Fast track surgery aims to accelerate recovery from surgery through a coordinated multidisciplinary approach. It combines preoperative patient education, minimally invasive techniques, regional anesthesia when possible, and aggressive postoperative rehabilitation including early feeding and mobilization. The goal is to shorten hospitalization, reduce complications, and speed recovery. It requires collaboration between surgeons, anesthesiologists, nurses, physiotherapists and patients.

1. © 2004 WebMD Inc. All rights reserved. ACS Surgery: Principles and Practice
ELEMENTS OF CONTEMPORARY PRACTICE 10 Fast Track Surgery — 1
10 FAST TRACK SURGERY
Henrik Kehlet, M.D., Ph.D., F.A.C.S. (Hon.), and Douglas W.Wilmore, M.D., F.A.C.S.
Over the past several decades, surgery has undergone revolution- surgery must be based on a process of multidisciplinary collabo-
ary changes that are leading to improved treatments (involving ration that embraces not only the surgeon, the anesthesiologist,
lower risk and better outcome) for an increasing number of dis- the physiotherapist, and the surgical nurse but also the patient.
eases. These salutary developments are the result of more ad- More specifically, fast track surgery depends on the inclusion and
vanced anesthetic techniques, new methods of reducing the peri- integration of a number of key constituent elements (see below).
operative stress response, wider application of minimally invasive
techniques, improved understanding of perioperative pathophysi-
ology, and more sophisticated approaches to the prevention of Constituent Elements
postoperative organ dysfunction. Currently, many operations that
EDUCATION OF THE PATIENT
once necessitated hospitalization can readily be performed in the
outpatient setting; in addition, many major procedures are now To obtain the full advantages of a fast track surgical program,
associated with a significantly reduced duration of hospitalization it is essential to provide patients with information about their peri-
and a shorter convalescence. operative care in advance of the procedure. Such educational
Although these anesthetic and surgical developments are the efforts often serve to reduce patients’ level of anxiety and need for
result of basic scientific and clinical research, they have also been pain relief, thereby providing a rational basis for collaboration
influenced by governmental and managed care policies aimed at with health care personnel, a process that is crucial for enhancing
encouraging more cost-effective treatments. Such extraclinical postoperative rehabilitation.1-3 Patients can supplement the infor-
influences, coupled with new clinical developments, have resulted mation they receive directly from health care providers by access-
in novel approaches designed to enhance the cost-effectiveness of ing reference sources such as www.facs.org/public_info/operation/
health care, such as so-called fast track surgery, critical pathways, aboutbroch.html, a collection of electronic brochures on specific
and various types of clinical guidelines. To understand the true clinical procedures that is provided by the American College of
potential value of such approaches, it is essential to recognize that Surgeons.
their aim is not merely to ensure that fewer health care dollars are
OPTIMIZATION OF ANESTHESIA
spent but, more important, to ensure that better and more effi-
cient health care is delivered. Although these novel approaches The introduction of rapid-onset, short-acting volatile anesthet-
may reduce cost, their primary purpose is to improve surgical ics (e.g., desflurane and sevoflurane), opioids (e.g., remifentanil),
management by reducing complications and providing better out- and muscle relaxants has enabled earlier recovery from anesthesia
comes. In what follows, we outline the basic concept, primary and thereby facilitated ambulatory and fast track surgery.4 Al-
components, and current results of fast track surgery, which is a though use of these newer general anesthetic agents has resulted
comprehensive approach to the elective surgical patient that is in quicker recovery of vital organ function after minor surgical
designed to accelerate recovery, reduce morbidity, and shorten procedures, it has not been shown to decrease stress responses or
convalescence. mitigate organ dysfunction after major procedures.
Regional anesthetic techniques (e.g., peripheral nerve blocks
and spinal or epidural analgesia), on the other hand, have several
Basic Concept advantages in addition to providing anesthesia. Such advantages
Fast track surgery involves a coordinated effort to combine (1) include improved pulmonary function, decreased cardiovascular
preoperative patient education; (2) newer anesthetic, analgesic, demands, reduced ileus, and more effective pain relief. Neural
and surgical techniques whose aim is to reduce surgical stress blockade is the most effective technique for providing postopera-
responses, pain, and discomfort; and (3) aggressive postoperative tive pain relief, and it has been shown to reduce endocrine and
rehabilitation, including early enteral nutrition and ambulation. It metabolic responses to surgery [see 1:6 Postoperative Pain]. For a
also includes an up-to-date approach to general principles of pronounced reduction in perioperative stress after a major opera-
postoperative care (e.g., use of tubes, drains, and catheters; mon- tion, continuous epidural analgesia for 24 to 72 hours is neces-
itoring; and general rehabilitation) that takes into account the sary.5,6 A meta-analysis of randomized trials evaluating regional
revisions to traditional practice mandated by current scientific anesthesia (primarily involving patients undergoing operations on
findings. It is believed that by these means, fast track surgery can the lower body) found that morbidity was 30% lower with region-
shorten the time required for full recovery, reduce the need for al anesthesia than with general anesthesia.7 However, the effect of
hospitalization and convalescence, and lower the incidence of continuous epidural analgesia on outcome after major abdominal
generalized morbidity related to pulmonary, cardiac, thromboem- or thoracic procedures has been questioned in the past several
bolic, and infectious complications.1-3 years. In three large randomized trials,8-10 no beneficial effect on
For an accelerated recovery program of this type to succeed, overall morbidity could be demonstrated, except for a slight
proper organization is essential. In general terms, fast track improvement in pulmonary outcome, and the duration of hospi-

2. © 2004 WebMD Inc. All rights reserved. ACS Surgery: Principles and Practice
ELEMENTS OF CONTEMPORARY PRACTICE 10 Fast Track Surgery — 2
talization was not reduced. It should be remembered, however, tions for hip fracture received either low-dose GH (20 mg/kg/day)
that in these studies, either an epidural opioid regimen or a pre- or placebo.28 Overall, those in the GH group were able to return
dominantly epidural opioid regimen was employed and that the to their prefracture living situation earlier than those in the place-
perioperative care regimens either were not described or were not bo group. A 1999 study reported increased mortality when GH
revised according to current scientific data regarding the use of was administered to ICU patients,29 but a 2001 meta-analysis
nasogastric tubes, early oral feeding, mobilization, and other care failed to confirm this observation.30 More work is necessary
parameters.3 We believe, therefore, that for further assessment of before definitive conclusions can be formed in this regard.
