It is a ppt about is HPLC should be used as routine screening test for anemic and antenatal cases.This ppt is prepared by taking information from journal
Anemia and Iron Deficiency Anemia in Egyptiosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
This study examined the prevalence of hemoglobin variants in 875 Greek patients. Testing found that 13.14% of patients had at least one abnormal hemoglobin level. Specifically, 11.2% had beta-thalassemia trait with elevated HbA2 levels, 0.91% had sickle cell trait, and 0.22% had hereditary persistence of fetal hemoglobin. These results are consistent with previous reports on the prevalence of beta-thalassemia trait and sickle cell trait in Greece. Hemoglobinopathies represent a major public health issue given their frequency and severity, and international collaboration will be needed to effectively address this problem.
case presentation on diagnosis of beta thalassemia majorDrShinyKajal
case history of 9 month old infant
Paediatric Clinical Approach to this case
examination
workup at blood centre
HPLC screening
laboratory findings
screening of father mother
prominent facial features
PBF and bone marrow findings
usg abdomen
xray skull
prbc transfusion therapy in thalassemia major
classification of thalassemia
national burden in india
pathogenesis- anemia skull bone iron overload
world thalassemia day
Background: Anemia is a common Feature of chronic kidney disease, but the management of anemia in children is complex. Erythropoietin and Supplemental iron are used to maintain hemoglobin levels. The aim of this study to determine the Frequency of anemia and possible Risk Factors Among children with End stage renal disease.
Methods: A total of 96 children, 61males (63.5%) and 35 Females (36.5%), were attended at hemodialysis units in Khartoum state were enrolled in the study and Frequency of anemia was estimated by analyzing CBC on blood counter (sysmex). The concentration of iron profile, C-reactive protein and parathyroid hormone was measured using COBAS INTEGRA 400 PLUS and COBAS E411.
Results: 99% of children were anemic, 4.17% of them were suffering from iron deficiency anemia and there are other causes contributing to anemia in ESRD patients which are inflammation and hyperparathyroidism.
Conclusion: The prevalence of anemia in children on hemodialysis in Sudan appears to be higher than that reported in other studies despite extensive use of rHuEPO and iron supplementation.
ABSTRACT- Sickle cell disease (SCD) is an inherited hematological disorder that causes red blood cells to break down continuously. This leads to a rigid, sickle like shape under certain conditions, causing polymerization of the sickled hemoglobin. This study was undertaken to know whether sex hormones (estradiol, progesterone, testosterone and prolactin) exert any effect on the polymerization of sickle cell erythrocytes in vitro and the possibility of these hormones having an effect on the sickling phenomenon. The hemoglobin polymerization test was carried out when hemoglobin S undergoes gelation after it was deprived of oxygen using 2% sodium metabisulphite as reductant. The polymerization inhibition studies were shown that estrogen, progesterone, testosterone and not prolactin had a statistical significant reduction effect (P<0.05) on the polymerization of the sickle cell erythrocytes. The polymerization of the sickle cell erythrocytes was reduced to 50.90%, 62.74%, 67.56% and 92.16% at the concentration of 50.0 pg/ml of estrogen, 5.0 ng/ml of progesterone, 6.0 ng/ml of testosterone and 7.0 ng/ml of prolactin in the same order. This effect was achieved at a low concentration of these hormones. Higher concentrations of the hormones increased polymerization. The result suggests that using the hormones substances at low concentrations can help to ameliorate the intracellular polymerization of sickle cell hemoglobin.
Key-words- Sickle cell, Hormones, Polymerization, Progesterone, Estradiol, Testosterone, Prolactin
Prevalence of hypochromic microcytic anemia in the Hematology-oncology depart...Premier Publishers
Introduction: Microcytic hypochromic anemia is a distinct morphologic subtype of anemia with well-defined etiology and treatment. Anemia is a major public health problem worldwide despite the remarkable improvement in living conditions. This study aimed to determine the prevalence of hypochromic microcytic anemia and to identify the different etiologies in patients hospitalized in the ward during the study period. Methods: This was a retrospective study two years, including patients hospitalized in the Hematology-oncology department. Results: Out of a total of 114 patients hospitalized for anemia, we collected 65 cases of hypochromic microcytic anemia (57.02%). The mean age was of 37.43 years. The sex ratio was 1.95. Pallor was the physical sign predominantly 100% of the cases. The most predominant associated pathology was malaria (95.38%). Twenty one patients (32.3%) had a hemoglobin level between 4 and 5 g/dl. The most incriminated causes in the occurrence of hypochromic microcytic anemia were anemia due to iron deficiency 50.77% and anemia due to inflammatory syndrome 43.08%. Conclusion: Our study shows that hypochromic microcytic anemia has various etiologies and its prevalence is not negligible in the Hematology-oncology department of Donka Hospital.
