This master's thesis discusses the development of a DNA relational database and experiments manipulating data. The author proposes a data model where the database is constructed from genome DNA and information tags that can be directly manipulated through chemical reactions. This allows similar data to be abstracted in parallel by taking advantage of how single-stranded DNA associates with complementary and similar strands. The relational data model is preferable for genome analysis requiring set operations on data with attributes. The author executes relational algebra experiments on the DNA database and develops a scheme to convert SQL queries to experimental operations. Computer analysis and chemical experiments on the resulting sequences successfully demonstrate data retrieval from the DNA relational database.

1. 複合情報学専攻 修士論文 (2006 年 2 月 7 日)
研究題目（DNA リレーショナルデータベースの開発とデータ操作に
関する研究）
複雑系工学講座 調和系工学研究室 修士 2 年 北 豊
英文題目（Development of DNA Relational Database and Data
Manipulation Experiments）
Research Group of Complex Systems Engineering,
Laboratory of Harmonious Systems Engineering
MC2 Yutaka Kita
Abstract: Genom e represents genetic information and is a just arrangem ent of base
sequences. Many researchers have dealt genome database to execute genome analysis.
However, it is troublesom e that convert genom e into electronic data and synthesis DN A to
execute chemical experim ents with the analysis results. If genom e database is constructed
by genom e DNA and information tag (synthesis DNA), they can be directly manipulated by
chemical reactions. In a DNA database we can abstract similar data in parallel to utilize
property in which a single stranded DNA (ssDNA) is associated not only with
complem entary ssDN A but som e ssDN A that are similar to complem entary ssDN A. In
addition, storing and processing individual genetic inform ation in electronic data has many
problems from the viewpoint of the protection of individual information. It is preferable that
the data model of database on DN A database is relational model because genome analyses
require set operation such as abstraction data with attribute information. In this paper, I
propose data model of DN A relational database and execute relational algebra with chemical
experim ents. I also construct a conversion schem e of SQL to experimental operations.
Finally, by computer analyses and chemical experim ents with these experim ental sequences,
we successful data reference from DNA relational database.
研究業績：
1. Yutaka Kita, Satoshi Kashiwamura, Atsushi Kameda, Masahito Yamamoto, Azuma Ohuchi:
“Data Manipulation of DNA Relational Database”,
Proceedings of the The Eleventh International Symposium on Artificial Life and Robotics (AROB 11th ‘06),
Beppu (Japan), CD-ROM, (2006, 1)
2. 北 豊, 柏村 聡, 亀田 充史, 山本 雅人, 大内 東：
“DNA 分子を利用したリレーショナルデータベースの開発”,
第 4 回情報科学技術フォーラム講演論文集 (FIT2005), 東京, CD-ROM, (2005, 9)
その他 国際学会 1 編，国内学会 1 編