the role of continuous epidural local analgesic regimens that Postoperative insulin resistance is an important metabolic fac-
include local anesthetics in improving outcome, an integrated tor for catabolism. There is evidence to suggest that preoperative
approach within the context of fast track surgery is required.6 oral or intravenous carbohydrate feeding may reduce postopera-
Perioperative measures should also be taken to preserve intra- tive insulin resistance.31 Whether this approach yields clinical
operative normothermia. Hypothermia may lead to an augment- benefits in terms of improved recovery remains to be deter-
ed stress response during rewarming, impaired coagulation and mined,31,32 but its simplicity, its clear pathophysiologic rationale,
leukocyte function, and increased cardiovascular demands. and its low cost make it a potentially attractive option.
Preservation of intraoperative and early postoperative normother-
CONTROL OF NAUSEA, VOMITING, AND ILEUS
mia has been shown to decrease surgical site infection, intraoper-
ative blood loss, postoperative cardiac morbidity, and overall The ability to resume a normal diet after a surgical procedure
catabolism.11 (whether minor or major) is essential to the success of fast track
surgery. To this end, postoperative nausea, vomiting, and ileus
REDUCTION OF SURGICAL STRESS
must be controlled. Principles for rational prophylaxis of nausea
The neuroendocrine and inflammatory stress responses to and vomiting have been developed on the basis of systematic
surgery increase demands on various organs, and this increased reviews33: for example, 5-HT3 receptor antagonists, droperidol,
demand is thought to contribute to the development of postop- and dexamethasone have been shown to be effective in this
erative organ system complications. At present, the most impor- regard, whereas metoclopramide is ineffective.There is some rea-
tant of the techniques used to reduce the surgical stress response son to think that multimodal antiemetic combinations may be
are regional anesthesia, minimally invasive surgery, and pharma- superior to single antiemetic agents; unfortunately, the data cur-
cologic intervention (e.g., with steroids, beta blockers, or anabol- rently available on combination regimens are relatively sparse. In
ic agents).12 addition, analgesic regimens in which opioids are cut back or
Neural blockade with local anesthetics reduces endocrine and eliminated have been shown to decrease postoperative nausea
metabolic (specifically, catabolic) activation and sympathetic stim- and vomiting.
ulation, thereby decreasing the demands placed on organs and Paralytic ileus remains a significant cause of delayed recovery
reducing loss of muscle tissue; however, regional anesthetic tech- from surgery and contributes substantially to postoperative dis-
niques have no relevant effect on inflammatory responses.5,6 comfort and pain. Of the various techniques available for manag-
Minimally invasive surgical techniques clearly decrease pain ing ileus,34,35 continuous epidural analgesia with local anesthetics
and lessen inflammatory responses,13-15 but they appear to have is the most effective, besides providing excellent pain relief. Now
relatively little, if any, effect on endocrine and metabolic responses. that cisapride has been taken off the market, no effective anti-
Pharmacologic intervention with a single dose of a glucocorti- ileus drugs are available. In a 2001 study, however, a peripheral-
coid (usually dexamethasone, 8 mg) given before a minor proce- ly acting mu opioid receptor antagonist significantly reduced
dure has led to reduced nausea, vomiting, and pain, as well as to nausea, vomiting, and ileus after abdominal procedures, without
decreased inflammatory responses (interleukin-6), with no ob- reducing analgesia.36 If further studies confirm these findings, use
served side effects.16,17 This intervention may facilitate recovery of peripherally acting opioid antagonists may become a popular
from minor (i.e., ambulatory) procedures18; however, the data and effective way of improving postoperative recovery; this treat-
from major procedures are inconclusive.The use of perioperative ment is simple and apparently has no major side effects.