A case of red cell membrane defect with distal renal tubular acidosis present...Apollo Hospitals
A 10-year-old male child who presented with nephrolithiasis due to distal renal tubular acidosis (dRTA) was found to have red blood cell (RBC) membrane defect as well. On review of literature, we found that both the conditions are caused by mutations in anion exchanger gene 1 (AE1) on chromosome 17 which is expressed on the RBC membrane and on the membrane of renal tubule alfa intercalated cell. It has now been shown that some AE1 mutations are responsible for causing autosomal-recessive dRTA. These patients should be either homozygous or double heterozygous with other AE1 mutations, one of which is the SAO (Southeast Asian ovalocytosis) mutation. In the latter situation, both the phenotypes, that is, dRTA and RBC membrane defect will coexist in the same patient.
Haemoglobinopathies are genetic blood disorders caused by abnormalities in haemoglobin. Common types include beta-thalassaemia, alpha-thalassaemia, and sickle cell disease. The GP's role is to discuss carrier testing and investigate potential carriers through blood tests and refer those identified to specialist services. Carrier testing is recommended for individuals with risk factors like certain ethnicities or a family history. Blood tests can identify carriers but DNA testing is often needed to confirm carrier status, especially for alpha-thalassaemia. Management depends on the specific haemoglobinopathy but may include genetic counselling, monitoring, or treatment.
Anemia and Iron Deficiency Anemia in Egyptiosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
This study examined the prevalence of hemoglobin variants in 875 Greek patients. Testing found that 13.14% of patients had at least one abnormal hemoglobin level. Specifically, 11.2% had beta-thalassemia trait with elevated HbA2 levels, 0.91% had sickle cell trait, and 0.22% had hereditary persistence of fetal hemoglobin. These results are consistent with previous reports on the prevalence of beta-thalassemia trait and sickle cell trait in Greece. Hemoglobinopathies represent a major public health issue given their frequency and severity, and international collaboration will be needed to effectively address this problem.
case presentation on diagnosis of beta thalassemia majorDrShinyKajal
case history of 9 month old infant
Paediatric Clinical Approach to this case
examination
workup at blood centre
HPLC screening
laboratory findings
screening of father mother
prominent facial features
PBF and bone marrow findings
usg abdomen
xray skull
prbc transfusion therapy in thalassemia major
classification of thalassemia
national burden in india
pathogenesis- anemia skull bone iron overload
world thalassemia day
Background: Anemia is a common Feature of chronic kidney disease, but the management of anemia in children is complex. Erythropoietin and Supplemental iron are used to maintain hemoglobin levels. The aim of this study to determine the Frequency of anemia and possible Risk Factors Among children with End stage renal disease.
Methods: A total of 96 children, 61males (63.5%) and 35 Females (36.5%), were attended at hemodialysis units in Khartoum state were enrolled in the study and Frequency of anemia was estimated by analyzing CBC on blood counter (sysmex). The concentration of iron profile, C-reactive protein and parathyroid hormone was measured using COBAS INTEGRA 400 PLUS and COBAS E411.
Results: 99% of children were anemic, 4.17% of them were suffering from iron deficiency anemia and there are other causes contributing to anemia in ESRD patients which are inflammation and hyperparathyroidism.
Conclusion: The prevalence of anemia in children on hemodialysis in Sudan appears to be higher than that reported in other studies despite extensive use of rHuEPO and iron supplementation.
ABSTRACT- Sickle cell disease (SCD) is an inherited hematological disorder that causes red blood cells to break down continuously. This leads to a rigid, sickle like shape under certain conditions, causing polymerization of the sickled hemoglobin. This study was undertaken to know whether sex hormones (estradiol, progesterone, testosterone and prolactin) exert any effect on the polymerization of sickle cell erythrocytes in vitro and the possibility of these hormones having an effect on the sickling phenomenon. The hemoglobin polymerization test was carried out when hemoglobin S undergoes gelation after it was deprived of oxygen using 2% sodium metabisulphite as reductant. The polymerization inhibition studies were shown that estrogen, progesterone, testosterone and not prolactin had a statistical significant reduction effect (P<0.05) on the polymerization of the sickle cell erythrocytes. The polymerization of the sickle cell erythrocytes was reduced to 50.90%, 62.74%, 67.56% and 92.16% at the concentration of 50.0 pg/ml of estrogen, 5.0 ng/ml of progesterone, 6.0 ng/ml of testosterone and 7.0 ng/ml of prolactin in the same order. This effect was achieved at a low concentration of these hormones. Higher concentrations of the hormones increased polymerization. The result suggests that using the hormones substances at low concentrations can help to ameliorate the intracellular polymerization of sickle cell hemoglobin.
