Autoimmune disorders occur when the immune system attacks the body's own tissues, though the causes are unclear. Dipeptidyl peptidase IV (DPP IV) is a key enzyme that modulates the immune system by cleaving proteins to activate or deactivate immune responses. Lower DPP IV activity can lead to the accumulation of undigested peptides that may trigger autoimmunity. DPP ZYMETM provides standardized DPP IV to support healthy immune function and digestion by breaking down dietary peptides implicated in autoimmune diseases.

1. DPP Zyme TM
Autoimmune disorders are some of the most disabling health conditions we face today. The
reason why some of us develop an immune response to our own body remains unclear. We
know that autoimmunity runs in families, which indicates that genes may be partly to blame.
It is also likely that how our immune system responds to environmental triggers plays a large
part in the development of autoimmune conditions.
Peptidases are enzymes that are responsible for the breakdown of proteins. Peptidases
embedded in cellular membranes cleave foreign proteins in order to present their antigens
to immune cells. This activates or inactivates the immune response, making peptidases a key
to the modulation of the immune system.
Dipeptidylpeptidase IV (DPP IV) is an essential peptidase for antigen presentation. DPP IV
promotes a normal cellular immune response and is important for the production of immune
messengers that regulate immunity and inflammation. Preliminary research has shown that
DPP IV cleaves and inactivates tumor necrosis factor alpha (TNF-a), regulating the
extracellular TNF-a concentration. TNF-a is an immune messenger that promotes
inflammation and plays a significant part in autoimmune disorders such as inflammatory AOR04140
bowel disease, rheumatoid arthritis and ankylosing spondylitis. 90 Vegi-caps 100mg
Over activation of the immune system during an infection can SUPPLEMENT FACTS: Serving Size: 1 Capsule
drive the immune system into a state of autoimmunity, which leads
Protease (from Aspergillus oryzae) 30,000 HUT
to cellular damage and chronic inflammation. Autoimmunity can
Protease (from A. oryzae) 500 DPP-IV
be promoted through the inappropriate activation of white blood
Protease AM (from Aspergillus melleus) 8.5 AP
cells by dietary peptide sequences such as gliadins found in
gluten.
The problem is made worse by a lack of DPP IV enzyme activity in certain gastrointestinal conditions. Lower
peptidase levels reduce the body's ability to metabolize proteins, especially proteins containing proline because
DPP IV is needed for their assimilation. This results in the accumulation of undigested peptide fragments, which are
thought to elicit an immune response that can inflame the lining of the gastrointestinal tract.
Oral supplementation with DPP IV enzymes prevents the activation of the immune system by breaking down
dietary peptides from food - a significant benefit for those suffering from autoimmune diseases.
DPP ZYME™ from AOR is a unique protease formula that provides standardized DPP IV activity.
References
Vojdani A, Bazargan M, Vojdani E, Samadi J, Nourian AA, Eghbalieh N, Cooper EL. Heat shock protein and gliadin
peptide promote development of peptidase antibodies in children with autism and patients with autoimmune
disease. Clin Diagn Lab Immunol. 2004 May;11(3):515-24.
Sedo A, Malik R. Dipeptidyl peptidase IV-like molecules: homologous proteins or homologous activities? Biochim
Biophys Acta. 2001 Dec 17;1550(2):107-16. Review.
Tiruppathi C, Miyamoto Y, Ganapathy V, Leibach FH. Genetic evidence for role of DPP IV in intestinal hydrolysis
and assimilation of prolyl peptides. Am J Physiol. 1993 Jul;265(1 Pt 1):G81-9.
The information and product descriptions are for information purposes only, and are not intended to provide medical advice to individuals. Consult with your physician if you have any health
concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes. @AOR 2006

2. DPP IV and Autoimmunity
2- Antigen presenting cell (APC)
recognizes the antigen.
Antigen is cleaved into smaller proteins
by peptidases such as DPP IV and
presented to immune cells
1- Infection:
Presence of bacteria
or virus (antigens) in the body
3- Immune activation:
White blood cells are
activated and scavenge
antigens.
Infection clears
5- Autoimmune
disease
6- Oral supplementation with proteases
and DPP IV promotes the complete
digestion of dietary peptides and reduces the
improper activation of the immune system 4- Cross reactivity: immune system is activated
by the incomplete breakdown of dietary proteins
such as casein from dairy and gluten from wheat
Advanced Orthomolecular Research www.aor.ca Innovative Research & Scientific Integrity
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