beta blockade to reduce sympathetic stimulation and thereby
ADEQUATE TREATMENT OF POSTOPERATIVE PAIN
attenuate cardiovascular demands has been shown to reduce car-
diac morbidity,19 as well as to reduce catabolism in burn patients Despite ongoing development and documentation of effective
[see Elements of Contemporary Practice:6 Risk Stratification, Pre- postoperative analgesic regimens—such as continuous epidural
operative Testing, and Operative Planning].20,21 Perioperative beta analgesia in major operations, patient-controlled analgesia
blockade may therefore become an important component of efforts (PCA), and multimodal (balanced) analgesia that includes non-
to facilitate recovery in fast track surgical programs. steroidal anti-inflammatory drugs as well as stronger agents37-39
For patients whose nutritional status is normal, oral feeding ad [see 1:6 Postoperative Pain]—postoperative pain still is too often
libitum is appropriate in the postoperative period. For patients inadequately treated. Improved pain relief, facilitated by an acute
who are elderly or nutritionally depleted, nutritional supplementa- pain service,40 is a central component of any fast track surgery
tion, administration of an anabolic agent (e.g., oxandrolone or an- program and is a prerequisite for optimal mobilization and oral
other anabolic steroid,22-24 insulin,25 or growth hormone [GH]26,27) nutrition, as well as a valuable aid in reducing surgical stress
to enhance deposition of lean tissue, or both may be beneficial. responses.37
Most of the studies addressing the use of anabolic agents have
APPROPRIATE USE OF TUBES, DRAINS, AND CATHETERS
focused on critically ill catabolic patients, in whom both indirect
effects (e.g., improved nitrogen balance26) and direct effects (e.g., There is substantial support in the literature for the idea that
improved wound healing and decreased length of stay with GH in nasogastric tubes should not be used routinely in patients undergo-
burned children27 and decreased mortality with insulin in critical- ing elective abdominal surgery.1,2 Randomized trials indicated that
ly ill patients25) on outcome have been demonstrated. In a study drains offered little benefit after cholecystectomy, joint replace-
published in 2000, a group of elderly patients undergoing opera- ments, colon resection, thyroidectomy, radical hysterectomy, or

3. © 2004 WebMD Inc. All rights reserved. ACS Surgery: Principles and Practice
ELEMENTS OF CONTEMPORARY PRACTICE 10 Fast Track Surgery — 3
pancreatic resection1,3,41 but that they might limit seroma forma- or a slightly modified fast track care program. On the whole, the
tion after mastectomy.1,3 Such postmastectomy drainage does not preliminary results from these studies are very positive: fast track
necessarily impede hospital discharge, and the patient generally surgery is associated with shorter hospital stays, reduced or at
may be treated on an outpatient basis. Urinary catheterization has least comparable morbidities, and low readmission rates, with no
been routinely performed after many operations, but scientific doc- apparent decrease in safety.
umentation of the requirement for this measure is often lacking. In Studies of fast track surgery in which organ function was
general, catheterization beyond 24 hours is not recommended with assessed postoperatively and compared with organ function after
colorectal procedures, except with the lowest rectal procedures, for traditional care found fast track surgery to be associated with ear-
which 3 to 4 days of catheterization may be indicated.3 lier ambulation,43,44 superior postoperative muscle function,44
Although tubes, drains, and catheters may lead to morbidity improved oral nutritional intake,45 better preservation of lean body
only when used for extended periods, they do tend to hinder mass,43,45 reduced postoperative impairment of pulmonary func-
mobilization, and they can raise a psychological barrier to the pa- tion,43 earlier recovery of GI motility,46 and mitigation of the de-
tient’s active participation in postoperative rehabilitation. There- crease in exercise capacity and impairment of cardiovascular
fore, such devices should be used not routinely but selectively, in response to exercise that are usually expected after an operation.43
accordance with the available scientific documentation. The few randomized trials performed to date (mostly involving
patients undergoing cholecystectomy, colonic resection, or mastec-
NURSING CARE, NUTRITION, AND MOBILIZATION
tomy) reported that fast track programs increased or at least main-
Postoperative nursing care should include psychological sup- tained patient satisfaction while achieving major cost reductions.
port for early rehabilitation, with a particular focus on encourag-
ing the patient to resume a normal diet and become ambulatory
as soon as possible. Early resumption of an oral diet is essential for Future Developments
self-care; furthermore, according to a 2001 meta-analysis of con- The initial promising results from the fast track surgical pro-
trolled trials, it may reduce infectious complications and shorten grams studied suggest that such programs can achieve major care
hospital stay after abdominal procedures, without increasing the improvements in terms of reducing postoperative stay. At present,
risk of anastomotic dehiscence.42 In addition, early resumption of however, sufficient scientific documentation is lacking for many
enteral feeding may reduce catabolism and may be facilitated by commonly performed major operations. Thus, there is a need for
the methods used to reduce postoperative nausea, vomiting, and additional data—in particular, data on the potential positive
ileus (see above). effects of fast track surgery on postoperative morbidity. The nec-
Postoperative bed rest is undesirable because it increases mus- essary data would probably be best obtained through multicenter
cle loss, decreases strength, impairs pulmonary function and tis- trials using identical protocols. Randomized trials within the same
sue oxygenation, and predisposes to venous stasis and throm- unit that allocate some patients to suboptimal care recommenda-
boembolism.3 Accordingly, every effort should be made to enforce tions for pain relief, mobilization, and nutrition would be difficult
postoperative mobilization; adequate pain relief is a key adjuvant to perform, if not unethical, though a few such reports have been
measure in this regard. published on colon surgery patients.44,47
Organization is essential for good postoperative nursing care: a As yet, it has not been conclusively demonstrated that reducing
prescheduled care map should be drawn up, with goals for reha- the duration of hospitalization necessarily reduces morbidity,48
bilitation listed for each day. though data from studies addressing colonic and vascular proce-
dures suggest that nonsurgical (i.e., cardiopulmonary and throm-
DISCHARGE PLANNING
boembolic) morbidity may be reduced and overall postoperative
Given that a primary result of fast track surgery is reduced recovery (assessed in terms of exercise performance and muscle