Key-words- Sickle cell, Hormones, Polymerization, Progesterone, Estradiol, Testosterone, Prolactin
Prevalence of hypochromic microcytic anemia in the Hematology-oncology depart...Premier Publishers
Introduction: Microcytic hypochromic anemia is a distinct morphologic subtype of anemia with well-defined etiology and treatment. Anemia is a major public health problem worldwide despite the remarkable improvement in living conditions. This study aimed to determine the prevalence of hypochromic microcytic anemia and to identify the different etiologies in patients hospitalized in the ward during the study period. Methods: This was a retrospective study two years, including patients hospitalized in the Hematology-oncology department. Results: Out of a total of 114 patients hospitalized for anemia, we collected 65 cases of hypochromic microcytic anemia (57.02%). The mean age was of 37.43 years. The sex ratio was 1.95. Pallor was the physical sign predominantly 100% of the cases. The most predominant associated pathology was malaria (95.38%). Twenty one patients (32.3%) had a hemoglobin level between 4 and 5 g/dl. The most incriminated causes in the occurrence of hypochromic microcytic anemia were anemia due to iron deficiency 50.77% and anemia due to inflammatory syndrome 43.08%. Conclusion: Our study shows that hypochromic microcytic anemia has various etiologies and its prevalence is not negligible in the Hematology-oncology department of Donka Hospital.
A case of red cell membrane defect with distal renal tubular acidosis present...Apollo Hospitals
A 10-year-old male child who presented with nephrolithiasis due to distal renal tubular acidosis (dRTA) was found to have red blood cell (RBC) membrane defect as well. On review of literature, we found that both the conditions are caused by mutations in anion exchanger gene 1 (AE1) on chromosome 17 which is expressed on the RBC membrane and on the membrane of renal tubule alfa intercalated cell. It has now been shown that some AE1 mutations are responsible for causing autosomal-recessive dRTA. These patients should be either homozygous or double heterozygous with other AE1 mutations, one of which is the SAO (Southeast Asian ovalocytosis) mutation. In the latter situation, both the phenotypes, that is, dRTA and RBC membrane defect will coexist in the same patient.
Haemoglobinopathies are genetic blood disorders caused by abnormalities in haemoglobin. Common types include beta-thalassaemia, alpha-thalassaemia, and sickle cell disease. The GP's role is to discuss carrier testing and investigate potential carriers through blood tests and refer those identified to specialist services. Carrier testing is recommended for individuals with risk factors like certain ethnicities or a family history. Blood tests can identify carriers but DNA testing is often needed to confirm carrier status, especially for alpha-thalassaemia. Management depends on the specific haemoglobinopathy but may include genetic counselling, monitoring, or treatment.
Introduction: The hemoglobinopathy is a real public health problem in the world The aim of this study to épister of children with abnormalities of hemoglobin in schools, especially kindergartens in the city of Parakou Republic of Benin.
Methods: This is a descriptive cross-sectional study, conducted in kindergartens in the city of Parakou in Benin republic and having concerned 690 children aged 2 ½ to 5 years. The hemoglobin electrophoresis was done using alkaline pH hydragel and the quantification of haemoglobin fractions were performed with Hyrys densitometer; in some cases the medium is reduced for precipitation test.
Results: Five types of Hb were identified: A, S, M, C and K probably Woolwich. Qualitative hemoglobinopathy was found in 31.45% of the study population. The Hb-S was the most frequent (16.52%) followed by hemoglobin C (15.65%). Hereditary persistence of hemoglobin F was associated with phenotypes AA, AC and SS in 1.16% of cases. The hemoglobinopathies were found in all the major ethnic groups in Parakou with a clear predominance among "Lokpa" (53.3%) and "Adja" (37.5%).
Conclusion: The hemoglobinopathy is a real public health problem in Parakou, it is necessary to establish or to legislate for mandatory testing for hemoglobinopathies at birth.
