An agent-based simulation model for estimating bicycle flows at the local scale level.
Presentation slides from International Cycling Safety Congress (ICSC) 2018 in Barcelona.
Spatial analysis and modelling of bicycle accidents and safety threatsMartin L
This presentation was given at the International Cycling Safety Congress 2015 in Hannover/Germany.
I have argued, that bicycle accidents are spatial by their very nature. Thus GIS analysis and geospatial models can help to gain a better understanding of bicycle accidents and to develop evidence-based safety strategies.
Lessons learned from the winter cycling surveyMartin L
For a recently finished project we conducted an online survey on winter cycling in February 2015. The outcome serve as evidence basis for future developments of information tools for winter cyclists.
Apart from the results as such (which were enormously helpful, to some extent surprising and indeed relevant for what we are doing), we have learned quite a lot about the winter cycling community and how to engage with them. Additionally some fundamental and methodological insights could have been gained.
Polis Conference 2015: OGD for bicycle promotionMartin L
In this presentation I demonstrate how the standardization and publication of authoritative road data as OGD can boost efforts in bicycle promotion. The case study is from Salzburg, Austria, where a comprehensive bicycle routing portal (www.radlkarte.info) is fueld by OGD.
Agent-based simulation of bicycle traffic - Background informationMartin L
Brief introduction for a student project which deals with the possibilities of agent-based simulation approaches for estimating bicycle traffic in an urban road network.
Spatial analysis and modelling of bicycle accidents and safety threatsMartin L
This presentation was given at the International Cycling Safety Congress 2015 in Hannover/Germany.
I have argued, that bicycle accidents are spatial by their very nature. Thus GIS analysis and geospatial models can help to gain a better understanding of bicycle accidents and to develop evidence-based safety strategies.
Lessons learned from the winter cycling surveyMartin L
For a recently finished project we conducted an online survey on winter cycling in February 2015. The outcome serve as evidence basis for future developments of information tools for winter cyclists.
Apart from the results as such (which were enormously helpful, to some extent surprising and indeed relevant for what we are doing), we have learned quite a lot about the winter cycling community and how to engage with them. Additionally some fundamental and methodological insights could have been gained.
Polis Conference 2015: OGD for bicycle promotionMartin L
In this presentation I demonstrate how the standardization and publication of authoritative road data as OGD can boost efforts in bicycle promotion. The case study is from Salzburg, Austria, where a comprehensive bicycle routing portal (www.radlkarte.info) is fueld by OGD.
Agent-based simulation of bicycle traffic - Background informationMartin L
Brief introduction for a student project which deals with the possibilities of agent-based simulation approaches for estimating bicycle traffic in an urban road network.
Safety and accessibility as major keys for bicycle-friendly citiesMartin L
Bikeability can significantly contribute to liveable cities. This presentation presents 3 spatial analysis tools that support planners and decision makers in their effort for more bicycle-friendly cities. The presentation was given at a miniconference on "Quality of Life" at the Department of Geoinformatics, University of Salzburg
Mining dockless bikeshare and dockless scootershare trip data - Stefanie Brod...PyData
In September 2017, dockless bikeshare joined the transportation options in the District of Columbia. In March 2018, scooter share followed. During the pilot of these technologies, Python has helped District Department of Transportation answer some critical questions. This talk will discuss how Python was used to answer research questions and how it supported the evaluation of this demonstration.
A presentation conducted by Mr Matthew Berryman, SMART Infrastructure Facility, University of Wollongong. Presented on Tuesday the 1st of October 2013.
Modelling and analysis of large systems of infrastructure systems carries with it a number of challenges, in particular around the volume of data and the requisite
complexity (and thus computing resources required) of models. In this paper we discuss both some novel architectures for scalability of modelling as well as for fusion and relevant visualisation of large data sets. We have a particular focus on geospatial infrastructure data visualisation.
Planning for accessibility in growing citiespeter_kant
How to keep your city/region accessible if there is no such thing as an average day? The transport network is contiously under disruption due to roadworks and events. Inhabitants, visitors and companies are faced with (unexpected) hindrance. The Road Works Optimizer is a planning instrument that helps cities in optimizing their road works and event schedules to minimize hindrance.
OmniUpdate User Training Conference 2015: Custom Maps Integrated with Campus ...C. Daniel Chase
There's no denying it – campus maps are important. Students need to locate their classes, visitors need to find offices and performance venues, and prospective students need to view the campus layout. It's time to move away from static PDFs and toward dynamic maps integrated into your site. In this session, Dan will overview how to directly integrate data from GIS systems and separate data stores, such as a database or XML maintained in OU Campus. Learn how to embed open data maps into your web pages and customize them with locations, bus routes, accessible routes, and more. Additionally, find out how to edit your underlying base map using open source tools.
Last week I gave another PhD progress report at ZGIS' PhD seminar. I showed a couple of preliminary results of a study I'm planning to publish in spring 2016.