length of hospitalization, discharge planning must be a major con- power) enhanced. More study is required in this area. Future tri-
sideration in the preoperative patient information program, as als should also focus on identifying any factors that might be lim-
well as during hospitalization. Careful, detailed discharge plan- iting even more aggressive early recovery efforts, so that more
ning is essential for reducing readmissions and increasing patient effective fast track programs can be designed. Finally, studies are
safety and satisfaction. The discharge plan should include (1) needed to identify potential high-risk patient groups for whom fast
detailed information on the expected time course of recovery, (2) track surgery may not be appropriate or who may need to be hos-
recommendations for convalescence, and (3) encouragement of pitalized for slightly longer periods to optimize organ function.47
enteral intake and mobilization. For patients with a significant There has been considerable interest in whether the use of crit-
degree of postoperative disability, various acute care facilities are ical pathways improves postoperative care. Preliminary studies
available after hospital discharge. It should be kept in mind, how- involving coronary artery bypass grafting, total knee replacement,
ever, that the integrated care approach fundamental to fast track colectomy, thoracic procedures, and hysterectomy suggested that
surgery is specifically intended as a way of limiting or preventing critical pathways may reduce length of hospital stay, but the
such disability, thereby reducing patients’ need for and depen- reduction is no greater than can be observed in neighboring hos-
dence on postdischarge care facilities. pitals that do not use critical pathways.49 Thus, the initial enthusi-
asm for critical pathways notwithstanding, conclusive evidence
that they have a beneficial effect on postoperative care is still lack-
Reported Results ing.The continuously decreasing length of stay noted in hospitals
Ongoing efforts to formulate multimodal strategies aimed at without fast track programs may be partly attributable to the
improving postoperative outcome have led to the development of intense competition within the health care system, which can lead
a variety of fast track surgical programs [see Table 1]. Most of the to changes in care principles even without the formal adoption of
studies published to date have been descriptive ones reporting critical pathways or similar systems.49
consecutive patient series from single centers, the findings from All of the studies on the economic implications of fast track sur-
which have often been confirmed by other groups using the same gical programs and critical pathways have documented substantial

4. © 2004 WebMD Inc. All rights reserved. ACS Surgery: Principles and Practice
ELEMENTS OF CONTEMPORARY PRACTICE 10 Fast Track Surgery — 4
Table 1 Results from Selected Fast Track Surgical Programs
Type of Operation Postoperative Hospital Stay Comments and Other Findings
Abdominal procedures
Inguinal hernia repair59-61 1.5–6 hr Large consecutive series using local infiltration anesthesia in > 95%, with one
series59 using unmonitored anesthesia; documented low morbidity, with no urinary
retention; patient satisfaction ~90%, cost reduction > $250 with local anesthesia
Cholecystectomy (laparoscopic,62-67 > 80% discharge on same day Large consecutive series, with documented safety and patient satisfaction > 80%;
mini-incision68) cost reduction of $750/patient in randomized study64; recovery of organ functions
within 2–3 days, with <1 wk convalescence67; similar results with mini-incision in
consecutive series68
Fundoplication69,70 > 90% < 23 hr Large consecutive series with documented safety70
Open43,44,46,47,56,71-76 and laparo- 2–4 days Consecutive series including high-risk patients; reduced cardiopulmonary morbidity,
scopic72,77-79 colorectal procedures readmission rates 0%–15%; no documented advantages of laparoscopy-assisted
colonic resection, though costs may be reduced72; ileus reduced to < 48 hr in
> 90% of patients,46,56 with improved muscle and pulmonary function in fast track
patients and better preservation of postoperative body composition43; one random-
ized study showed similar morbidity, readmissions, and satisfaction with fast track
versus traditional care47
Complex pelvic-colorectal 3–6 days Short stay80 (~4–6 days) even with additional stoma; low readmission rate (7%)
procedures80,81
Rectal prolapse82 80% < 24 hr Consecutive series (N = 63) with Altemeier repair; 5% readmission rate (nonserious
indications)
Pancreaticoduodenectomy,83,84 — Hospital stay decreased by implementation of clinical pathway
complex biliary tract procedures85
Mastectomy86-90 90% < 1 day Large cumulative series; documented safety and major cost reduction with high
patient satisfaction; no increased morbidity with fast track, but less wound pain and
improved arm movement and no increase in risk of psychosocial complications
Vascular procedures
Carotid endarterectomy91-94 90% < 1 day Surgery done with local anesthesia; specialized nurses and wards
Lower-extremity arterial bypass95 2–3 days Large series (N = 130); documented safety
Abdominal aortic aneurysmectomy96,97 ~3 days Preliminary studies (N = 5096 and N = 7797); documented early recovery and safety;
one study with epidural analgesia,97 one without96
Urologic procedures
Radical prostatectomy98 ~75% 1 day Large consecutive series (N = 252); documented safety and patient satisfaction
Laparoscopic adrenalectomy99-101 < 1 day Small series; safety and low morbidity suggested
Cystectomy102,103 7 days Improved mobilization, bowel function, and sleep recovery with fast track surgery102;
low mortality; ileus a problem102,103
Laparoscopic donor nephrectomy104 < 1 day Preliminary study (N = 41); low readmission rate (2%)
Open donor nephrectomy105 2 days —
Pulmonary procedures106-110 ~1 day in some series,106,107 Shortest stay with fast track protocol including revision of drainage principles106,107;
~4–5 days in others safety with very early discharge suggested
Other procedures
Craniotomy111 ~40% < 24 hr Large consecutive series (N = 241) including tumor surgery; local anesthesia used;
low readmission rate; safety suggested
Parathyroid procedures112 ~90% ambulatory Selected consecutive series (N = 100); regional anesthesia and intraoperative
adenoma localization employed; documented safety
Vaginal procedures113 ~1 day Consecutive series (N = 108); surgery done with local anesthesia
cost savings. It should, however, be borne in mind that the last thereby achieving additional cost savings. As noted, the large-scale
portion of a hospital stay is much less expensive than the initial data with detailed patient description and stratification that are
portion; thus, the cost savings in this area may turn out to be needed to clarify the improvements achieved by fast track surgery
smaller than they would at first appear.50-52 This cavil should not are, unfortunately, lacking at present, but so far, all indications are
hinder further development and documentation of fast track that postoperative morbidity is comparable or reduced.