MOLECULAR PATHOGENESIS OF PREVALENT HEMOGLOBINOPATHIESChelsea Osayande
Hemoglobinopathies are congenital disorders resulting from hemoglobin abnormalities. Major forms are often severe, their management is difficult and associated with a great psychosocial impact on patients and their families.
These hemoglobinopathies may be due to alterations in certain globin chains that include:
Absence of production
Diminished production
Abnormal structure.
The clinically significant hemoglobinopathies include α- and β-thalassemia, sickle cell disease, HbE disease, and HbC disease.
simlpe approach to anemia in children , how to diagnose anemia in kids ,types of anemias ,causes of anemia , iron deficeincy anemia, hemolytic anemias , laboratory tests in anemia ,
The document discusses modern trends in the management of thalassemia. It summarizes that thalassemia is a genetic blood disorder resulting from reduced or absent production of hemoglobin chains. For patients with thalassemia major, regular blood transfusions are the main treatment to prevent anemia and suppress ineffective red blood cell production. The transfusions aim to maintain hemoglobin levels between 10-12 gm/dl. Managing iron overload from frequent transfusions also requires chelation therapy.
1) This study examined hematologic abnormalities in 64 HIV-infected children on highly active antiretroviral therapy (HAART) in Ethiopia.
2) The prevalence of anemia, thrombocytopenia and neutropenia decreased after starting HAART, from 53.1%, 18.8%, and 7.8% to 21.9%, 7.8%, and 4.7% respectively.
3) Mean hemoglobin levels, CD4 count, platelet count, and total leukocyte count increased significantly after HAART initiation.
IDA is the most common form of anemia worldwide, affecting approximately 50% of anemia cases. It results from prolonged negative iron balance in the body due to factors like inadequate iron intake, decreased absorption, increased demand, or blood loss. Diagnosis involves a complete history, physical exam, and lab tests showing low indicators of iron stores like serum ferritin and iron, along with an elevated TIBC. Treatment aims to replenish iron stores and typically consists of oral iron supplementation of 200mg elemental iron per day for 3-6 months.
1. The study examined gene frequencies and disease characteristics of sickle cell disease among tribal and Chetti communities in Wayanad district, Kerala, India.
2. Gene frequencies for the sickle cell trait ranged from 1.9-19.6% across communities, with the highest in Wayanadan Chettis. Many homozygotes were observed with the oldest being 48 years old.
3. The disease was mild in 52.2% of cases, with painful crises in 43.5% and splenomegaly and leg ulcers each in 4.3%. Survival of patients appears higher in Kerala than other states.
Iron deficiency anemia (IDA) is the most common type of anemia globally, affecting approximately 1.6 billion people. It results from prolonged negative iron balance in the body due to inadequate intake, decreased absorption, increased demand, or losses. Diagnosis involves a complete blood count and serum iron studies showing microcytic anemia and low iron stores. Treatment focuses on oral iron supplementation of 200 mg elemental iron daily for 3-6 months to replenish stores and resolve symptoms, with intravenous options for intolerances or malabsorption. Education aims to prevent recurrences through lifestyle modifications.
This document discusses iron deficiency anemia (IDA), including its definition, epidemiology, etiology, diagnosis, and treatment. Some key points include:
- IDA is the most common type of anemia worldwide, affecting approximately 1.6 billion people. It occurs when iron levels and stores in the body are depleted.
- Risk factors for IDA include blood loss, inadequate iron intake, increased iron demands, and impaired iron absorption. Young children, women of childbearing age, and those with chronic blood loss are most at risk.
- IDA is diagnosed based on low hemoglobin and iron indicator levels. Treatment involves oral or intravenous iron supplementation to replenish iron stores. Managing the underlying cause is also important for preventing
Globin_gene_haplotype_analysis_in_a_ghanian_population_presentationSifuma Andrew Njenga
This document discusses globin gene haplotype analysis in a Ghanaian population. It provides background on sickle cell disease and how it is caused by inheritance of two Hb S alleles from a mutation in the β-globin gene. The main objective is to analyze dried blood samples to determine haemoglobin haplotypes. Restriction fragment length polymorphism analysis will be used to amplify DNA from samples and digest with restriction enzymes to identify which β-globin haplotypes are present in Ghanaians. The hypothesis is that samples will exhibit a higher proportion of Cameroon, Bantu, and Benin haplotypes.