Suggestions, comments and questions are highly welcome at this stage.
Safety and accessibility as major keys for bicycle-friendly citiesMartin L
Bikeability can significantly contribute to liveable cities. This presentation presents 3 spatial analysis tools that support planners and decision makers in their effort for more bicycle-friendly cities. The presentation was given at a miniconference on "Quality of Life" at the Department of Geoinformatics, University of Salzburg
Mining dockless bikeshare and dockless scootershare trip data - Stefanie Brod...PyData
In September 2017, dockless bikeshare joined the transportation options in the District of Columbia. In March 2018, scooter share followed. During the pilot of these technologies, Python has helped District Department of Transportation answer some critical questions. This talk will discuss how Python was used to answer research questions and how it supported the evaluation of this demonstration.
A presentation conducted by Mr Matthew Berryman, SMART Infrastructure Facility, University of Wollongong. Presented on Tuesday the 1st of October 2013.
Modelling and analysis of large systems of infrastructure systems carries with it a number of challenges, in particular around the volume of data and the requisite
complexity (and thus computing resources required) of models. In this paper we discuss both some novel architectures for scalability of modelling as well as for fusion and relevant visualisation of large data sets. We have a particular focus on geospatial infrastructure data visualisation.
Planning for accessibility in growing citiespeter_kant
How to keep your city/region accessible if there is no such thing as an average day? The transport network is contiously under disruption due to roadworks and events. Inhabitants, visitors and companies are faced with (unexpected) hindrance. The Road Works Optimizer is a planning instrument that helps cities in optimizing their road works and event schedules to minimize hindrance.
OmniUpdate User Training Conference 2015: Custom Maps Integrated with Campus ...C. Daniel Chase
There's no denying it – campus maps are important. Students need to locate their classes, visitors need to find offices and performance venues, and prospective students need to view the campus layout. It's time to move away from static PDFs and toward dynamic maps integrated into your site. In this session, Dan will overview how to directly integrate data from GIS systems and separate data stores, such as a database or XML maintained in OU Campus. Learn how to embed open data maps into your web pages and customize them with locations, bus routes, accessible routes, and more. Additionally, find out how to edit your underlying base map using open source tools.
Last week I gave another PhD progress report at ZGIS' PhD seminar. I showed a couple of preliminary results of a study I'm planning to publish in spring 2016.
Suggestions, comments and questions are highly welcome at this stage.
Extraction of bicycle commuter trips from day long gps trajectoriescdc2013workshop
Gerald Richter, Christian Rudloff, Anita Graser
Austrian Institute of Technology, Austria
Topic: “Extraction of bicycle commuter trips from day-long GPS trajectories”
This presentation was featured at the 11th OECD Rural Development Conference held on 9-12 April 2018 in Edinburgh, Scotland (UK).
More information: www.oecd.org/rural/rural-development-conference/
S4C Colloquium Aveiro 2016
https://scientistsforcyclingaveiro2016.wordpress.com/
University of Aveiro (Portugal),
Region of Aveiro (CIRA), ABIMOTA/Portugal Bike Value
and the European Cyclists’ Federation (ECF)
with its global network Scientists for Cycling (S4C)
Micromobility at TU Berlin: Analysis of demand across locations and drafting ...Sarah Westphal
The technical university Berlin is located in Berlin with campus locations across the city. The locations Ernst-Reuter-Platz, Severingelände/PTZ, Kaiserin-Augusta-Allee, Wedding Hum-boldthain, Wedding Seestraße, Steglitz-Zehlendorf and Campus EUREF were analyzed in re-gard to available mobility options such as local public transport and micromobility sharing ser-vices. It was concluded that it is in some cases not possible to travel from one location to anoth-er in the time available between two courses. To determine the need for an own micromobility service operated by the TU Berlin, university members were surveyed.
Within the scope of this thesis, the term micromobility refers to light vehicles for personal transport which are permitted for road transport in Germany and are currently used in sharing services. This includes:
• Bicycles
• Pedelecs
• E-Scooters (footbikes)
• larger E-Scooters (electric motor scooters)
The analyses and survey revealed an existing need and interest in the use of an own Micromo-bility service at the TU Berlin.
I compared various ways of transportation modeling. The traditional, four-step model was demonstrated using FSUTMS (the standard Florida model, running on CUBE/Voyager). The activity-based model for South Florida was in development at the time, but not yet ready for prime time. The paper analyzed the benefits of the newer activity-based methodology, which is essentially a form of agent-based modeling. Since popular city simulation games such as SimCity 5 use agent-based modeling, I demonstrated how this works with a similar program (Cities in Motion 2) and suggested that this type of game could be used in planning, perhaps even as a public involvement tool to let citizens see firsthand how a scenario might play out.
CycleStreets: Our Story - presentation to Net2Camb eventCycleStreets
Here is our presentation at the Net2Camb event.
