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ABC Primetime Investigative Report on Oxidative Stress Studies
1.
2. ABC Primetime Investigative Report
Clip used to say... For more information go to
ABCnews.com.
l $5 Million Dollars in orders came in.
l Stock went from $1 to over $20 Overnight!
l
Was Not Ready
No Infrastructure
l No Sales Team
l No Marketing Team
l
3. Research Initiated & Funded
University of Colorado
Children’s Hospital of Denver
University of Florida
University of Kentucky
University of Michigan
Louisiana State University
Ohio State University
Vanderbilt University
Glamorgan University, Wales
University Hospital, Brno, Czech Republic
University of Toronto/St. Michelle’s Hospital
Mexican Institute of Social Security, Mexico City
Sahlgrenska University Hospital, Goteberg, Sweden
4. Research Being Conducted
Skin Cancer
Altitude Sickness
Photo Aging of the Skin
Renal Failure
Osteoarthritis
Pulmonary Hypertension
Periodontal Disease
Optic Neuropathy
Heart Disease
Coronary Artery Bypass Graft Failure
Asthma
Duchenne Muscular Dystrophy
Metabolic Syndrome
Non-Alcoholic Fatty Liver Disease
HIV/AIDS - Associated Lipodystrophy
7. PUBMED.GOV
U.S. National Library of Medicine
Natitional Institutes of Health
(Studies listed on Oxidative Stress and Nrf2)
STUDIES
OXIDATIVE STRESS STUDIES
119,938
DNA
19,780
Cancer
13,094
Cardiovascular Disease
18,823
Stroke
2,203
Inflammation
14,519
Diabetes
10,253
Parkinson’s
3,515
Liver
14,373
Aging
9,833
Alzheimer’s
4,608
Dementia
3,527
Kidney Disease
5,309
Depression
872
Schizophrenia
396
Glutathione
26,056
Source: pubmed.gov
11/18/2013
NRF2 STUDIES
3,741
781
996
269
65
567
172
116
595
167
87
44
102
9
3
1,026
8. The induction of human superoxide dismutase and
catalase in vivo: A fundamentally new approach to
antioxidant therapy | 2006
Protandim is Clinically Proven to Reduce
Oxidative Stress by 40% in 30 Days.
Current Completed Studies on Protandim
15 Published Peer-Reviewed Studies
& Scientific Papers
6 US Patents
# 7,241,461 , # 7,384,655, # 7,579,026,
# 7,923,045, # 8,221,805, # 8,435,574
9. VIRGINIA COMMONWEALTH UNIVERSITY
Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure.
American Heart Association Journal, Circulation (2009)
Clinical Perspective - Protandim can prevent Right Ventricular (RV) dysfunction and pathological
remodeling in the setting of persistent pressure overload. “Induction of myocardial nuclear factor
E2-related factor 2 and heme-oxygenase 1 with a dietary supplement (Protandim) prevented
fibrosis and capillary loss and preserved RV function despite continuing pressure overload.”
Conclusions: “Protandim also prevented the death of heart cells and significantly lowered osteopontin (OPN-1) levels by more than 50%.” Protandim has the ability to “effectively activate the
transcription factor Nrf2, a signal to the cell’s DNA to increase expression of a network of antioxidants, anti-inflammatory, and anti-fibrotic genes.” Nrf2 preserves the expression of vascular
endothelial growth factor and prevents RV failure without modifying lung angioproliferation.
10. THE OHIO STATE UNIVERSITY
Protandim attenuates intimal hyperplasia in human saphenous veins cultured
ex vivo via a catalase-dependent pathway
Free Radical Biology and Medicine (2010)
Abstract: Human saphenous veins (HSV) are widely used for bypass grafts despite their relatively low
long-term patency. To evaluate the role of reactive oxygen species (ROS) signaling in intima hyperplasia
(IH), an early stage pathology of vein graft disease, and to explore the potential therapeutic effects of
up-regulating endogenous antioxidant enzymes, we studied segments of HSV cultured ex vivo in an
established ex vivo model of HSV IH. Protandim, known to activate Nrf2 and increase the expression of
endogenous antioxidant enzymes in several in vitro and in vivo models, was used in this study.
Results: Protandim inhibits the formation of IH and the increase in cellular proliferation in HSV
cultured ex vivo. Further, Protandim attenuates rise in superoxide (O2-.) levels in HSV, attenuates rise
in lipid peroxidation (4-HNE) levels in HSV, enhances increases the activities of HO-1, total SOD and
catalase in HSV, enhances the protein level andd immunoflourescent intensity of catalase in HSV,
blocks medial thickening as well as cellular proliferation in established ex-vivo model of the early
stages of vein-graft disease. These abilities of Protandim, as demonstrated in HSV harvested from
patients undergoing coronary artery bypass grafting, makes it an attractive candidate for future
consideration as a pharmacological treatment of vein-graft failure.