Anemia is a common complication of chronic kidney disease that can cause fatigue. While the kidneys normally produce erythropoietin to stimulate red blood cell production, CKD patients have relative erythropoietin deficiency. This leads to anemia which, if left untreated, can negatively impact quality of life and cardiovascular health. Erythropoiesis-stimulating agents and iron supplementation are used to treat anemia in CKD, though the appropriate hemoglobin target level remains an area of ongoing research and debate given risks identified with higher targets in some studies.
Genetics of fetal hemoglobin in tribal Indian patients sickle cell anemiaSujata Singh
This study investigated the association between genetic variants known to influence fetal hemoglobin (HbF) levels and HbF levels in 240 Indian patients with sickle cell anemia and 60 with sickle cell trait. Genotyping was performed for variants in the BCL11A, HMIP, and HBB genes. All three quantitative trait loci were associated with HbF levels, with the strongest association seen for the HBB Xmn1 variant. The BCL11A and HMIP variants were also associated with HbF levels and explained a percentage of trait variance. This is the first such study in India and indicates these genetic factors influence HbF levels and likely disease severity in this population.
Inherited abnormalities of hemoglobin synthesis characterised by structurally abnormal hemoglobin variants.
The disorders of Hb divided into 2 main groups :-
Structural globin chain variants such as Sickle cell anaemia
Disorders of synthesis of globin chains such as Thalassemia
The document discusses haemoglobin disorders and haemoglobinopathies. It provides details on the molecular basis, inheritance patterns, clinical presentation and diagnosis of conditions like thalassaemia, sickle cell disease and other haemoglobin variants. Key points include that haemoglobin disorders are globally common due to ancestral mutations, are usually inherited in an autosomal recessive pattern, and can be diagnosed through blood tests, family history and molecular genetic analysis. Screening programs have helped identify carriers and provide prenatal diagnosis services.
This document presents a case study of a rare HbSE disorder detected in a 24-year-old male in Balasore District, Odisha, India. Testing confirmed the patient had a double heterozygous state of sickle cell and hemoglobin E through various lab tests. Further testing found the patient's mother was a sickle cell carrier and father a hemoglobin E carrier, explaining how the patient acquired this rare disorder. The patient was mostly asymptomatic with occasional joint/bone pains and was advised on genetic counseling and testing. This represents the first reported case of HbSE disorder in Northern Coastal Odisha.
This document provides an introduction and background to a study on sickle cell anemia (SCA) in Jos North, Nigeria. It discusses SCA as a genetic blood disorder with high morbidity and mortality. The incidence, prevalence, diagnosis and treatment of SCA in Jos North is examined. Improving outcomes for children with SCA through early diagnosis, prophylactic therapy and bone marrow transplants is discussed. The research problem is identified as a lack of knowledge among residents about SCA implications and the need for screening before marriage. The study aims to educate residents on SCA and identify carriers to reduce disease transmission risk. The scope covers selected primary health centers in Jos North.
A Study of Anemia Among children in Mansoura University Children's Hospital; ...Kareem Alnakeeb
A "Study of Anemia" Among children in Mansoura University Children's Hospital. It involved 30 male and female children aged from 5 to 120 months old, who were hospitalized in Mansoura University Children's Hospital. The study was performed in the period between 19 March 2018 and 18 April 2018.
This document discusses thalassemia in Bangladesh and advances in the management of beta thalassemia major. It notes that Bangladesh has high carrier and frequency rates of thalassemia major and hemoglobin E. The key advances in managing beta thalassemia major discussed include regular blood transfusions to maintain optimal hemoglobin levels, iron monitoring and chelation therapy to remove excess iron, and hematopoietic stem cell transplantation which can cure thalassemia major in some cases. Complications from iron overload continue to be a major challenge in the long term management of patients.
Đặc điểm điện di huyết sắc tố và kiểu gene hội chứng thai tích dịch do Hb Bart'sVõ Tá Sơn
Electrophoresis features and genotypes of Hb Bart’s hydrops fetalis
Đặc điểm điện di huyết sắc tố và kiểu gene hội chứng thai tích dịch do Hb Bart's
bsvotason
bs võ tá sơn
bác sĩ võ tá sơn
How to Add Chatter in the odoo 17 ERP ModuleCeline George
In Odoo, the chatter is like a chat tool that helps you work together on records. You can leave notes and track things, making it easier to talk with your team and partners. Inside chatter, all communication history, activity, and changes will be displayed.
A workshop hosted by the South African Journal of Science aimed at postgraduate students and early career researchers with little or no experience in writing and publishing journal articles.
