthworkers assess a child’s symptoms on arrival using a mobile phone app, specially created by the charity. It’s based on a traffic light system of triage developed by the World Health Organisation.
[Sounds from clinic]
In this crowded clinic in Bangwe, a healthworker assesses a sick baby girl. Guided by a series of questions on his phone he quickly identifies her as a ‘Priority’ for the doctor.
During the 6-month pilot phase, 42,000 children 0-14yrs were triaged.
Evaluation showed the system improves patient pathways and has increased recognition of severe illness among lower level HCW unfamiliar with triage beforehand.
41,358 children aged between 0 and 14 were triaged through the triage system during the six month pilot period
Of these Bangwe, clinic we’ve just seen, triaged the most cases and Mpemba the least.
Bangwe serves a peri-urban population, situated on the outskirts of Blantyre with a large catchment population of 132K.
Mpemba serves a rural population spread over a large catchment area with a population of only 50K.
The majority of triage within each of the 5 clinics was conducted by Health Surveillance Assistants, or HSAs
These are salaried community health workers. On average receive clinical training of 8 weeks from the Ministry of Health.
At outset of project, HSAs received a 4-day training in triage, and how to use the phone. Included in this was one day in their own clinic, working as a team to find out the best way to implement the system there.
One way in which we tested the quality of triage done by HSAs, was by correlating their triage classification with the assessment by the clinician.
We found in general levels of agreement were high overall between triage and clinician assessments with an above chance level of agreement (Kappa value) of 0.71.
93% of Queue assignments were consistent across triage and clinician assessment, but this was reduced for priority and emergency assessments with75% agreement for priority and only 54.5% agreement for emergency assessments.
The total figures of 131 are low for Emergency assessments, but we would expect some Emergencies to be recognised immediately, bypassing the triage system. ( 27 patient carers who reached Queens reported that they had not passed through triage due to immediate recognition of severity).
Their main role is to provide prevention and some basic curative health services at community level.
However they are increasingly involved in primary level clinics, taking up a range of roles such as HIV testing and ART provision.
a total of 10,507 HSAs working across Malawi in 2009, each possessing an average clinical training of 8 weeks from the Ministry of Health.
Phones automatically record time and date.
So we can measure the waiting times within the clinic, between the initial triage evaluation by HSA and subsequent evaluation by clinician.
For all 41,000 patients
Time taken to be seen by the clinician was on average significantly shorter for emergencies, than priorities and longest for queue cases
28m
45m
60m
which is what we would expect to see with the introduction of a system that prioritises according to the severity of the illness.
We were able to tracked all referrals from each of the five primary centres.
Fieldworkers based at tertiary referral hospital armed with mobile phone captured data at the A&E department of the tertiary referral hospital (QECH)
around the clock so were able to capture all patients entering the hospital from all 5 participating clinics.
Of all patients seen by the primary level clinicians who had been triaged using tool, 644 or 1.6% were referred.
However only 37% reached hospital.
Amongst those who reached Queens mean time between initial triage assessment and arrival at QECH was 5.5 hours.
This 63% is of concern. We do not know what happened to them. and something we would like to investigate further.
15.5%(100) - Emergency
74.9%(482) - Priority
9.6% (62) - Queue
Overall the intervention was viewed very positively by primary health staff with a strong perception that it had improved patient pathways through the clinic.
PJM identified positive changes in patient flows and ssi health care worker satisfaction high.
One comment that was mentioned time and time again and reflected in this quote is how the intervention brought the hcws together to work as a team.
40 additional HCWs trained in 3 centres
Data collection for analysis, evaluation, evidence for success and scaling up
Since ETAT triage up and running – Dec 2013
Triaged over 148,000 children
mHealth technologies have the potential to improve primary level services with high patient numbers and over burdened staff.
How best to adapt our ETAT system, originally developed for hospitals, to the primary setting, still needs to be shown.
Understanding 63% dropout between primary level referral and arrival at tertiary.
Since we aim to improve pathways this dropout is of concern.
Understanding the appropriateness of referral decisions through follow up of referrals through QECH system, particularly tracking admission rates from referrals and obtaining detailed symptom profiles of all referral patients, exploring the links between identification of symptoms as severe and referral decisions.
Building on a successful foundation we aim to provide MOH with evidence that ETAT can be successfully implemented in a sustainable and cost-effective way.
So, returning to the story of Edith. When we went back to see her last year her father said that his one wish was for PHCs to improve on recognising symptoms earlier....
This sudy has shown that mHealth technologies have the potential to improve primary level services with high patient numbers and over burdened staff.
There is a trend as can be seen here though not significant especially because the sample sizes were small for Qs and Es.
Since 2001 MRF has sought to improve the very severe outcomes from meningitis in Malawi, where half of childhood cases of meningitis are fatal, by funding research into improved treatments
But these were found to be of no benefit, due to patients late presentation to hospital