The document outlines the historical relationship between slavery and the growing divisions in the United States leading up to the Civil War, covering key events such as the Missouri Compromise, the Mexican-American War, and the tensions caused by the Compromise of 1850 and the Kansas-Nebraska Act. It highlights the impact of these events on sectionalism, including the Dred Scott decision and John Brown's raid, culminating in the election of 1860, which sparked secession among Southern states. The interplay of legislative compromises and conflicts over slavery is traced as a critical factor in the nation’s descent into civil war.