Introduction: The hemoglobinopathy is a real public health problem in the world The aim of this study to épister of children with abnormalities of hemoglobin in schools, especially kindergartens in the city of Parakou Republic of Benin.
Methods: This is a descriptive cross-sectional study, conducted in kindergartens in the city of Parakou in Benin republic and having concerned 690 children aged 2 ½ to 5 years. The hemoglobin electrophoresis was done using alkaline pH hydragel and the quantification of haemoglobin fractions were performed with Hyrys densitometer; in some cases the medium is reduced for precipitation test.
Results: Five types of Hb were identified: A, S, M, C and K probably Woolwich. Qualitative hemoglobinopathy was found in 31.45% of the study population. The Hb-S was the most frequent (16.52%) followed by hemoglobin C (15.65%). Hereditary persistence of hemoglobin F was associated with phenotypes AA, AC and SS in 1.16% of cases. The hemoglobinopathies were found in all the major ethnic groups in Parakou with a clear predominance among "Lokpa" (53.3%) and "Adja" (37.5%).
Conclusion: The hemoglobinopathy is a real public health problem in Parakou, it is necessary to establish or to legislate for mandatory testing for hemoglobinopathies at birth.
MOLECULAR PATHOGENESIS OF PREVALENT HEMOGLOBINOPATHIESChelsea Osayande
Hemoglobinopathies are congenital disorders resulting from hemoglobin abnormalities. Major forms are often severe, their management is difficult and associated with a great psychosocial impact on patients and their families.
These hemoglobinopathies may be due to alterations in certain globin chains that include:
Absence of production
Diminished production
Abnormal structure.
The clinically significant hemoglobinopathies include α- and β-thalassemia, sickle cell disease, HbE disease, and HbC disease.
simlpe approach to anemia in children , how to diagnose anemia in kids ,types of anemias ,causes of anemia , iron deficeincy anemia, hemolytic anemias , laboratory tests in anemia ,
The document discusses modern trends in the management of thalassemia. It summarizes that thalassemia is a genetic blood disorder resulting from reduced or absent production of hemoglobin chains. For patients with thalassemia major, regular blood transfusions are the main treatment to prevent anemia and suppress ineffective red blood cell production. The transfusions aim to maintain hemoglobin levels between 10-12 gm/dl. Managing iron overload from frequent transfusions also requires chelation therapy.
1) This study examined hematologic abnormalities in 64 HIV-infected children on highly active antiretroviral therapy (HAART) in Ethiopia.
2) The prevalence of anemia, thrombocytopenia and neutropenia decreased after starting HAART, from 53.1%, 18.8%, and 7.8% to 21.9%, 7.8%, and 4.7% respectively.
3) Mean hemoglobin levels, CD4 count, platelet count, and total leukocyte count increased significantly after HAART initiation.
IDA is the most common form of anemia worldwide, affecting approximately 50% of anemia cases. It results from prolonged negative iron balance in the body due to factors like inadequate iron intake, decreased absorption, increased demand, or blood loss. Diagnosis involves a complete history, physical exam, and lab tests showing low indicators of iron stores like serum ferritin and iron, along with an elevated TIBC. Treatment aims to replenish iron stores and typically consists of oral iron supplementation of 200mg elemental iron per day for 3-6 months.
1. The study examined gene frequencies and disease characteristics of sickle cell disease among tribal and Chetti communities in Wayanad district, Kerala, India.
2. Gene frequencies for the sickle cell trait ranged from 1.9-19.6% across communities, with the highest in Wayanadan Chettis. Many homozygotes were observed with the oldest being 48 years old.
3. The disease was mild in 52.2% of cases, with painful crises in 43.5% and splenomegaly and leg ulcers each in 4.3%. Survival of patients appears higher in Kerala than other states.
Iron deficiency anemia (IDA) is the most common type of anemia globally, affecting approximately 1.6 billion people. It results from prolonged negative iron balance in the body due to inadequate intake, decreased absorption, increased demand, or losses. Diagnosis involves a complete blood count and serum iron studies showing microcytic anemia and low iron stores. Treatment focuses on oral iron supplementation of 200 mg elemental iron daily for 3-6 months to replenish stores and resolve symptoms, with intravenous options for intolerances or malabsorption. Education aims to prevent recurrences through lifestyle modifications.
This document discusses iron deficiency anemia (IDA), including its definition, epidemiology, etiology, diagnosis, and treatment. Some key points include:
- IDA is the most common type of anemia worldwide, affecting approximately 1.6 billion people. It occurs when iron levels and stores in the body are depleted.