surgery, because inherent in the concept is the idea that revision A commonly expressed concern is that fast track surgery might
and optimization of perioperative care may also reduce morbidity, increase the burden on general practitioners and other parts of the

5. © 2004 WebMD Inc. All rights reserved. ACS Surgery: Principles and Practice
ELEMENTS OF CONTEMPORARY PRACTICE 10 Fast Track Surgery — 5
nonhospital care system. The evidence currently available clearly addressed patient functional status after fast track colonic surgery
indicates that increased use of ambulatory surgery is safe and is suggested that muscle function, exercise capacity, and body compo-
associated with a very low readmission rate.53,54 After major proce- sition are better preserved with this approach than with traditional
dures such as colorectal surgery, however, readmissions are often care, in which surgical stress, insufficient nutrition, and prolonged
unpredictable, and the readmission rate is not significantly reduced immobilization typically lead to significant deterioration of organ
by keeping patients in the hospital for an additional 2 to 3 days.55,56 function. Accordingly, an optimal fast track surgery regimen should
Moreover, in some studies of patients who have undergone coro- aim at early recovery of organ function, not just early discharge.
nary bypass57 and hip replacement,58 earlier discharge and hospital In summary, the basic concept of fast track surgery, which
cost savings have been offset by increased use of postacute rehabil- could be expressed as multimodal control of perioperative patho-
itation services. Thus, any assessment of the costs associated with physiology, seems to be a highly promising approach to improving
fast track surgery should include the total period during which care surgical outcome. We believe that the principles and techniques
(including both hospital care and rehabilitation care) is delivered. embodied in this approach will eventually be integrated into the
Again, however, it should be emphasized that the basic concept care of all surgical patients. To this end, resources should be allo-
of fast track surgery implies control of perioperative pathophysiolo- cated for evaluation and documentation of the effects of fast track
gy with the aim of enhancing recovery and thereby reducing the surgery and related systems on cost, postoperative morbidity, safe-
need for postdischarge care.The relatively few published studies that ty, and overall patient well-being.
References
1. Kehlet H: Multimodal approach to control postop- 17. Holte K, Kehlet H: Perioperative single dose gluco- tance and elective surgery. Surgery 128:757, 2001
erative pathophysiology and rehabilitation. Br J corticoid administration: pathophysiological effects 32. Henriksen MG, Hessov I, Vind Hansen H, et al:
Anaesth 78:606, 1997 and clinical implications. J Am Coll Surg 195:694, Effects of preoperative oral carbohydrates and pep-
2002 tides on postoperative endocrine response, mobi-
2. Wilmore DW, Kehlet H: Management of patients
in fast track surgery. BMJ 322:473, 2001 18. Bisgaard T, Klarskov B, Kehlet H, et al: Preopera- lization, nutrition and muscle function in abdomi-
tive dexamethasone improves surgical outcome nal surgery. Acta Anaesthesiol Scand 47:191, 2003
3. Kehlet H, Wilmore DW: Multi-modal strategies after laparoscopic cholecystectomy: a randomized
to improve surgical outcome. Am J Surg 183:630, 33. Gan TJ, Meyer T, Apfel CC, et al: Consensus guide-
double-blind placebo-controlled trial. Ann Surg
2002 lines for managing postoperative nausea and vomit-
238:651, 2003
ing. Anesth Analg 97:62, 2003
4. White PF: Ambulatory anesthesia—advances into 19. Schmidt M, Lindenauer PK, Fitzgerald JL, et al:
the new millennium. Anesth Analg 98:1234, 2000 34. Holte K, Kehlet H: Postoperative ileus: a prevent-
Forecasting the impact of a clinical practice guide-
able event. Br J Surg 87:1480, 2000
5. Kehlet H: Modification of responses to surgery line for perioperative beta-blockers to reduce car-
by neural blockade: clinical implications. Neural diovascular morbidity and mortality. Arch Intern 35. Holte H, Kehlet H: Postoperative ileus: progress
Blockade in Clinical Anesthesia and Management Med 162:63, 2002 towards effective management. Drugs 62:2603,
of Pain. Cousins MJ, Bridenbaugh PO, Eds. JB 2002
20. Herndon DN, Hart DW,Wolf SE, et al: Reversal of
Lippincott Co, Philadelphia, 1998, p 129 catabolism by beta-blockade after severe burns. N 36. Taguchi A, Sharma N, Saleem RM, et al: Selective
6. Holte K, Kehlet H: Epidural anaesthesia and anal- Engl J Med 345:1223, 2001 postoperative inhibition of gastrointestinal opioid
gesia: effects on surgical stress responses and impli- 21. Hart DW, Wolf SE, Chinkes DL, et al: Beta-block- receptors. N Engl J Med 345:935, 2001