See:
http://www.cyclestreets.net/blog/2010/12/29/net2camb-meetup-building-cyclestreets/
http://net2camb.org/2011/01/january-net2camb-meetup-building-cyclestreets/
Similar to A very high resolution bicycle flow model (20)
Mehr Rad im Kreis Ravensburg – Fachseminar für Gemeinden.
Im Rahmen der AGFK Weiterbildung referiert Dr. Martin Loidl über die Möglichkeit den Arbeitsweg zur Gesundheitsförderung zu nutzen. Dabei berichtet er u.a. aus dem interdisziplinären Forschungsprojekt GISMO (www.gismoproject.com).
Looking at cycling mobility through geographical lensesMartin L
The Cycling Competence Austria network hosted an entire session at VeloCity 2019 in Dublin. This contribution covers some aspects of cycling research, done at the University of Salzburg.
GISMO - Interdisziplinäre Forschung zur Förderung aktiver, gesunder Pendelmob...Martin L
Das Forschungsprojekt GISMO (www.gismoproject.com) untersuchte ob und mit welchen Effekten aktive Pendelmobilität als Mittel zur Gesundheitsförderung in Unternehmen propagiert werden kann.
Das Forschungsprojekt und die wesentlichen Ergebnisse werden bei der Jahrestagung der Österreichischen Gesellschaft für Public Health (ÖGPH) 2019 vorgestellt.
Spatial Information for Bicycle Flow ModellingMartin L
Slides (in German language) from #GeoSummit2018 presentation.
The agent-based simulation model of cycling flows, developed in the FamoS project, is presented.
Was haben Gesundheit, Pendeln und räumliche Gegebenheiten miteinander zu tun?
In diesem allgemeinverständlichen Vortrag wird das Forschungsprojekt GISMO vorgestellt. In diesem Vorhaben werden Evidenzgrundlagen erstellt und zusammengefügt, die die Förderung aktiver, gesunder Pendelmobilität im Rahmen eines betrieblichen Mobilitätsmanagements unterstützen.
Das Forschungsforum Mobilität 2017, veranstaltet vom BMVIT, stand unter dem Motto "Mobilität & Gesundheit". Ein idealer Anlass den knapp 200 Delegierten einen Updatebericht zum Projekt GISMO zu geben.
Mehr Informationen gibt es unter www.gismoproject.com.
This presentation was given at the fourth "Floating Car Data Forum", organized by Salzburg Research. The idea was to transfer concepts and methods from FCD research and application to bicycle traffic. The presentation provides a rough overview of potential future research avenues.
Räumliche Information und RadverkehrssicherheitMartin L
Im Rahmen der Ringvorlesung "Aktive Mobilität" an der TU Wien, standen am 5.4.2017 räumliche Informationssyteme und deren Beitrag zu einer Erhöhung der Radverkehrssicherheit im Vordergrund.
#AAG2015 presentation on OSM attribute inconsistency and semantic heterogeneityMartin L
This presentation was given in a session dedictated to OpenStreetMap studies during the annual meeting of the Association of the American Geographers (AAG) in Chicago, IL.
Spatial Modelling with OGD and OSM data - UNIGIS Workshop, SalzburgMartin L
Spatial modelling allows for the employment of different data sources in a harmonized application. In this context knowledge about the data model and data quality are the main success factors.
This presentation, held in German language at the recent UNIGIS MSc workshop, gives a thematic overview and demonstrates core concepts based on a current project (www.radlkarte.info), where OGD and OSM data were used in order to provide user-tailored routing recommendations for bicyclists.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Nucleic Acid-its structural and functional complexity.
A very high resolution bicycle flow model
1. A very high resolution
bicycle flow model
Dr. Martin Loidl | martin.loidl@sbg.ac.at
Barcelona, October 10 2018
2. 2
LOIDL, M., TRAUN, C. & WALLENTIN, G. 2016. Spatial patterns and temporal dynamics of urban bicycle crashes—A case study from Salzburg (Austria). Journal of Transport
Geography, 52, 38-50.
19. 19
Travel time, s
min max avg std
simulated 1 186 16.61 16.09
bc 1 8450 766.55 883.83
Distance, m
min max avg std
simulated 67.86 19938.01 3743.62 2708.73
bc 2.7 52583.85 4060.07 5912.52
Speed, m/s (including stops)
min max avg std
simulated 0.58 34.6 4.69 1.9
bc 0.05 35.65 4.76 1.64
21. 21
LOIDL, M., WALLENTIN, G., WENDEL, R. & ZAGEL, B. 2016. Mapping Bicycle Crash Risk Patterns on the Local Scale. Safety, 2, 17.
22. 22
integration of existing data
into simulation model
temporal resolution: second
spatial resolution: meter
application use cases:
a. simulating infrastructural measures
b. simulation of interventions and
cycling promotion
c. spatially and temporally explicit
exposure data
it‘s still a model
data demand and dependency
model complexity and required
computing power
ongoing research
bicycle-observatory.zgis.at
@gicycle_
gicycle.wordpress.com