This thesis presents a new method for modeling propeller-airframe interaction using a three dimensional vortex particle-panel code. The method combines a flexible aerodynamic panel code with a pseudo-steady slipstream model that discretizes rotational effects onto vortex particle point elements. Verification and validation studies were conducted to ensure an accurate model. The method provides a useful tool for conceptual aircraft design by allowing rapid testing of configurations without requiring volume grids. The thesis describes the development of the new method and presents simulations of several configurations to demonstrate its capabilities.