11. Multiple Sclerosis Journal
www.msj.sagepub.com
5th Joint Triennial Congress of the European and Americas Committees for Treatment and
Research in Multiple Sclerosis Amsterdam, The Netherlands (2011) | Dr. J. van Horssen
Nrf2 activators: a novel strategy to promote oligodendrocyte survival in multiple sclerosis?
Results:
1. BG-12, tBHQ, SFN and protandim are well-tolerated and strongly induce Nrf2-driven antioxidant
enzyme production in oligodendrocytes, with protandim showing the most potent induction.
2. Nrf2 activators are able to protect oligodendrocytes against ROS-induced cytotoxicity.
Conclusions: Our findings indicate that several Nrf2 activators are able to significantly increase
antioxidant enzyme production in oligodendrocytes. Interestingly, protandim, a dietary supplement
consisting of herbal ingredients, was the most potent inducer and therefore may be the most suited
as a therapeutic strategy. Importantly, Nrf2-mediated antioxidant enzyme expression in
oligodendrocytes resulted in enhanced oligodendrocyte survival during an oxidative attack.
Dr. J. van Horssen received research grants from BiogenIdec, the maker of Tecfidera (BG-12)
12. What is
- Protandim is a Nrf2 Synergizer not just an antioxidant
VS
- SYNERGY... 1800% more effective with the composition
- Clinically proven to reduce oxidative stress by 40%
and slow the aging process.
1 to 1 Ratio
1,000,000 to 1 Ratio
Milk Thistle
Supports liver
health
Turmeric
Provides
a healthy
response to
inflammation
Green Tea
Increases
metabolism;
burns fat
Bacopa
Ashwagandha
Increases
Used for
SOD and
centuries in
catalase
India for
production numerous
applications
13. TrueScience Anti-Aging Cream
Offers Unsurpassed Anti-Aging Benefits:
TrueScience Anti-Aging Cream provides the latest in skin care technology. Its powerful anti-wrinkle formula
boosts six skin-rebuilding essentials and contains 11 ingredients effective in improving skin tone, texture
and appearance. Unlock the science of anti-aging and unlock the secret of a younger-looking you with
TrueScience Anti-Aging Cream.
1st Day
60 Days
- Protects skin from free radical damage
- Lifts and firms, brightens and protects
- Promotes even skin tone for a youthful glow
- Moisturizes and hydrates without an oily residue
- Utilizes proven benefits of Protandim
- Lightens age spots and evens skin tone
- Dermatologist tested
- Noticeably diminishes fine lines and deep
wrinkles, smooths crow’s feet
- Reduces the cycle of inflammatory effects that
lead to premature aging
- Softens creases and plumps visible fine lines
14. LifeVantage Canine Health Case-Control Study
Rowdy Conclusions
Attribute Measured
Duration (minutes)
177
8,800
Distance
Day 25
88
# of Throws
Day 0
17,700
18.5
33.8
Improvement
Over 2x the number of throws
Twice the distance covered
1.82 Longer time to lameness
82% Improvement
In Performance and Endurance
After 25 Days of Taking Canine Health
15. Attribute Measured
Day 0
Day 25
Improvement
DESCRIPTION:
LifeVantage’s laser focus on the fight against oxidative stress has benefitted humans the
world over. Now, we have developed Canine Health, a daily supplement specifically
formulated for dogs. Using Nrf2 activating ingredients, collagen, glucosamine,
chondrotin, hyaluronic acid and omega-3 fatty acids, it is specifically formulated to:
Reduce oxidative stress
Support brain, skin and eye functions
Support joint function, mobility and flexibility
Support cognitive function
Reducing oxidative stress in dogs may help to reduce problems associated with normal
aging in canines such as decreased social interaction, loss of prior house-training,
sleep disturbance, decreased mobility and possible disorientation.
16. VALIDATION:
Animal Health Consultants, a premier third-party animal health testing company, has conducted a double-blind,
placebo-controlled clinical study to validate that Canine Health reduces oxidative stress in dogs. The results of
the study indicated a trend in the reduction of oxidative stress, improvement in mobility and improved cognitive
function. LifeVantage will continue to conduct additional clinical studies to further support our findings and the
efficacy of Canine Health.
