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David Wadsworth Vice President Global Product Strategy
A Passion for Noni Research
 
 
7 bottles/day/7 years 2155 days 17,885 bottles 4,471 cases 7 Liters of TNJ/Day
$300,000. 2 Years.
 
 
Obsessed with Noni Research
Brunswick Labs Press Release ,[object Object],[object Object],[object Object]
 
Placebo is TNJ without Noni
TNJ is a Superior Antioxidant
TNJ Aids in Quality of Life
TNJ Increases Energy & Physical Performance
 
Human Clinical Studies – to Date ,[object Object],[object Object],[object Object],[object Object],[object Object],© 2007 TAHITIAN NONI INTERNATIONAL
The effect of TAHITIAN NONI® Juice on antioxidant and immune function ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Testing of antioxidant activity of TNJ on blood plasma and erythrocytes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
2001-2006 Journal Publications
2007 Journal Publications
2008 Journal Publications—so far
 
TNI and Its Research on Noni Johannes Westendorf University of Hamburg  Germany
Soon after its foundation, Morinda Inc. began  with systematic research on noni. They built up their own  Department of Research and Development (R&D) and a  Health and Technical Advisory Board (HTAB) , later replaced by the  Global Advisory Board (GAB).
Foundation of the company  Morinda Inc.  Ralph Heinicke publication on noni Furusawa and Hirazumi Anti-cancer effects of noni
Topic of research No. of publications  % of total ______________________________________________________ Ethnopharmacology 84 19.5 Chemistry  74 17.2 Toxicology 42   9.76 Cancer&Immunsystem 37   8.60 Pharmacology 33   7.67 Inflammation 25   5.81 Antimicrobial 24   5.58 Antioxidant 24   5.58 Review articles 24   5.58 Botany of Noni 18   4.18 Other topics 17   3.95 Noni Plant cell culture 16   3.72 Hormonal action of Noni   7   1.62 Product quality   5   1.16 Total 430 100
Ethno-Pharmacology
The old Polynesians took  noni juice to increase their endurance at long fishing trips. Do we have evidence that noni juice increases the endurance?
Experiment on athletes (N=20)
Cortisol plasma level Day time Cortisol blood level (ng/ml) Day light Thalamus Hypothalamus Pituitary Adrenals Cortisol ACTH CRF Start End
200 ml TNJ
 
Jonas Student Susanne Student Johannes Supervisor
Simla Postdoc
Cortisol blood level (mean of N=4) Values are  Mean of 4
The endurance is very much dependent  on the body's load with antioxidants.  Endogenous antioxidants Katalase Superoxid dismutase Glutathion NADH/NADPH Exogenous antioxidants Vitamin C Vitamin E Flavonoids Catechines Selenium et c.
Exogenous antioxidants   have to be absorbed and distributed to the site,  where the radicals are, in order  to be effective Endogenous antioxidants   are always present in our body. Their concentration can be influenced by exogenous compounds (food ingredients)
Role of Antioxidants O 2  H 2 O + CO 2 SAR Hydroxyl- radicals Tissue damage Antioxidants destroy Glucose Inflammation Ageing Cancer
Depletion of antioxidants causes exhaustion (fatigue)
Measurement of Antioxidant capacity The measurement of the  antioxidant capacity (AOA) should be performed  inside  of our body in order to be predictive
Antioxidative potency of blood, one hour after intake of 200ml of test compound 20 volunteers per group Serum Red blood cells O.118 0.055 0.6 2.7
Research on the safety of TNJ ,[object Object],[object Object],[object Object],[object Object]
Genotoxicity studies performed with TNJ ,[object Object],[object Object]
Animals on the Marquesa islands  eat noni leaf and fruit. They are healthy, and especially their liver is very clean.
As a result of TNI’s intense  studies on the safety of TNJ, the EU commission stated: “ Noni juice is safe for human consumption”
This statement was  confirmed   by the EU after some publications stated that noni juice could damage the liver.
Research on the quality of TNJ TNI invested enormous money and effort in the definition and maintenance of the quality of their noni products. The company controls and defines every step from the harvest until distribution of the products. Other companies often buy noni concentrates prepared at tropical islands far from their control, dilute it and add preservatives and artificial flavoring compounds.
CPX = (2 E ,4 Z ,7 Z )-Decatrienoic acid) Other polyunsaturated fatty acids (PUFA) Quercetin Scopoletin HPLC-chromatogram of a TNJ ethylacetat extract  with marker compounds indicated
HPLC-Analysis of a competitor noni   (black) and TNJ (red) Collection of peak and further analysis bc GC/MS
GC/MS analysis of peak isolated from HPLC run of the competitor noni
Summary ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object]
 