cations for postoperative nutrition. Clin Nutr 21: ade and growth hormone after burn. Ann Surg 37. Kehlet H, Dahl JB: Anaesthesia, surgery and chal-
199, 2002 236:450, 2002 lenges in postoperative recovery. Lancet (in press)
7. Rodgers A, Walker N, Schug S, et al: Reduction of 22. Demling RH, Orgill DP: The anticatabolic and 38. Jin F, Chung F: Multimodal analgesia for postoper-
post-operative mortality and morbidity with epi- wound healing effects of the testosterone analog ative pain control. J Clin Anesth 13:524, 2001
dural or spinal anaesthesia: results from an over- oxandrolone after severe burn injury. J Crit Care
view of randomized trials. BMJ 321:1493, 2000 39. Shang AB, Gan TJ: Optimising postoperative pain
15:12, 2000 management in the ambulatory patient. Drugs 63:
8. Park WY, Thompson JS, Lee KK: Effect of epidur- 23. Basaria S, Wahlstrom JT, Dobs AS: Anabolic- 855, 2003
al anesthesia and analgesia on perioperative out- androgenic steroid therapy in the treatment of
come: a randomized, controlled Veterans Affairs 40. Werner MU, Søholm L, Rotbøll-Nielsen P, et al:
chronic diseases. J Clin Endocrinol Metab 86:5108, Does an acute pain service improve postoperative
cooperative study. Ann Surg 234:560, 2001 2001
outcome? Anesth Analg 95:1361, 2002
9. Norris EJ, Beattie C, Perler BA, et al: Double- 24. Wolf SE,Thomas SJ, Dasu MR, et al: Improved net
masked randomized trial comparing alternate com- 41. Conlon KC, Labow D, Leung D, et al: Prospective
protein balance, lean mass and gene expression
binations of intraoperative anesthesia and postoper- randomized clinical trial of the value of intraperi-
changes with oxandrolone treatment in the severely
ative analgesia in abdominal aortic surgery. Anes- toneal drainage after pancreatic resection. Ann Surg
burned. Ann Surg 237:801, 2003
thesiology 95:1054, 2001 234:487, 2001
25. Van der Berghe G, Wouters P, Weekers F, et al:
10. Rigg JR, Jamrozik K, Myles PS, et al: Epidural 42. Lewis SJ, Egger M, Sylvester PA, et al: Early enter-
Intensive insulin therapy in critically ill patients. N
anaesthesia and analgesia and outcome of major al feeding versus “nil by mouth” after gastrointesti-
Engl J Med 345:1359, 2001
surgery: a randomized trial. Lancet 359:1276, 2002 nal surgery: systematic review and meta-analysis of
26. Jiang ZM, He GZ, Zhang SY, et al: Low-dose controlled trials. BMJ 323:773, 2001
11. Sessler DI: Mild perioperative hypothermia. N growth hormone and hypocaloric nutrition attenu-
Engl J Med 336:1730, 1997 43. Basse L, Raskov HH, Jacobsen DH, et al: Acceler-
ate the protein-catabolic response of a major oper-
ation. Ann Surg 210:513, 1989 ated postoperative recovery program after colonic
12. Wilmore DW: From Cuthbertson to fast-track resection improves physical performance, pul-
surgery: 70 years of progress in reducing stress in 27. Ramirez RJ, Wolf SE, Barrow RE, et al: Growth monary function and body composition. Br J Surg
surgical patients. Ann Surg 236:643, 2002 hormone treatment in pediatric burns: a safe thera- 89:446, 2002
13. Kehlet H: Surgical stress response: does endoscop- peutic approach. Ann Surg 228:439, 1998
44. Henriksen MG, Jensen MB, Hansen HV, et al:
ic surgery confer an advantage? World J Surg 23: 28. Van der Lely AJ, Lamberts SW, Jauch KW, et al: Enforced mobilization, early oral feeding and bal-
801, 1999 Use of human GH in elderly patients with acciden- anced analgesia improve convalescence after colo-
14. Vittimberga FJ Jr, Foley DP, Kehlet H, et al: Lap- tal hip fracture. Eur J Endocrinol 143:585, 2000 rectal surgery. Nutrition 18:147, 2002
aroscopic surgery and the systemic immune re- 29. Takala J, Ruokonen E,Webster NR, et al: Increased 45. Henriksen MG, Hansen HV, Hessov I: Early oral
sponse. Ann Surg 227:326, 1998 mortality associated with growth hormone treat- nutrition after elective surgery: influence of bal-
15. Gupta A, Watson DI: Effect of laparoscopy on ment in critically ill adults. N Engl J Med 341:785, anced analgesia and enforced mobilization. Nu-
immune function. Br J Surg 88:1296, 2001 1999 trition 18:263, 2002
16. Henzi I,Walder B,Tramer MR: Dexamethasone for 30. Raguso CA, Genton L, Pichard C: Growth hor- 46. Basse L, Madsen L, Kehlet H: Normal gastroin-
the prevention of postoperative nausea and vomit- mone (rhGH) administration to ICU patients: a lit- testinal transit after colonic resection using epidur-
ing: a quantitative systematic review. Anesth Analg erature survey. Clin Nutr 20:16, 2001 al analgesia, enforced oral nutrition and laxative. Br
90:186, 2000 31. Ljungqvist O, Nygren J, Thorell A: Insulin resis- J Surg 88:1498, 2001

6. © 2004 WebMD Inc. All rights reserved. ACS Surgery: Principles and Practice
ELEMENTS OF CONTEMPORARY PRACTICE 10 Fast Track Surgery — 6
47. Delaney CP, Zutshi M, Senagore AJ, et al: Pro- 70. Finley CR, McKernan JB: Laparoscopic antireflux 92. Bourke BM: Overnight hospital stay for carotid en-