DIRECTIONS FOR DAILY TABLET USE:
PRODUCTINGREDIENTS:
Dosage is based on weight
Toy 4-10 lbs. ½ tablet
Small 11-29 lbs. 1 tablet
Medium 30-69 lbs. 2 tablets
Large 70-109 lbs. 3 tablets
Giant 110+ lbs. 4 Tablets
Active Ingredients per 1.85 gram tablet:
Milk Thistle Extract (Silybum marianum) seed, Ashwagandha
Extract (Withania somnifera) root, Green Tea Extract
(Camellia sinensis) leaf, Bacopa Extract (Bacopa monnieri)
whole herb, Turmeric Extract (Curcuma longa) rhizome,
Omega-3 Fatty Acids, Type II Chicken Sternum Collagen
Inactive Ingredients:
Chicken Flavoring, Chicken Liver Flavoring, Dicalcium
Phosphate, Hydroxypropyl Cellulose, Hydroxypropyl
Methylcellulose, Magnesium Stearate, Maltodextrin,
Microcrystalline Cellulose, Silicon Dioxide, Smoked Bacon
Flavoring, Stearic Acid, Sucrose Fatty Acid Ester
CAUTIONS:
Safe use in pregnant animals or animals
intended for breeding has not been proven.
If animal’s condition worsens or does not
improve, stop product administration and
consult your veterinarian.
18. Back to the Story...
- Stock dropped from $20.00 to $0.07!
- Online... Didn’t work
- In stores... 1/2 bottle per store per month
19. “This needs to be person to person.
There is a giant story here that
needs to be told.”
- 2009 Direct Sales vs Retail Sales
- Network Marketing out sold retail by 300%
David Brown
20. “The FIRST 135,000 Distributors
to join a Network Marketing
Company with predictable
success, participate in a
Once-in-a-Lifetime
Opportunity!”
- Direct Selling Association
LFVN as
Network Marking
2010 $11M
2011 $39M
2012 $126M
2013 $208M
21. LIFEVANTAGE CORPORATION
DISTRIBUTOR COMPENSATION S UMMARY
COMPANY OVERVIEW
LifeVantage Corporation (Nasdaq:LFVN), a leader in Nrf2 science and the maker of Protandim® , the Nrf2 Synergizer ®
patented dietary supplement, is a science based network marketing company. LifeVantage is dedicated to visionary
science that looks to transform wellness and anti-aging internally and externally with products that dramatically reduce
oxidative stress at the cellular level. As of October 1, 2013, we sell our products in the United States, Japan, Hong Kong,
Australia, Mexico and Canada primarily through a network of independent distributors, and to preferred customers. The
Company was founded in 2003 and is headquartered in Salt Lake City, UT.
OUR PRODUCTS
LifeVantage offers scientifically-validated products focused on healthy living and the reduction of oxidative stress.
Protandim ® is a patented dietary supplement clinically proven to combat oxidative stress. Oxidative stress is a natural
consequence of cellular metabolism and is associated with many of the undesirable effects of aging. Our skin care
cream, LifeVantage TrueScience ® , is a unique, scientifically based anti-aging skin care product formulated to target the
visible signs of aging on the skin. Our companion pet supplement, Canine Health ®, incorporates some of the same active ingredients as Protandim ® to combat oxidative stress in dogs.
DISTRIBUTORS
LifeVantage markets its products through a network of independent contractors called Distributors. For purposes of this
summary, an “Active Distributor” is a Distributor who placed an order for products or promotional materials during the
most recent three-month period. In the United States, the Company had approximately 67,000 Active Distributors as of
the end of its most recent Fiscal Year 2013 (July 1, 2012 – June 30, 2013).
22. LIFEVANTAGE CORPORATION
DISTRIBUTOR COMPENSATION S UMMARY
COMPENSATION
The LifeVantage compensation plan enables Distributors to earn compensation early and often as they sell our products.
Some elements of our compensation plan are paid weekly, allowing new Distributors to receive compensation quickly.
We believe more frequent payments of earned compensation help us retain new Distributors by allowing them to experi ence success soon after enrolling. We also offer a variety of incentive programs to our Distributors for achieving speci fied sales goals. We also offer various training resources to help our Distributors become more effective. We believe our
compensation plan, incentive programs and training resources help to motivate and prepare our Distributors for success.
INDEPENDENT DISTRIBUTOR MOTIVATION AND TRAINING
In addition to our compensation plan, we have established a broad array of programs and tools to support, motivate
and train our Distributors, including:
• professionally-designed training materials Distributors can utilize in their sales efforts;
• A wide variety of incentive programs and promotions; and
• Local, national and worldwide company-sponsored events.
