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Iontophoresis
Phenophoresis
ROUTE /ONSET OF ACTION ABSORPTION MECHANISM DRUGS
Buccal/ Sublingual (3-5 mins) Passive diffusion, carrier
mediated transport
Nitrites and nitrates,
antianginals, nifedipine,
morphine, etc
Rectal (5-30mins) Passive diffusion Aspirin, Paracetamol,
Theophylline, etc
Transdermal (mins-hours) Passive diffusion Nitroglycerin, lidocaine,
scopolamine, etc
Subcutaneous (15-30mins) Passive diffusion Insulin, heparin
Comparison of different routes
Inhalation (2-3mins) Passive diffusion, pore
transport
Sulbutamol, cromolyn,
beclomethasone
Intramuscular (10-20mins) Passive diffusion,
endocytosis, pore transport
Phenytoin, dioxin, steroids
and antibiotics etc
Intranasal (3-5mins) Passive diffusion, pore
transport
Phenylpropylamine,
antihistamines
Intraocular Passive diffusion Atropine, pilocarpine,
adrenaline
Absorption of drugs from extravascular routes

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Absorption of drugs from extravascular routes

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  • 41. ROUTE /ONSET OF ACTION ABSORPTION MECHANISM DRUGS Buccal/ Sublingual (3-5 mins) Passive diffusion, carrier mediated transport Nitrites and nitrates, antianginals, nifedipine, morphine, etc Rectal (5-30mins) Passive diffusion Aspirin, Paracetamol, Theophylline, etc Transdermal (mins-hours) Passive diffusion Nitroglycerin, lidocaine, scopolamine, etc Subcutaneous (15-30mins) Passive diffusion Insulin, heparin Comparison of different routes
  • 42. Inhalation (2-3mins) Passive diffusion, pore transport Sulbutamol, cromolyn, beclomethasone Intramuscular (10-20mins) Passive diffusion, endocytosis, pore transport Phenytoin, dioxin, steroids and antibiotics etc Intranasal (3-5mins) Passive diffusion, pore transport Phenylpropylamine, antihistamines Intraocular Passive diffusion Atropine, pilocarpine, adrenaline