spective, randomized, controlled trial between a surgery at an outpatient surgery center. Surg darterectomy. Med J Aust 168:157, 1998
pathway of controlled rehabilitation with early Endosc 15:823, 2001 93. Kaufman JL, Frank D, Rhee SW, et al: Feasibility
ambulation and diet and traditional postoperative 71. Basse L, Hjort Jakobsen D, Billesbølle P, et al: A and safety of 1-day postoperative hospitalization
care after laparotomy and intestinal resection. Dis clinical pathway to accelerate recovery after for carotid endarterectomy. Arch Surg 131:751,
Colon Rectum 46:851, 2003 colonic resection. Ann Surg 232:51, 2000 1996
48. Weingarten S, Riedinger MS, Sandhu M, et al: 72. Delaney CP, Kiran RP, Senagore AJ, et al: Case- 94. Littooy FN, Steffen G, Greisler HP, et al: Short
Can practice guidelines safely reduce hospital matched comparison of clinical and financial out- stay carotid surgery for veterans: an emerging stan-
length of stay? Results from a multicenter inter- come after laparoscopic or open colorectal surgery. dard. J Surg Res 95:32, 2001
ventional study. Am J Med 105:33, 1998 Ann Surg 238:67, 2003 95. Collier PE: Do clinical pathways for major vascu-
49. Pearson SD, Kleefield SF, Soukop JR, et al: 73. Di Fronzo LA, Cymerman J, O’Connell TX: Fac- lar surgery improve outcomes and reduce cost? J
Critical pathways intervention to reduce length of Vasc Surg 26:179, 1997
tors affecting early postoperative feeding following
hospital stay. Am J Med 110:175, 2001
elective open colon resection. Arch Surg 134:941, 96. Podore PC, Throop EB: Infrarenal aortic surgery
50. Weingarten S: Critical pathways: what do you do 1999 with a 3-day hospital stay: a report on success with
when they do not seem to work? Am J Med a clinical pathway. J Vasc Surg 29:787, 1999
74. Smedh K, Strand E, Jansson P, et al: Rapid recov-
110:224, 2001
ery after colonic resection using Kehlet’s multi- 97. Renghi A, Brustia P, Gramaglia L, et al: Mini-
51. Taheri PA, Butz DA, Greenfield LJ: Length of stay modal rehabilitation program. Läkartidningen invasive abdominal surgery: early recovery and
has minimal impact on the cost of hospital admis- 98:2568, 2001 reduced hospitalization after a multi-disciplinary
sion. J Am Coll Surg 191:124, 2000
75. Basse L, Hjort Jakobsen D, Billesbølle P, et al: approach. J Cardiovasc Surg (in press)
52. Barkun JS: Relevance of length of stay reductions. Colostomy closure after Hartmann’s procedure 98. Kirsh EJ,Worwag EM, Sinner M, et al: Using out-
J Am Coll Surg 191:192, 2000 with fast-track rehabilitation. Dis Colon Rectum come data and patient satisfaction surveys to
53. Twersky R, Fishman D, Homel P: What happens 45:1661, 2002 develop policies regarding minimum length of hos-
after discharge? Return hospital visits after ambu- 76. Stephen AE, Berger DL: Shortened length of stay pitalization after radical prostatectomy. Urology
latory surgery. Anesth Analg 84:319, 1997 and hospital cost reduction with implementation 56:101, 2000
54. Mezei G, Chung F: Return hospital visits and hos- of an accelerated clinical care pathway after elec- 99. Gill IS, Hobart MG, Schweizer D, et al:
pital readmissions after ambulatory surgery. Ann tive colon resection. Surgery 133:277, 2003 Outpatient adrenalectomy. J Urol 163:717, 2000
Surg 230:721, 1999 77. Bardram L, Funch-Jensen P, Kehlet H: Rapid re- 100. Edwin B, Ræder I, Trondsen E, et al: Outpatient
55. Azimuddin K, Rosen L, Reed JF, et al: Re- habilitation in elderly patients after laparoscopic laparoscopic adrenalectomy in patients with
admissions after colorectal surgery cannot be pre- colonic resection. Br J Surg 87:1540, 2000 Conn’s syndrome. Surg Endosc 15:589, 2001
dicted. Dis Colon Rectum 7:942, 2001 78. Senagore AJ,Whalley D, Delaney P, et al: Epidural 101. Rayan SS, Hodin RA: Short-stay laparoscopic ad-
56. Basse L, Thorbøll JE, Løssl K, et al: Colonic sur- anesthesia-analgesia shortens length of stay after renalectomy. Surg Endosc 14:568, 2000
gery with accelerated rehabilitation or convention- laparoscopic segmental colectomy for benign
pathology. Surgery 129:672, 2001 102. Brodner G, Van Aken H, Hertle L, et al: Mul-
al care. Dis Colon Rectum (in press)
timodal perioperative management—combining
57. Bohmner RM, Newell J, Torchiana DF: The effect 79. Senagore AJ, Duepree HJ, Delaney CP, et al: Re- thoracic epidural analgesia, forced mobilization,
of decreasing length of stay on discharge destina- sults of a standardized technique and postoperative and oral nutrition—reduces hormonal and meta-
tion and readmission after coronary bypass opera- care plan for laparoscopic sigmoid colectomy: a bolic stress and improves convalescence after
tion. Surgery 132:10, 2002 30-month experience. Dis Colon Rectum 46:503, major urologic surgery. Anesth Analg 92:1594,
2003 2001
58. Ganz SB, Wilson PD, Cioppa-Mosca J, et al: The
day of discharge after total hip arthroplasty and the 80. Delaney CP, Fazio VW, Senagore AJ, et al: Fast 103. Chang SS, Cookson MS, Baumgartner RG, et al:
achievement of rehabilitation functional mile- track postoperative management protocol for Analysis of early complications after radical cystec-
stones. J Arthroplast 18:453, 2003 patients with high co-morbidity undergoing com- tomy: results of a collaborative care pathway. J Urol
plex abdominal pelvic colorectal surgery. Br J Surg 167:2012, 2002
59. Callesen T, Bech K, Kehlet H: One-thousand con-
88:1533, 2001
secutive inguinal hernia repairs under unmoni- 104. Kuo PC, Johnson LB, Sitzmann JV: Laparoscopic
tored local anesthesia. Anesth Analg 93:1373, 81. Archer SB, Burnett RJ, Flesch LV, et al: Im- donor nephrectomy with a 23-hour stay. Ann Surg
2001 plementation of a clinical pathway decreases length 31:772, 2000
of stay and hospital charges for patients undergo-
60. Kark AE, Kurzer NM, Belsham PA: Three thou- 105. Knight MK, Dimarco DS, Myers RP, et al: Sub-
ing total colectomy and ileal pouch/anal anasto-
sand one hundred seventy-five primary inguinal jective and objective comparison of critical care
mosis. Surgery 122:699, 1997
hernia repairs: advantages of ambulatory open pathways for open donor nephrectomy. J Urol
mesh repair using local anesthesia. J Am Coll Surg 82. Kimmins MH, Evetts BK, Isler J, et al: The Al- 167:2368, 2002
186:447, 1998 temeier repair: outpatient treatment of rectal pro-
lapse. Dis Colon Rectum 44:565, 2001 106. Tovar EA, Roethe RA, Weissing MD, et al: One-
61. Kingsnorth AN, Bowley DMG, Porter C: A pro- day admission for lung lobectomy: an incidental
spective study of 1000 hernias: results of the 83. Brooks AD, Marcus SG, Gradek C, et al: Decreas- result of a clinical pathway. Ann Thorac Surg
Plymouth Hernia Service. Ann R Coll Surg Engl ing length of stay after pancreatoduodenectomy. 65:803, 1998
85:18, 2003 Arch Surg 135:823, 2000
107. Tovar EA: One-day admission for major lung resec-
62. Mjåland O, Raeder J, Aasboe V, et al: Outpatient 84. Porter GA, Pisters PTW, Mansyur C, et al: Cost tions in septuagenarians and octogenarians: a com-
laparoscopic cholecystectomy. Br J Surg 84:958, and utilization impact of a clinical pathway for parative study with a younger cohort. Eur J Car-
1997 patients undergoing pancreatico-duodenectomy. diothorac Surg 20:449, 2001
Ann Surg Oncol 7:484, 2000
63. Voitk AJ: Establishing outpatient cholecystectomy 108. Cerfolio RJ, Pickens A, Bass C, et al: Fast-tracking
as a hospital routine. Can J Surg 40:284, 1997 85. Pitt HA, Murray KP, Bowman HM, et al: Clinical pulmonary resections. J Thor Cardiovasc Surg 122:
pathway implementation improves outcomes for 318, 2001
64. Keulemans Y, Eshuis J, deHaes H, et al: Laparo-
complex biliary surgery. Surgery 126:751, 1999
scopic cholecystectomy: day-care versus clinical 109. Zehr KJ, Dawson PB,Yang SC, et al: Standardized
observation. Ann Surg 228:734, 1998 86. Warren JL, Riley GF, Potosky AL:Trends and out- clinical care pathways for major thoracic cases
comes of outpatient mastectomy in elderly women. reduce hospital costs. Ann Thorac Surg 66:914,
65. Calland JF, Tanaka K, Foley E, et al: Outpatient
J Natl Cancer Inst 90:833, 1998 1998
laparoscopic cholecystectomy: patient outcomes
after implementation of a clinical pathway. Ann 87. Ferrante J, Gonzalez E, Pal N, et al: The use and 110. Wright CD, Wain JC, Grillo HC, et al: Pulmonary
Surg 233:704, 2001 outcomes of outpatient mastectomy in Florida. lobectomy patient care pathway: a model to control
66. Richardson WS, Fuhrman GS, Burch E, et al: Am J Surg 179:253, 2000 cost and maintain quality. Ann Thorac Surg 64:
Outpatient laparoscopic cholecystectomy. Surg 88. Bundred N, Maguire P, Reynolds J, et al: Ran- 299, 1997
Endosc 15:193, 2001 domized controlled trial of effects of early dis- 111. Blanchard HJ, Chung F, Manninen PH, et al:
67. Bisgaard T, Klarskov B, Kehlet H, et al: Recovery charge after surgery for breast cancer. BMJ Awake craniotomy for removal of intracranial
after uncomplicated laparoscopic cholecystectomy. 317:1275, 1998 tumor: considerations for early discharge. Anesth
Surgery 132:817, 2002 89. Margolese RG, Jean-Claude M: Ambulatory Analg 92:89, 2001
68. Seale AK, Ledet WP: Minicholecystectomy: a safe, surgery for breast cancer patients. Ann Surg Oncol 112. Udelsman R, Donovan PI, Sokoll LJ: One hun-
cost-effective day surgery procedure. Arch Surg 7:181, 2000 dred consecutive minimally invasive parathyroid
134:308, 1999 90. Dooley WC: Ambulatory mastectomy. Am J Surg explorations. Ann Surg 232:331, 2000
69. Trondsen E, Mjåland O, Raeder J, et al: Day-case 184:545, 2002 113. Petros PEP: Development of generic models for
laparoscopic fundoplication for gastro-esophageal 91. Collier PE: Are one-day admissions for carotid ambulatory vaginal surgery—a preliminary report.
reflux disease. Br J Surg 87:1708, 2000 endarterectomy feasible? Am J Surg 170:140, 1995 Int Urogynecol J 9:19, 1998