- Risk factors for IDA include blood loss, inadequate iron intake, increased iron demands, and impaired iron absorption. Young children, women of childbearing age, and those with chronic blood loss are most at risk.
- IDA is diagnosed based on low hemoglobin and iron indicator levels. Treatment involves oral or intravenous iron supplementation to replenish iron stores. Managing the underlying cause is also important for preventing
Globin_gene_haplotype_analysis_in_a_ghanian_population_presentationSifuma Andrew Njenga
This document discusses globin gene haplotype analysis in a Ghanaian population. It provides background on sickle cell disease and how it is caused by inheritance of two Hb S alleles from a mutation in the β-globin gene. The main objective is to analyze dried blood samples to determine haemoglobin haplotypes. Restriction fragment length polymorphism analysis will be used to amplify DNA from samples and digest with restriction enzymes to identify which β-globin haplotypes are present in Ghanaians. The hypothesis is that samples will exhibit a higher proportion of Cameroon, Bantu, and Benin haplotypes.
Anemia is a common complication of chronic kidney disease that can cause fatigue. While the kidneys normally produce erythropoietin to stimulate red blood cell production, CKD patients have relative erythropoietin deficiency. This leads to anemia which, if left untreated, can negatively impact quality of life and cardiovascular health. Erythropoiesis-stimulating agents and iron supplementation are used to treat anemia in CKD, though the appropriate hemoglobin target level remains an area of ongoing research and debate given risks identified with higher targets in some studies.
Genetics of fetal hemoglobin in tribal Indian patients sickle cell anemiaSujata Singh
This study investigated the association between genetic variants known to influence fetal hemoglobin (HbF) levels and HbF levels in 240 Indian patients with sickle cell anemia and 60 with sickle cell trait. Genotyping was performed for variants in the BCL11A, HMIP, and HBB genes. All three quantitative trait loci were associated with HbF levels, with the strongest association seen for the HBB Xmn1 variant. The BCL11A and HMIP variants were also associated with HbF levels and explained a percentage of trait variance. This is the first such study in India and indicates these genetic factors influence HbF levels and likely disease severity in this population.
Inherited abnormalities of hemoglobin synthesis characterised by structurally abnormal hemoglobin variants.
The disorders of Hb divided into 2 main groups :-
Structural globin chain variants such as Sickle cell anaemia
Disorders of synthesis of globin chains such as Thalassemia
The document discusses haemoglobin disorders and haemoglobinopathies. It provides details on the molecular basis, inheritance patterns, clinical presentation and diagnosis of conditions like thalassaemia, sickle cell disease and other haemoglobin variants. Key points include that haemoglobin disorders are globally common due to ancestral mutations, are usually inherited in an autosomal recessive pattern, and can be diagnosed through blood tests, family history and molecular genetic analysis. Screening programs have helped identify carriers and provide prenatal diagnosis services.
This document presents a case study of a rare HbSE disorder detected in a 24-year-old male in Balasore District, Odisha, India. Testing confirmed the patient had a double heterozygous state of sickle cell and hemoglobin E through various lab tests. Further testing found the patient's mother was a sickle cell carrier and father a hemoglobin E carrier, explaining how the patient acquired this rare disorder. The patient was mostly asymptomatic with occasional joint/bone pains and was advised on genetic counseling and testing. This represents the first reported case of HbSE disorder in Northern Coastal Odisha.
This document provides an introduction and background to a study on sickle cell anemia (SCA) in Jos North, Nigeria. It discusses SCA as a genetic blood disorder with high morbidity and mortality. The incidence, prevalence, diagnosis and treatment of SCA in Jos North is examined. Improving outcomes for children with SCA through early diagnosis, prophylactic therapy and bone marrow transplants is discussed. The research problem is identified as a lack of knowledge among residents about SCA implications and the need for screening before marriage. The study aims to educate residents on SCA and identify carriers to reduce disease transmission risk. The scope covers selected primary health centers in Jos North.
A Study of Anemia Among children in Mansoura University Children's Hospital; ...Kareem Alnakeeb
A "Study of Anemia" Among children in Mansoura University Children's Hospital. It involved 30 male and female children aged from 5 to 120 months old, who were hospitalized in Mansoura University Children's Hospital. The study was performed in the period between 19 March 2018 and 18 April 2018.