LifeVantage and our Distributors conduct thousands of events to educate and motivate our Distributors each year. We
have an on-line media channel, LVN Media, through which we deliver educational and motivational content to our Dis tributors. We introduced LifeVantage University, an on-line training system consisting of interactive modules designed to
create a personalized learning experience for our Distributors, in fiscal 2013.
23. COMMISSIONS
Distributors can earn commissions based on the sale of products by Distributors in his/her network of sponsored Distribu tors in all countries where the Company does business. The Company also sells promotional materials that do not gener ate commissions for Distributors.
For the period September 1, 2012 through August 31, 2013, the Company paid approximately $91,978,180 in com missions and sales compensation globally. The following table shows the average commissions paid during the period
(September 1, 2012 through August 31, 2013) to Distributors at various ranks in the LifeVantage Compensation Plan,
including the average percentage of total active Distributors and the average earned commissions at each level.
The average commission paid to active Distributors each month was $285.48, or $3,425.75 on an annualized basis.
Note that these figures do not represent a Distributor’s profit, as they do not consider expenses incurred by a Distributor
in the promotion of his/her business and do not include retail markup income.
Commission
1
2
3
4
5
6
7
8
9
10
19.04%
11.73%
4.10%
1.98%
0.85%
0.32%
0.10%
0.05%
0.02%
0.01%
The earnings of the Distributors in this chart are not necessarily representative of the income, if any, that a Distributor can or
will earn through the LifeVantage Compensation Plan. Distributors’ success will depend on individual diligence, work effort
and market conditions. LifeVantage does not guarantee any income or rank success.
24. Commission
1
2
3
4
5
6
7
8
9
10
This Summary is intended to provide truthful comprehensive information regarding the income earned by LifeVantage
Distributors. A copy of this Summary must be presented to prospective Distributors anytime Distributor compensation is
presented or discussed, or any type of income claim or earnings representation is made, including one-on-one meetings.
Earnings representations include: (1) statements of average Distributor earnings, (2) statements of non-average Distribu tor earnings, (3) statements of Distributor earnings ranges, (4) Distributor income testimonials, (5) Distributor lifestyle
claims, and (6) hypothetical claims.
Copies of this Summary may be printed or downloaded from the LifeVantage website, www.LifeVantage.com .
1
1
4
1
0
0
0
0
0
0
25. Commission
1
2
3
4
5
6
7
8
9
10
This Summary is intended to provide truthful comprehensive information regarding the income earned by LifeVantage
Distributors. A copy of this Summary must be presented to prospective Distributors anytime Distributor compensation is
presented or discussed, or any type of income claim or earnings representation is made, including one-on-one meetings.
Earnings representations include: (1) statements of average Distributor earnings, (2) statements of non-average Distribu tor earnings, (3) statements of Distributor earnings ranges, (4) Distributor income testimonials, (5) Distributor lifestyle
claims, and (6) hypothetical claims.
Copies of this Summary may be printed or downloaded from the LifeVantage website, www.LifeVantage.com .
1
1
4
1
0
0
0
0
0
0
31. 6. ELITE POOL
Paid Monthly
4% of the total global commissionable sales are put into a pool and are paid to qualified Elite Pro 7
through Master Pro 10 distributors as seen below.
33. Master Track System
(OJT)
On The Job
Training
GETTING STARTED
CHECKLIST
Day One
Enroll by completing a LifeVantage application (see page 6).
Establish clearly defined “written goals,” your “why” and contact your
support team (see page 7).
50%
Start your “Database” of your top-20 contacts (see page 13-14).
Invite 3-5 contacts with the help of your enroller to attend your
two days (see pages 21-24).
Date: _____________________ Time: ______________________
Keep a record of each person you invite and follow up with by
logging this information on your Accountability & Tracking sheet
100%
100%
YO U
50%
A DV I S O R
YO U
Use Protandim daily. Suggested serving size: one tablet per day.
Borrow one bottle and 10 samples from your enroller to get your
business started today. Replace the bottles and samples when you
receive your business pack.
Start your On the Job Training (OJT) with your enroller - this is the
secret to success. (see page 2-3)
Day Two
Invite
three-way call, etc.)
Track each person you invite and follow up with, by logging this
information on your Accountability & Tracking sheet (25-28).
A
Set-up your personal website by going to: lifevantage.com and login
Prepare your schedule and participate in weekly conference calls
Attend weekly “The Proven Plan Training Call”
Review LifeVantage website at lifevantage.com.
Plan to attend the next Leadership Training Event. To enroll go to
lifevantage.com and register early.
Date: _____________________ Location: ______________________
B
C
You Bridge Clients
To Your Advisors
35. Ask Yourself These Life-Changing Questions...
Are you looking for better health?
Are you looking for financial freedom?
Can you see yourself sharing this with others?