Two Additional Novel Food Applications
Extension of Use of Fruit
Noni Leaf as Food
Benefits of Noni Leaf
Green tea infusion Noni leaf infusion
World Class Research

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A Passion for Noni Research

  • 1. David Wadsworth Vice President Global Product Strategy
  • 2. A Passion for Noni Research
  • 3.  
  • 4.  
  • 5. 7 bottles/day/7 years 2155 days 17,885 bottles 4,471 cases 7 Liters of TNJ/Day
  • 7.  
  • 8.  
  • 10.
  • 11.  
  • 12. Placebo is TNJ without Noni
  • 13. TNJ is a Superior Antioxidant
  • 14. TNJ Aids in Quality of Life
  • 15. TNJ Increases Energy & Physical Performance
  • 16.  
  • 17.
  • 18.
  • 19.
  • 23.  
  • 24. TNI and Its Research on Noni Johannes Westendorf University of Hamburg Germany
  • 25. Soon after its foundation, Morinda Inc. began with systematic research on noni. They built up their own Department of Research and Development (R&D) and a Health and Technical Advisory Board (HTAB) , later replaced by the Global Advisory Board (GAB).
  • 26. Foundation of the company Morinda Inc. Ralph Heinicke publication on noni Furusawa and Hirazumi Anti-cancer effects of noni
  • 27. Topic of research No. of publications % of total ______________________________________________________ Ethnopharmacology 84 19.5 Chemistry 74 17.2 Toxicology 42 9.76 Cancer&Immunsystem 37 8.60 Pharmacology 33 7.67 Inflammation 25 5.81 Antimicrobial 24 5.58 Antioxidant 24 5.58 Review articles 24 5.58 Botany of Noni 18 4.18 Other topics 17 3.95 Noni Plant cell culture 16 3.72 Hormonal action of Noni 7 1.62 Product quality 5 1.16 Total 430 100
  • 29. The old Polynesians took noni juice to increase their endurance at long fishing trips. Do we have evidence that noni juice increases the endurance?
  • 31. Cortisol plasma level Day time Cortisol blood level (ng/ml) Day light Thalamus Hypothalamus Pituitary Adrenals Cortisol ACTH CRF Start End
  • 33.  
  • 34. Jonas Student Susanne Student Johannes Supervisor
  • 36. Cortisol blood level (mean of N=4) Values are Mean of 4
  • 37. The endurance is very much dependent on the body's load with antioxidants. Endogenous antioxidants Katalase Superoxid dismutase Glutathion NADH/NADPH Exogenous antioxidants Vitamin C Vitamin E Flavonoids Catechines Selenium et c.
  • 38. Exogenous antioxidants have to be absorbed and distributed to the site, where the radicals are, in order to be effective Endogenous antioxidants are always present in our body. Their concentration can be influenced by exogenous compounds (food ingredients)
  • 39. Role of Antioxidants O 2 H 2 O + CO 2 SAR Hydroxyl- radicals Tissue damage Antioxidants destroy Glucose Inflammation Ageing Cancer
  • 40. Depletion of antioxidants causes exhaustion (fatigue)
  • 41. Measurement of Antioxidant capacity The measurement of the antioxidant capacity (AOA) should be performed inside of our body in order to be predictive
  • 42. Antioxidative potency of blood, one hour after intake of 200ml of test compound 20 volunteers per group Serum Red blood cells O.118 0.055 0.6 2.7
  • 43.
  • 44.
  • 45. Animals on the Marquesa islands eat noni leaf and fruit. They are healthy, and especially their liver is very clean.
  • 46. As a result of TNI’s intense studies on the safety of TNJ, the EU commission stated: “ Noni juice is safe for human consumption”
  • 47. This statement was confirmed by the EU after some publications stated that noni juice could damage the liver.
  • 48. Research on the quality of TNJ TNI invested enormous money and effort in the definition and maintenance of the quality of their noni products. The company controls and defines every step from the harvest until distribution of the products. Other companies often buy noni concentrates prepared at tropical islands far from their control, dilute it and add preservatives and artificial flavoring compounds.
  • 49. CPX = (2 E ,4 Z ,7 Z )-Decatrienoic acid) Other polyunsaturated fatty acids (PUFA) Quercetin Scopoletin HPLC-chromatogram of a TNJ ethylacetat extract with marker compounds indicated
  • 50. HPLC-Analysis of a competitor noni (black) and TNJ (red) Collection of peak and further analysis bc GC/MS
  • 51. GC/MS analysis of peak isolated from HPLC run of the competitor noni
  • 52.
  • 53.
  • 54.
  • 55.  
  • 56. Two Additional Novel Food Applications
  • 57. Extension of Use of Fruit
  • 58. Noni Leaf as Food
  • 60. Green tea infusion Noni leaf infusion