This document discusses thalassemia in Bangladesh and advances in the management of beta thalassemia major. It notes that Bangladesh has high carrier and frequency rates of thalassemia major and hemoglobin E. The key advances in managing beta thalassemia major discussed include regular blood transfusions to maintain optimal hemoglobin levels, iron monitoring and chelation therapy to remove excess iron, and hematopoietic stem cell transplantation which can cure thalassemia major in some cases. Complications from iron overload continue to be a major challenge in the long term management of patients.
Đặc điểm điện di huyết sắc tố và kiểu gene hội chứng thai tích dịch do Hb Bart'sVõ Tá Sơn
Electrophoresis features and genotypes of Hb Bart’s hydrops fetalis
Đặc điểm điện di huyết sắc tố và kiểu gene hội chứng thai tích dịch do Hb Bart's
bsvotason
bs võ tá sơn
bác sĩ võ tá sơn
How to Add Chatter in the odoo 17 ERP ModuleCeline George
In Odoo, the chatter is like a chat tool that helps you work together on records. You can leave notes and track things, making it easier to talk with your team and partners. Inside chatter, all communication history, activity, and changes will be displayed.
A workshop hosted by the South African Journal of Science aimed at postgraduate students and early career researchers with little or no experience in writing and publishing journal articles.
A review of the growth of the Israel Genealogy Research Association Database Collection for the last 12 months. Our collection is now passed the 3 million mark and still growing. See which archives have contributed the most. See the different types of records we have, and which years have had records added. You can also see what we have for the future.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Introduction to AI for Nonprofits with Tapp NetworkTechSoup
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
This slide is special for master students (MIBS & MIFB) in UUM. Also useful for readers who are interested in the topic of contemporary Islamic banking.
Strategies for Effective Upskilling is a presentation by Chinwendu Peace in a Your Skill Boost Masterclass organisation by the Excellence Foundation for South Sudan on 08th and 09th June 2024 from 1 PM to 3 PM on each day.
2. INTRODUCTION:
Hemoglobin mutations form the most common human single disorders
About 698 genetically different hemoglobin variants are found scattered all over the world causing various
hemoglobinopathies.
About 5.2% of the world population (and more than 7% of pregnant females) carry a significant variant.
. About 1.1% of couples around the world are at risk for having children with a hemoglobin disorder of which 2.7
per 1000 conceptions are actually affected.
Hemoglobin disorders contribute to 3.4% of mortality in children aged less than five years worldwide.
Among these disorders, sickle cell syndromes and thalassemia constitute major public health problems.
The frequency of beta-thalassemia trait in India has been reported to vary from <1 to 17% depending on the
region studied, with an average of 3.3%.
The average frequency of sickle cell disease is 4.3%.
Hemoglobin E has been reported as the most common hemoglobin (Hb) variant in Southeast Asia and the
second most prevalent worldwide.
The clinical manifestations of these hemoglobinopathies can vary from asymptomatic states to severe, lifelong,
transfusion-dependent anemia with multi organ involvement and severely reduced life expectancy.
3. AIM & OBJECTIVES
To determine the prevalence of hemoglobinopathies in patients with microcytic hypochromic
anemia and to assess the suitability of using high performance liquid chromatography (HPLC)
routinely for screening antenatal cases and patients with anemia.
4. MATERIALS & METHODS
- A total of 4335 cases received from Mar 2007 - Nov 2011 for hemoglobin (Hb) variant analysis were studied for
various hemoglobinopathies and variants. The tests were performed on BIO RAD ‘VARIANT’.
- The instrument utilizes the principle of high performanc liquid chromatography (HPLC).
- Patients included cases of microcytic hypochromic anemia, referred to this centre where a co-existent
hemoglobinopathy was suspected, while other cases were of anemia with no apparent underlying cause,
antenatal cases, transfusion requiring children and adults and their family members.
- About 2 ml of blood sample was collected in EDTA vial. They were stored at 4-8°C and were analyzed in batches
once a week.
- Patients referred to us either already had a hemogram and a peripheral blood smear (PBS) reported or it was
concurrently asked for.
- Concurrent iron deficiency anemia (IDA) was ruled out on the basis of iron studies including serum iron
levels, total iron binding capacity, transferrin saturation and serum ferritin levels.
- Samples with abnormal results were also run on KX-21 hematologyanalyzer to obtain hemoglobin values and
indices.
5. - Sickling test was performed using freshly prepared sodium meta bisulphite when S-window was
eluted in the sample.
- Other confirmatory tests including acid and alkaline electrophoresis were done when required.